CN1091012A - A kind of Tongdan Zhongyao Chongji and manufacture method - Google Patents
A kind of Tongdan Zhongyao Chongji and manufacture method Download PDFInfo
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- CN1091012A CN1091012A CN 93101523 CN93101523A CN1091012A CN 1091012 A CN1091012 A CN 1091012A CN 93101523 CN93101523 CN 93101523 CN 93101523 A CN93101523 A CN 93101523A CN 1091012 A CN1091012 A CN 1091012A
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Abstract
A kind of Tongdan Zhongyao Chongji and manufacture method.
The Chinese herbal medicine that the present invention adopts multi-flavor to have and shrinks gallbladder, anti-inflammatory and choleretic, liver-smoothing, qi-regulating is formed, with the treatment hepatobiliary system disease.Through animal pharmacology, toxicity and clinical trial certificate: this electuary was taken one month, and the complete free rate of calculus is 19%, and effectively lithagogue rate is 85%; And have an anti-inflammatory and choleretic, calculus, parasite removing, effects such as antibacterial pain relieving.This electuary is taken for a long time to the human body no side effects, be the treatment in, the calculous good medicine of old people, especially more suitable to old people's complication, the misery that can exempt operation.
Description
The present invention relates to a kind of Tongdan Zhongyao Chongji and manufacture method for the treatment of hepatobiliary system disease.
Cholelithiasis, choledocholithiasis and hepatic calculus have become common clinical and frequently-occurring disease, generally adopt medicine and operative treatment, and Chinese medicine commonly used all is according to prescription for a medical decoction plus-minus prescription, with the fried one-tenth decoction of traditional method, tablet and pill etc.This class medical instrument has the anti-inflammatory and choleretic effect, and lithagogue effect is not good enough.As the Chinese patent medicine cholagogic and lithagogue tablet, lithagogue rate only has 7.05% fully, effectively lithagogue rate 55%; Chemical drugs has chenodeoxycholic acid and ursodesoxycholic acid etc.According to external report, the complete lithodialysis rate of chenodeoxycholic acid is 13.6%, and effectively the lithodialysis rate is 40.5%.The lithodialysis rate of ursodesoxycholic acid is 25.8%, and the effective lithodialysis rate of domestic report is 39.5%, and its pair effect is more, be not suitable for educating making women and hepatic and kidney function obstacle patient take, and ursodesoxycholic acid can make the calculus calcification, is unfavorable for lithodialysis.Clinical practice proves: chenodeoxycholic acid and ursodesoxycholic acid medication cycle are long, and lithodialysis blood fat reducing lithagogue effect is poor; Use operative treatment, some is merged important viscera function do not reach the critical patient entirely and should not adopt, and postoperative still has part retained calculus and recurrent stones, second operation is difficulty relatively, and is dangerous, still has the part patient that operation is had fear, do not undergo surgery.
The purpose of this invention is to provide a kind of Tongdan Zhongyao Chongji and manufacture method that the prevention calculus forms and the calculus parasite removing acts on that have.
The present invention adopts has the Chinese medicine that shrinks gallbladder, anti-inflammatory and choleretic, calculus parasite removing dual function, changes the bile Main Ingredients and Appearance, makes the cholic acid lowering of concentration, suppresses the formation of calculus; Press by increasing gallbladder, liver juice flow, dissolving cholesterol reaches the purpose of calculus dissolving and excreting.Concrete scheme and manufacture method are as follows:
The compositing range of this Tongdan Zhongyao Chongji (weight %) is:
Herba Desmodii Styracifolii 14.1-26.1
Fructus Mume 14.5-26.4
Semen Arecae 13.8-25.6
Radix Scutellariae 9.4-17.4
Pericarpium Citri Reticulatae 12.5-23.3
Radix Et Rhizoma Rhei 4.2-7.8
This Tongdan Zhongyao Chongji and manufacture method are:
(1), clean, concoct Six-element Chinese medicine standby.
(2), get Pericarpium Citri Reticulatae distillating extracting oil, the device collection in addition of the aqueous solution after the distillation.
(3), will put through the raw material of choosing system and add 8 times of amounts of water in the container, soaked 120 minutes, decocted 90 minutes; Four layers of filtered through gauze of decoction liquor, filtrate for later use; Fry in shallow oil residual middle 6 times of water gagings that add, decocted 60 minutes, decoct four layers of filtered through gauze; Merge twice decoction liquor and Pericarpium Citri Reticulatae aqueous solution, leave standstill, it is standby to receive supernatant.
(4), will reclaim liquid and be concentrated into the extractum that relative density is 1.38-1.40 at (50-60 ℃), getting the powdered sugar of 2 times of amounts of extractum adding and the dextrin of 0.25 times of amount mixes evenly, dry below 70 ℃, and be ground into 100 order fine powders, adjust humidity with 70% ethanol, make at the bottom of the 12-14 purpose granule wet dryly, add Pericarpium Citri Reticulatae volatile oil, mixing, granulate Tongdan Zhongyao Chongji.
This Tongdan Zhongyao Chongji treatment cholelithiasis, diseases such as choledocholithiasis and biliary tract infection, cholecystitis, through the pharmacological evaluation of experiment in vitro and animal, toxicological experiment and clinical experiment have all obtained satisfied effect.Be summarized as follows with regard to every experimental result below:
Tongdan Zhongyao Chongji shows the experimental result of prevention cholelithiasis formation effect: this electuary composition has the plasma cholesterol of reduction, dissolving cholesterol, promote bile secretion, increase effects such as the gallbladder contraction and the enterocinesia of wriggling, make the unlikely imbalance of cholesterol metabolism, the unlikely delay of bile is so calculus is difficult to form.
Tongdan Zhongyao Chongji shows the experimental result of gallbladder inner cholesterol calculus effect: cholagogic and lithagogue tablet: 10 rabbit cholelithiasises, have only a routine calculus to discharge; Tongdan Zhongyao Chongji: 10 rabbit cholelithiasises are all discharged.The calculus effect of Tongdan Zhongyao Chongji obviously is better than cholagogic and lithagogue tablet.
Tongdan Zhongyao Chongji is antibacterial, antiinflammatory, analgesia and acute and chronic, toxicity test result show: this electuary has tangible bacteriostasis to staphylococcus aureus; Multiple inflammatory model all there is better antiphlogistic effects; Analgesic activity is better than chenodeoxycholic acid, takes for a long time and pays effect to the nontoxic nothing of human body.
Tongdan Zhongyao Chongji 30 routine gallbladders are that the gallbladder volume determination result of patient before and after taking medicine shows: fry an egg with tradition, magnesium sulfate to the gallbladder shrinkage ratio, evident difference is arranged.Tongdan Zhongyao Chongji is effective, and acting duration is long.
Observed in one month through clinical 140 routine gallstone treatments, lithagogue rate is 19% fully, and the complete lithagogue rate of cholagogic and lithagogue tablet is 7.05%.Compare not only short treating period with the calculus medicine of extensive use both at home and abroad at present, instant effect do not have misery, the nothing pair effect of operating on, and method is easy, safe and reliable, expense is cheap, only is 1/5 of surgery cost.Confirm that through cholecystography and B ultrasonic check take the Tongdan Zhongyao Chongji treatment after one month, it is 85% that calculus is discharged effective percentage, and cholagogic and lithagogue tablet is taken in contrast, it is 55% that calculus is discharged effective percentage.
Case: the patient, the section * *, woman, 54 years old, the peasant.Suffered from cholecystitis before 5 years, cholelithiasis, often outbreak repeatedly, because of right upper quadrant of the abdomen aches, companion's nausea and vomiting is takeed on the back radiating pain to the right, goes into local hospitalize on the 2nd in December in 1987, the state of an illness increases the weight of after three days, continuing changes one week of county hospital over to, does not feel any better, and changes regional hospital surgical treatment again over to, due to illness the people refuses operation and leaves hospital the symptomatic treatment of going home.Successively invalid through three hospitalizes, health is extremely weak, can not take food.Come me institute to go to a doctor.Look into: acute disease is painful, and upper right abdominal pressure is painful, and knock-on is painful, leukocyte 15000, and neutrality 85%, B ultrasonic and cholecystography all do not develop.Clinical diagnosis is a chronic cholecystitis, is full of the type cholelithiasis, acute attack.Through adopting supporting treatment, obey Tongdan Zhongyao Chongji after one day, free movement of the bowels, abdominal symptoms is alleviated; Laggard semi-fluid food on the two, but out-of-bed activity.In stool, flushed out three (1.1 * 1.0 centimetres) calculus in continuous four days, behind the continued treatment, follow up a case by regular visits to and do not have recurrence half a year.
The present invention is described in detail as follows in conjunction with the embodiments:
Embodiment
The first step: choose batching (weight %)
Herba Desmodii Styracifolii 21.1
Fructus Mume 24.1
Semen Arecae 22.1
Radix Scutellariae 4.8
Pericarpium Citri Reticulatae 26.1
Radix Et Rhizoma Rhei 1.8
Second step: clean, concoct above-mentioned Six-element Chinese medicine standby.
The 3rd step: get the Pericarpium Citri Reticulatae distillating extracting oil, the aqueous solution after distillation device is in addition collected.
The 4th step: will add 8 times of amounts of water in the container through selecting the raw material of making put, soak 120 minutes, decoct 90 minutes; Four layers of filtered through gauze of decoction liquor, filtrate for later use; Fry in shallow oil residual middle 6 times of water gagings that add, decocted 60 minutes, decoct four layers of filtered through gauze; Merge twice decoction liquor and Pericarpium Citri Reticulatae aqueous solution, leave standstill, it is standby to receive supernatant.
The 5th step: it is 1.08 o'clock that decoction liquor is concentrated into relative density at (90-95 ℃) by method for concentration commonly used, adds 95% ethanol of equimultiple, does not contain in the medicinal liquid till the ethanol.
The 6th step: will reclaim liquid and be concentrated into the extractum that relative density is 1.38-1.40 by method for concentration commonly used at (50-60 ℃), getting the powdered sugar of 2 times of amounts of extractum adding and the dextrin of 0.25 times of amount mixes evenly, common drying means drying below 70 ℃, and be ground into 100 order fine powders, adjust humidity with 70% ethanol, make at the bottom of the 12-14 purpose granule wet dryly, add Pericarpium Citri Reticulatae volatile oil, mixing, granulate Tongdan Zhongyao Chongji.This electuary total amount is 1000 pairs, 2 bags of every pair of packing, every bag 25 gram, totally 2000 bags.
Claims (2)
1, a kind of Tongdan Zhongyao Chongji and manufacture method that is made into by Herba Desmodii Styracifolii, Fructus Mume, Semen Arecae, Radix Scutellariae, Pericarpium Citri Reticulatae, Radix Et Rhizoma Rhei.The compositing range (weight %) that it is characterized in that this electuary is:
Herba Desmodii Styracifolii 14.1-26.1
Fructus Mume 14.5-26.4
Semen Arecae 13.8-25.6
Radix Scutellariae 9.4-17.4
Pericarpium Citri Reticulatae 12.5-23.3
Radix Et Rhizoma Rhei 4.2-7.8
2, described Tongdan Zhongyao Chongji of claim 1 and manufacture method are:
(1), clean, concoct above Six-element raw material of Chinese medicine standby.
(2), get Pericarpium Citri Reticulatae distillating extracting oil, the device collection in addition of the aqueous solution after the distillation.
(3), will put through the raw material of choosing system and add 8 times of amounts of water in the container, soaked 120 minutes, decocted 90 minutes; Four layers of filtered through gauze of decoction liquor, filtrate for later use; Fry in shallow oil residual middle 6 times of water gagings that add, decocted 60 minutes, decoct four layers of filtered through gauze; Merge twice decoction liquor and Pericarpium Citri Reticulatae aqueous solution, leave standstill, it is standby to receive supernatant.
(4), decoction liquor is concentrated into relative density at (90-95 ℃) is 1.08 o'clock, adds 95% ethanol of equimultiple, do not contain in the medicinal liquid till the ethanol.
(5), will reclaim liquid and be concentrated into the extractum that relative density is 1.38-1.40 at (50-60 ℃), getting the powdered sugar of 2 times of amounts of extractum adding and the dextrin of 0.25 times of amount mixes evenly, dry below 70 ℃, and be ground into 100 order fine powders, adjust humidity with 70% ethanol, make at the bottom of the 12-14 purpose granule wet dryly, add Pericarpium Citri Reticulatae volatile oil, mixing, granulate Tongdan Zhongyao Chongji.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101523 CN1091012A (en) | 1993-02-15 | 1993-02-15 | A kind of Tongdan Zhongyao Chongji and manufacture method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101523 CN1091012A (en) | 1993-02-15 | 1993-02-15 | A kind of Tongdan Zhongyao Chongji and manufacture method |
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| Publication Number | Publication Date |
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| CN1091012A true CN1091012A (en) | 1994-08-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 93101523 Pending CN1091012A (en) | 1993-02-15 | 1993-02-15 | A kind of Tongdan Zhongyao Chongji and manufacture method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063088C (en) * | 1998-11-03 | 2001-03-14 | 巫茂成 | Medicine for curing hepatic and gallbladder diseases |
| CN102579980A (en) * | 2012-03-02 | 2012-07-18 | 张国栋 | Medicine for treating calculus in hepatobiliary system |
-
1993
- 1993-02-15 CN CN 93101523 patent/CN1091012A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063088C (en) * | 1998-11-03 | 2001-03-14 | 巫茂成 | Medicine for curing hepatic and gallbladder diseases |
| CN102579980A (en) * | 2012-03-02 | 2012-07-18 | 张国栋 | Medicine for treating calculus in hepatobiliary system |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |