CN109069477A - 用于利用促蠕动蛋白2激动剂和拮抗剂来治疗昼夜节律紊乱的组合物和方法 - Google Patents

用于利用促蠕动蛋白2激动剂和拮抗剂来治疗昼夜节律紊乱的组合物和方法 Download PDF

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CN109069477A
CN109069477A CN201780022483.7A CN201780022483A CN109069477A CN 109069477 A CN109069477 A CN 109069477A CN 201780022483 A CN201780022483 A CN 201780022483A CN 109069477 A CN109069477 A CN 109069477A
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compound
optionally
activity
pkr2
receptor
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周群勇
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN201780022483.7A 2016-04-06 2017-04-06 用于利用促蠕动蛋白2激动剂和拮抗剂来治疗昼夜节律紊乱的组合物和方法 Pending CN109069477A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662319009P 2016-04-06 2016-04-06
US62/319,009 2016-04-06
PCT/US2017/026387 WO2017177026A1 (en) 2016-04-06 2017-04-06 Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists

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CN109069477A true CN109069477A (zh) 2018-12-21

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CN201780022483.7A Pending CN109069477A (zh) 2016-04-06 2017-04-06 用于利用促蠕动蛋白2激动剂和拮抗剂来治疗昼夜节律紊乱的组合物和方法

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US (1) US10780095B2 (https=)
EP (1) EP3439652A4 (https=)
JP (2) JP7212930B2 (https=)
KR (1) KR102461227B1 (https=)
CN (1) CN109069477A (https=)
AU (1) AU2017248277B2 (https=)
CA (1) CA3019662A1 (https=)
WO (1) WO2017177026A1 (https=)

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Publication number Priority date Publication date Assignee Title
WO2021164770A1 (en) * 2020-02-21 2021-08-26 Peking University Agents and methods for adjusting sleep
CN121154344A (zh) * 2025-09-04 2025-12-19 中国人民解放军联勤保障部队第九二三医院 一种骨科患者皮肤牵引护理方法与系统

Citations (5)

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US20030235535A1 (en) * 2002-04-15 2003-12-25 Qun-Yong Zhou Screening and therapeutic methods for treating circadian rhythm disorders
US20060172935A1 (en) * 2005-01-31 2006-08-03 Qun-Yong Zhou Screening and therapeutic methods for treating circadian rhythm disorders
WO2007067511A2 (en) * 2005-12-06 2007-06-14 Merck & Co., Inc. Morpholine carboxamide prokineticin receptor antagonists
US20080287445A1 (en) * 2005-12-29 2008-11-20 Coats Steven J Prokineticin 2 receptor antagonists
US20120035149A1 (en) * 2008-12-17 2012-02-09 The Regents Of The University Of California Prokineticin Receptor Antagonists And Uses Thereof

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JP2011502154A (ja) 2007-10-30 2011-01-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アミノヘテロアリールを含むプロキネチシン１受容体拮抗物質連邦政府支援研究又は開発に関する陳述下に記述される本発明の研究及び開発は、連邦政府の支援によるものではない。
GB201209587D0 (en) 2012-05-30 2012-07-11 Takeda Pharmaceutical Therapeutic compounds
JP5437525B1 (ja) 2012-12-28 2014-03-12 株式会社ナード研究所 チロシン誘導体およびチロシン誘導体の製造方法
EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists

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US20030235535A1 (en) * 2002-04-15 2003-12-25 Qun-Yong Zhou Screening and therapeutic methods for treating circadian rhythm disorders
US20060172935A1 (en) * 2005-01-31 2006-08-03 Qun-Yong Zhou Screening and therapeutic methods for treating circadian rhythm disorders
WO2007067511A2 (en) * 2005-12-06 2007-06-14 Merck & Co., Inc. Morpholine carboxamide prokineticin receptor antagonists
US20080287445A1 (en) * 2005-12-29 2008-11-20 Coats Steven J Prokineticin 2 receptor antagonists
US20120035149A1 (en) * 2008-12-17 2012-02-09 The Regents Of The University Of California Prokineticin Receptor Antagonists And Uses Thereof

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DEBORA OLIOSO等: "effects of gelsemium sempervirens l. on pathway-focused gene expression profiling in neuronal cells", 《JOURNAL OF ETHNOPHARMACOLOGY》 *
JIA-DA LI等: "Disruption of the circadian output molecule prokineticin 2 results in anxiolytic and antidepressant-like effects in mice", 《NEUROPSYCHOPHARMACOLOGY》 *
MICHELLE Y. CHENG: "Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus", 《NATURE》 *
QUN-YONG ZHOU等: "Prokineticin 2 and circadian clock output", 《FEBS J.》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021164770A1 (en) * 2020-02-21 2021-08-26 Peking University Agents and methods for adjusting sleep
CN121154344A (zh) * 2025-09-04 2025-12-19 中国人民解放军联勤保障部队第九二三医院 一种骨科患者皮肤牵引护理方法与系统

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JP2021169524A (ja) 2021-10-28
JP2019513738A (ja) 2019-05-30
KR20180127491A (ko) 2018-11-28
AU2017248277A1 (en) 2018-11-22
JP7212930B2 (ja) 2023-01-26
CA3019662A1 (en) 2017-10-12
WO2017177026A1 (en) 2017-10-12
US20190117668A1 (en) 2019-04-25
EP3439652A4 (en) 2020-02-26
KR102461227B1 (ko) 2022-10-31
US10780095B2 (en) 2020-09-22
AU2017248277B2 (en) 2021-08-12
EP3439652A1 (en) 2019-02-13

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