CN109157768B - Transcranial ultrasonic and magnetoacoustic stimulation system with mobile rotating device and method - Google Patents
Transcranial ultrasonic and magnetoacoustic stimulation system with mobile rotating device and method Download PDFInfo
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- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
A transcranial ultrasonic and magnetoacoustic stimulation system with a mobile rotating device and a method thereof are provided, which comprises a first signal generator for generating a repetitive pulse signal, a second signal generator for generating an ultrasonic excitation signal, a power amplifier for amplifying the power of the ultrasonic excitation signal, an ultrasonic transducer for converting an electric signal into an acoustic signal and an acoustic collimator which is connected on the bottom surface of the ultrasonic transducer and is injected with an ultrasonic coupling agent, the brain stereotaxic apparatus comprises a brain stereotaxic apparatus for positioning a measured sample, an ultrasonic transducer bracket for positioning an ultrasonic transducer, a rotary moving bracket for loading a static magnet for generating a magnetic field, the measured sample is positioned on a heating pad of the brain stereotaxic apparatus, the ultrasonic transducer is positioned on the ultrasonic transducer bracket, and the ultrasonic transducer bracket is positioned on a base of the brain stereotaxic apparatus and enables an acoustic signal to vertically target a stimulation area of the measured sample. The invention realizes the introduction and the withdrawal of the magnetic field, can carry out accurate stimulation and has very high spatial resolution.
Description
Technical Field
The invention relates to a transcranial ultrasonic and magnetoacoustic stimulation device. In particular to a transcranial ultrasonic and magnetoacoustic stimulation system with a mobile rotating device and a method thereof.
Background
Transcranial ultrasonic stimulation is a novel nerve regulation and control technology, and has attracted more and more attention due to the characteristics of non-invasiveness, high spatial resolution, realization of deep stimulation and the like. Transcranial magnetoacoustic stimulation, namely, a magnetic field is introduced based on transcranial ultrasonic stimulation, but the principles of the two are different. Transcranial ultrasonic stimulation is to use low-intensity ultrasonic waves to regulate and control nerve activity, and the mechanism of the stimulation can be mechanical sensitivity of cell ion channels and can also be activation of molecular receptors caused by sound pressure, and the mechanism is not clear yet. The principle of transcranial magnetoacoustic stimulation is that ions in nerve tissues vibrate under the action of ultrasonic waves, so that magnetic induction lines are cut to generate induction currents and electric fields, nerve electrical activity is directly regulated and controlled, and the transcranial magnetoacoustic stimulation is based on the Hall effect of conductive tissues. Transcranial magnetoacoustic stimulation has the characteristics of ultrasound and the characteristics of an electric field, so that the transcranial magnetoacoustic stimulation has unique advantages in the aspect of nerve regulation and gradually becomes a new technology for people to research the field of neuroscience.
The development and application of the technology are limited to a certain extent by unclear transcranial ultrasonic stimulation mechanism, and the function and functions of transcranial magnetic acoustic stimulation as a novel nerve regulation and control technology need to be explored more. Both the mechanism research of transcranial ultrasonic stimulation and the research of the effect and potential mechanism of transcranial magnetoacoustic stimulation need perfect devices and methods.
Disclosure of Invention
The invention aims to solve the technical problem of providing a transcranial ultrasonic and magnetoacoustic stimulation system and method with a movable rotating device, which are simple to operate and convenient to use and can perform accurate stimulation.
