CN109157652A - The spontaneous hotting mask of promotion burn wound reparation containing Radix Arnebiae extract - Google Patents
The spontaneous hotting mask of promotion burn wound reparation containing Radix Arnebiae extract Download PDFInfo
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- CN109157652A CN109157652A CN201811104333.3A CN201811104333A CN109157652A CN 109157652 A CN109157652 A CN 109157652A CN 201811104333 A CN201811104333 A CN 201811104333A CN 109157652 A CN109157652 A CN 109157652A
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A61M2205/36—General characteristics of the apparatus related to heating or cooling
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Abstract
The spontaneous hotting mask for the promotion burn wound reparation containing Radix Arnebiae extract that the invention discloses a kind of, the spontaneous hotting mask respectively includes the outer layer being made of gas permeable material from outside to inside, it is mounted with the heat-generating composition to generate heat and contacting with air and is the heating layer that gas permeable material is constituted with the cover of the outer layer, the insulating layer constituted with waterproof thermal-insulated performance material, bionics skin layer, repair layer, the restoration includes the storage bag of outer layer and deposits in the restoration in storage bag, the restoration is made of the raw material of following parts by weight: 10-50 parts of Radix Arnebiae extract, 20-50 parts of pure water, 0.1-0.5 parts of interleukin 12, 0.1-2 parts of amino acid, 0.1-2 parts of vitamin, 0.05-0.5 parts of magnesium chloride, 0.5-5 parts of odium stearate, sodium palmitate 0.5-5 parts.A possibility that spontaneous hotting mask disclosed in this invention can effectively improve the repairing effect of burned skin, reduce scar and infection.
Description
Technical field
The present invention relates to a kind of spontaneous hotting masks for promoting burn wound reparation, and the promotion especially containing Radix Arnebiae extract is burnt
Hurt the spontaneous hotting mask of wound repair.
Background technique
Skin is made of epidermis and corium, is the vitals of human body, can be prevented the invasion of microorganism.But skin is usually easy
It is damaged because the external world influences, the large area that especially burn will cause skin is damaged, and is caused skin repair difficult, is also easy to produce
The tissue such as scar, cutaneous normal function.In addition, the skin of burnt degree corrodes in repair process vulnerable to extraneous bacterium,
Cause skin repair difficult.
Existing burn cream is only applied to be wound the surface of skin, passively skin can only be waited to absorb, can not used
The modes such as heating promote absorption of the skin to beneficial.
Summary of the invention
The spontaneous hotting mask for the promotion burn wound reparation containing Radix Arnebiae extract that the present invention provides a kind of, to improve skin
Repairing effect, reduce scar and infection a possibility that.
The spontaneous hotting mask for the promotion burn wound reparation containing Radix Arnebiae extract that the present invention provides a kind of, the spontaneous heating
Film respectively includes the outer layer being made of gas permeable material from outside to inside, is mounted with the heat-generating composition to generate heat and contacting with air
And the heating layer constituted with the cover of the outer layer for gas permeable material, the heat preservation constituted with waterproof thermal-insulated performance material
Layer, repair layer, the restoration include the storage bag of outer layer and deposit in the restoration in storage bag, and the restoration is by following
The raw material of parts by weight is constituted: 10-50 parts of Radix Arnebiae extract, 20-50 parts of pure water, 0.1-0.5 parts of interleukin 12, amino
0.1-2 parts sour, 0.1-2 parts of vitamin, 0.05-0.5 parts of magnesium chloride, 0.5-5 parts of odium stearate, 0.5-5 parts of sodium palmitate, it is described
Radix Arnebiae extract the preparation method is as follows:
Step 1: taking Asian puccoon to freeze in liquid nitrogen, and be lyophilized for 24 hours, the Asian puccoon after freeze-drying is pulverized；Into lithospermum powder
Be added with the water of lithospermum powder equivalent weight, and ultrasound 10min formation lithospermum powder liquid, lithospermum powder liquid is placed in liquid nitrogen carry out it is cold
Freeze, after secondary freeze-drying for 24 hours, regrinding is crushed, and makes Arnebia Root grain thickness 100-300 mesh；
Step 2: taking the Arnebia Root of 1 parts by weight in the mixed liquor of 10 parts by weight ether and 10 parts by weight low boiling point alkane
In, it flows back for 24 hours and filters at 35 DEG C, collect filtrate；
Step 3: being at reduced pressure conditions evaporated ether, the low boiling point alkane in filtrate, the final product being collected into is purple
Careless extract.
Further, the restoration further includes 0.5-2 parts of potassium dihydrogen phosphate, 1-5 parts of disodium hydrogen phosphate, potassium sorbate
0.1-5 parts.
It further, further include 20-60 parts of collagenous fibres in the restoration, polysaccharide 10-20 parts glutinous.
Further, the glutinous polysaccharide is chondroitin.
Further, the restoration the preparation method is as follows:
Step 1: by potassium dihydrogen phosphate, disodium hydrogen phosphate, potassium sorbate, amino acid, vitamin, magnesium chloride, odium stearate
It is added in pure water, and shear agitation 1h；
Step 2: collagenous fibres, glutinous polysaccharide, the shear agitation 5-16h at 40-80 DEG C being added into step 1 gained liquid；
Step 3: step 2 gained liquid being cooled to 30-40 DEG C, Radix Arnebiae extract, interleukin 12, stirring is added
10min, and it is placed at room temperature for 1h, obtain restoration.
Further, low boiling point alkane is pentane in the preparation method of the Radix Arnebiae extract.
Further, it is provided with grid in the heating layer, heat-generating composition, the hair are uniformly mounted in the grid
Heat-generating composition in thermosphere includes: 30~50 parts of medical iron powders, 10~15 parts of active carbons, 1~5 part of salt, 3 in parts by weight
~13 parts of vermiculites, 1~5 part of water-absorbing resins, 1~5 part of water.
Further, the outer layer is the non-woven fabrics or textile cloth of natural fiber or synthetic fibers, and the insulating layer is PET
Metal coating.
Further, bionics skin layer is additionally provided between the insulating layer, repair layer, the bionics skin layer is silicon rubber
Film.
Further, the storage bag is polylactic acid bag.
It is more that Asian puccoon contains naphthalene Quinone Pigments, including Shikonin, Acetylshikonin, acryloyl alkannin, alkannin etc.
Kind pigment composition, these ingredients have antibacterial, antiinflammation, and curative effect is related with the content of naphthoquinones class total pigment.It was found that Asian puccoon
Alkannin, dimethyl pentene acyl alkannin, B- dimethylacrylshikonin in extract is to staphylococcus aureus, large intestine
Bacillus, hay bacillus etc. have inhibiting effect；Alkannin is to Escherichia coli, typhoid bacillus, shigella dysenteriae, Pseudomonas aeruginosa and golden yellow
Staphylococcus has obvious bacteriostasis；And the naphthoquinones in Asian puccoon also has strong antifungic action.Research is it is also shown that Asian puccoon
Certain in extract can inhibit capillary permeability, have inhibiting effect to exudation and oedema, have the protection surface of a wound, prevent from feeling
Dye promotes epithelial proliferation and reparation, accelerates the effect of wound healing.Extracting method of the invention can effectively extract Asian puccoon
In effective component, promote the therapeutic effect of burned skin.
Moreover, the present invention is compared with the existing technology, setting has the spontaneous hotting mask of spontaneous heat function on restoration, uses
Person can promote spontaneous hotting mask to send out after spontaneous hotting mask is fitted in wound upper surface by causing the reaction of heat-generating composition
A possibility that heat improves absorption of the affected part to restoration, improves the repairing effect of skin, reduces scar and infection.In addition, this hair
It is bright to use Radix Arnebiae extract and interleukin 12, while improving skin recovery capability, reduce the possibility of affected part infection
Property, spontaneous hotting mask is further improved to the therapeutic effect of burned skin.
