CN109071642B - 连接蛋白(Cx)43半通道结合抗体及其用途 - Google Patents

连接蛋白(Cx)43半通道结合抗体及其用途 Download PDF

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CN109071642B
CN109071642B CN201780025896.0A CN201780025896A CN109071642B CN 109071642 B CN109071642 B CN 109071642B CN 201780025896 A CN201780025896 A CN 201780025896A CN 109071642 B CN109071642 B CN 109071642B
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CN109071642A (zh
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姜欣
安志强
张凝艳
熊伟
曼努埃尔·A·里克尔梅
顾肃敏
娜奥米·L·塞尔
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780025896.0A 2016-02-26 2017-02-27 连接蛋白(Cx)43半通道结合抗体及其用途 Active CN109071642B (zh)

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US201662300492P 2016-02-26 2016-02-26
US62/300,492 2016-02-26
PCT/US2017/019605 WO2017147561A1 (en) 2016-02-26 2017-02-27 CONNEXIN (Cx) 43 HEMICHANNEL-BINDING ANTIBODIES AND USES THEREOF

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EP (1) EP3419998A4 (https=)
JP (1) JP7098527B2 (https=)
CN (2) CN109071642B (https=)
AU (2) AU2017224122B2 (https=)
CA (1) CA3015839A1 (https=)
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CN114621346B (zh) 2013-08-21 2025-06-10 德克萨斯州大学系统董事会 用于靶向连接蛋白半通道的组合物和方法
WO2017147561A1 (en) 2016-02-26 2017-08-31 The Board Of Regents Of The University Of Texas System CONNEXIN (Cx) 43 HEMICHANNEL-BINDING ANTIBODIES AND USES THEREOF
ES2710220A1 (es) * 2017-10-19 2019-04-23 Fund Profesor Novoa Santos Compuestos anti-conexina para su uso en la prevención y/o el tratamiento de enfermedades degenerativas de las articulaciones
CA3095897A1 (en) * 2018-04-02 2019-10-10 Alamab Therapeutics, Inc. Connexin 43 antibodies and use thereof
WO2019222800A1 (en) * 2018-05-21 2019-11-28 Hudson Institute of Medical Research Methods for the treatment or prevention of autoimmune or autoinflammatory diseases
AU2020219112A1 (en) * 2019-02-04 2021-08-26 Alamab Therapeutics, Inc. Connexin 43 antibodies and use thereof
US20220162298A1 (en) * 2019-02-28 2022-05-26 Board Of Regents, The University Of Texas System Compositions for treating osteosarcoma and methods of use
KR20220113355A (ko) * 2019-10-02 2022-08-12 알라맵 테라퓨틱스, 인크. 항-코넥신 항체 제제
WO2022026914A1 (en) * 2020-07-31 2022-02-03 Alamab Therapeutics, Inc. Anti-connexin antibody formulations
EP3981421A1 (en) * 2020-10-06 2022-04-13 Fundación Profesor Novoa Santos Connexin 43 for use in the treatment of a cancer type characterized by the activation of a mitogen-activated protein kinase
WO2022155299A1 (en) * 2021-01-13 2022-07-21 Board Of Regents, The University Of Texas System Compositions and methods for treating osteoarthritis, rheumatoid arthritis, and joint and tendon disorders
US20250277017A1 (en) * 2022-04-29 2025-09-04 Board Of Regents, The University Of Texas System Compositions and methods for treating eye diseases
EP4519320A1 (en) * 2022-05-04 2025-03-12 VST Bio Corporation Compositions and methods for selective regulation of vascular permeability
EP4642807A2 (en) * 2022-12-30 2025-11-05 Board of Regents, The University of Texas System Compositions for treating osteoporosis and bone loss and methods of use thereof
WO2024206157A1 (en) * 2023-03-24 2024-10-03 Board Of Regents, The University Of Texas System Compositions and methods for treating obesity and reducing fat accumulation
WO2025199516A1 (en) * 2024-03-22 2025-09-25 Board Of Regents, The University Of Texas System Compositions and methods for preserving or increasing lean muscle mass
CN118791620B (zh) * 2024-07-02 2025-04-04 北京市华信行生物科技有限公司 抗糖原磷酸化酶gpbb单克隆抗体及其应用
CN120484112A (zh) * 2025-05-15 2025-08-15 南京农业大学 牛支原体pdhb蛋白单克隆抗体、制备方法及其在鉴定b细胞表位中的应用

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US20240254212A1 (en) 2024-08-01
EP3419998A4 (en) 2019-09-25
US20260078177A1 (en) 2026-03-19
US20190359696A1 (en) 2019-11-28
AU2024204761A1 (en) 2024-08-01
EP3419998A1 (en) 2019-01-02
WO2017147561A1 (en) 2017-08-31
AU2017224122A1 (en) 2018-09-20
CN109071642A (zh) 2018-12-21
US11912758B2 (en) 2024-02-27
JP7098527B2 (ja) 2022-07-11
JP2019509283A (ja) 2019-04-04
US20210253680A1 (en) 2021-08-19
US10889637B2 (en) 2021-01-12
US12503500B2 (en) 2025-12-23
CN116672445A (zh) 2023-09-01
AU2017224122B2 (en) 2024-04-11
CA3015839A1 (en) 2017-08-31

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