The technical scheme adopted by the invention is as follows: a transcranial ultrasonic and magnetic-acoustic stimulation system with a mobile rotating device comprises a first signal generator, a second signal generator, a power amplifier, an ultrasonic transducer and an acoustic collimator, wherein the first signal generator is used for generating repeated pulse signals, the second signal generator is used for generating ultrasonic excitation signals, the power amplifier is used for amplifying the power of the ultrasonic excitation signals, the ultrasonic transducer is used for converting electric signals into acoustic signals, the acoustic collimator is connected to the bottom surface of the ultrasonic transducer, an ultrasonic coupling agent is injected into the acoustic collimator, a brain stereotaxic instrument is further arranged for positioning a measured sample, an ultrasonic transducer support is arranged for positioning the ultrasonic transducer, and a rotary moving support is loaded with static magnets used for generating magnetic fields acting on the measured sample, wherein the measured sample is positioned on a heating pad of the brain stereotaxic instrument, and the ultrasonic transducer is positioned on the ultrasonic transducer support, the ultrasonic transducer bracket is positioned on a base of the brain stereotaxic apparatus, and enables an acoustic signal converted by an acoustic collimator below the acoustic transducer to be vertically targeted to a stimulation area of a tested sample.
The rotary moving bracket comprises a movable base and a supporting rod vertically fixed on the base, the top end of the supporting rod is hinged with one end of a static magnet supporting rod through a spherical hinge, and a loading groove for loading static magnet is formed at the other end of the static magnet supporting rod.
The static magnet support rod can rotate 360 degrees in the horizontal direction and can rotate 90 degrees in the vertical direction.
Ultrasonic transducer support including unable adjustment base, unable adjustment base on be provided with perpendicularly and carry out the Z axle support subassembly of vertical regulation, the upper end of Z axle support arm is connected the one end that the level set up and can carry out the X axle support arm of level regulation through first cross fastener, the other end of X axle support arm is connected the transducer fixed subassembly that is used for fixed ultrasonic transducer through second cross fastener, X axle support arm on be provided with the scale that is used for carrying on horizontal regulation.
The Z axle support subassembly include: the bottom mounting is adjusted on unable adjustment base, the Z axle support arm that can reciprocate has been inserted to the upper end of adjusting the collet, the Z axle support arm on be provided with the scale that is used for height-adjusting, threaded connection has the high back of setting for to adjust Z axle support arm on the lateral wall of adjusting the collet, supports the arm to carry out the first fixed screw of fixing to Z axle, the one end of X axle support arm is connected through first cross fastener in the upper end of Z axle support arm.
The first cross fastener comprises a first columnar body, wherein a transverse insertion hole for penetrating one end of an X-axis support arm and a longitudinal insertion hole for penetrating the upper end of a Z-axis support arm in a Z-axis support assembly are formed in the first columnar body respectively, a second fixing screw which is arranged corresponding to the transverse insertion hole and is used for fixing the first columnar body and the X-axis support arm mutually and a third fixing screw which is arranged corresponding to the longitudinal insertion hole and is used for fixing the first columnar body and the upper end of the Z-axis support arm and adjusting the rotation angle of the first columnar body are formed in the first columnar body.
The second cross-shaped fastener comprises a first columnar main body, a horizontal through hole which is horizontally formed in the first columnar main body and is used for penetrating through the X-axis support arm, a fourth fixing screw which is arranged corresponding to the horizontal through hole and is used for fixing the first columnar main body and the X-axis support arm to each other, a transducer fixing component inserting hole which is used for installing the transducer fixing component and a fifth fixing screw which is arranged corresponding to the transducer fixing component inserting hole and is used for fixing the first columnar main body and the transducer fixing component to each other are longitudinally formed on one side, close to the horizontal through hole, of the first columnar main body.
The energy converter fixing component comprises an energy converter fixing sleeve for mounting an ultrasonic energy converter, an energy converter clamp for clamping the energy converter fixing sleeve, an energy converter clamp mounting column which is integrally formed at the top end of the energy converter clamp and used for being inserted into an energy converter fixing component insertion hole of the second cross fastener, and a fixing nut which is used for connecting the upper port of the energy converter fixing component insertion hole with the top end of the energy converter clamp mounting column in a threaded manner, wherein the energy converter clamp mounting column is mutually fixed with the first columnar main body through a fifth fixing screw in the second cross fastener, and a circle of limiting boss which plays a limiting role is formed on the outer side of the energy converter fixing sleeve.