Detailed description of the invention
Fig. 1 is spontaneous heating of embodiment of the present invention membrane structure diagram.
Specific embodiment
It in order to enable those skilled in the art to better understand the solution of the present invention, below will be to the skill in the embodiment of the present invention
Art scheme is clearly and completely described, it is clear that and the described embodiment is only a part of the embodiment of the present invention, without
It is whole embodiments.
Spontaneous heating membrane structure used by 1-3 of the embodiment of the present invention, reference examples 1 is as follows:
As shown in Figure 1, respectively including the outer layer 1 being made of gas permeable material from outside to inside, being mounted with by being contacted with air
And the heat-generating composition to generate heat and the cover that contact with the outer layer 1 be gas permeable material constitute heating layer 2, there is waterproof guarantor
Insulating layer 3, the bionics skin layer 4, restoration 5 of warm performance materials composition, the restoration 5 include the storage bag 51 of outer layer and deposit
The restoration 52 being put in storage bag 51, outer layer 1, heating layer 2, insulating layer 3, bionics skin layer 4, between restoration 5 to cohere
Mode is fixed.
Wherein, outer layer 1 is the textile cloth of natural fiber.It is provided with grid in the heating layer 2, is uniformly filled in the grid
It is loaded with heat-generating composition, the heat-generating composition in the heating layer 2 includes: 50 parts of medical iron powders, 15 parts of activity in parts by weight
Charcoal, 5 parts of salt, 13 parts of vermiculites, 5 parts of water-absorbing resins, 5 parts of water.Insulating layer is PET aluminium plated film.Bionics skin layer is silicon rubber
Film.Storage bag is polylactic acid bag.The partial size of active carbon is 100-300 μm, and salt is ferric sulfate, and water-absorbing resins are isobutene-
The liquor-saturated copolymer of maleic acid, the partial size of vermiculite are 300 μm or less.
In actual use, user can be used scissors and scratch storage bag 51, be exposed to restoration 52 outer, then
Spontaneous hotting mask is fitted in burned skin surfaces with restoration 52 on one side, heating layer 2 generates heat under oxygen effect.
1-2 of the embodiment of the present invention and reference examples 1-2 Radix Arnebiae extract the preparation method is as follows:
Step 1: taking Asian puccoon to freeze in liquid nitrogen, and be lyophilized for 24 hours, the Asian puccoon after freeze-drying is pulverized；Into lithospermum powder
Be added in the water of lithospermum powder equivalent weight, and ultrasound 10min formation lithospermum powder liquid, lithospermum powder liquid is placed in liquid nitrogen carry out it is cold
Freeze, after secondary freeze-drying for 24 hours, regrinding is crushed, and makes Arnebia Root grain thickness 100-300 mesh；
Step 2: taking the Arnebia Root of 1 parts by weight in the ether of 10 parts by weight and the pentane of 10 parts by weight, at 35 DEG C
It is lower to flow back for 24 hours and filter, collect filtrate；
Step 3: being at reduced pressure conditions evaporated ether, the pentane in filtrate, the final product being collected into mentions for Asian puccoon
Take object.
Embodiment 1:
1 restoration of the embodiment of the present invention is made of the raw material of following parts by weight: 50 parts of Radix Arnebiae extract, 50 parts of pure water,
0.5 part of interleukin 12,2 parts of potassium dihydrogen phosphate, 5 parts of disodium hydrogen phosphate, 5 parts of potassium sorbate, 2 parts of amino acid, vitamin 2
Part, 0.5 part of magnesium chloride, 5 parts of odium stearate, 0.5 part of sodium palmitate.Wherein collagenous fibres are ox bone collagen albumen, amino acid is
Alanine, vitamin are vitamin C.
1 restoration of the embodiment of the present invention the preparation method is as follows:
Step 1: by potassium dihydrogen phosphate, disodium hydrogen phosphate, potassium sorbate, amino acid, vitamin, magnesium chloride, odium stearate
It is added in pure water, and in 70-80 DEG C of shear agitation 1h；
Step 2: step 1 gained liquid being cooled to 30-40 DEG C, Radix Arnebiae extract, interleukin 12, stirring is added
10min, and it is placed at room temperature for 1h, obtain restoration.
Embodiment 2:
2 restoration of the embodiment of the present invention is made of the raw material of following parts by weight: 50 parts of Radix Arnebiae extract, 50 parts of pure water,
0.1-0.5 parts of interleukin 12,2 parts of potassium dihydrogen phosphate, 5 parts of disodium hydrogen phosphate, 5 parts of potassium sorbate, 2 parts of amino acid, dimension life
Plain 2 parts, 0.5 part of magnesium chloride, 5 parts of odium stearate, 0.5 part of sodium palmitate, 60 parts of collagenous fibres, 10 parts of chondroitin.Wherein collagen
Fiber is ox bone collagen albumen, amino acid is alanine, vitamin is vitamin C.
2 restoration of the embodiment of the present invention the preparation method is as follows:
Step 1: by potassium dihydrogen phosphate, disodium hydrogen phosphate, potassium sorbate, amino acid, vitamin, magnesium chloride, odium stearate
It is added in pure water, and shear agitation 1h；
Step 2: collagenous fibres, glutinous polysaccharide, the shear agitation 16h at 70-80 DEG C being added into step 1 gained liquid；
Step 3: step 2 gained liquid being cooled to 40 DEG C, Radix Arnebiae extract, interleukin 12, stirring is added
10min, and it is placed at room temperature for 1h, obtain restoration.
Embodiment 3:
3 restoration of the embodiment of the present invention is made of the raw material of following parts by weight: 50 parts of Radix Arnebiae extract, 50 parts of pure water,
0.5 part of interleukin 12,2 parts of potassium dihydrogen phosphate, 5 parts of disodium hydrogen phosphate, 5 parts of potassium sorbate, 2 parts of amino acid, vitamin 2
Part, 0.5 part of magnesium chloride, 5 parts of odium stearate, 0.5 part of sodium palmitate, 60 parts of collagenous fibres, 10 parts of chondroitin.Wherein collagenous fibres
For ox bone collagen albumen, amino acid be alanine, vitamin is vitamin C.
3 restoration of the embodiment of the present invention the preparation method is as follows:
Step 1: by potassium dihydrogen phosphate, disodium hydrogen phosphate, potassium sorbate, amino acid, vitamin, magnesium chloride, odium stearate
It is added in pure water, and shear agitation 1h；
Step 2: collagenous fibres, glutinous polysaccharide, the shear agitation 16h at 70-80 DEG C being added into step 1 gained liquid；
Step 3: step 2 gained liquid being cooled to 40 DEG C, Radix Arnebiae extract, interleukin 12, stirring is added
10min, and it is placed at room temperature for 1h, obtain restoration.
Wherein, 3 Radix Arnebiae extract of the embodiment of the present invention the preparation method is as follows:
It takes the Asian puccoon of 1 parts by weight in the ethyl alcohol of 10 parts by weight, flow back at 80 DEG C for 24 hours and filters, collect filtrate；Subtracting
Ether, the pentane in filtrate are evaporated under the conditions of pressure, the final product being collected into is Radix Arnebiae extract.
Reference examples 1
1 restoration of reference examples of the present invention is made of the raw material of following parts by weight: 50 parts of Radix Arnebiae extract, 50 parts of pure water,
0.5 part of interleukin 12,2 parts of potassium dihydrogen phosphate, 5 parts of disodium hydrogen phosphate, 5 parts of potassium sorbate, 2 parts of amino acid, vitamin 2
Part, 0.5 part of magnesium chloride, 5 parts of odium stearate, 0.5 part of sodium palmitate, 60 parts of collagenous fibres, 10 parts of chondroitin.Wherein collagenous fibres
For ox bone collagen albumen, amino acid be alanine, vitamin is vitamin C.
