CN109125659A - A kind of nourishing and protecting liver drug and its processing technology - Google Patents

A kind of nourishing and protecting liver drug and its processing technology Download PDF

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Publication number
CN109125659A
CN109125659A CN201810932632.XA CN201810932632A CN109125659A CN 109125659 A CN109125659 A CN 109125659A CN 201810932632 A CN201810932632 A CN 201810932632A CN 109125659 A CN109125659 A CN 109125659A
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powder
parts
galanga
hyacinth bean
extracting solution
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陈太兴
黄冬
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Chongqing Bai Cao Tai Xing Biotechnology Co Ltd
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Chongqing Bai Cao Tai Xing Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9062Alpinia, e.g. red ginger or galangal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention discloses a kind of nourishing and protecting liver drug and its processing technologys, the drug includes a kind of Chinese medicine composition that can improve the stomach trouble such as raw splenic and gastric incoordination, taste, gastritis, gastric ulcer, gastric erosion, the Chinese medicine composition is made of following component: hoveniae semoveniae semen, radix polygonati officinalis, galanga, black mulberries, fructus lycii and hyacinth bean, wherein each ingredient is formed according to following parts by weight: 15-21 parts of 7-11 parts of raisin tree seed extract, 11-17 parts of fragrant solomonseal rhizome polyoses slurry, 20-30 parts of galanga extracting solution, black 12-14 parts of mulberries Ultramicro-powder, 6-8 parts of fructus lycii Ultramicro-powder and hyacinth bean extract.The important composition is ointment preparation.By adopting the above technical scheme, the present invention provide it is a kind of can be with the drug of nourishing and protecting liver.

Description

A kind of nourishing and protecting liver drug and its processing technology
Technical field
The present invention relates to diet-therapy health-preserving field, specially a kind of nourishing and protecting liver drug and its processing technology.
Background technique
Hepatopathy is a kind of common disease for seriously threatening human health, can be divided into virus hepatitis, wine according to the cause of disease Essence hepatitis, nonalcoholic fatty liver, oneself immunity hepatitis, drug poisoning hepatitis, hereditary metabolic disorders hepatopathy and other senses Contaminate hepatitis caused by the factor.
Various additives are increased currently, liver-nourishing medicine is many kinds of, but without exception, injury is caused to human body, The absorption for also affecting nutritional ingredient simultaneously, taking can cause to damage to liver, there is certain side effect.
Hoveniae semoveniae semen enters stomach meridian, has effects that cough-relieving relieving restlessness, tranquilizing the mind of sobering up, dispelling wind and removing obstruction in the meridians and tonneau stool and urine;Radix polygonati officinalis, Quench the thirst with Yin nourishing and lung moistening, relieving restlessness, stomach strengthening and digestion promoting and antitumor effect;Galanga has strengthening spleen and nourishing stomach, warming spleen and stomach for dispelling cold, promoting the circulation of qi The effect of analgesic, antibacterial anti-inflammatory;Black mulberries have effects that nourishing and strengthening Yin and Yang, supplementing the kidney to control the nocturnal, UFA eyesight and toxin-expelling and face nourishing;Chinese holly Qi has effects that nourish the liver to improve visual acuity, kidney tonifying, essence replenishing, beautifying face and moistering lotion and oxidation resistant;Hyacinth bean, dampness elimination relieves summer heat, strengthening spleen and invigorating qi, antibacterial Removing toxic substances and Antitumor virus.
Summary of the invention
The present invention provides one kind can be with the drug of nourishing and protecting liver.
In order to solve the above-mentioned technical problem, the technical solution of the present invention is as follows: a kind of nourishing and protecting liver drug, the drug include A kind of Chinese medicine composition improving the stomach trouble such as raw splenic and gastric incoordination, taste, gastritis, gastric ulcer, gastric erosion, the Chinese traditional medicine composition Object is made of following component: hoveniae semoveniae semen, radix polygonati officinalis, galanga, black mulberries, fructus lycii and hyacinth bean, wherein each ingredient is according to following parts by weight Composition: 7-11 parts of raisin tree seed extract, fragrant solomonseal rhizome polyoses starch 11-17 parts, 20-30 parts of galanga extracting solution, black mulberries Ultramicro-powder 15-21 parts of 12-14 parts, 6-8 parts of fructus lycii Ultramicro-powder and hyacinth bean extract.The important composition is ointment preparation.
The method of the preparation nourishing and protecting liver drug the following steps are included:
(1) preparation of raw material:
A, raisin tree seed extract: hoveniae semoveniae semen being cleaned up, is shredded, and is put into pulverizer after air-drying, is crushed to 80-100 Mesh, using water, ethyl alcohol mixed aqueous solution as Extraction solvent, hoveniae semoveniae semen powder is added, refluxing extraction 2-3 times, is extracted Liquid;It is filtered after extracting solution is concentrated using 200 mesh silks, collects filtrate, then the remaining dregs of a decoction are put into water, sodium hydroxide Aqueous slkali in, be heated to reflux 2 hours, using 200 mesh silks filter, collect filtrate, by the filtrate collected twice distinguish it is dense Being reduced to specific gravity is 1.10-1.14g/cm3Liquid extract;B, Rhizoma Polygonati Odorati extract: water and enzyme is added in radix polygonati officinalis, is uniformly mixed laggard Row enzyme digestion reaction, wherein the additional amount of the water is 4-8 times of radix polygonati officinalis weight, and the additional amount of enzyme is the 0.2-of radix polygonati officinalis weight 0.6%, after enzymatic hydrolysis, heating is stirred radix polygonati officinalis, stands 2-4 hours, is separated by solid-liquid separation, and carries out to gained extracting solution Concentrate is mixed, stood and is separated by solid-liquid separation operation with dehydrated alcohol, and separating obtained precipitating is dried by concentration To moisture content 20-40%, fragrant solomonseal rhizome polyoses slurry is obtained;C, galanga extracting solution: taking the galanga powder of 60-80 mesh, and edible wine is added The weight ratio of essence, galanga powder and edible alcohol is 1:10-1:12, stirs the mixture for uniformly being placed on ultrasonic extractor, obtain To galanga extracting solution;D, black mulberries Ultramicro-powder: taking fresh black mulberries to clean, dry, and carries out at low temperature to black mulberries cold rapidly Freeze, then makes the direct lyophilization of moisture under vacuum conditions, then pulverized, obtain black mulberries Ultramicro-powder;E, Chinese holly Qi Ultramicro-powder: taking dry fructus lycii tentatively to be crushed, and the fructus lycii after coarse crushing is carried out brittle processing, then to embrittlement at The Chinese medicine managed is pulverized, and fructus lycii Ultramicro-powder is obtained;F, hyacinth bean extract: by hyacinth bean in 40-50 DEG C of water Impregnate 6-8 hours, the practical ball mill of hyacinth bean after immersion crushed into defibrination, be added and just all volume ratio be 1:2 clear water, The solid particle degree in Semen Lablab Album slurry is controlled at 120-140 μm, hyacinth bean magma is obtained, with hyacinth bean magma volume ratio 1:4- The physiological saline of 1:6 extracts, then extracting solution is saltoutd with ammonium sulfate, obtained precipitating through distillation water desalination, Hyacinth bean extract is obtained after freeze-drying.
(2) according to raisin tree seed extract obtained above, fragrant solomonseal rhizome polyoses slurry, galanga extracting solution, black mulberries Ultramicro-powder, Chinese holly Qi Ultramicro-powder and hyacinth bean extract, are proportionally uniformly mixed, and are put into 60-70 DEG C of baking oven after sterilization, directly Moisture content to mixture is 8-12%, is packed into packaging bag, and sealing saves to get nourishing and protecting liver drug.
Nearly half, in step (1), when preparing raisin tree seed extract, use the mixed aqueous solution of water, ethyl alcohol as mentioning Take solvent, the weight fraction ratio of water and ethyl alcohol is 1:4-1:10.
Further, in step (1), when preparing galanga extracting solution, galanga extracting solution moisture content 60-80%.
By adopting the above technical scheme, because joined hoveniae semoveniae semen, glucose containing volume, potassium nitrate and potassium malate, fructose Have effects that relieving alcoholism, relieving restlessness of quenching the thirst, preventing or arresting vomiting, sharp stool and urine with sucrose;Because joined fructus lycii, there is that anti-oxidant, nourishing the liver is bright The effect of mesh, kidney tonifying, essence replenishing, beautifying face and moistering lotion;Because joined black mulberries, there are nourishing and strengthening Yin and Yang, supplementing the kidney to control the nocturnal, UFA eyesight and row The effect of malicious beauty treatment;Because joined galanga, there is the effect of strengthening spleen and nourishing stomach, warming spleen and stomach for dispelling cold, promoting qi circulation and relieving pain and antibacterial anti-inflammatory;Cause To joined hyacinth bean, there is dampness elimination to relieve summer heat, strengthening the spleen and stomach polishing, antibacterial and detoxicating, antiviral and antitumor, the function improved the immunity of the human body Effect;Because joined radix polygonati officinalis, Yin nourishing and lung moistening, relieving restlessness quench the thirst and the effect of stomach strengthening and digestion promotings.
Specific embodiment
Specific embodiments of the present invention will be further explained below.It should be noted that for these implementations The explanation of mode is used to help understand the present invention, but and does not constitute a limitation of the invention.In addition, this hair disclosed below Technical characteristic involved in bright each embodiment can be combined with each other as long as they do not conflict with each other.
Embodiment one:
A kind of nourishing and protecting liver drug, the drug include one kind can improve raw splenic and gastric incoordination, taste, gastritis, gastric ulcer, The Chinese medicine composition of the stomach trouble such as gastric erosion, the Chinese medicine composition are made of following component: hoveniae semoveniae semen, radix polygonati officinalis, galanga, black mulberries, Fructus lycii and hyacinth bean, wherein each ingredient is formed according to following parts by weight: 7 parts of raisin tree seed extract, fragrant solomonseal rhizome polyoses starch 11 parts, galanga 20 parts of extracting solution, 12 parts of black mulberries Ultramicro-powder, 6 parts of fructus lycii Ultramicro-powder and 15 parts of hyacinth bean extract.The important composition is Ointment preparation.
The method of the preparation nourishing and protecting liver drug the following steps are included:
(1) preparation of raw material:
A, raisin tree seed extract: hoveniae semoveniae semen being cleaned up, is shredded, and is put into pulverizer after air-drying, is crushed to 80 mesh, with Water, ethyl alcohol mixed aqueous solution as Extraction solvent, hoveniae semoveniae semen powder is added, refluxing extraction 2 times, obtains extracting solution;It will extract It is filtered after liquid concentration using 200 mesh silks, collects filtrate, then the remaining dregs of a decoction are put into the aqueous slkali of water, sodium hydroxide In, it is heated to reflux 2 hours, is filtered using 200 mesh silks, collect filtrate, the filtrate collected twice is concentrated into specific gravity respectively For 1.10g/cm3Liquid extract.
B, Rhizoma Polygonati Odorati extract: water and enzyme is added in radix polygonati officinalis, carries out enzyme digestion reaction after mixing, wherein the water adds Enter 4 times that amount is radix polygonati officinalis weight, the additional amount of enzyme is the 0.2% of radix polygonati officinalis weight, and after enzymatic hydrolysis, radix polygonati officinalis is stirred in heating Mix, stand 2 hours, be separated by solid-liquid separation, gained extracting solution is concentrated, concentrate is mixed with dehydrated alcohol, stand and It is separated by solid-liquid separation operation, and separating obtained precipitating is dried to moisture content 20%, obtains fragrant solomonseal rhizome polyoses slurry.
C, galanga extracting solution: taking the galanga powder of 60 mesh, is added edible alcohol, and the weight ratio of galanga powder and edible alcohol is 1:10 stirs the mixture for uniformly being placed on ultrasonic extractor, obtains galanga extracting solution.
D, black mulberries Ultramicro-powder: taking fresh black mulberries to clean, dry, and carries out quick freeze to black mulberries at low temperature, so Make the direct lyophilization of moisture under vacuum conditions afterwards, then pulverized, obtains black mulberries Ultramicro-powder.
E, fructus lycii Ultramicro-powder: taking dry fructus lycii tentatively to be crushed, and the fructus lycii after coarse crushing is carried out brittle processing, Then the processed Chinese medicine of embrittlement is pulverized, obtains fructus lycii Ultramicro-powder.
F, hyacinth bean extract: hyacinth bean is impregnated 6 hours in 40 DEG C of water, by the practical ball mill powder of hyacinth bean after immersion Comminution slurry, is added and just all volume ratio is the clear water of 1:2, controls the solid particle degree in Semen Lablab Album slurry at 120 μm, obtains It to hyacinth bean magma, is extracted with the physiological saline of hyacinth bean magma volume ratio 1:4, then extracting solution is carried out with ammonium sulfate It saltouts, obtained precipitating obtains hyacinth bean extract after distillation water desalination, freeze-drying.
(2) according to raisin tree seed extract obtained above, fragrant solomonseal rhizome polyoses slurry, galanga extracting solution, black mulberries Ultramicro-powder, Chinese holly Qi Ultramicro-powder and hyacinth bean extract, are proportionally uniformly mixed, and are put into 60 DEG C of baking oven after sterilization, until mixed The moisture content for closing object is 8%, is packed into packaging bag, and sealing saves to get nourishing and protecting liver drug.
Embodiment two:
A kind of nourishing and protecting liver drug, the drug include one kind can improve raw splenic and gastric incoordination, taste, gastritis, gastric ulcer, The Chinese medicine composition of the stomach trouble such as gastric erosion, the Chinese medicine composition are made of following component: hoveniae semoveniae semen, radix polygonati officinalis, galanga, black mulberries, Fructus lycii and hyacinth bean, wherein each ingredient is formed according to following parts by weight: 9 parts of raisin tree seed extract, fragrant solomonseal rhizome polyoses starch 14 parts, galanga 25 parts of extracting solution, 13 parts of black mulberries Ultramicro-powder, 7 parts of fructus lycii Ultramicro-powder and 18 parts of hyacinth bean extract.The important composition is Ointment preparation.
The method of the preparation nourishing and protecting liver drug the following steps are included:
(1) preparation of raw material:
A, raisin tree seed extract: hoveniae semoveniae semen being cleaned up, is shredded, and is put into pulverizer after air-drying, is crushed to 90 mesh, with Water, ethyl alcohol mixed aqueous solution as Extraction solvent, hoveniae semoveniae semen powder is added, refluxing extraction 2 times, obtains extracting solution;It will extract It is filtered after liquid concentration using 200 mesh silks, collects filtrate, then the remaining dregs of a decoction are put into the aqueous slkali of water, sodium hydroxide In, it is heated to reflux 2 hours, is filtered using 200 mesh silks, collect filtrate, the filtrate collected twice is concentrated into specific gravity respectively For 1.12g/cm3Liquid extract.
B, Rhizoma Polygonati Odorati extract: water and enzyme is added in radix polygonati officinalis, carries out enzyme digestion reaction after mixing, wherein the water adds Enter 6 times that amount is radix polygonati officinalis weight, the additional amount of enzyme is the 0.4% of radix polygonati officinalis weight, and after enzymatic hydrolysis, radix polygonati officinalis is stirred in heating Mix, stand 3 hours, be separated by solid-liquid separation, gained extracting solution is concentrated, concentrate is mixed with dehydrated alcohol, stand and It is separated by solid-liquid separation operation, and separating obtained precipitating is dried to moisture content 30%, obtains fragrant solomonseal rhizome polyoses slurry.
C, galanga extracting solution: taking the galanga powder of 60-80 mesh, and edible alcohol, the weight of galanga powder and edible alcohol is added Than stirring the mixture for uniformly being placed on ultrasonic extractor, obtaining galanga extracting solution for 1:10-1:12.
D, black mulberries Ultramicro-powder: taking fresh black mulberries to clean, dry, and carries out quick freeze to black mulberries at low temperature, so Make the direct lyophilization of moisture under vacuum conditions afterwards, then pulverized, obtains black mulberries Ultramicro-powder.
