CN109157768A - A kind of TCD,transcranial Doppler and magnetosonic stimulating system and method with mobile rotating device - Google Patents
A kind of TCD,transcranial Doppler and magnetosonic stimulating system and method with mobile rotating device Download PDFInfo
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- CN109157768A CN109157768A CN201811044649.8A CN201811044649A CN109157768A CN 109157768 A CN109157768 A CN 109157768A CN 201811044649 A CN201811044649 A CN 201811044649A CN 109157768 A CN109157768 A CN 109157768A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/002—Magnetotherapy in combination with another treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/12—Magnetotherapy using variable magnetic fields obtained by mechanical movement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
- A61N2007/0026—Stimulation of nerve tissue
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Abstract
A kind of TCD,transcranial Doppler and magnetosonic stimulating system and method with mobile rotating device, there is the first signal generator for generating repetition pulse signal, for generating the second signal generator of ultrasonic excitation signal, for carrying out the power amplifier of power amplification to ultrasonic excitation signal, the sound collimator for being injected with ultrasonic coupling agent for converting electrical signals to the ultrasonic transducer of acoustical signal and being connected on ultrasonic transducer bottom surface, for positioning the stereotaxic apparatus of tested sample, for positioning the ultrasonic transducer bracket of ultrasonic transducer, load the moving in rotation bracket for generating the static magnet in magnetic field, tested sample is located on the heating cushion of stereotaxic apparatus, ultrasonic transducer is located on ultrasonic transducer bracket, ultrasonic transducer bracket is located on the pedestal of stereotaxic apparatus, and enable acoustical signal be vertically targeted to by The stimulated zone of test sample sheet.The present invention realizes the introducing in magnetic field and removes, and accurate stimulation is able to carry out, with very high spatial resolution.
Description
Technical field
The present invention relates to a kind of TCD,transcranial Dopplers and magnetosonic stimulating apparatus.More particularly to a kind of with mobile rotating device
TCD,transcranial Doppler and magnetosonic stimulating system and method.
Background technique
TCD,transcranial Doppler stimulation as a kind of novel neuromodulation technology, because with Noninvasive, spatial resolution height, can
The features such as realizing deep stimulation is attracting more and more attention of people.And stimulated through cranium magnetosonic, it is to be stimulated in TCD,transcranial Doppler
On the basis of introduce magnetic field, but the principle of the two is not identical.TCD,transcranial Doppler stimulation is using low intensive ultrasonic wave to mind
Regulated and controled through activity, mechanism may be the mechanical sensitivity of cell ion channel, it is also possible to molecule caused by acoustic pressure by
The activation of body, mechanism are still unintelligible.And the principle stimulated through cranium magnetosonic is then effect of the ion in nerve fiber in ultrasonic wave
It is lower to vibrate, and then cutting magnetic induction line generates induced current and electric field, carries out direct regulation and control to neural electrical activity, is to be based on leading
The Hall effect of electrical tissue.Through the stimulation of cranium magnetosonic in addition to having the characteristics that ultrasound, it is also equipped with the characteristic of electric field, thus in neural tune
Prosecutor face has unique advantage, is increasingly becoming the new technology that people study neuroscience field.
TCD,transcranial Doppler stimulates the still unintelligible in the development and application that still limit the technology to a certain degree of mechanism, and through cranium
Magnetosonic stimulation also needs more to explore as a kind of novel neuromodulation technology, all various action and functions.No matter
It is to probe into the mechanism of TCD,transcranial Doppler stimulation, or all needed to the research of the effect and potential mechanism stimulated through cranium magnetosonic perfect
Apparatus and method.
Summary of the invention
It is easy to use the technical problem to be solved by the invention is to provide a kind of easy to operate, it is able to carry out accurate stimulation
The TCD,transcranial Doppler and magnetosonic stimulating system and method with mobile rotating device.
The technical scheme adopted by the invention is that: a kind of TCD,transcranial Doppler and magnetosonic stimulation system with mobile rotating device
System includes the first signal generator for generating repetition pulse signal being sequentially connected in series, for generating ultrasonic action
The second signal generator of signal, is used for electric signal the power amplifier for carrying out power amplification to ultrasonic excitation signal
The sound collimator for being converted to the ultrasonic transducer of acoustical signal and being connected on the ultrasonic transducer bottom surface, the sound collimator
It is inside injected with ultrasonic coupling agent, the stereotaxic apparatus for positioning tested sample is additionally provided with, for positioning ultrasonic transducer
Ultrasonic transducer bracket, and load for generate the magnetic field for acting on tested sample static magnet moving in rotation bracket,
Wherein, the tested sample is located on the heating cushion of the stereotaxic apparatus, and the ultrasonic transducer is located in described
On ultrasonic transducer bracket, the ultrasonic transducer bracket is located on the pedestal of stereotaxic apparatus, and makes below sonic transducer
The conversion of sound collimator after acoustical signal can vertically be targeted to the stimulated zone of tested sample.
The moving in rotation bracket includes the pedestal that can be moved, the support rod being vertically fixed on the pedestal,
The supporting bar top is articulated and connected one end of static magnet support rod by flexural pivot, and the other end of the static magnet support rod formed
There is the loading chute for loading static magnet.
The static magnet support rod can horizontal direction be rotated by 360 ° and can vertical direction be rotated by 90 °.
The ultrasonic transducer bracket includes firm banking, is vertically installed with and is able to carry out on the firm banking
The Z axis support component of vertical adjustment, the upper end of the Z axis support arm is horizontally disposed by the connection of the first cruciform fastening for falsework and can be into
The other end of one end of the X-axis support arm of row Level tune, the X-axis support arm is connected by the second cruciform fastening for falsework for fixing
The energy converter fixation kit of ultrasonic transducer is provided with the scale for being laterally adjusted on the X-axis support arm.
The Z axis support component includes: the fixed adjusting collet on the fixed base in bottom end, the adjusting collet
Upper end is provided with the scale for adjusting height inserted with the Z axis support arm that can be moved up and down on the Z axis support arm,
It is threaded with after the height that Z axis support arm adjusts to setting on the side wall for adjusting collet, Z axis support arm is consolidated
The first fixed fixed screw, the upper end of the Z axis support arm connect one end of X-axis support arm by the first cruciform fastening for falsework.
First cruciform fastening for falsework includes the first columnar body, is respectively formed with and is used in first columnar body
Through the laterally inserted hole of X-axis support arm one end and being longitudinally inserted into for the Z axis support arm upper end in Z axis support component
Hole, and setting corresponding with the laterally inserted hole for making the first columnar body and X-axis support arm is fixed to each other
Second fixed screw, and with it is described be longitudinally inserted into the corresponding setting in hole for making the first columnar body and Z axis support arm
End is fixed and adjusts the third fixed screw of the first columnar body rotation angle.
Second cruciform fastening for falsework includes the first columnar body, the use being horizontally formed in first columnar body
In the horizontal through hole for running through the X-axis support arm, setting corresponding with the horizontal through hole is used to make the first columnar body
The 4th fixed screw being fixed to each other with the X-axis support arm, the neighbouring horizontal through hole in first columnar body
Side is longitudinally formed with the insertion of the energy converter fixation kit for installing energy converter fixation kit hole, solid with the energy converter
Determine the corresponding setting of module insertion aperture for making the first columnar body and the energy converter fixation kit is fixed to each other the
Five fixed screws.
The energy converter fixation kit includes the energy converter fixes sleeve for installing ultrasonic transducer, for clamping
The energy converter fixture of energy converter fixes sleeve, be integrally formed in energy converter fixture top for being inserted into the second cross buckle
The energy converter fixture mounting post that the energy converter fixation kit of part inserts in the hole, and for being inserted in the energy converter fixation kit
Enter the fixture nut that the upper port in hole is threadedly coupled with the top of the energy converter fixture mounting post, wherein the transducing
Device fixture mounting post also passes through the 5th fixed screw in the second cruciform fastening for falsework and is fixed to each other with first columnar body, institute
State the positive stop lug boss of position-limiting action from being formed with one week on the outside of energy converter fixes sleeve.