1 restoration of reference examples of the present invention the preparation method is as follows:
Step 1: by potassium dihydrogen phosphate, disodium hydrogen phosphate, potassium sorbate, amino acid, vitamin, magnesium chloride, odium stearate
It is added in pure water, and shear agitation 1h；
Step 2: collagenous fibres, glutinous polysaccharide, the shear agitation 16h at 70-80 DEG C being added into step 1 gained liquid；
Step 3: step 2 gained liquid being cooled to 40 DEG C, Radix Arnebiae extract, interleukin 12, stirring is added
10min, and it is placed at room temperature for 1h, obtain restoration.
Reference examples 2
2 restoration of reference examples of the present invention is made of the raw material of following parts by weight: 50 parts of Radix Arnebiae extract, 50 parts of pure water,
2 parts of potassium dihydrogen phosphate, 5 parts of disodium hydrogen phosphate, 5 parts of potassium sorbate, 2 parts of amino acid, 2 parts of vitamin, 0.5 part of magnesium chloride, tristearin
5 parts of sour sodium, 0.5 part of sodium palmitate, 60 parts of collagenous fibres, 10 parts of chondroitin.Wherein collagenous fibres are ox bone collagen albumen, amino
Acid is alanine, vitamin is vitamin C.
2 restoration of reference examples of the present invention the preparation method is as follows:
Step 1: by potassium dihydrogen phosphate, disodium hydrogen phosphate, potassium sorbate, amino acid, vitamin, magnesium chloride, odium stearate
It is added in pure water, and shear agitation 1h；
Step 2: collagenous fibres, glutinous polysaccharide, the shear agitation 16h at 70-80 DEG C being added into step 1 gained liquid；
Step 3: step 2 gained liquid being cooled to 40 DEG C, Radix Arnebiae extract is added, stirs 10min, and be placed at room temperature for
1h obtains restoration.
It chooses 100 healthy rats (250~300g of weight, unlimited male and female) and is equally divided into that the first experiment is organized greatly and second is real
Big group is tested, the big group of the first experiment and the big group of the second experiment are respectively divided into 5 groups (including the embodiment 1 under the big group of the first experiment
Group, 2 group of embodiment, 3 group of embodiment, 1 group of reference examples, 2 group of reference examples, second tests the embodiment 1 under big group
Group, 2 group of embodiment, 3 group of embodiment, 1 group of reference examples, 2 group of reference examples).Using hot water scald method each
The back surfaces of rat form the round deep ii degree burn wound that radius is 1cm.
The cultivating process of the big group rat of first experiment is as follows:
It is big that the restoration of 1-3 of the embodiment of the present invention, the spontaneous hotting mask of reference examples 1 and reference examples 2 are covered on the first experiment
On the back wound of the lower rat of group, the rat under the big group of the first experiment is cultivated according to conventional breeding condition, and observes big
The recovery process of mouse wound and the healing state of wound.
The cultivating process of the big group rat of second experiment is as follows:
It will be wiped infected with the cotton swab of the staphylococcus aureus wound for organizing lower rat big to the second experiment, and incite somebody to action this
It is big that the restoration of inventive embodiments 1-3, the spontaneous hotting mask of reference examples 1 and reference examples 2 are covered on the second experiment great Zu Xiage group
On the back wound of mouse, the rat under the big group of the second experiment is cultivated according to conventional breeding condition, and observe rat wound
Recovery process and wound healing state.
The character of embodiment 1-3 and reference examples 1-2 restoration and as shown in the table to rat skin repairing effect
It is mentioned from Asian puccoon in 1-2 of the embodiment of the present invention and reference examples 1-2 using the method that low-temperature frozen dry grinding, room temperature extract
Radix Arnebiae extract is taken, directlys adopt alcohol reflux compared to embodiment 3, can extract to the greatest extent and retain having in Asian puccoon
Beneficial composition, and then restoration is improved to the repairing effect of rat wound.Meanwhile 1-3 of the embodiment of the present invention and reference examples 1 have
Spontaneous heat structure can effectively improve rat wound to the assimilation effect of restoration nutrition, further shorten recovery time,
And spontaneous heat structure can effectively slow down the evaporation of moisture in restoration, improve the up time of restoration, reduce patient's
Use cost, and the restoration of reference examples 2 will harden after 2 day time because moisture evaporates, and need replacing, lead to restoration
Up time it is shorter, higher cost.In addition, the combination of the Radix Arnebiae extract and interleukin 12 of the embodiment of the present invention
Bactericidal effect can be effectively played, alleviates the influence that staphylococcus aureus restores wound, and reduce the possibility for forming scar
Property, and have and the embodiment 3 of Radix Arnebiae extract is extracted using alcohol reflux and lacks the reference examples 1 of interleukin 12, rat
Recovery time be obviously prolonged, and there is the case where scar after healing.
Note also when, the restorations of embodiment 2-3 and reference examples 1 makes the restoration be in using collagenous fibres, glutinous polysaccharide
Existing gelatinous solid, can effectively save moisture and beneficial, be improved the up time of restoration, reduce and repair
The replacement frequency of object, and then reduce use cost.
Finally it should be noted that the above embodiments are merely illustrative of the technical scheme of the present invention and are not intended to be limiting thereof, to the greatest extent
Invention is explained in detail referring to above-described embodiment for pipe, it should be understood by a person of ordinary skill in the art that technology
Personnel read present specification after still can with modifications or equivalent substitutions are made to specific embodiments of the invention, but this
A little modifications are changed within all without departing from the present patent application accompanying claims protection scope.
Claims (10)
1. a kind of spontaneous hotting mask of the promotion burn wound reparation containing Radix Arnebiae extract, which is characterized in that the spontaneous hotting mask
Respectively include from outside to inside the outer layer being made of gas permeable material, be mounted with by with air contact and generate heat heat-generating composition and
Cover with the outer layer is the heating layer that gas permeable material is constituted, the heat preservation constituted with waterproof thermal-insulated performance material
Layer, repair layer, the restoration include the storage bag of outer layer and deposit in the restoration in storage bag, and the restoration is by following
The raw material of parts by weight is constituted: 10-50 parts of Radix Arnebiae extract, 20-50 parts of pure water, 0.1-0.5 parts of interleukin 12, amino
0.1-2 parts sour, 0.1-2 parts of vitamin, 0.05-0.5 parts of magnesium chloride, 0.5-5 parts of odium stearate, 0.5-5 parts of sodium palmitate, it is described
Radix Arnebiae extract the preparation method is as follows:
Step 1: taking Asian puccoon to freeze in liquid nitrogen, and be lyophilized for 24 hours, the Asian puccoon after freeze-drying is pulverized；It is added into lithospermum powder
With the water of lithospermum powder equivalent weight, and ultrasound 10min formed lithospermum powder liquid, lithospermum powder liquid is placed in liquid nitrogen and is freezed, two
After secondary freeze-drying for 24 hours, regrinding is crushed, and makes Arnebia Root grain thickness 100-300 mesh；
Step 2: take the Arnebia Root of 1 parts by weight in the mixed liquor of 10 parts by weight ether and 10 parts by weight low boiling point alkane,
It flows back for 24 hours and filters at 35 DEG C, collect filtrate；
Step 3: being at reduced pressure conditions evaporated ether, the low boiling point alkane in filtrate, the final product being collected into mentions for Asian puccoon
Take object.
2. spontaneous hotting mask according to claim 1, which is characterized in that the restoration further includes potassium dihydrogen phosphate 0.5-2
Part, 1-5 parts of disodium hydrogen phosphate, 0.1-5 parts of potassium sorbate.
3. spontaneous hotting mask according to claim 1, which is characterized in that further include collagenous fibres 20-60 in the restoration
Part sticks polysaccharide 10-20 parts.
4. spontaneous hotting mask according to claim 3, which is characterized in that the glutinous polysaccharide is chondroitin.
5. spontaneous hotting mask according to claim 3, which is characterized in that the restoration the preparation method is as follows:
Step 1: potassium dihydrogen phosphate, disodium hydrogen phosphate, potassium sorbate, amino acid, vitamin, magnesium chloride, odium stearate are added
In pure water, and shear agitation 1h；
Step 2: collagenous fibres, glutinous polysaccharide, the shear agitation 5-16h at 40-80 DEG C being added into step 1 gained liquid；
Step 3: step 2 gained liquid being cooled to 30-40 DEG C, Radix Arnebiae extract, interleukin 12, stirring is added
10min, and it is placed at room temperature for 1h, obtain restoration.
6. spontaneous hotting mask according to claim 1, which is characterized in that low boiling point in the preparation method of the Radix Arnebiae extract
Alkane is pentane.
7. spontaneous hotting mask according to claim 1, which is characterized in that be provided with grid, the grid in the heating layer
In be uniformly mounted with heat-generating composition, the heat-generating composition in the heating layer includes: 30~50 parts of medical iron in parts by weight
Powder, 10~15 parts of active carbons, 1~5 part of salt, 3~13 parts of vermiculites, 1~5 part of water-absorbing resins, 1~5 part of water.
8. spontaneous hotting mask according to claim 1, which is characterized in that the outer layer is the nothing of natural fiber or synthetic fibers
Woven fabric or textile cloth, the insulating layer are PET metal coating.
9. spontaneous hotting mask according to claim 1, which is characterized in that be additionally provided between the insulating layer, repair layer bionical
Skin layer, the bionics skin layer are silicon rubber film.
10. spontaneous hotting mask according to claim 1, which is characterized in that the storage bag is polylactic acid bag.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811104333.3A CN109157652A (en) | 2018-09-21 | 2018-09-21 | The spontaneous hotting mask of promotion burn wound reparation containing Radix Arnebiae extract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811104333.3A CN109157652A (en) | 2018-09-21 | 2018-09-21 | The spontaneous hotting mask of promotion burn wound reparation containing Radix Arnebiae extract |
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| CN109157652A true CN109157652A (en) | 2019-01-08 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612290A (en) * | 2008-06-27 | 2009-12-30 | 李伟芳 | A kind of pharmaceutical composition for the treatment of burn and scald and preparation method thereof |
| CN102038937A (en) * | 2009-10-12 | 2011-05-04 | 张志群 | External medicament for treating dermatosis and anti-aging and preparation method thereof |
| CN102091203A (en) * | 2011-01-19 | 2011-06-15 | 李惠斌 | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof |
| CN104146812A (en) * | 2014-08-06 | 2014-11-19 | 陈蕾 | Spontaneous heating and heat preserving film and application thereof |
| CN107714749A (en) * | 2017-09-14 | 2018-02-23 | 湖南晓林生物科技发展有限公司 | A kind of Asian puccoon extract and preparation method and application |
| CN108186908A (en) * | 2018-03-12 | 2018-06-22 | 大连军门保健食品有限公司 | A kind of burn and scald Chinese medicine film and preparation method thereof |
-
2018
- 2018-09-21 CN CN201811104333.3A patent/CN109157652A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612290A (en) * | 2008-06-27 | 2009-12-30 | 李伟芳 | A kind of pharmaceutical composition for the treatment of burn and scald and preparation method thereof |
| CN102038937A (en) * | 2009-10-12 | 2011-05-04 | 张志群 | External medicament for treating dermatosis and anti-aging and preparation method thereof |
| CN102091203A (en) * | 2011-01-19 | 2011-06-15 | 李惠斌 | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof |
| CN104146812A (en) * | 2014-08-06 | 2014-11-19 | 陈蕾 | Spontaneous heating and heat preserving film and application thereof |
| CN107714749A (en) * | 2017-09-14 | 2018-02-23 | 湖南晓林生物科技发展有限公司 | A kind of Asian puccoon extract and preparation method and application |
| CN108186908A (en) * | 2018-03-12 | 2018-06-22 | 大连军门保健食品有限公司 | A kind of burn and scald Chinese medicine film and preparation method thereof |
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Application publication date: 20190108 |