E, fructus lycii Ultramicro-powder: taking dry fructus lycii tentatively to be crushed, and the fructus lycii after coarse crushing is carried out brittle processing, Then the processed Chinese medicine of embrittlement is pulverized, obtains fructus lycii Ultramicro-powder.
F, hyacinth bean extract: hyacinth bean is impregnated 7 hours in 45 DEG C of water, by the practical ball mill powder of hyacinth bean after immersion Comminution slurry, is added and just all volume ratio is the clear water of 1:2, controls the solid particle degree in Semen Lablab Album slurry at 130 μm, obtains It to hyacinth bean magma, is extracted with the physiological saline of hyacinth bean magma volume ratio 1:5, then extracting solution is carried out with ammonium sulfate It saltouts, obtained precipitating obtains hyacinth bean extract after distillation water desalination, freeze-drying.
(2) according to raisin tree seed extract obtained above, fragrant solomonseal rhizome polyoses slurry, galanga extracting solution, black mulberries Ultramicro-powder, Chinese holly Qi Ultramicro-powder and hyacinth bean extract, are proportionally uniformly mixed, and are put into 65 DEG C of baking oven after sterilization, until mixed The moisture content for closing object is 10%, is packed into packaging bag, and sealing saves to get nourishing and protecting liver drug.
Embodiment three:
A kind of nourishing and protecting liver drug, the drug include one kind can improve raw splenic and gastric incoordination, taste, gastritis, gastric ulcer, The Chinese medicine composition of the stomach trouble such as gastric erosion, the Chinese medicine composition are made of following component: hoveniae semoveniae semen, radix polygonati officinalis, galanga, black mulberries, Fructus lycii and hyacinth bean, wherein each ingredient is formed according to following parts by weight: 11 parts of raisin tree seed extract, fragrant solomonseal rhizome polyoses starch 17 parts, galanga 30 parts of extracting solution, 14 parts of black mulberries Ultramicro-powder, 8 parts of fructus lycii Ultramicro-powder and 21 parts of hyacinth bean extract.The important composition is Ointment preparation.
The method of the preparation nourishing and protecting liver drug the following steps are included:
(1) preparation of raw material:
A, raisin tree seed extract: hoveniae semoveniae semen being cleaned up, is shredded, and is put into pulverizer after air-drying, is crushed to 100 mesh, with Water, ethyl alcohol mixed aqueous solution as Extraction solvent, hoveniae semoveniae semen powder is added, refluxing extraction 3 times, obtains extracting solution;It will extract It is filtered after liquid concentration using 200 mesh silks, collects filtrate, then the remaining dregs of a decoction are put into the aqueous slkali of water, sodium hydroxide In, it is heated to reflux 2 hours, is filtered using 200 mesh silks, collect filtrate, the filtrate collected twice is concentrated into specific gravity respectively For 1.14g/cm3Liquid extract.
B, Rhizoma Polygonati Odorati extract: water and enzyme is added in radix polygonati officinalis, carries out enzyme digestion reaction after mixing, wherein the water adds Enter 8 times that amount is radix polygonati officinalis weight, the additional amount of enzyme is the 0.6% of radix polygonati officinalis weight, and after enzymatic hydrolysis, radix polygonati officinalis is stirred in heating Mix, stand 4 hours, be separated by solid-liquid separation, gained extracting solution is concentrated, concentrate is mixed with dehydrated alcohol, stand and It is separated by solid-liquid separation operation, and separating obtained precipitating is dried to moisture content 40%, obtains fragrant solomonseal rhizome polyoses slurry.
C, galanga extracting solution: taking the galanga powder of 80 mesh, is added edible alcohol, and the weight ratio of galanga powder and edible alcohol is 1:12 stirs the mixture for uniformly being placed on ultrasonic extractor, obtains galanga extracting solution.
D, black mulberries Ultramicro-powder: taking fresh black mulberries to clean, dry, and carries out quick freeze to black mulberries at low temperature, so Make the direct lyophilization of moisture under vacuum conditions afterwards, then pulverized, obtains black mulberries Ultramicro-powder.
E, fructus lycii Ultramicro-powder: taking dry fructus lycii tentatively to be crushed, and the fructus lycii after coarse crushing is carried out brittle processing, Then the processed Chinese medicine of embrittlement is pulverized, obtains fructus lycii Ultramicro-powder.
F, hyacinth bean extract: hyacinth bean is impregnated 8 hours in 50 DEG C of water, by the practical ball mill powder of hyacinth bean after immersion Comminution slurry, is added and just all volume ratio is the clear water of 1:2, controls the solid particle degree in Semen Lablab Album slurry at 140 μm, obtains It to hyacinth bean magma, is extracted with the physiological saline of hyacinth bean magma volume ratio 1:6, then extracting solution is carried out with ammonium sulfate It saltouts, obtained precipitating obtains hyacinth bean extract after distillation water desalination, freeze-drying.
(2) according to raisin tree seed extract obtained above, fragrant solomonseal rhizome polyoses slurry, galanga extracting solution, black mulberries Ultramicro-powder, Chinese holly Qi Ultramicro-powder and hyacinth bean extract, are proportionally uniformly mixed, and are put into 60-70 DEG C of baking oven after sterilization, directly Moisture content to mixture is 12%, is packed into packaging bag, and sealing saves to get nourishing and protecting liver drug.
Embodiment two is most preferred embodiment.
Using raisin tree seed extract, relieving restlessness of quenching the thirst is cured mainly, the concentration of clearing away damp-heat, relieving alcoholism function, extract is high, takes There can be preferable nourishing the liver effect on a small quantity.
The present invention is not limited to described embodiments.For a person skilled in the art, the present invention is not being departed from In the case where principle and spirit, a variety of change, modification, replacement and modification are carried out to these embodiments, are still fallen within of the invention In protection scope.

Claims (3)

1. a kind of nourishing and protecting liver drug, it is characterised in that: the drug include one kind can improve raw splenic and gastric incoordination, taste, gastritis, The Chinese medicine composition of the stomach trouble such as gastric ulcer, gastric erosion, the Chinese medicine composition are made of following component: hoveniae semoveniae semen, radix polygonati officinalis, galanga, Black mulberries, fructus lycii and hyacinth bean, wherein each ingredient is formed according to following parts by weight: 7-11 parts of raisin tree seed extract, fragrant solomonseal rhizome polyoses slurry 11-17 parts, 20-30 parts of galanga extracting solution, black 12-14 parts of mulberries Ultramicro-powder, 6-8 parts of fructus lycii Ultramicro-powder and hyacinth bean extract 15-21 parts;
The important composition is ointment preparation;
The method of the preparation nourishing and protecting liver drug the following steps are included:
(1) preparation of raw material:
A, raisin tree seed extract: hoveniae semoveniae semen being cleaned up, is shredded, and is put into pulverizer after air-drying, is crushed to 80-100 mesh, with Water, ethyl alcohol mixed aqueous solution as Extraction solvent, hoveniae semoveniae semen powder is added, refluxing extraction 2-3 times, obtains extracting solution;It will mention It is filtered after taking liquid to be concentrated using 200 mesh silks, collects filtrate, then the remaining dregs of a decoction are put into the aqueous slkali of water, sodium hydroxide In, it is heated to reflux 2 hours, is filtered using 200 mesh silks, collect filtrate, the filtrate collected twice is concentrated into specific gravity respectively is 1.10—1.14g/cm3Liquid extract;
B, Rhizoma Polygonati Odorati extract: water and enzyme is added in radix polygonati officinalis, carries out enzyme digestion reaction after mixing, wherein the additional amount of the water Be 4-8 times of radix polygonati officinalis weight, the additional amount of enzyme is 0.2-the 0.6% of radix polygonati officinalis weight, after enzymatic hydrolysis, heating, to radix polygonati officinalis into Row stirring, stands 2-4 hours, is separated by solid-liquid separation, gained extracting solution is concentrated, concentrate is mixed with dehydrated alcohol, Operation is stood and be separated by solid-liquid separation, and separating obtained precipitating is dried to moisture content 20-40%, obtains fragrant solomonseal rhizome polyoses slurry;
C, galanga extracting solution: taking the galanga powder of 60-80 mesh, is added edible alcohol, and the weight ratio of galanga powder and edible alcohol is 1: 10-1:12 stir the mixture for uniformly being placed on ultrasonic extractor, obtain galanga extracting solution;
D, black mulberries Ultramicro-powder: taking fresh black mulberries to clean, dry, and carries out quick freeze to black mulberries at low temperature, then exists Make the direct lyophilization of moisture under vacuum condition, then pulverized, obtains black mulberries Ultramicro-powder;
E, fructus lycii Ultramicro-powder: taking dry fructus lycii tentatively to be crushed, and the fructus lycii after coarse crushing is carried out brittle processing, then right The processed Chinese medicine of embrittlement is pulverized, and fructus lycii Ultramicro-powder is obtained;
F, hyacinth bean extract: hyacinth bean is impregnated 6-8 hours in 40-50 DEG C of water, by the practical ball mill of hyacinth bean after immersion Defibrination is crushed, is added and just all volume ratio is the clear water of 1:2, control the solid particle degree in Semen Lablab Album slurry 120-140 μm, hyacinth bean magma is obtained, is extracted with the physiological saline of hyacinth bean magma volume ratio 1:4-1:6, then by extracting solution ammonium sulfate Solution is saltoutd, and obtained precipitating obtains hyacinth bean extract after distillation water desalination, freeze-drying;
(2) according to raisin tree seed extract obtained above, fragrant solomonseal rhizome polyoses slurry, galanga extracting solution, black mulberries Ultramicro-powder, fructus lycii ultra micro Powder and hyacinth bean extract, are proportionally uniformly mixed, and are put into 60-70 DEG C of baking oven after sterilization, until mixture Moisture content be 8-12%, be packed into packaging bag, sealing save to get nourishing and protecting liver drug.
2. a kind of nourishing and protecting liver drug as described in claim 1, it is characterised in that: in step (1), prepare raisin tree seed extract When, use the mixed aqueous solution of water, ethyl alcohol as Extraction solvent, the weight fraction ratio of water and ethyl alcohol is 1:4-1:10.
3. a kind of nourishing and protecting liver drug as described in claim 1, it is characterised in that: in step (1), prepare galanga extracting solution When, galanga extracting solution moisture content 60-80%.
CN201810932632.XA 2018-08-16 2018-08-16 A kind of nourishing and protecting liver drug and its processing technology Pending CN109125659A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110050759A (en) * 2019-05-09 2019-07-26 泸水富兴生物科技发展有限公司 A kind of cultural method of scoliid

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CN1679890A (en) * 2005-01-10 2005-10-12 于吉善 Sobering up infusion granule and preparation thereof
CN101549006A (en) * 2008-04-01 2009-10-07 中国人民解放军军事医学科学院野战输血研究所 White lablab seed extract as well as extracting method and application thereof in preparing ultraviolet injury resistant preparations
CN103565960A (en) * 2013-11-27 2014-02-12 哈药集团中药二厂 Semen hoveniae extract preparation method adopting semi-bionic extraction technology
CN108359023A (en) * 2018-03-02 2018-08-03 北京国康本草物种生物科学技术研究院有限公司 A kind of extracting method and fragrant solomonseal rhizome polyoses extract of fragrant solomonseal rhizome polyoses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679890A (en) * 2005-01-10 2005-10-12 于吉善 Sobering up infusion granule and preparation thereof
CN101549006A (en) * 2008-04-01 2009-10-07 中国人民解放军军事医学科学院野战输血研究所 White lablab seed extract as well as extracting method and application thereof in preparing ultraviolet injury resistant preparations
CN103565960A (en) * 2013-11-27 2014-02-12 哈药集团中药二厂 Semen hoveniae extract preparation method adopting semi-bionic extraction technology
CN108359023A (en) * 2018-03-02 2018-08-03 北京国康本草物种生物科学技术研究院有限公司 A kind of extracting method and fragrant solomonseal rhizome polyoses extract of fragrant solomonseal rhizome polyoses

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110050759A (en) * 2019-05-09 2019-07-26 泸水富兴生物科技发展有限公司 A kind of cultural method of scoliid

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