A method of it is that will be used to generate weight for TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device
The pulse signal of the repetition rate for the setting that first signal generator of recovering pulse signal generates is sent into for generating ultrasonic action
The second signal generator of signal, second signal generator generates ultrasonic excitation signal by external trigger mode, and is sent into use
In the power amplifier for carrying out power amplification to ultrasonic excitation signal, the ultrasonic signal feeding through power amplifier amplification is used for will
Electric signal is converted to the ultrasonic transducer of acoustical signal, and the acoustical signal after conversion is vertically targeted to the thorn of tested sample through sound collimator
Swash region；Meanwhile the static magnet being supported movement being placed in immediately ahead of tested sample by moving in rotation bracket, it realizes through cranium magnetic
Acoustical coupling electro photoluminescence.
It, will be quiet by the static magnet support rod for passing through moving in rotation bracket when only carrying out TCD,transcranial Doppler stimulation to tested sample
Magnet rotates horizontally 180 °, makes static magnet far from tested sample；When needing to change the big of induction field that magnetic field and sound field are formed
Hour, static magnet vertical direction or horizontal direction are rotated by set angle by the static magnet support rod of moving in rotation bracket.
A kind of TCD,transcranial Doppler and magnetosonic stimulating system and method with mobile rotating device of the invention, can pass through shifting
The rotation of dynamic moving in rotation bracket realizes the introducing in magnetic field and removes, and conveniently realizing TCD,transcranial Doppler and stimulating stimulates with through cranium magnetosonic
The mutual conversion of two kinds of stimulation modes, and the change of magnetic direction can be realized by moving in rotation bracket, to realize electric thorn
Excitation answers the adjusting of direction of an electric field and size, and then studies TCD,transcranial Doppler stimulation and regulate and control to nervous activity through the stimulation of cranium magnetosonic
Effect and mechanism.Operation of the present invention is simple, easy to use, is able to carry out accurate stimulation, has very high spatial resolution.To grind
Study carefully TCD,transcranial Doppler stimulation and provides easy-to-use method with the function and effect and potential mechanism stimulated through cranium magnetosonic.
Detailed description of the invention
Fig. 1 is that a kind of overall structure of TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device of the present invention is illustrated
Figure；
Fig. 2 is the overall structure diagram of moving in rotation bracket in the present invention；
Fig. 3 is the structural schematic diagram that moving in rotation bracket loads static magnet rotation in the present invention；
Fig. 4 is the overall structure diagram of ultrasonic transducer bracket in the present invention；
Fig. 5 is the schematic perspective view after Fig. 4 rotates by a certain angle；
Fig. 6 is the structural schematic diagram of Z axis support component in the present invention；
Fig. 7 is the structural schematic diagram of the first cruciform fastening for falsework in the present invention；
Fig. 8 is the structural schematic diagram of the second cruciform fastening for falsework in the present invention；
Fig. 9 is the structural schematic diagram of energy converter fixation kit and the assembling of the second cruciform fastening for falsework in the present invention；
Figure 10 is the structural schematic diagram of energy converter fixes sleeve in the present invention.
In figure
1: the first signal generator 2: second signal generator
3: power amplifier 4: ultrasonic transducer
5: sound collimator 6: static magnet
7: moving in rotation bracket 7.1: pedestal
7.2: support rod 7.3: flexural pivot
7.4: static magnet support rod 7.5: loading chute
8: stereotaxic apparatus 9: tested sample
10: ultrasonic transducer bracket 10.1: firm banking
10.2:Z axis support component 10.21: collet is adjusted
10.23: the first fixed screw of 10.22:Z axis support arm
10.3: the first cruciform fastening for falsework, 10.31: the first columnar body
10.32: laterally inserted hole 10.33: being longitudinally inserted into hole
10.34: 10.35: the second fixed screw of third fixed screw
10.5: the second cruciform fastening for falsework of 10.4:X axis support arm
10.51: the second columnar bodies 10.52: horizontal through hole
10.53: the four fixed screws 10.54: energy converter fixation kit is inserted into hole
10.55: the five fixed screws 10.6: energy converter fixation kit
10.61: energy converter fixes sleeve 10.62: energy converter fixture
10.63: energy converter fixture mounting post 10.64: fixture nut
10.65: positive stop lug boss
Specific embodiment
A kind of TCD,transcranial Doppler and magnetosonic with mobile rotating device of the invention is pierced below with reference to embodiment and attached drawing
Sharp System and method for is described in detail.
As shown in Figure 1, a kind of TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device of the invention, includes
The first signal generator 1 for generating repetition pulse signal for being sequentially connected in series, for generating ultrasonic excitation signal
Binary signal generator 2, for ultrasonic excitation signal carry out power amplification power amplifier 3, for converting electrical signals to
The ultrasonic transducer 4 of acoustical signal, i.e. the energy conversion of realization ultrasonic signal, and be provided with and be connected to the ultrasonic transducer 4
Sound collimator 5 on bottom surface is injected with ultrasonic coupling agent in the sound collimator 5, is additionally provided with for positioning tested sample 9
Stereotaxic apparatus 8, for positioning the ultrasonic transducer bracket 10 of ultrasonic transducer 4, and installation for generate act on by
The moving in rotation bracket 7 of the static magnet 6 in the magnetic field of test sample sheet 9, the static magnet 6 are a permanent magnet, specific strong for generating
The magnetic field of degree.Wherein, the tested sample 9 is located on the heating cushion of the stereotaxic apparatus 8, the ultrasonic transducer
4 are located on the ultrasonic transducer bracket 10, and the ultrasonic transducer bracket 10 is located on the pedestal of stereotaxic apparatus 8,
And the acoustical signal after enabling the sound collimator for filling couplant below sonic transducer 4 to convert vertically is targeted to tested sample 9
Stimulated zone.Reduce decaying of the ultrasound in communication process.
As shown in Figure 1 and Figure 2, the moving in rotation bracket 7 includes the pedestal 7.1 that can be moved, and is vertically fixed on institute
The support rod 7.2 on pedestal 7.1 is stated, 7.2 top of support rod passes through the articulated connection static magnet support rod 7.4 of flexural pivot 7.3
One end, the other end of the static magnet support rod 7.4 are formed with the loading chute 7.5 for loading static magnet 6.Static magnet support rod
7.4, for adjusting the direction in magnetic field, realize the direction for the induction field that magnetic field and sound field are formed and the change of size.Such as Fig. 3 institute
Show, the static magnet support rod 7.4 can horizontal direction be rotated by 360 °.The static magnet support rod 7.4 can be square vertically
To being rotated by 90 °.
As shown in Figure 4, Figure 5, the ultrasonic transducer bracket 10 includes firm banking described in firm banking 10.1
The Z axis support component 10.2 for being able to carry out vertical adjustment is vertically installed on 10.1, the upper end of the Z axis support arm 10.2 passes through
The connection of first cruciform fastening for falsework 10.3 is horizontally disposed and is able to carry out one end of the X-axis support arm 10.4 of Level tune, the X-axis branch
The other end of brace 10.4 connects the energy converter fixation kit for fixing ultrasonic transducer by the second cruciform fastening for falsework 10.5
10.6, the scale for being laterally adjusted is provided on the X-axis support arm 10.4.
As shown in fig. 6, the Z axis support component 10.2 includes: bottom end is fixed on the adjusting on firm banking 10.1
Collet 10.21, the upper end for adjusting collet 10.21 is inserted with the Z axis support arm 10.22 that can be moved up and down, the Z axis
It is provided with the scale for adjusting height on support arm 10.22, is threaded on the side wall for adjusting collet 10.21 in Z
Axis support arm 10.22 is adjusted to after the height of setting, to the first fixed screw 10.23 that Z axis support arm 10.22 is fixed,
The upper end of the Z axis support arm 10.22 connects one end of X-axis support arm 10.4 by the first cruciform fastening for falsework 10.3.
As shown in fig. 7, first cruciform fastening for falsework 10.3 includes the first columnar body 10.31, first column
It is respectively formed in main body 10.31 for the laterally inserted hole 10.32 through 10.4 one end of X-axis support arm and for through Z axis
10.22 upper end of Z axis support arm in support component 10.2 is longitudinally inserted into hole 10.33, and with the laterally inserted hole
The second fixed screw for making the first columnar body 10.31 be fixed to each other with X-axis support arm 10.4 of 10.32 corresponding settings
10.35, and with it is described be longitudinally inserted into the corresponding setting in hole 10.33 for making the first columnar body 10.31 and Z axis support arm
10.22 upper ends are fixed and adjust the third fixed screw 10.34 of the first columnar body 10.31 rotation angle.
As shown in figure 8, second cruciform fastening for falsework 10.5 includes the first columnar body 10.51, it is horizontally formed on institute
The horizontal through hole 10.52 being used for through the X-axis support arm 10.4 in the first columnar body 10.51 is stated, with the level
The for making that the first columnar body 10.51 and the X-axis support arm 10.4 be fixed to each other of the corresponding setting of through-hole 10.52
Four fixed screws 10.53, the side of the neighbouring horizontal through hole 10.52 is longitudinally formed in first columnar body 10.51
Energy converter fixation kit for installing the energy converter fixation kit 10.6 is inserted into hole 10.54, with the fixed group of the energy converter
The part insertion corresponding setting in hole 10.54 is used to make the first columnar body 10.51 and 10.6 phase of energy converter fixation kit
Mutually the 5th fixed fixed screw 10.55.
As shown in Figure 9, Figure 10, the energy converter fixation kit 10.6 includes the transducing for installing ultrasonic transducer
Device fixes sleeve 10.61 is integrally formed in described change for clamping the energy converter fixture 10.62 of energy converter fixes sleeve 10.61
In the energy converter fixation kit insertion hole 10.54 for being inserted into the second cruciform fastening for falsework 10.5 on 10.62 top of energy device fixture
Energy converter fixture mounting post 10.63, and in described energy converter fixation kit insertion hole 10.54 upper port with it is described
Energy converter fixture mounting post 10.63 the fixture nut 10.64 that is threadedly coupled of top, wherein the described energy converter fixture peace
Dress column 10.63 also passes through the 5th fixed screw 10.55 and first columnar body 10.51 in the second cruciform fastening for falsework 10.5
It is fixed to each other.The positive stop lug boss 10.65 of position-limiting action from the outside of the energy converter fixes sleeve 10.61 is formed with one week leads to
The rotatable transducer fixes sleeve 10.61 in energy converter fixture 10.62 is crossed, can reach and adjust ultrasonic transducer vertical angle.
In the embodiment of the present invention, first signal generator 1 selects the product of model TFG6920A；Described
The product of the selection of binary signal generator 2 model Tektronix-AFG3252；The power amplifier 3 selects model NF-
The product of HSA4101 can amplify the signal from DC to 1MHz, while the voltage value of highest output 150Vpp；The ultrasound
Energy converter 4 selects model Olympus-V301 plane ultrasonic transducer, centre frequency 500kHz, or selects focusing ultrasound
Energy converter, centre frequency 1MHz；The static magnet 6 is the permanent magnet of intensity 0.3T；The stereotaxic apparatus 8 is electromagnetic compatibility
Type stereotaxic apparatus.
