CN1091011A

CN1091011A - A kind of lithodialysis Chinese traditional medicines depressing lipid electuary and manufacture method

Info

Publication number: CN1091011A
Application number: CN 93101517
Authority: CN
Inventors: 张国栋; 张燕
Original assignee: Individual
Current assignee: Individual
Priority date: 1993-02-15
Filing date: 1993-02-15
Publication date: 1994-08-24

Abstract

A kind of lithodialysis Chinese traditional medicines depressing lipid electuary and manufacture method.

The present invention is that pure medium-height grass YAOJING is carried, and makes electuary treatment hepatobiliary system disease, and through animal pharmacology, toxicity and clinical experiment result show: this electuary has effects such as the contraction of the gallbladder of promotion, cholagogic and litholytic, blood fat reducing calculus, the antibacterial pain relieving of antiinflammatory.Course of treatment of clinical 164 routine calculus patient treatments, cholecystography and B ultrasonic check, the lithodialysis rate is 29% fully, effectively the lithodialysis rate is 98.28%, compares with present similar medicine, has not only improved curative effect, and the medication phase has reduced 21 months, especially old people's complication has special curative effect, can avoid the hardship of operation.

Description

A kind of lithodialysis Chinese traditional medicines depressing lipid electuary and manufacture method

The present invention relates to a kind of lithodialysis Chinese traditional medicines depressing lipid electuary and manufacture method for the treatment of hepatobiliary system disease.

Hepatobiliary system disease has become the commonly encountered diseases and the frequently-occurring disease of acute abdomen in recent years, usually adopt medicine and operative treatment, Chinese medicine commonly used generally all is to add and subtract according to prescription for a medical decoction, make decoction, tablet and pill etc. with traditional method, this class Chinese medicine has the anti-inflammatory and choleretic effect, and the calculus dissolving and excreting effect is not ideal enough; The common chemical medicine has chenodeoxycholic acid and ursodesoxycholic acid etc., according to external report, the complete lithodialysis rate of chenodeoxycholic acid is 13.6%, effectively the lithodialysis rate is 40.5%, the lithodialysis rate of ursodesoxycholic acid is 25.8%, the effective lithodialysis rate of domestic report is 39.5%, and its side effect is more, is not suitable for educating making women and hepatic and kidney function obstacle patient take.In addition, ursodesoxycholic acid can make the calculus calcification, is unfavorable for lithodialysis.Practical application proves: chenodeoxycholic acid and ursodesoxycholic acid medication cycle are long, and lithodialysis blood fat reducing lithagogue effect is poor; Use operative treatment, some is merged important viscera function do not reach the critical patient entirely and should not adopt, and postoperative still has the part retained calculus, the second operation difficulty is bigger, and is dangerous.Also have the part patient that fear is arranged, do not undergo surgery.

The purpose of this invention is to provide a kind of lithodialysis Chinese traditional medicines depressing lipid electuary and manufacture method for the treatment of hepatobiliary system disease, having no side effect.

The present invention is that pure medium-height grass YAOJING is carried, adopt in the prescription multiplely have the contraction of the gallbladder of promotion, cholagogic and litholytic, blood fat reducing calculus, antiinflammatory is antibacterial and the Chinese herbal medicine of analgesic effect, make electuary, promote bile secretion and drainage, adjust the cholesterol metabolism, the relative concentration of cholesterol, cholate and phospholipid in the bile is tending towards normally, thereby reaches the purpose of lithodialysis blood fat reducing, also prevented the formation of liver and bile stone.The concrete scheme and the practice are as follows:

The compositing range (weight %) of this lithodialysis Chinese traditional medicines depressing lipid electuary is:

