CN109125255A - A kind of auristilla - Google Patents
A kind of auristilla Download PDFInfo
- Publication number
- CN109125255A CN109125255A CN201811159646.9A CN201811159646A CN109125255A CN 109125255 A CN109125255 A CN 109125255A CN 201811159646 A CN201811159646 A CN 201811159646A CN 109125255 A CN109125255 A CN 109125255A
- Authority
- CN
- China
- Prior art keywords
- auristilla
- parts
- isopropanol
- ethyl alcohol
- glycerine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Abstract
The invention discloses a kind of auristilla, containing glycerine, also by one or both of isopropanol, ethyl alcohol at being grouped as.Compared with prior art, the invention has the following beneficial effects: that 1) moisture in ear canal can be made quickly to reduce using auristilla of the invention, make ear canal rapid draing, after can be used for swimming, have a bath, washing hair, and using conveniently, safely；2) auristilla of the invention also has the effect of skin surface disinfection, can be used for preparing disinfectant of skin surface.
Description
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of auristilla.
Background technique
Human ear structure is made of external ear, middle ear, inner ear three parts.External auditory canal is about 2.5cm, bending and warm and moist, ear
It is abound with tragus in road and ear canal secretion is earwaxed.In swimming, bathing, hair washing, external auditory canal is easy into water people.After ear canal water inlet
Moisture film easy to form is adsorbed on tragus, and water is made more to be not easy to flow out, and is earwaxed and contacted for a long time with water and can cause to earwax
External auditory canal is expanded and blocks, if the water entered is not clean, it is also possible to cause otitis externa, external auditory canal furuncle, obstruction of earwaxing, eardrum
The otopathy such as inflammation, otitis media suppurative.Human ear water inlet, which is dealt with improperly, may cause the otopathy such as auditory distortion and tympanitis.
The main still physical method for the treatment of measures after human ear water inlet at present.External auditory canal method of cleaning: need to clean cotton swab or
Earpick gently probes into external auditory canal, while ear of intaking laterally descends wide-angle tilt to flow out water under the effect of gravity or with dry cotton swab
Suck dry moisture；Monopodia jump method: water inlet ear laterally descends wide-angle tilt, the mode jumped repeatedly with monopodia, constantly change head
The direction of motion, promote water droplet pleasing to the ear outflow under the action of inertia and gravity into ear canal；External auditory canal mobilization: water inlet ear
Laterally lower wide-angle tilt using drawing ear corridor repeatedly, or does repeatedly and dehisces to act, and movable temporomandibular joint makes skin of external auditory canal
Constantly move up and down, change moisture film stability and pressure it is steady, promote water break, the pleasing to the ear outflow of water flow；Outside
Ear canal pressurization or depressurization: water inlet ear laterally descends wide-angle tilt, and after continuously oppressing earhole with palm, palm is quickly left, and utilizes hand
The high pressure generated when palm compressing, the moment low pressure generated when quickly leaving change the stability of moisture film, utilize the intracorporal height of closing
Pressure and water column gravity, stave moisture film, make the pleasing to the ear outflow of water.
But there is also defects for these methods, such as with swab stick cleaning ear canal ponding than relatively hazardous, external auditory canal is more curved
Song, the bad grasp of depth of swab stick merging, and if cleared up to child, movement is easy to cause swab stick to damage suddenly on child head
Eardrum fractures in stenosis incarceration or swab stick；Torticollis makes for the people for laterally descending wide-angle tilt bad for cervical vertebra into water ear
It is more difficult to accomplish, or even aggravate the cervical vertebra state of an illness；And jump method is just more unfriendly for the people of physical disabilities repeatedly for monopodia.Therefore,
To overcome disadvantages described above, the present invention provides a kind of auristilla that can quickly, easily and safely remove ear canal ponding.
Summary of the invention
The present invention provides a kind of auristilla, and the auristilla is formulated by the raw material of following weight proportion:
2-4 parts of glycerine
96-98 parts of isopropanol
The present invention provides a kind of auristilla, and the auristilla is formulated by the raw material of following weight proportion:
2-10 parts of glycerine
90-98 parts of ethyl alcohol
The present invention provides a kind of auristilla, and the auristilla is formulated by the raw material of following weight proportion:
2-10 parts of glycerine
90-98 parts of mixed solution of isopropanol and ethyl alcohol
Wherein, in the mixed solution of isopropanol and ethyl alcohol, the weight ratio of isopropanol and ethyl alcohol is arbitrary proportion.
Alcohol disinfectant is the most commonly used is ethyl alcohol and isopropanol, because its coagulable protein causes microorganism dead, is
Disinfectant is imitated, bacterium procreation body can be killed, damage most lipophilic virus, such as herpes simplex virus, hepatitis type B virus.Cause
Ethyl alcohol, isopropanol all have sterilizing effect, therefore auristilla of the invention can also be used for skin surface disinfection.
Specific embodiment
Below by specific embodiment, the invention will be further described, and it is not limit that following embodiment, which is descriptive,
Qualitatively, the protection scope of this reverse side cannot be limited with this.
Embodiment 1
Prescription: glycerine 2g, isopropanol 98g.Raw material is uniformly mixed, 100g auristilla is configured to and is dispensed, every 10g.
Embodiment 2
Prescription: glycerine 4g, isopropanol 96g.Raw material is uniformly mixed, 100g auristilla is configured to and is dispensed, every 10g.
Embodiment 3
Prescription: glycerine 2g, ethyl alcohol 98g.Raw material is uniformly mixed, 100g auristilla is configured to and is dispensed, every 10g.
Embodiment 4
Prescription: glycerine 10g, ethyl alcohol 90g.Raw material is uniformly mixed, 100g auristilla is configured to and is dispensed, every 10g.
Embodiment 5
Prescription: the mixed solution 98g of glycerine 2g, isopropanol and ethyl alcohol, wherein the mixed solution of the isopropanol and ethyl alcohol is containing different
Propyl alcohol 49g, ethyl alcohol 49g.Raw material is uniformly mixed, 100g auristilla is configured to and is dispensed, every 10g.
The present invention is further illustrated below by way of experimental data.
Plastic sheet is placed at 25 DEG C of room temperature according to a series of auristilla that the present invention prepares glycerol concentration gradients
On balance, after zero, 50 μ l water are added dropwise on plastic sheet, certain concentration that 4 drops prepare then is added dropwise on water droplet with plastic dropper
Auristilla, read weight readings at this time, read again in 2min, 3min, 5min, 8min, 10min, 12min, the data obtained
Slope is obtained according to the weight mapping that changes with time.Slope is bigger, shows that the concentration auristilla can make water quickly volatilize.
Blank control is done with 50 μ l water simultaneously.As a result it see the table below 1.
The experimental result of the different auristilla prescriptions of table 1
As it can be seen from table 1 the auristilla prescription being made of glycerine and isopropanol, the absolute value of slope is with isopropanol
Concentration increases and increases, the prescription containing 98% isopropanol, and for slope absolute value up to 0.0065, effect is best.And by glycerine
With the auristilla prescription of ethyl alcohol composition, the absolute value of slope is also to increase as concentration of alcohol increases.By glycerine and isopropyl
The prescription of pure and mild alcohol mixed solution composition, glycerol concentration is lower, and slope is bigger, and the volatilization of water is faster, and auristilla is not added
When, water volatilization is most slow.
The experimental results showed that auristilla prepared by prescription of the invention can substantially speed up the volatilization of water, it can quick, letter
Just, safely solve the problems, such as people's swimming or have a bath, endaural hydrops after hair washing.
Claims (5)
1. a kind of auristilla, contains glycerine, which is characterized in that also by one or both of isopropanol, ethyl alcohol at being grouped as.
2. auristilla according to claim 1, which is characterized in that by weight be 100 parts in terms of, glycerine accounts for 2-4 parts, isopropyl
Alcohol accounts for 96-98 parts.
3. auristilla according to claim 1, which is characterized in that by weight be 100 parts in terms of, glycerine accounts for 2-10 parts, second
Alcohol accounts for 90-98 parts.
4. auristilla according to claim 1, which is characterized in that by weight be in terms of 100 parts, glycerine accounts for 2-10 parts, different
The mixed solution of propyl alcohol and ethyl alcohol accounts for 90-98 parts, wherein the mixed solution of isopropanol and ethyl alcohol be by isopropanol and ethyl alcohol according to
Any weight ratio is formulated.
5. application of the auristilla described in claim 1 in preparation disinfectant of skin surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811159646.9A CN109125255A (en) | 2018-09-30 | 2018-09-30 | A kind of auristilla |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811159646.9A CN109125255A (en) | 2018-09-30 | 2018-09-30 | A kind of auristilla |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109125255A true CN109125255A (en) | 2019-01-04 |
Family
ID=64814219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811159646.9A Pending CN109125255A (en) | 2018-09-30 | 2018-09-30 | A kind of auristilla |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109125255A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931170A (en) * | 2006-09-07 | 2007-03-21 | 王廷春 | Gatifloxacin ear drop and its prepn process |
| WO2008030359A2 (en) * | 2006-09-06 | 2008-03-13 | Isw Group, Inc. | Topical compositions |
| CN101428000A (en) * | 2008-12-05 | 2009-05-13 | 北京博时安泰科技发展有限公司 | Azithromycin auristillae and method of producing the same |
| CN103283722A (en) * | 2013-07-02 | 2013-09-11 | 宁波华欣医疗器械有限公司 | Compound disinfectant for hospital and application thereof |
| CN106361585A (en) * | 2016-08-29 | 2017-02-01 | 李冠林 | Ear canal water absorbing agent for promoting discharge of accumulated water in ear canal |
| WO2018015182A1 (en) * | 2016-07-18 | 2018-01-25 | Schülke & Mayr GmbH | Alcoholic disinfectant with good skincare effect and high efficacy |
| CN107970257A (en) * | 2017-12-22 | 2018-05-01 | 成都博创必成医药技术有限公司 | A kind of ear pharmaceutical composition, preparation method and applications and ear pharmaceutical preparation |
-
2018
- 2018-09-30 CN CN201811159646.9A patent/CN109125255A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008030359A2 (en) * | 2006-09-06 | 2008-03-13 | Isw Group, Inc. | Topical compositions |
| CN1931170A (en) * | 2006-09-07 | 2007-03-21 | 王廷春 | Gatifloxacin ear drop and its prepn process |
| CN101428000A (en) * | 2008-12-05 | 2009-05-13 | 北京博时安泰科技发展有限公司 | Azithromycin auristillae and method of producing the same |
| CN103283722A (en) * | 2013-07-02 | 2013-09-11 | 宁波华欣医疗器械有限公司 | Compound disinfectant for hospital and application thereof |
| WO2018015182A1 (en) * | 2016-07-18 | 2018-01-25 | Schülke & Mayr GmbH | Alcoholic disinfectant with good skincare effect and high efficacy |
| CN106361585A (en) * | 2016-08-29 | 2017-02-01 | 李冠林 | Ear canal water absorbing agent for promoting discharge of accumulated water in ear canal |
| CN107970257A (en) * | 2017-12-22 | 2018-05-01 | 成都博创必成医药技术有限公司 | A kind of ear pharmaceutical composition, preparation method and applications and ear pharmaceutical preparation |
Non-Patent Citations (1)
| Title |
|---|
| 陶正德主编: "《耳鼻咽喉科理论和实践》", 31 January 1991, 人民卫生出版社 * |
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|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190104 |