CN109172583A - A kind of pharmaceutical composition for burn and scald knife wound and preparation method thereof and purposes - Google Patents
A kind of pharmaceutical composition for burn and scald knife wound and preparation method thereof and purposes Download PDFInfo
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- CN109172583A CN109172583A CN201810979770.3A CN201810979770A CN109172583A CN 109172583 A CN109172583 A CN 109172583A CN 201810979770 A CN201810979770 A CN 201810979770A CN 109172583 A CN109172583 A CN 109172583A
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- Prior art keywords
- pharmaceutical composition
- burn
- wound
- knife wound
- scald
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of pharmaceutical composition for burn and scald knife wound and preparation method thereof and purposes, which includes following component: berberine, tetracycline, chloramphenicol and terramycin.Preferably, the berberine in the pharmaceutical composition, tetracycline, chloramphenicol, terramycin weight ratio be 1: 1: 1: 1.The present invention also provides the preparation method of the pharmaceutical composition for burn and scald knife wound, this method are as follows: weighs berberine, tetracycline, chloramphenicol and terramycin in proportion, smashs powdering to pieces, then with filtered through gauze be fine powder, bottling sealing is spare after evenly mixing.Present invention provides the purposes of the pharmaceutical composition for burn and scald knife wound of this method preparation.Pharmaceutical composition provided by the present invention for burn and scald knife wound and preparation method thereof and purposes, the composition of preparation can accomplish quick anti-inflammatory analgetic, reduce patient's pain, shorten treatment time, and preventing from scar.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof and purposes, and in particular, to one kind is used for burn and scald
Pharmaceutical composition of knife wound and preparation method thereof and purposes.
Background technique
Burn, scald are a kind of unexpected accident multiple acute injuries often occurred in daily life, they
Usually human body is by disorganization caused by extraneous different factor injuries.Chinese medicine claims " burning sore ", " burn and scald ", the origin cause of formation
Mainly since the high-temperature factors such as flame, hot water cause human skin and subcutaneous tissue to be burnt, so that fur is not deposited, sepage
Saliva is flowed, stain loses skin.It is light then influence beauty, it is heavy then cause a variety of constitutional symptoms.If without emergent management or treatment, often
Will cause patient by great pain, stay scar, even cause infection and cause complication and sequelae.
Knife wound is then another common exterior trauma in daily life, and traumatic hemorrhage needs hemostasis in time, Massive Bleeding
When can lead to shock, cause life danger, while bleeding is also with pain, inflammation etc..If bleeding cannot stop blooding in time, can
It deposits in vivo, macrophage swallows bacterium, initiationization clothes or initiation other diseases.
Currently, the surface of a wound is mainly smeared or be applied to the conventional method for the treatment of burn and scald knife wound with external drug, and will
Wound, which wraps up, to be prevented from infecting.Above-mentioned external drug is mostly ointment, and existing wound ointment deposits treatment burn and scald knife wound etc.
In following disadvantage: wound healing is slow, and treatment time is long；There is feeling of pain during treatment；For big face burn and scald knife wound therapeutic effect
Difference；Malpractice meeting scar etc..
Summary of the invention
The object of the present invention is to provide a kind of composition for exterior trauma and preparation method thereof and purposes, the compositions
Can quickly alleviating pain, repair rapidly epidermal tissue, erosion prevention and muscle growing, more after not from scar, it is without any side effects, and pharmaceutical formulation
Simply, economical and practical.
In order to achieve the above object, the present invention provides a kind of pharmaceutical compositions for burn and scald knife wound, wherein the medicine
Compositions include following component: berberine, tetracycline, chloramphenicol and terramycin.
The above-mentioned pharmaceutical composition for burn and scald knife wound, wherein berberine, Fourth Ring in the pharmaceutical composition
Element, chloramphenicol, terramycin weight ratio be (1~3): (1~4): (1~2): (1~2.5).
The above-mentioned pharmaceutical composition for burn and scald knife wound, wherein berberine, Fourth Ring in the pharmaceutical composition
Element, chloramphenicol, terramycin weight ratio be 1: 1: 1: 1.
The present invention also provides the preparation methods of the above-mentioned pharmaceutical composition for burn and scald knife wound, wherein described
Method are as follows: weigh berberine, tetracycline, chloramphenicol and terramycin in proportion, smash powdering to pieces, then with filtered through gauze be thin
Powder, bottling sealing is spare after evenly mixing.Berberine 100 are preferably used, 100, tetracycline, 100, chloramphenicol, soil is mould
Element 100；First these medicinal machines are smashed to pieces as powdery, then with filtered through gauze are fine powder, medication is bottled good spare.
The preparation method of the above-mentioned pharmaceutical composition for burn and scald knife wound, wherein smash into powder to pieces in the method
The particle size range of shape is 30~40 mesh；It is 80~120 mesh with the particle size range that filtered through gauze is fine powder.
Present invention provides the purposes of the pharmaceutical composition for burn and scald knife wound of above-mentioned method preparation, wherein
The pharmaceutical composition is used to prepare the external application medicinal powder for the treatment of burn and scald knife wound.
The purposes of the above-mentioned pharmaceutical composition for burn and scald knife wound, wherein the pharmaceutical composition when in use,
Cold boiling water wash clean affected part is first used, then is spread at injury with medicinal powder prepared by the pharmaceutical composition, until surface is equal at injury
Until perfusing, then wrapped up.Medicinal powder perfuses wound bleeding i.e. only, and exanthemv person can also be same as above method.
The purposes of the above-mentioned pharmaceutical composition for burn and scald knife wound, wherein the pharmaceutical composition when in use,
Cold boiling water wash clean affected part is first used, then with 800,000 units of Penicillin and analgin injection, Components In Antongding Injectate by 1: 1: 1
Volume ratio is converted together, is externally applied to affected part after being picked with absorbent cotton, the time be greater than or equal to 30 minutes after absorbent cotton is removed, then use institute
The medicinal powder for the pharmaceutical composition preparation stated is spread at injury, until wound perfuses, is finally wrapped up.For mild trauma
Person can use ancillary drug, can also not have to the above ancillary drug, directly use the pharmaceutical composition.For hurting severe one
It then needs to operate using ancillary drug by above procedure.The medicinal powder is served only for skin surface, does not take orally, if patient wound applies
Ointment for treating burn is crossed, has to ointment be cleaned up wound with cold boiling water, can use.If patient can it is very reluctantly if,
It can remove at burn and scald epidermis, then cold boiling water wash clean injury, direct drug injection powder is uniformly spread at injury, such
Words can not have to ancillary drug, burn and scald person's better effect, and what knife wound, bullet wound, wound festered infection or wounds streamed blood can
Can also clean affected part with cold boiling water with iodophor disinfection wash clean affected part, then medication powder is spread at injury, and haemostatic effect is aobvious
It writes, outside can not had to and wrapped up, be only the need to ensure that wound not drench water during medication.General scalds of motorcycle exhaust pipe,
Boiled water scald, can fully recover in these weeks of knife wound, and burn and scald mouth medicinal powder, which has spread pain and stood, to be subtracted, and medicinal powder, which has been spread, not to be had to
Wrapping.
Pharmaceutical composition provided by the present invention for burn and scald knife wound and preparation method thereof and having for purposes are following excellent
Point:
This is used for the pharmaceutical composition of burn and scald knife wound, is applied with wound pain after five minutes and reduces, upper complete medicine burn and scald person wound
Mouthful no pain, clearing heat and detoxicating, reducing internal heat, wound not easy infection burn dry mouth, wound healing time is fast, will not fester, not stay scar.
In use, the composition can accomplish quick anti-inflammatory, reduce patient's pain, shorten treatment time, patient can be made to exist
It is relieved pain in 10 minutes, and preventing from scar.To burn, scald, knife wound, wound infection person, the wound person of festering, bullet wound, ammunition wound
Deng there is significant curative effect.
Specific embodiment
A specific embodiment of the invention is further described below.
Provided by the present invention for the pharmaceutical composition of burn and scald knife wound, which includes following component: the coptis
Element, tetracycline, chloramphenicol and terramycin.
Preferably, the berberine in the pharmaceutical composition, tetracycline, chloramphenicol, terramycin weight ratio be (1~3): (1
~4): (1~2): (1~2.5).
It is highly preferred that the weight ratio of berberine, tetracycline, chloramphenicol, terramycin in the pharmaceutical composition is 1: 1: 1:
1。
Wherein, berberine is a kind of important alkaloid, can be extracted from the plants such as the coptis, Cortex Phellodendri, barberry.It has
Significant bacteriostasis.Common Halomine is called Berberine hydrochloride.Berberine can be to resisting pathogenic microbes, to a variety of thin
Bacterium such as shigella dysenteriae, tubercle bacillus, pneumococcus, typhoid bacillus and corynebacterium diphtheriae etc. has inhibiting effect, wherein to dysentery bar
Bacterium effect is most strong, is commonly used to the disease of digestive tracts such as treatment bacterial gastroenteritis, dysentery.
Tetracycline is compound most basic in Cyclomycin family antibiotic, itself and its esters are all yellow or flaxen
Crystal, it is extremely stable in the dry state.Tetracycline antibiotics are a kind of broad-spectrum antibiotics with perhydrophenanthrene parent nucleus, such is anti-
Raw element is widely used in infection caused by Grain-positive and negative bacteria, intracellular mycoplasma, Chlamydia and rickettsia.This
Outside, some countries including the U.S., tetracycline are also widely used as growth promoter and feed to animal.
Chloramphenicol is white or colourless needle-shaped or flaky crystal.In chloramphenicol molecule containing contraposition nitrophenyl group,
Propylene glycol and dichloroacetyl amido.Due to there is 2 asymmetric carbon atoms in chloramphenicol molecule, so chloramphenicol has 4 optics different
Structure body, wherein only laevoisomer has antibacterial ability.Chloromycetin series antibiotics may act on bacterium ribosome
50S subunit, and the synthesis of protein is obstructed, belong to biocidal property broad-spectrum antibiotic.Can be used for treat by typhoid bacillus, shigella dysenteriae,
It is infected caused by Escherichia coli, Bacillus influenzae, Brucella, pneumococcus etc..
Terramycin is yellowish color chips or sugar coated tablet, belongs to Tetracyclines, can be used for treating rickettsiosis, including popularity
The diseases such as typhus, matlazahuatl, black fever, yochubio, Mycoplasma Infections and chlamydia infections.Soil is mould
Element has the effect of broad-spectrum disease resistance pathogenic microorganism, is quick bacteriostatic agent, to certain bacteriums in bactericidal effect when high concentration.Terramycin pair
Staphylococcus aureus, pneumococcus, micrococcus scarlatinae, gonococcus, meningococcus, Escherichia coli, aerobacteria, will are congratulated
Pseudomonas, Yersinia, monocyte Listeria etc. have stronger antibacterial activity；In addition, terramycin to Richettsia, mycoplasma,
Chlamydia, actinomyces etc. also have strong effect.
The present invention also provides the preparation method of the pharmaceutical composition for burn and scald knife wound, this method are as follows: in proportion
Berberine, tetracycline, chloramphenicol and terramycin are weighed, smashs powdering to pieces, then with filtered through gauze is fine powder, is filled after evenly mixing
Bottle sealing is spare.Preferably use berberine 100,100, tetracycline, 100, chloramphenicol, terramycin 100；First by these
Medicinal machine is smashed to pieces as powdery, then with filtered through gauze is fine powder, and medication is bottled good spare.
Preferably, the particle size range for smashing powdering to pieces is 30~40 mesh；It is 80 with the particle size range that filtered through gauze is fine powder
~120 mesh.
Present invention provides the purposes of the pharmaceutical composition for burn and scald knife wound of this method preparation, the pharmaceutical compositions
Object is used to prepare the external application medicinal powder for the treatment of burn and scald knife wound.
The pharmaceutical composition when in use, first uses cold boiling water wash clean affected part, then the medicinal powder prepared with the pharmaceutical composition
It is spread at injury, until surface perfuses at injury, then is wrapped up.
For mild trauma person, ancillary drug can be used, ancillary drug can also not had to, directly use the pharmaceutical composition
Object.It then needs for hurting severe one using ancillary drug.
Below with reference to embodiment to pharmaceutical composition provided by the present invention for burn and scald knife wound and preparation method thereof with
Purposes is further described.
Examples 1 to 4
Material composition proportion preparation pharmaceutical composition shown in each embodiment difference according to the form below 1.Each raw material corresponds with phase
The national standard answered.
The list of ingredients (according to parts by weight) of 1. pharmaceutical composition of table.
| Raw material | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Berberine | 1 part | 3 parts | 2 parts | 2.5 part |
| Tetracycline | 1 part | 4 parts | 2 parts | 3 parts |
| Chloramphenicol | 1 part | 2 parts | 1.2 part | 1.8 part |
| Terramycin | 1 part | 2.5 part | 1.5 part | 2 parts |
The present invention also provides the preparation methods of the pharmaceutical composition of each embodiment, and the drug of each embodiment prepared
The purposes of composition.
This method are as follows: weigh berberine, tetracycline, chloramphenicol and terramycin in proportion, smash powdering, particle size range to pieces
For 30~40 mesh；It is again fine powder with filtered through gauze, particle size range is 80~120 mesh；Bottling sealing is spare after evenly mixing.
The pharmaceutical composition is used to prepare the external application medicinal powder for the treatment of burn and scald knife wound.When in use, it is first washed with cold boiling water
Clean affected part, then be spread at injury with medicinal powder prepared by the pharmaceutical composition, until surface perfuses at injury, then wrapped
It pricks.Medicinal powder perfuses wound bleeding i.e. only, and exanthemv person can also be same as above method.
Preferably for mild trauma person, ancillary drug can be used, ancillary drug can also not had to, directly use the medicine
Compositions.Then need to operate using ancillary drug by following procedure for hurting severe one: the pharmaceutical composition is when in use, first
With cold boiling water wash clean affected part, 1: 1: 1 body is then pressed with 800,000 units of Penicillin and analgin injection, Components In Antongding Injectate
Product ratio is converted together, is externally applied to affected part after being picked with absorbent cotton, the time more than or equal to 30 minutes after absorbent cotton is removed, then with the medicine
The medicinal powder of compositions preparation is spread at injury, until wound perfuses, is finally wrapped up.The medicinal powder is served only for skin table
Layer, does not take orally, if the coated ointment for treating burn of patient wound, has to ointment be cleaned up wound with cold boiling water, can make
With.If patient can it is very reluctantly if, can remove at burn and scald epidermis, then cold boiling water wash clean injury, direct drug injection powder is equal
Even is spread at injury, in this case can not have to ancillary drug, burn and scald person's better effect.Knife wound, bullet wound, wound
What mouth festered infection or wounds streamed blood can use iodophor disinfection wash clean affected part, and affected part can also be cleaned with cold boiling water, is then used
Medicinal powder is spread at injury, and haemostatic effect is significant, can not had to outside and be wrapped up, only be the need to ensure that wound not drench during medication
Water.General scalds of motorcycle exhaust pipe, boiled water scald, can fully recover, burn and scald mouth medicinal powder has spread pain in these weeks of knife wound
Pain is vertical to be subtracted, and medicinal powder, which has been spread, can also not have to wrapping.
Provided by the present invention for the pharmaceutical composition of burn and scald knife wound, it is orange-yellow medicinal powder, is directly spread on burn and scald knife
Affected parts, the ammunition wounds such as wound can all be cured with this medicine.It is reduced through over thousands of example clinical experiments have proved that being applied with wound pain after five minutes,
And can be relieved pain in 10 minutes, it for mild trauma, can be cured within 10 days and preventing from scar, for the tight of large area
Heavy losses wound, can cure and basic preventing from scar within 30 days.The surface of a wound is several close to periwound skin tissue after wound healing
No color differnece, cure rate are up to 94% or more.Over the course for the treatment of, the composition can accomplish quick anti-inflammatory, reduce patient's pain
Hardship shortens treatment time, and preventing from scar.
It is discussed in detail although the contents of the present invention have passed through above preferred embodiment, but it should be appreciated that above-mentioned
Description is not considered as limitation of the present invention.After those skilled in the art have read above content, for of the invention
A variety of modifications and substitutions all will be apparent.Therefore, protection scope of the present invention should be limited to the appended claims.
Claims (8)
1. a kind of pharmaceutical composition for burn and scald knife wound, which is characterized in that the pharmaceutical composition includes following component:
Berberine, tetracycline, chloramphenicol and terramycin.
2. being used for the pharmaceutical composition of burn and scald knife wound as described in claim 1, which is characterized in that the pharmaceutical composition
In berberine, tetracycline, chloramphenicol, terramycin weight ratio be (1~3): (1~4): (1~2): (1~2.5).
3. being used for the pharmaceutical composition of burn and scald knife wound as claimed in claim 2, which is characterized in that the pharmaceutical composition
In berberine, tetracycline, chloramphenicol, terramycin weight ratio be 1: 1: 1: 1.
4. a kind of preparation method of the pharmaceutical composition for burn and scald knife wound as described in any one of claims 1 to 3,
It is characterized in that, the method are as follows: berberine, tetracycline, chloramphenicol and terramycin are weighed in proportion, smash powdering to pieces,
It is again fine powder with filtered through gauze, bottling sealing is spare after evenly mixing.
5. the preparation method for the pharmaceutical composition of burn and scald knife wound as claimed in claim 4, which is characterized in that described
The particle size range for smashing powdering in method to pieces is 30~40 mesh；It is 80~120 mesh with the particle size range that filtered through gauze is fine powder.
6. a kind of purposes of the pharmaceutical composition for burn and scald knife wound of method as claimed in claim 4 preparation, feature
It is, the pharmaceutical composition is used to prepare the external application medicinal powder for the treatment of burn and scald knife wound.
7. the purposes for the pharmaceutical composition of burn and scald knife wound as claimed in claim 6, which is characterized in that the drug
Composition when in use, first uses cold boiling water wash clean affected part, then be spread at injury with medicinal powder prepared by the pharmaceutical composition,
Until surface perfuses at injury, then wrapped up.
8. the purposes for the pharmaceutical composition of burn and scald knife wound as claimed in claim 7, which is characterized in that the drug
Composition when in use, first uses cold boiling water wash clean affected part, then with 800,000 units of Penicillin and analgin injection, antondin
Injection is converted together by 1: 1: 1 volume ratio, and affected part, general after the time is greater than or equal to 30 minutes are externally applied to after being picked with absorbent cotton
Absorbent cotton removal, then be spread at injury with medicinal powder prepared by the pharmaceutical composition, until wound perfuses, finally wrapped
It pricks.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810979770.3A CN109172583A (en) | 2018-08-27 | 2018-08-27 | A kind of pharmaceutical composition for burn and scald knife wound and preparation method thereof and purposes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810979770.3A CN109172583A (en) | 2018-08-27 | 2018-08-27 | A kind of pharmaceutical composition for burn and scald knife wound and preparation method thereof and purposes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109172583A true CN109172583A (en) | 2019-01-11 |
Family
ID=64916236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810979770.3A Pending CN109172583A (en) | 2018-08-27 | 2018-08-27 | A kind of pharmaceutical composition for burn and scald knife wound and preparation method thereof and purposes |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686548A (en) * | 2005-05-08 | 2005-10-26 | 纪辉 | Ulcer quieting medicine its preparation and use |
| CN101352450A (en) * | 2008-09-10 | 2009-01-28 | 孟华 | Prescription of compound external-use ulcer powder |
| CN101850000A (en) * | 2010-06-22 | 2010-10-06 | 张十方 | Chinese and western medicinal composition for treating empyrosis |
| CN104383286A (en) * | 2014-12-08 | 2015-03-04 | 湖南科技大学 | Paste for treating burns and scalds and preparation method of paste |
| CN106074738A (en) * | 2016-06-02 | 2016-11-09 | 刘国珍 | A kind of medicine treating skin injury and preparation method thereof |
| CN107625724A (en) * | 2016-07-15 | 2018-01-26 | 张立军 | 'Compound berberine ointment |
-
2018
- 2018-08-27 CN CN201810979770.3A patent/CN109172583A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686548A (en) * | 2005-05-08 | 2005-10-26 | 纪辉 | Ulcer quieting medicine its preparation and use |
| CN101352450A (en) * | 2008-09-10 | 2009-01-28 | 孟华 | Prescription of compound external-use ulcer powder |
| CN101850000A (en) * | 2010-06-22 | 2010-10-06 | 张十方 | Chinese and western medicinal composition for treating empyrosis |
| CN104383286A (en) * | 2014-12-08 | 2015-03-04 | 湖南科技大学 | Paste for treating burns and scalds and preparation method of paste |
| CN106074738A (en) * | 2016-06-02 | 2016-11-09 | 刘国珍 | A kind of medicine treating skin injury and preparation method thereof |
| CN107625724A (en) * | 2016-07-15 | 2018-01-26 | 张立军 | 'Compound berberine ointment |
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| Title |
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| 项嫣: "黄连素液外敷治疗烧伤42例分析", 《吉林医学》 * |
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Application publication date: 20190111 |
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