Method for TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device of the invention, is that will be used to produce
The pulse signal of the repetition rate for the setting that first signal generator 1 of raw repetition pulse signal generates, is sent into super for generating
The second signal generator 2 of acoustically-driven signal, second signal generator 2 generate ultrasonic excitation signal by external trigger mode,
And it is sent into the power amplifier 3 for carrying out power amplification to ultrasonic excitation signal, the ultrasonic signal amplified through power amplifier 3
It is sent into the ultrasonic transducer 4 for converting electrical signals to acoustical signal, the acoustical signal after conversion is targeted to tested through sound collimator 5
The stimulated zone of sample 9；Meanwhile by moving in rotation bracket 7 by the static magnet 6 being supported is mobile be placed in tested sample 9 just before
Side realizes and couples electro photoluminescence through cranium magnetosonic.
When only carrying out TCD,transcranial Doppler stimulation to tested sample 9, the static magnet support rod of moving in rotation bracket 7 will be passed through
Static magnet 6 is rotated horizontally 180 ° by 7.4, makes static magnet 6 far from tested sample 9.
When needing to change the size of induction field in magnetic field and sound field formation, pass through the static magnet of moving in rotation bracket 7
6 vertical direction of static magnet or horizontal direction are rotated set angle by support rod 7.4.
When needing makes ultrasonic transducer rotate horizontally 0~90 °, the first cross is adjusted by third fixed screw 10.34
Rotation angle between fastener 10.3 and X-axis support arm 10.4；When needing to make 0~90 ° of ultrasonic transducer vertical rotary,
Adjusting the rotation angle between the second cruciform fastening for falsework 10.5 and energy converter fixation kit 10.6 by the 5th fixed screw 10.55 is
It can.Either reached by rotatable transducer fixes sleeve 10.61 and adjusts ultrasonic transducer vertical angle.It is ultrasonic when needing to adjust
When the height of energy converter, Z axis support arm 10.22 is adjusted by the first fixed screw 10.23 and is inserted into adjusting collet 10.21
Depth；When needing to adjust the lateral position of ultrasonic transducer, pass through the second fixed screw 10.35 or the 4th fixed screw
10.53 adjust the left-right position on the X-axis support arm 10.4 of the first cruciform fastening for falsework 10.3 or the second cruciform fastening for falsework 10.5.
In the following, being provided in conjunction with Fig. 1 using example using mouse as tested sample:
1) mouse is shaved to head hair after gas anesthesia or intraperitoneal injection of anesthesia and is fixed on stereotaxic apparatus 8
On fixed pad, if you need to lasting gas fiber crops, mouse nostril is placed in anesthesia slot, continues inhalation anesthesia gas；
2) the first signal generator 1, the parameters such as setting waveform, repetition rate, repetition period are opened；Open second signal hair
Raw device 2, fundamental frequency, voltage magnitude needed for setting stimulation etc., the ultrasonic signal of generation is output to power amplifier 3；
3) power amplifier 3 is opened, amplification factor is set as 100, amplified pumping signal is output to ultrasonic transduction
Device 4, electric signal are converted to acoustical signal through ultrasonic transducer 4；
4) sound collimator 5 is filled into ultrasonic coupling agent, is coupled with ultrasonic transducer 4.The position of adjustment sound collimator 5, makes
Alignment mouse brain stimulation target area, coat ultrasonic coupling agent in the target area that mouse head is in contact with sound collimator 5, reduce
Decaying in transonic process；
5) static magnet 6 is loaded into the loading chute 7.5 of moving in rotation bracket 7, rotates moving in rotation bracket 7, makes magnetostatic
Iron 6 is placed in the front side of mouse, and realization is stimulated through cranium magnetosonic, and can be by adjusting the static magnet support rod 7.4 of moving in rotation bracket 7
Direction of the angulation change magnetic field relative to ultrasonic wave；
6) static magnet support rod 7.4 is rotated, makes static magnet 6 far from mouse, removes magnetic field, is i.e. the stimulation of realization TCD,transcranial Doppler.
Embodiment described above only describe the preferred embodiments of the invention, not to model of the invention
It encloses and is defined, without departing from the spirit of the design of the present invention, those of ordinary skill in the art are to technical side of the invention
The various changes and improvements that case is made should all be fallen into the protection scope that claims of the present invention determines.
Claims (10)
1. a kind of TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device includes to be sequentially connected in series for producing
The first signal generator (1) of raw repetition pulse signal, is used the second signal generator (2) for generating ultrasonic excitation signal
In carrying out the power amplifier (3) of power amplification to ultrasonic excitation signal, change for converting electrical signals to the ultrasound of acoustical signal
The sound collimator (5) that can device (4) and be connected on the ultrasonic transducer (4) bottom surface, the sound collimator (5) is interior to be injected with
Ultrasonic coupling agent, which is characterized in that it is additionally provided with the stereotaxic apparatus (8) for positioning tested sample (9), it is super for positioning
The ultrasonic transducer bracket (10) of sonic transducer (4), and load for generating the magnetostatic of the magnetic field for acting on tested sample (9)
The moving in rotation bracket (7) of iron (6), wherein the tested sample (9) is located in the heating of the stereotaxic apparatus (8)
On pad, the ultrasonic transducer (4) is located on the ultrasonic transducer bracket (10), ultrasonic transducer bracket (10) position
In on the pedestal of stereotaxic apparatus (8), and enable the acoustical signal after sound collimator (5) conversion of sonic transducer (4) below
Vertically it is targeted to the stimulated zone of tested sample (9).
2. a kind of TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device according to claim 1, feature
It is, the moving in rotation bracket (7) includes the pedestal (7.1) that can be moved, and is vertically fixed on the pedestal (7.1)
Support rod (7.2), support rod (7.2) top by flexural pivot (7.3) articulated connection static magnet support rod (7.4) one
End, the other end of the static magnet support rod (7.4) are formed with the loading chute (7.5) for loading static magnet (6).
3. a kind of TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device according to claim 2, feature
Be, the static magnet support rod (7.4) can horizontal direction be rotated by 360 ° and can vertical direction be rotated by 90 °.
4. a kind of TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device according to claim 1, feature
It is, the ultrasonic transducer bracket (10) includes firm banking (10.1), vertical on the firm banking (10.1)
It is provided with the Z axis support component (10.2) for being able to carry out vertical adjustment, the upper end of the Z axis support arm (10.2) passes through the 10th
Word fastener (10.3) connection is horizontally disposed and is able to carry out one end of the X-axis support arm (10.4) of Level tune, the X-axis support
The other end of arm (10.4) connects the energy converter fixation kit for fixing ultrasonic transducer by the second cruciform fastening for falsework (10.5)
(10.6), the scale for being laterally adjusted is provided on the X-axis support arm (10.4).
5. a kind of TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device according to claim 4, feature
It is, the Z axis support component (10.2) includes: bottom end is fixed on the adjusting collet on firm banking (10.1)
(10.21), the upper end for adjusting collet (10.21) is inserted with the Z axis support arm (10.22) that can be moved up and down, the Z
It is provided with the scale for adjusting height on axis support arm (10.22), is threadedly coupled on the side wall for adjusting collet (10.21)
Have after the height that Z axis support arm (10.22) adjust to setting, the first fixed spiral shell that Z axis support arm (10.22) is fixed
The upper end of silk (10.23), the Z axis support arm (10.22) passes through the first cruciform fastening for falsework (10.3) connection X-axis support arm (10.4)
One end.
6. a kind of TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device according to claim 4, feature
It is, first cruciform fastening for falsework (10.3) includes the first columnar body (10.31), first columnar body
(10.31) it is respectively formed on for the laterally inserted hole (10.32) through X-axis support arm (10.4) one end and for through Z
Z axis support arm (10.22) upper end in axis support component (10.2) is longitudinally inserted into hole (10.33), and with the transverse direction
Insertion hole (10.32) corresponding setting is used to that the first columnar body (10.31) and X-axis support arm (10.4) to be made to be fixed to each other
Second fixed screw (10.35), and with it is described be longitudinally inserted into hole (10.33) corresponding setting for making the first columnar body
(10.31) the first columnar body (10.31) rotate angle the is fixed and adjust with Z axis support arm (10.22) upper end
Three fixed screws (10.34).
7. a kind of TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device according to claim 4, feature
It is, second cruciform fastening for falsework (10.5) includes the first columnar body (10.51), is horizontally formed on first column
The horizontal through hole (10.52) being used for through the X-axis support arm (10.4) in main body (10.51), with the horizontal through hole
(10.52) corresponding setting for making the first columnar body (10.51) and the X-axis support arm (10.4) is fixed to each other
4th fixed screw (10.53), the side of neighbouring horizontal through hole (10.52) is vertical on first columnar body (10.51)
Hole (10.54) are inserted into the energy converter fixation kit that is formed with for installing the energy converter fixation kit (10.6), and it is described
Insertion hole (10.54) the corresponding setting of energy converter fixation kit is used to make the first columnar body (10.51) and the transducing
The 5th fixed screw (10.55) that device fixation kit (10.6) is fixed to each other.
8. a kind of TCD,transcranial Doppler and magnetosonic stimulating system with mobile rotating device according to claim 4, feature
It is, the energy converter fixation kit (10.6) includes the energy converter fixes sleeve for installing ultrasonic transducer
(10.61), for clamping the energy converter fixture (10.62) of energy converter fixes sleeve (10.61), it is integrally formed in the energy converter
In energy converter fixation kit insertion hole (10.54) for being inserted into the second cruciform fastening for falsework (10.5) on fixture (10.62) top
Energy converter fixture mounting post (10.63), and for the upper port in described energy converter fixation kit insertion hole (10.54)
The fixture nut (10.64) being threadedly coupled with the top of the energy converter fixture mounting post (10.63), wherein described changes
Can device fixture mounting post (10.63) also by the 5th fixed screw (10.55) in the second cruciform fastening for falsework (10.5) and described
First columnar body (10.51) is fixed to each other, and limits and makees from being formed with one week on the outside of the energy converter fixes sleeve (10.61)
Positive stop lug boss (10.65).
9. a kind of method for the TCD,transcranial Doppler with mobile rotating device and magnetosonic stimulating system described in claim 1,
It is characterized in that, being the repetition rate that will be used to generate the setting of the first signal generator (1) generation of repetition pulse signal
Pulse signal, is sent into the second signal generator (2) for generating ultrasonic excitation signal, and second signal generator (2) passes through outer
Portion's triggering mode generates ultrasonic excitation signal, and is sent into the power amplifier for carrying out power amplification to ultrasonic excitation signal
(3), the ultrasonic signal amplified through power amplifier (3) is sent into the ultrasonic transducer (4) for converting electrical signals to acoustical signal,
Acoustical signal after conversion is vertically targeted to the stimulated zone of tested sample (9) through sound collimator (5)；Meanwhile passing through moving in rotation
The static magnet being supported (6) movement is placed in immediately ahead of tested sample (9) by bracket (7), is realized and is coupled electro photoluminescence through cranium magnetosonic.
10. the method for the TCD,transcranial Doppler and magnetosonic stimulating system according to claim 9 for mobile rotating device,
It is characterized in that, the static magnet of moving in rotation bracket (7) will be passed through when only carrying out TCD,transcranial Doppler stimulation to tested sample (9)
Static magnet (6) are rotated horizontally 180 ° by support rod (7.4), make static magnet (6) far from tested sample (9)；When needing to change magnetic field
When the size of the induction field formed with sound field, by the static magnet support rod (7.4) of moving in rotation bracket (7) by static magnet
(6) vertical direction or horizontal direction rotate set angle.
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