CN109090512A - A kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract - Google Patents
A kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract Download PDFInfo
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- 239000000284 extract Substances 0.000 title claims abstract description 43
- 230000002218 hypoglycaemic effect Effects 0.000 title claims abstract description 28
- 102100024295 Maltase-glucoamylase Human genes 0.000 claims abstract description 15
- 108010028144 alpha-Glucosidases Proteins 0.000 claims abstract description 15
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 13
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 241001466453 Laminaria Species 0.000 claims description 16
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 claims description 6
- 229960002632 acarbose Drugs 0.000 claims description 6
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 229930182478 glucoside Natural products 0.000 claims 1
- 150000008131 glucosides Chemical class 0.000 claims 1
- 241000512259 Ascophyllum nodosum Species 0.000 abstract description 11
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 239000002994 raw material Substances 0.000 abstract description 7
- 235000013402 health food Nutrition 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 235000001497 healthy food Nutrition 0.000 abstract description 4
- 230000003345 hyperglycaemic effect Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 2
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 8
- 238000001704 evaporation Methods 0.000 description 6
- 239000006228 supernatant Substances 0.000 description 6
- 102000004877 Insulin Human genes 0.000 description 4
- 108090001061 Insulin Proteins 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229940125396 insulin Drugs 0.000 description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000012452 mother liquor Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000001291 vacuum drying Methods 0.000 description 3
- 241000195493 Cryptophyta Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 208000024799 Thyroid disease Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000021510 thyroid gland disease Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
- A23L17/60—Edible seaweed
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
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Abstract
The present invention provides a kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract, is after the kelp by fermenting extracts by edible alcohol, is dry, pulverizing, to obtain, preparation method is simple, hypoglycemic activity is strong, to the IC of alpha-Glucosidase inhibitory activity50The IC of value and Remedies for diabetes acarbose50Value is suitable, it is the effective technology for improving kelp high value added utilization, extract can healthy food, health food directly as auxiliary hyperglycemic, also raw material and other materials fit applications be can be used as in the production of the healthy food, health food of auxiliary hyperglycemic, or as the raw material of further purification effect of lowering blood sugar ingredient.
Description
Technical field
The present invention relates to health food and algae essence deep process technology field, specifically a kind of hypoglycemic kelp is extracted
Object.
Background technique
Diabetes are one of most high-incidence diseases of today's society, and in become younger, the trend of wide crowdization, diabetes are and pancreas islet
Element generates and the abnormal chronic disease related, characterized by blood glucose increases of effect, including the I type based on absolutely being lacked with insulin
Diabetes (insulin-dependent) and with insulin it is opposite lack or insulin resistance based on type-2 diabetes mellitus (insulin it is non-according to
Rely type) two types, wherein being therefore concentrated mainly at present for the Therapy study of diabetes more than 90% for type-2 diabetes mellitus
Type II diabetes, main to hinder the absorption of blood glucose using drop to reduce blood glucose level, it is main that alpha-glucosidase, which inhibits model,
Hypoglycemic research model evaluates its inhibitory activity its hypoglycemic activity by measuring drug, and alpha-glucosidase inhibits
Agent is the treatment diabetes medicament of comparative maturity, is widely used to clinic, but with the toxic side effect of chemicals gradually by
Understanding, people start to find effective medicine source from natural products.Kelp is a kind of edible algae, and source area is for Northeast Asia
Area, current China are that maximum laminaria production state, China's kelp yield have accounted for the 76% of world wide production, reached 4.86 in the world
×106 Ton, kelp have become the important marine economy crop in China's Coastal Areas, as the food of people's daily life, and have
There are the bioactivity such as prevention and treatment thyroid disease, anti-oxidant, antitumor, hypoglycemic, blood pressure lowering, immunological regulation, is a kind of important
Health medicine and food.In order to make full use of kelp resource, the economic value and health-care efficacy of kelp are improved, we utilize fermentation
Kelp is raw material, has carried out the method for extracting active blood sugar-lowering substances from fermented laminaria, has made the hypoglycemic activity of fermented laminaria
It is significantly improved, to develop efficient function of blood sugar reduction food using kelp and health care product provides new technological approaches.
Summary of the invention
It is an object of the invention to using fermented laminaria as raw material, the technical problem to be solved is that overcome the above-mentioned prior art
Deficiency, used technical solution is: a kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract, feature include the following steps:
(1) a kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract described in the present invention, is to be extracted using fermented laminaria as raw material using edible alcohol；
(2) a kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract described in the present invention is the weight by fermented laminaria and edible alcohol according to 1:30-50
Amount: volume ratio under 40-60 degree, is extracted 2-4 hours, then be centrifuged 20-30 minutes through 5000-6000rpm, is received after mixing
Collect supernatant, repeats aforesaid operations 3 times；
(3) present invention described in a kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract, be by the supernatant in step (2) in Rotary Evaporators
Under 30-50 degree, it is evaporated on a small quantity, moves into evaporating dish；
(4) a kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract described in the present invention, is to put the evaporating dish in step (3) in a vacuum drying oven
Under 30-50 degree, by extract, drying to constant weight；
(5) a kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract described in the present invention, is by the constant weight extract micronizer in step (4)
It crushes, that is, obtains hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract；
(6) a kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract described in the present invention, is that the Thallus Laminariae (Thallus Eckloniae) extract in step (5) is used phlorose
Glycosides enzyme inhibits its hypoglycemic activity of model determination, and testing result Thallus Laminariae (Thallus Eckloniae) extract of the invention is to alpha-Glucosidase inhibitory activity
IC50Value is 0.029-0.030 mg/ml, compares non-fermented laminaria extract to the IC of alpha-Glucosidase inhibitory activity50Value is
0.300-0.440 mg/ml, IC of the Remedies for diabetes acarbose to alpha-Glucosidase inhibitory activity50Value is 0.033-
0.035 mg/ml；
Hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract preparation method prepared by the present invention is simple, hypoglycemic activity is strong, inhibits to live to alpha-Glucosidase
The IC of property50The IC of value and Remedies for diabetes acarbose50Value is the effective skill for improving kelp high value added utilization quite
Art, extract can healthy food, health food directly as auxiliary hyperglycemic, also can be used as raw material and answered with other materials cooperation
The production of healthy food, health food for auxiliary hyperglycemic, or the raw material as further purification effect of lowering blood sugar ingredient.
Specific embodiment
Below with reference to embodiment, the present invention will be further described, but does not therefore limit the present invention to the implementation
Among example range, the equivalent changes and modifications that all the scope of the patents according to the present invention are done belong to covering scope of the invention.
Embodiment 1: the preparation of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract
(1) 500 milliliters of 10 grams of fermented laminaria and 95% edible alcohol are uniformly mixed, and under 60 degree, are extracted 4 hours, then pass through
6000rpm is centrifuged 30 minutes, collects supernatant, is repeated aforesaid operations 3 times；
(2) above-mentioned supernatant under 50 degree, is evaporated on a small quantity, is moved into evaporating dish in Rotary Evaporators；
(3) evaporating dish is put into 50 degree of lower drying in a vacuum drying oven, drying to constant weight by extract；
(4) extract of constant weight is crushed with micronizer, that is, obtains hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract.
Embodiment 2: the preparation of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract
(1) by 50 grams of fermented laminaria with 95% edible alcohol 2 liters be uniformly mixed, under 50 degree, extract 4 hours, then through 6000rpm
Supernatant is collected in centrifugation 30 minutes, is repeated aforesaid operations 3 times；
(2) above-mentioned supernatant under 40 degree, is evaporated on a small quantity, is moved into evaporating dish in Rotary Evaporators；
(3) evaporating dish is put into 40 degree of lower drying in a vacuum drying oven, drying to constant weight by extract；
(4) extract of constant weight is crushed with micronizer, that is, obtains hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract Ultramicro-powder.
Embodiment 3: the hypoglycemic activity measurement of Thallus Laminariae (Thallus Eckloniae) extract
(1) Ultramicro-powder for accurately weighing a certain amount of fermented laminaria extract, is configured to the mother liquor of 1mg/ml；
(2) a certain amount of acarbose is accurately weighed, the mother liquor of 1mg/ml is configured to；
(3) Ultramicro-powder for accurately weighing a certain amount of non-Thallus Laminariae (Thallus Eckloniae) extract, is configured to the mother liquor of 10mg/ml；
(4) fermented laminaria extract and acarbose are configured to 0.02,0.05,0.08,0.11,0.14,0.17,0.20 respectively
The serial solution of mg/ml；
(5) non-fermented laminaria extract is configured to the serial solution of 0.2,0.5,0.8,1.1,1.4,1.7,2.0 mg/ml；
(6) inhibit the experimental method of model according to alpha-glucosidase, the extract or acarbose for measuring various concentration are to α-
The active inhibiting rate of glucuroide establishes the regression equation between concentration and inhibiting rate, calculates and obtains extract or Ah Ka
IC of the wave sugar to alpha-Glucosidase inhibitory activity50Value, fermented laminaria extract of the present invention is to alpha-Glucosidase inhibitory activity
IC50Value is 0.029-0.030 mg/ml, compares non-fermented laminaria extract to the IC of alpha-Glucosidase inhibitory activity50Value is
0.300-0.440 mg/ml, IC of the Remedies for diabetes acarbose to alpha-Glucosidase inhibitory activity50Value is 0.033-
0.035 mg/ml。
Claims (2)
1. a kind of hypoglycemic Thallus Laminariae (Thallus Eckloniae) extract, which is characterized in that fermented laminaria is extracted with edible alcohol, extract drying
With after ultramicro grinding to get the extract with hypoglycemic activity.
2. extract according to claim 1 inhibits model determination hypoglycemic activity through alpha-glucosidase, to α-Portugal
The IC of glucoside inhibiting activity50Value is 0.029-0.030mg/ml, compares non-fermented laminaria extract and inhibits to alpha-Glucosidase
Active IC50Value is 0.300-0.440mg/ml, and Remedies for diabetes acarbose is to alpha-Glucosidase inhibitory activity
IC50Value is 0.033-0.035mg/ml.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112760038A (en) * | 2021-01-14 | 2021-05-07 | 安徽省路兴建设项目管理有限公司 | Water-soluble green tung oil environment-friendly asphalt separant |
| CN112760031A (en) * | 2021-01-13 | 2021-05-07 | 安徽省路兴建设项目管理有限公司 | Water-soluble methyl silane environment-friendly cement template anti-sticking agent |
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Application publication date: 20181228 |