Herba Artemisiae Scopariae 5.1-14.8

Fructus Aurantii 5.5-15.3

Radix Et Rhizoma Rhei 1.6-3.5

Fructus Gardeniae 3.2-11.4

Radix Scutellariae 3.4-10.2

Fructus Crataegi 5.1-16.9

Radix Salviae Miltiorrhizae 5.3-15.5

Endothelium Corneum Gigeriae Galli 2.8-8.6

Fructus Toosendan 2.6-7.5

Pericarpium Citri Reticulatae Viride 5.4-15.7

Pericarpium Citri Reticulatae 5.2-14.6

Radix Angelicae Sinensis 2.5-8.7

Radix Paeoniae Rubra 2.4-7.3

Natrii Sulfas 1.5-3.0

The manufacture method of lithodialysis Chinese traditional medicines depressing lipid electuary is:

(1) it is standby ten four Chinese medicines to be removed impurity, wherein Radix Scutellariae is put and is boiled ten minutes in the boiling water, takes out vexedly, thinly slices, and drying for standby is extracted volatile oil with Pericarpium Citri Reticulatae, and medicinal residues and medicinal liquid are standby.

(2) Pericarpium Citri Reticulatae medicinal residues and all the other 13 flavor medicines are added 8 times of amounts of water, boil and carry twice, boiled 90 minutes for the first time, boiled 60 minutes for the second time.

(3) with the Pericarpium Citri Reticulatae medicinal liquid and boil for twice and carry medicinal liquid and merge, be 1.15 o'clock in (90-95 ℃) thin film concentration to relative density, add 95% the ethanol precipitation 720 minutes of equivalent, go precipitation, alcohol deposit fluid is standby.

(4) alcohol deposit fluid reclaims ethanol, is evaporated to the extractum that relative density is 1.40-1.45 at (50-60 ℃), and concentrated extract is standby.

(5) every part of concentrated extract adds 0.25 times white dextrin and 2 times powdered sugar is granulated, and with granule oven dry 60 ℃ the time, adds Oleum Citri Reticulatae then and stir, and promptly can be made into lithodialysis Chinese traditional medicines depressing lipid electuary.

This lithodialysis Chinese traditional medicines depressing lipid electuary treatment cholelithiasis, choledocholithiasis, hepatic calculus, pharmacological evaluation, toxicological experiment and the clinical experiment of process experiment in vitro and animal all obtained satisfied effect.Now be summarized as follows with regard to every experimental result:

The experimental result of prevention cholelithiasis formation effect shows: after lithodialysis Chinese traditional medicines depressing lipid electuary is irritated stomach, each dosage group sees that all the gallbladder contraction frequency increases, in the time of 60 minutes, peak, and maintain higher level, do not return to original level yet until two hours, this just shows that this electuary can promote biliary secretion and drainage, adjusts the metabolism of cholesterol, the formation of prevention cholelithiasis.

Experimental result to the litholytic effect of calculus in the gallbladder shows: use chenodeoxycholic acid, and none dissolving of calculus, most weight increase, mostly be on the basis of former calculus, to add green calculus, and with lithodialysis Chinese traditional medicines depressing lipid electuary, the weight of most calculus obviously reduces, the then dissolving fully that has.

Bacteriostatic experiment is the result show: lithodialysis Chinese traditional medicines depressing lipid electuary has tangible bacteriostasis to golden yellow staphylococcus, to escherichia coli, the salmonella typhi inhibitory action a little less than.

Antiinflammatory and analgesic experiment result show: lithodialysis Chinese traditional medicines depressing lipid electuary has resist inflammation on repercussive function preferably, and analgesic activity is remarkable, is better than chenodeoxycholic acid.

Acute and long term toxicity test result shows: lithodialysis Chinese traditional medicines depressing lipid electuary clinical safety degree is very big, and large dose oral administration is to the human body no side effects.

The result that clinical 164 routine hepatobiliary system disease patients take a course of treatment of lithodialysis Chinese traditional medicines depressing lipid electuary shows: the lithodialysis rate is 29% fully, treat with chenodeoxycholic acid, the lithodialysis rate is 2.5% fully, compare with the dissolved stone medicine of extensive use both at home and abroad at present, not only improved curative effect, and the oral medicine phase can reduce 21 months.Confirm through cholecystography and B ultrasonic check, after taking lithodialysis blood fat reducing electuary, there is 98.28% calculus to diminish, and chenodeoxycholic acid has only after taking 37.5% calculus to diminish, and can dissolve discharge if take lithodialysis Chinese traditional medicines depressing lipid electuary continuously to 1.0-3.8 centimetre calculus in 0.5-2.5 in the bile duct centimetre huge gallstone or multiple calculus and the bile duct.

Case: patient Cui * *, woman, 37 years old, citizen, on January 30th, 1 went to a doctor, and right upper quadrant of the abdomen pain companion feels sick before March, pain is drawn the shoulder back of the body, and outpatient service B ultrasonic film making prompting: the gallbladder opaque dark area of fluid disappears, and 0.4 centimetre of strong reflection group of gallbladder tunicle is full of, the diagnosis calcareous cholecystitis, advise clothes lithodialysis Chinese traditional medicines depressing lipid electuary every day twice, each 25 grams, empty sooner or later clothes, the back ultrasound diagnosis prompting of three weeks: stay several high light group reflections of differing in size in the gallbladder, maximum is 0.6 centimetre.Through treatment all around, B ultrasonic film making prompting: the 2-3 of visible 0.1 centimetre of size is individual in the gallbladder, and total amount is 0.5 centimetre again, and check does not have recurrence after 1 year, and other are normal.

The present invention is described in detail as follows in conjunction with the embodiments:

Embodiment

The first step: choose batching (weight %), get Pericarpium Citri Reticulatae 8.5, Pericarpium Citri Reticulatae Viride 9.3, Radix Angelicae Sinensis 5.1, Radix Paeoniae Rubra 4.5, Natrii Sulfas 1.5, Radix Salviae Miltiorrhizae 12.3, Fructus Crataegi 12.5, Radix Scutellariae 5.8, Fructus Gardeniae 7.5, Radix Et Rhizoma Rhei 3.1, Fructus Aurantii 9.4, Herba Artemisiae Scopariae 10.2, Endothelium Corneum Gigeriae Galli 6.5, Fructus Toosendan 3.8.

Second step: it is standby that above ten four Chinese medicines are removed impurity, wherein Radix Scutellariae put and boiled ten minutes in the boiling water, takes out vexedly, thinly slices, and drying for standby, by distilling or method extraction volatile oil such as squeezing, medicinal residues and medicinal liquid are standby with Pericarpium Citri Reticulatae.

The 3rd step: Pericarpium Citri Reticulatae medicinal residues and all the other 13 flavor medicines are added 8 times of amounts of water, boil and carry twice, boiled 90 minutes for the first time, boiled 60 minutes for the second time.

The 4th step: the Pericarpium Citri Reticulatae medicinal liquid is carried medicinal liquid and merged with boiling for twice, is 1.15 o'clock in (90-95 ℃) thin film concentration to relative density, 95% ethanol precipitation of adding equivalent 12 hours, and redeposition is removed insoluble matter, and concentrated solution is standby.

The 5th step: alcohol deposit fluid reclaims ethanol, and (50-60 ℃) is evaporated to the extractum of relative density for (1.4-1.45) in spherical vacuum concentration pot or other airtight vaporizer, and concentrated extract is standby.

The 6th step: every part of concentrated extract adds 0.25 times white dextrin and 2 times powdered sugar stirs; make granule with comminutor; and with methods such as drying room or vibration type far-infrared ray dryings granule is dried about 60 ℃, again by nebulization or directly method such as adding Oleum Citri Reticulatae added stir.Promptly can be made into lithodialysis Chinese traditional medicines depressing lipid electuary.This electuary total amount is 1000 pairs, 4 bags of every secondary packing, every bag 25 gram, totally 4000 bags.

Claims

1, a kind of lithodialysis Chinese traditional medicines depressing lipid electuary and manufacture method of being made up of Herba Artemisiae Scopariae, Fructus Aurantii, Radix Et Rhizoma Rhei, Fructus Gardeniae, Radix Scutellariae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Endothelium Corneum Gigeriae Galli, Fructus Toosendan, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Radix Paeoniae Rubra and Natrii Sulfas is characterized in that the compositing range (weight %) of this electuary is: