KR102461227B1 - 프로키네티신 2 효능제 및 길항제를 이용한 24시간 주기 및 일주기 리듬 장애를 치료하기 위한 조성물 및 방법 - Google Patents
프로키네티신 2 효능제 및 길항제를 이용한 24시간 주기 및 일주기 리듬 장애를 치료하기 위한 조성물 및 방법 Download PDFInfo
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- KR102461227B1 KR102461227B1 KR1020187032118A KR20187032118A KR102461227B1 KR 102461227 B1 KR102461227 B1 KR 102461227B1 KR 1020187032118 A KR1020187032118 A KR 1020187032118A KR 20187032118 A KR20187032118 A KR 20187032118A KR 102461227 B1 KR102461227 B1 KR 102461227B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319009P | 2016-04-06 | 2016-04-06 | |
| US62/319,009 | 2016-04-06 | ||
| PCT/US2017/026387 WO2017177026A1 (en) | 2016-04-06 | 2017-04-06 | Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20180127491A KR20180127491A (ko) | 2018-11-28 |
| KR102461227B1 true KR102461227B1 (ko) | 2022-10-31 |
Family
ID=60001495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187032118A Active KR102461227B1 (ko) | 2016-04-06 | 2017-04-06 | 프로키네티신 2 효능제 및 길항제를 이용한 24시간 주기 및 일주기 리듬 장애를 치료하기 위한 조성물 및 방법 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10780095B2 (https=) |
| EP (1) | EP3439652A4 (https=) |
| JP (2) | JP7212930B2 (https=) |
| KR (1) | KR102461227B1 (https=) |
| CN (1) | CN109069477A (https=) |
| AU (1) | AU2017248277B2 (https=) |
| CA (1) | CA3019662A1 (https=) |
| WO (1) | WO2017177026A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021164770A1 (en) * | 2020-02-21 | 2021-08-26 | Peking University | Agents and methods for adjusting sleep |
| CN121154344A (zh) * | 2025-09-04 | 2025-12-19 | 中国人民解放军联勤保障部队第九二三医院 | 一种骨科患者皮肤牵引护理方法与系统 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007067511A2 (en) * | 2005-12-06 | 2007-06-14 | Merck & Co., Inc. | Morpholine carboxamide prokineticin receptor antagonists |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1575658A4 (en) * | 2002-04-15 | 2007-07-11 | Univ California | INVESTIGATION AND THERAPY PROCEDURE FOR THE TREATMENT OF DISORDERS OF THE CIRCADIAN RHYTHM |
| US20060172935A1 (en) * | 2005-01-31 | 2006-08-03 | Qun-Yong Zhou | Screening and therapeutic methods for treating circadian rhythm disorders |
| CA2635845A1 (en) * | 2005-12-29 | 2007-07-12 | Janssen Pharmaceutica N.V. | Prokineticin 2 receptor antagonists |
| JP2011502154A (ja) | 2007-10-30 | 2011-01-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アミノヘテロアリールを含むプロキネチシン1受容体拮抗物質連邦政府支援研究又は開発に関する陳述下に記述される本発明の研究及び開発は、連邦政府の支援によるものではない。 |
| WO2010077976A2 (en) | 2008-12-17 | 2010-07-08 | The Regents Of The University Of California | Prokineticin receptor antagonists and uses thereof |
| GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
| JP5437525B1 (ja) | 2012-12-28 | 2014-03-12 | 株式会社ナード研究所 | チロシン誘導体およびチロシン誘導体の製造方法 |
| EP2845850A1 (en) | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists |
-
2017
- 2017-04-06 CA CA3019662A patent/CA3019662A1/en active Pending
- 2017-04-06 US US16/090,044 patent/US10780095B2/en active Active
- 2017-04-06 AU AU2017248277A patent/AU2017248277B2/en active Active
- 2017-04-06 WO PCT/US2017/026387 patent/WO2017177026A1/en not_active Ceased
- 2017-04-06 JP JP2018552675A patent/JP7212930B2/ja active Active
- 2017-04-06 KR KR1020187032118A patent/KR102461227B1/ko active Active
- 2017-04-06 EP EP17779838.6A patent/EP3439652A4/en active Pending
- 2017-04-06 CN CN201780022483.7A patent/CN109069477A/zh active Pending
-
2021
- 2021-07-26 JP JP2021121456A patent/JP2021169524A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007067511A2 (en) * | 2005-12-06 | 2007-06-14 | Merck & Co., Inc. | Morpholine carboxamide prokineticin receptor antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021169524A (ja) | 2021-10-28 |
| JP2019513738A (ja) | 2019-05-30 |
| KR20180127491A (ko) | 2018-11-28 |
| AU2017248277A1 (en) | 2018-11-22 |
| CN109069477A (zh) | 2018-12-21 |
| JP7212930B2 (ja) | 2023-01-26 |
| CA3019662A1 (en) | 2017-10-12 |
| WO2017177026A1 (en) | 2017-10-12 |
| US20190117668A1 (en) | 2019-04-25 |
| EP3439652A4 (en) | 2020-02-26 |
| US10780095B2 (en) | 2020-09-22 |
| AU2017248277B2 (en) | 2021-08-12 |
| EP3439652A1 (en) | 2019-02-13 |
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