A method for using for moving the ultrasonic and magnetic acoustic stimulating system of cranium of the rotating device, the pulse signal of the set repetition frequency that the first signal generator used for producing the repetitive pulse signal produces, send into the second signal generator used for producing the ultrasonic excitation signal, the second signal generator produces the ultrasonic excitation signal through the external triggering mode, and send into the power amplifier used for carrying on the power amplification to the ultrasonic excitation signal, the ultrasonic signal amplified by the power amplifier is sent into the ultrasonic transducer used for changing the electrical signal into the acoustical signal, the acoustical signal after the conversion is targeted to the stimulation area of the measured sample vertically by the acoustic collimator; meanwhile, the supported static magnet is movably arranged right in front of the tested sample by rotating the movable bracket, so that transcranial magnetoacoustic coupling electrical stimulation is realized.
When only transcranial ultrasonic stimulation is carried out on the measured sample, the static magnet is horizontally rotated by 180 degrees through the static magnet supporting rod of the rotary moving bracket, so that the static magnet is far away from the measured sample; when the size of an induced electric field formed by a magnetic field and a sound field needs to be changed, the static magnet support rod of the movable support is rotated to rotate the static magnet by a set angle in the vertical direction or the horizontal direction.
The transcranial ultrasonic and magnetoacoustic stimulation system with the mobile rotating device and the method thereof can realize the introduction and the removal of a magnetic field through the rotation of the mobile rotating moving bracket, conveniently realize the interconversion of two stimulation modes of transcranial ultrasonic stimulation and transcranial magnetoacoustic stimulation, and realize the change of the direction of the magnetic field through the rotating moving bracket, thereby realizing the adjustment of the direction and the size of an electric stimulation induction electric field, and further researching the effect and the mechanism of the transcranial ultrasonic stimulation and the transcranial magnetoacoustic stimulation on the regulation and control of nerve activity. The invention has simple operation and convenient use, can carry out accurate stimulation and has very high spatial resolution. Provides a simple and easy method for researching the action effect and the potential mechanism of transcranial ultrasonic stimulation and transcranial magnetic acoustic stimulation.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a transcranial ultrasound and magnetoacoustic stimulation system with a mobile rotating device according to the present invention;
FIG. 2 is a schematic view of the overall structure of the rotating and moving stand according to the present invention;
FIG. 3 is a schematic view showing a structure of a rotating and moving gantry for loading a static magnet to rotate according to the present invention;
FIG. 4 is a schematic view of the overall structure of the ultrasonic transducer holder according to the present invention;
FIG. 5 is a schematic perspective view of FIG. 4 after rotation through a certain angle;
FIG. 6 is a schematic view of the construction of the Z-axis support assembly of the present invention;
FIG. 7 is a schematic view of a first fastening cross of the present invention;
FIG. 8 is a schematic view of a second fastening cross of the present invention;
FIG. 9 is a schematic view of the transducer mounting assembly of the present invention assembled with a second cross fastener;
FIG. 10 is a schematic diagram of the construction of a transducer retaining sleeve of the present invention.
In the drawings
1: first signal generator 2: second signal generator
3: the power amplifier 4: ultrasonic transducer
5: acoustic collimator 6: magnetostatic iron
7: rotating and moving bracket 7.1: base seat
7.2: supporting rod 7.3: spherical hinge
7.4: static magnet support rod 7.5: loading trough
8: brain stereotaxic apparatus 9: sample to be measured
10: ultrasound transducer holder 10.1: fixed base
10.2: z-axis support assembly 10.21: adjusting bottom support
10.22: z-axis support arm 10.23: first fixing screw
10.3: first fastening cross 10.31: a first columnar main body
10.32: lateral insertion hole 10.33: longitudinal insertion hole
10.34: third set screw 10.35: second fixing screw
10.4: x-axis support arm 10.5: the second cross fastener
10.51: second cylindrical body 10.52: horizontal through hole
10.53: fourth set screw 10.54: transducer fixing assembly insertion hole
10.55: fifth set screw 10.6: transducer fixing assembly
10.61: transducer retaining sleeve 10.62: transducer clamp
10.63: transducer clamp mounting post 10.64: fixing nut
10.65: spacing boss
Detailed Description
The transcranial ultrasound and magnetoacoustic stimulation system and method with a mobile rotating device according to the present invention will be described in detail with reference to the accompanying drawings and embodiments.
As shown in figure 1, the transcranial ultrasound and magnetic sound stimulation system with a mobile rotating device comprises a first signal generator 1 for generating repetitive pulse signals, a second signal generator 2 for generating ultrasonic excitation signals, a power amplifier 3 for amplifying the power of the ultrasonic excitation signals, an ultrasonic transducer 4 for converting electric signals into sound signals, namely realizing the energy conversion of the ultrasonic signals, and an acoustic collimator 5 connected to the bottom surface of the ultrasonic transducer 4, wherein an ultrasonic coupling agent is injected into the acoustic collimator 5, a brain stereotaxic apparatus 8 for positioning a sample 9 to be measured, an ultrasonic transducer support 10 for positioning the ultrasonic transducer 4, and a rotary mobile support 7 provided with a static magnet 6 for generating a magnetic field acting on the sample 9 to be measured, the static magnet 6 is a permanent magnet for generating a magnetic field of a specific strength. The measured sample 9 is positioned on the heating pad of the brain stereotaxic apparatus 8, the ultrasonic transducer 4 is positioned on the ultrasonic transducer support 10, the ultrasonic transducer support 10 is positioned on the base of the brain stereotaxic apparatus 8, and an acoustic signal converted by an acoustic collimator filled with coupling agent below the ultrasonic transducer 4 can be vertically targeted to a stimulation area of the measured sample 9. Reducing attenuation of ultrasound during propagation.
As shown in fig. 1 and 2, the rotating/moving frame 7 includes a movable base 7.1 and a support rod 7.2 vertically fixed to the base 7.1, a top end of the support rod 7.2 is hinged to one end of a static magnet support rod 7.4 by a ball hinge 7.3, and a loading slot 7.5 for loading a static magnet 6 is formed at the other end of the static magnet support rod 7.4. The static magnet support rods 7.4 are used for adjusting the direction of the magnetic field and realizing the change of the direction and the size of an induced electric field formed by the magnetic field and the sound field. As shown in fig. 3, the static magnet support rods 7.4 can be rotated 360 ° horizontally. The static magnet support rod 7.4 can rotate 90 degrees in the vertical direction.
As shown in fig. 4 and 5, the ultrasonic transducer support 10 includes a fixing base 10.1, a Z-axis support assembly 10.2 capable of being adjusted longitudinally is vertically disposed on the fixing base 10.1, an upper end of the Z-axis support arm 10.2 is connected to one end of an X-axis support arm 10.4 which is horizontally disposed and capable of being adjusted through a first cross fastener 10.3, the other end of the X-axis support arm 10.4 is connected to a transducer fixing assembly 10.6 for fixing an ultrasonic transducer through a second cross fastener 10.5, and a scale for performing lateral adjustment is disposed on the X-axis support arm 10.4.
As shown in fig. 6, the Z-axis support assembly 10.2 includes: an adjusting base 10.21 fixed on the fixing base 10.1 at the bottom end, a Z-axis support arm 10.22 capable of moving up and down is inserted into the upper end of the adjusting base 10.21, a scale for adjusting the height is arranged on the Z-axis support arm 10.22, a first fixing screw 10.23 for fixing the Z-axis support arm 10.22 after the Z-axis support arm 10.22 is adjusted to the set height is connected to the side wall of the adjusting base 10.21 in a threaded manner, and one end of an X-axis support arm 10.4 is connected to the upper end of the Z-axis support arm 10.22 through a first cross fastener 10.3.
As shown in fig. 7, the first cross fastener 10.3 includes a first cylindrical body 10.31, the first cylindrical body 10.31 is formed with a transverse insertion hole 10.32 for penetrating one end of the X-axis support arm 10.4 and a longitudinal insertion hole 10.33 for penetrating the upper end of the Z-axis support arm 10.22 of the Z-axis support assembly 10.2, a second fixing screw 10.35 corresponding to the transverse insertion hole 10.32 for fixing the first cylindrical body 10.31 and the X-axis support arm 10.4 to each other, and a third fixing screw 10.34 corresponding to the longitudinal insertion hole 10.33 for fixing the first cylindrical body 10.31 and the upper end of the Z-axis support arm 10.22 and adjusting the rotation angle of the first cylindrical body 10.31.
As shown in fig. 8, the second cross-shaped fastener 10.5 includes a first cylindrical body 10.51, a horizontal through hole 10.52 horizontally formed on the first cylindrical body 10.51 for passing through the X-axis support arm 10.4, a fourth fixing screw 10.53 disposed corresponding to the horizontal through hole 10.52 for fixing the first cylindrical body 10.51 and the X-axis support arm 10.4 to each other, a transducer fixing member insertion hole 10.54 formed on the first cylindrical body 10.51 in the longitudinal direction on a side adjacent to the horizontal through hole 10.52 for mounting the transducer fixing member 10.6, and a fifth fixing screw 10.55 disposed corresponding to the transducer fixing member insertion hole 10.54 for fixing the first cylindrical body 10.51 and the transducer fixing member 10.6 to each other.
As shown in fig. 9 and 10, the transducer fixing assembly 10.6 includes a transducer fixing sleeve 10.61 for mounting an ultrasonic transducer, a transducer clamp 10.62 for clamping the transducer fixing sleeve 10.61, a transducer clamp mounting post 10.63 integrally formed at the top end of the transducer clamp 10.62 for being inserted into the transducer fixing assembly insertion hole 10.54 of the second cross fastener 10.5, and a fixing nut 10.64 for being screwed with the top end of the transducer clamp mounting post 10.63 at the upper port of the transducer fixing assembly insertion hole 10.54, wherein the transducer clamp mounting post 10.63 is further fixed to the first cylindrical body 10.51 by a fifth fixing screw 10.55 in the second cross fastener 10.5. A circle of limiting bosses 10.65 for limiting are formed on the outer side of the transducer fixing sleeve 10.61, and the vertical angle of the ultrasonic transducer can be adjusted by rotating the transducer fixing sleeve 10.61 in the transducer clamp 10.62.
In the embodiment of the invention, the first signal generator 1 is a product with the model number of TFG 6920A; the second signal generator 2 is a product with the model of Tektronix-AFG 3252; the power amplifier 3 is a product with the model number of NF-HSA4101, can amplify signals from DC to 1MHz, and simultaneously outputs the highest voltage value of 150 Vpp; the ultrasonic transducer 4 is an Olympus-V301 planar ultrasonic transducer with the central frequency of 500kHz or a focusing ultrasonic transducer with the central frequency of 1 MHz; the static magnet 6 is a permanent magnet with the strength of 0.3T; the brain stereotaxic apparatus 8 is an electromagnetic compatible brain stereotaxic apparatus.
The invention is used for the method used for ultrasonic and magnetic acoustic stimulation system of transcranial with moving the rotary device, will be used for producing the pulse signal of the set repetition frequency that the first signal generator 1 of the repetitive pulse signal produces, send into the second signal generator 2 used for producing the ultrasonic excitation signal, the second signal generator 2 produces the ultrasonic excitation signal through the external triggering mode, and send into the power amplifier 3 used for carrying on the power amplification to the ultrasonic excitation signal, the ultrasonic signal amplified by the power amplifier 3 is sent into the ultrasonic transducer 4 used for changing the electrical signal into the acoustical signal, the acoustical signal after the conversion is targeted to the stimulation area of the measured sample 9 through the acoustic collimator 5; meanwhile, the supported static magnet 6 is movably arranged right in front of the tested sample 9 through the rotary movable support 7, so that transcranial magnetoacoustic coupling electrical stimulation is realized.
When transcranial ultrasonic stimulation is performed only on the sample 9 to be measured, the static magnet 6 is horizontally rotated by 180 ° by rotating the static magnet support rods 7.4 of the moving gantry 7, so that the static magnet 6 is away from the sample 9 to be measured.
When the size of the induced electric field formed by the magnetic field and the sound field needs to be changed, the static magnet 6 is rotated by a set angle in the vertical direction or the horizontal direction by rotating the static magnet support rod 7.4 of the moving bracket 7.
When the ultrasonic transducer needs to horizontally rotate by 0-90 degrees, the rotation angle between the first cross fastener 10.3 and the X-ray shaft supporting arm 10.4 is adjusted through the third fixing screw 10.34; when the ultrasonic transducer needs to vertically rotate by 0-90 degrees, the rotation angle between the second cross-shaped fastener 10.5 and the transducer fixing component 10.6 is adjusted through the fifth fixing screw 10.55. Or by rotating the transducer holder sleeve 10.61. When the height of the ultrasonic transducer needs to be adjusted, the depth of the Z-axis support arm 10.22 inserted into the adjusting bottom support 10.21 is adjusted through a first fixing screw 10.23; when the transverse position of the ultrasonic transducer needs to be adjusted, the left and right positions of the X-axis support arm 10.4 of the first cross fastener 10.3 or the second cross fastener 10.5 are adjusted through the second fixing screw 10.35 or the fourth fixing screw 10.53.
In the following, using mice as the test samples, use examples are given in conjunction with fig. 1:
1) after the mouse is anesthetized by gas anesthesia or intraperitoneal injection, the hair of the head is shaved and fixed on a fixing pad of a brain stereotaxic apparatus 8, if continuous anesthesia is needed, the nostril of the mouse is placed in an anesthesia groove, and the anesthesia gas is continuously inhaled;
2) turning on the first signal generator 1, and setting parameters such as waveform, repetition frequency and repetition period; turning on the second signal generator 2, setting fundamental frequency, voltage amplitude and the like required by stimulation, and outputting the generated ultrasonic signals to the power amplifier 3;
3) turning on the power amplifier 3, setting the amplification factor to be 100, outputting the amplified excitation signal to the ultrasonic transducer 4, and converting the electric signal into an acoustic signal through the ultrasonic transducer 4;
4) the acoustic collimator 5 is filled with an ultrasonic coupling agent and coupled with the ultrasonic transducer 4. Adjusting the position of the acoustic collimator 5 to align the acoustic collimator to a stimulation target area of the brain of the mouse, and coating an ultrasonic coupling agent on the target area of the head of the mouse, which is in contact with the acoustic collimator 5, so as to reduce attenuation in the ultrasonic transmission process;
5) loading the static magnet 6 into a loading slot 7.5 of a rotary moving bracket 7, rotating the rotary moving bracket 7 to enable the static magnet 6 to be placed at the front side of the mouse, realizing transcranial magnetoacoustic stimulation, and changing the direction of a magnetic field relative to ultrasonic waves by adjusting the angle of a static magnet supporting rod 7.4 of the rotary moving bracket 7;
6) rotating the static magnet support rod 7.4 to make the static magnet 6 far away from the mouse, and removing the magnetic field to realize transcranial ultrasonic stimulation.
The above-mentioned embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solution of the present invention by those skilled in the art should fall within the protection scope defined by the claims of the present invention without departing from the spirit of the present invention.
Claims (4)
1. A transcranial ultrasonic and magnetoacoustic stimulation system with a mobile rotating device comprises a first signal generator (1) for generating repeated pulse signals, a second signal generator (2) for generating ultrasonic excitation signals, a power amplifier (3) for amplifying the power of the ultrasonic excitation signals, an ultrasonic transducer (4) for converting electric signals into acoustic signals, and an acoustic collimator (5) connected to the bottom surface of the ultrasonic transducer (4), wherein an ultrasonic coupling agent is injected into the acoustic collimator (5), and the system is characterized by further comprising a brain stereotaxic apparatus (8) for positioning a sample (9) to be measured, an ultrasonic transducer support (10) for positioning the ultrasonic transducer (4), and a rotating mobile support (7) loaded with a static magnet (6) for generating a magnetic field acting on the sample (9) to be measured, wherein the tested sample (9) is positioned on a heating pad of the brain stereotaxic apparatus (8), the ultrasonic transducer (4) is positioned on the ultrasonic transducer bracket (10), the ultrasonic transducer bracket (10) is positioned on a base of the brain stereotaxic apparatus (8), and an acoustic signal converted by an acoustic collimator (5) below the ultrasonic transducer (4) can be vertically targeted to a stimulation area of the tested sample (9);
the rotary moving bracket (7) comprises a movable base (7.1) and a supporting rod (7.2) vertically fixed on the base (7.1), the top end of the supporting rod (7.2) is hinged with one end of a static magnet supporting rod (7.4) through a spherical hinge (7.3), and the other end of the static magnet supporting rod (7.4) is provided with a loading groove (7.5) for loading a static magnet (6);
the ultrasonic transducer support (10) comprises a fixed base (10.1), a Z-axis support assembly (10.2) capable of being longitudinally adjusted is vertically arranged on the fixed base (10.1), the upper end of the Z-axis support assembly (10.2) is connected with one end of an X-axis support arm (10.4) which is horizontally arranged and capable of being horizontally adjusted through a first cross fastener (10.3), the other end of the X-axis support arm (10.4) is connected with a transducer fixing assembly (10.6) for fixing an ultrasonic transducer through a second cross fastener (10.5), and scales for transverse adjustment are arranged on the X-axis support arm (10.4);
the Z-axis support assembly (10.2) comprises: the bottom end of the adjusting bottom support (10.21) is fixed on the fixing base (10.1), a Z-axis supporting arm (10.22) capable of moving up and down is inserted into the upper end of the adjusting bottom support (10.21), scales for adjusting the height are arranged on the Z-axis supporting arm (10.22), a first fixing screw (10.23) for fixing the Z-axis supporting arm (10.22) after the Z-axis supporting arm (10.22) is adjusted to the set height is in threaded connection with the side wall of the adjusting bottom support (10.21), and the upper end of the Z-axis supporting arm (10.22) is connected with one end of the X-axis supporting arm (10.4) through a first cross fastener (10.3);
the first cross fastener (10.3) comprises a first columnar main body (10.31), wherein a transverse insertion hole (10.32) for penetrating one end of the X-axis supporting arm (10.4) and a longitudinal insertion hole (10.33) for penetrating the upper end of the Z-axis supporting arm (10.22) in the Z-axis supporting assembly (10.2) are respectively formed on the first columnar main body (10.31), a second fixing screw (10.35) which is arranged corresponding to the transverse insertion hole (10.32) and is used for mutually fixing the first columnar main body (10.31) and the X-axis supporting arm (10.4), and a third fixing screw (10.34) which is arranged corresponding to the longitudinal insertion hole (10.33) and is used for fixing the first columnar main body (10.31) and the upper end of the Z-axis supporting arm (10.22) and adjusting the rotation angle of the first columnar main body (10.31);
the second cross fastener (10.5) comprises a first columnar main body (10.51), a horizontal through hole (10.52) horizontally formed on the first columnar main body (10.51) and used for penetrating through the X-axis supporting arm (10.4), a fourth fixing screw (10.53) which is arranged corresponding to the horizontal through hole (10.52) and used for fixing the first columnar main body (10.51) and the X-axis supporting arm (10.4) mutually, a transducer fixing component inserting hole (10.54) which is used for installing the transducer fixing component (10.6) is longitudinally formed on one side, adjacent to the horizontal through hole (10.52), of the first columnar main body (10.51), and a fifth fixing screw (10.55) which is arranged corresponding to the transducer fixing component inserting hole (10.54) and used for fixing the first columnar main body (10.51) and the transducer fixing component (10.6) mutually;
the transducer fixing component (10.6) comprises a transducer fixing sleeve (10.61) used for mounting an ultrasonic transducer, a transducer clamp (10.62) for clamping the transducer fixing sleeve (10.61), a transducer clamp mounting post (10.63) integrally formed at the top end of the transducer clamp (10.62) for insertion into the transducer fixing assembly insertion hole (10.54) of the second cross fastener (10.5), and a fixing nut (10.64) for screwing with the top end of the transducer clamp mounting column (10.63) at the upper port of the transducer fixing assembly insertion hole (10.54), wherein the transducer clamp mounting post (10.63) is further fixed to the first cylindrical body (10.51) by a fifth set screw (10.55) in a second cross fastener (10.5), a limit boss (10.65) for limiting is formed on the outer side of the transducer fixing sleeve (10.61);
adjusting the rotation angle between the first cross fastener (10.3) and the X-axis support arm (10.4) through a third fixing screw (10.34) to enable the ultrasonic transducer (4) to horizontally rotate for 0-90 degrees;
adjusting the rotation angle between the second cross fastener (10.5) and the transducer fixing component (10.6) through a fifth fixing screw (10.55) to enable the ultrasonic transducer (4) to vertically rotate for 0-90 degrees;
adjusting the vertical angle of the ultrasonic transducer (4) by rotating the transducer fixing sleeve (10.61);
the height of the ultrasonic transducer (4) is adjusted by adjusting the depth of the Z-axis supporting arm (10.22) inserted into the adjusting bottom support (10.21) through a first fixing screw (10.23);
the transverse position of the ultrasonic transducer (4) is adjusted by adjusting the left and right positions of the X-axis supporting arm (10.4) of the first cross fastener (10.3) or the second cross fastener (10.5) through the second fixing screw (10.35) or the fourth fixing screw (10.53).
2. The transcranial ultrasound and magnetoacoustic stimulation system with mobile rotating means according to claim 1, characterized in that the static magnet support rods (7.4) can rotate 360 ° horizontally and 90 ° vertically.
3. A method for the transcranial ultrasound and magnetoacoustic stimulation system with the mobile rotating device, according to claim 1, characterized in that the pulse signal with the set repetition frequency generated by the first signal generator (1) for generating the repetitive pulse signal is sent to the second signal generator (2) for generating the ultrasound excitation signal, the second signal generator (2) generates the ultrasound excitation signal by means of external triggering and sends to the power amplifier (3) for power amplifying the ultrasound excitation signal, the ultrasound signal amplified by the power amplifier (3) is sent to the ultrasound transducer (4) for converting the electrical signal into the acoustic signal, and the converted acoustic signal is vertically targeted to the stimulation area of the tested sample (9) by the acoustic collimator (5); meanwhile, the supported static magnet (6) is movably arranged right in front of the tested sample (9) through the rotary movable bracket (7), so that transcranial magnetoacoustic coupling electrical stimulation is realized.
4. The method for transcranial ultrasound and magnetoacoustic stimulation system with mobile rotating means according to claim 3, characterized in that when transcranial ultrasound stimulation is performed only on the sample (9) to be measured, the static magnet (6) is horizontally rotated 180 ° by rotating the static magnet support rod (7.4) of the mobile gantry (7) to keep the static magnet (6) away from the sample (9) to be measured; when the size of an induced electric field formed by a magnetic field and a sound field needs to be changed, the static magnet (6) is rotated by a set angle in the vertical direction or the horizontal direction through a static magnet supporting rod (7.4) of the rotating moving bracket (7).
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CN111167015B (en) * | 2020-01-10 | 2023-09-15 | 深圳大学 | Treatment equipment based on acoustic-magnetic combined physical field |
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