CN109069460A - 改进的药物制剂 - Google Patents

改进的药物制剂 Download PDF

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Publication number
CN109069460A
CN109069460A CN201780028973.8A CN201780028973A CN109069460A CN 109069460 A CN109069460 A CN 109069460A CN 201780028973 A CN201780028973 A CN 201780028973A CN 109069460 A CN109069460 A CN 109069460A
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CN
China
Prior art keywords
poly
cellulose
pharmaceutically acceptable
copolymer
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780028973.8A
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English (en)
Chinese (zh)
Inventor
达夫·A·米勒
丹尼尔·J·埃伦伯格
桑德拉·U·席林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diffusion technology co Ltd
Original Assignee
Diffusion technology co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diffusion technology co Ltd filed Critical Diffusion technology co Ltd
Publication of CN109069460A publication Critical patent/CN109069460A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780028973.8A 2016-05-09 2017-05-08 改进的药物制剂 Pending CN109069460A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662333482P 2016-05-09 2016-05-09
US62/333,482 2016-05-09
US201662334576P 2016-05-11 2016-05-11
US62/334,576 2016-05-11
PCT/US2017/031521 WO2017196712A1 (en) 2016-05-09 2017-05-08 Improved drug formulations

Publications (1)

Publication Number Publication Date
CN109069460A true CN109069460A (zh) 2018-12-21

Family

ID=60267508

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780028973.8A Pending CN109069460A (zh) 2016-05-09 2017-05-08 改进的药物制剂

Country Status (10)

Country Link
US (1) US20200009060A1 (https=)
EP (2) EP4552641A3 (https=)
JP (2) JP7112333B2 (https=)
CN (1) CN109069460A (https=)
AU (1) AU2017262586B2 (https=)
CA (1) CA3022878C (https=)
IL (1) IL262745B (https=)
MA (1) MA44987A (https=)
WO (1) WO2017196712A1 (https=)
ZA (1) ZA201807446B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111511365A (zh) * 2017-11-10 2020-08-07 分散技术有限责任公司 改进的药物制剂
CN114190538A (zh) * 2021-12-21 2022-03-18 郑州轻工业大学 一种促β′晶型形成的油脂促结晶剂及应用

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US20210128536A1 (en) * 2019-11-01 2021-05-06 Dispersol Technologies, Llc Weakly basic drug and ionic polymer pharmaceutical formulations and methods of formation and administration thereof
KR20220123689A (ko) * 2020-03-11 2022-09-08 사와이세이야쿠 가부시키가이샤 과립 및 그것을 이용한 제제
WO2022094817A1 (en) * 2020-11-04 2022-05-12 Janssen Pharmaceuticals, Inc. Pharmaceutical formulation
NL2028762B1 (en) * 2021-07-16 2023-01-23 Seranovo Holding B V Micelle-generating formulations for enhanced bioavailability
CN116173018A (zh) * 2021-11-26 2023-05-30 上海宣泰医药科技股份有限公司 一种达罗他胺药物组合物及其制备方法和用途

Citations (4)

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CN101835492A (zh) * 2007-08-21 2010-09-15 德克萨斯州立大学董事会 用于制药应用的热动力学混合
CN102083418A (zh) * 2008-04-24 2011-06-01 伊万斯彻有限公司 口服避孕药剂及其制备方法
WO2012116238A1 (en) * 2011-02-23 2012-08-30 Dispersol Technologies, Llc PHARMACEUTICAL FORMULATIONS OF ACETYL-11-KETO-β-BOSWELLIC ACID, DIINDOLYLMETHANE, AND CURCUMIN FOR PHARMACEUTICAL APPLICATIONS
WO2014170026A1 (en) * 2013-04-18 2014-10-23 Zentiva, K.S. Stabilized amorphous ticagrelor

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ATE255883T1 (de) * 1996-05-20 2003-12-15 Janssen Pharmaceutica Nv Fungizide mittel mit verbesserter bioverfügbarkeit
US20070218138A1 (en) * 2006-03-20 2007-09-20 Bittorf Kevin J Pharmaceutical Compositions
WO2009108077A2 (en) * 2008-02-28 2009-09-03 Bial - Portela & Ca., S.A. Pharmaceutical composition for poorly soluble drugs
US20110065800A1 (en) * 2008-05-14 2011-03-17 Haihong Fan Formulations for cathepsin k inhibitors
EP2568964B1 (en) * 2010-05-10 2018-08-01 Evonik Röhm GmbH Pharmaceutical dosage form comprising one or more antiretroviral active ingredients
EP2654726A1 (en) * 2011-03-08 2013-10-30 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
WO2015152433A1 (en) * 2014-03-31 2015-10-08 Hanmi Pharm. Co., Ltd. Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same
DK3131667T3 (da) * 2014-04-18 2021-10-25 Dispersol Technologies Llc Flerhastigheds fremgangsmåde og blander til konservering af varmefølsomme portioner af et termokinetisk smelte blandet parti
WO2015175505A1 (en) * 2014-05-15 2015-11-19 Lundbeck Llc Tetrabenazine modified release formulation
WO2016073421A1 (en) * 2014-11-03 2016-05-12 Dispersol Technologies, Llc Improved formulations of vemurafenib and methods of making the same
CN104434809B (zh) * 2014-12-10 2018-10-16 北京科莱博医药开发有限责任公司 一种奥拉帕尼固体分散体制剂及其制备方法
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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
CN101835492A (zh) * 2007-08-21 2010-09-15 德克萨斯州立大学董事会 用于制药应用的热动力学混合
CN102083418A (zh) * 2008-04-24 2011-06-01 伊万斯彻有限公司 口服避孕药剂及其制备方法
WO2012116238A1 (en) * 2011-02-23 2012-08-30 Dispersol Technologies, Llc PHARMACEUTICAL FORMULATIONS OF ACETYL-11-KETO-β-BOSWELLIC ACID, DIINDOLYLMETHANE, AND CURCUMIN FOR PHARMACEUTICAL APPLICATIONS
WO2014170026A1 (en) * 2013-04-18 2014-10-23 Zentiva, K.S. Stabilized amorphous ticagrelor

Non-Patent Citations (2)

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ZHU, Y ET AL.: "Influence of a lipophilic thermal lubricant on the processing conditions and drug release properties of chlorpheniramine maleate tablets prepared by hot-melt extrusion", 《JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY》 *
杨明山: "《塑料改性实用技术与应用》", 30 June 2014, 印刷工业出版社 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111511365A (zh) * 2017-11-10 2020-08-07 分散技术有限责任公司 改进的药物制剂
CN114190538A (zh) * 2021-12-21 2022-03-18 郑州轻工业大学 一种促β′晶型形成的油脂促结晶剂及应用
CN114190538B (zh) * 2021-12-21 2023-11-24 郑州轻工业大学 一种促β′晶型形成的油脂促结晶剂及应用

Also Published As

Publication number Publication date
JP7112333B2 (ja) 2022-08-03
US20200009060A1 (en) 2020-01-09
MA44987A (fr) 2019-03-20
EP3454847A1 (en) 2019-03-20
IL262745A (en) 2018-12-31
WO2017196712A1 (en) 2017-11-16
IL262745B (en) 2022-07-01
AU2017262586A1 (en) 2018-11-22
EP3454847A4 (en) 2019-12-18
CA3022878A1 (en) 2017-11-16
EP4552641A3 (en) 2025-07-30
JP7458440B2 (ja) 2024-03-29
AU2017262586B2 (en) 2023-04-13
EP4552641A2 (en) 2025-05-14
ZA201807446B (en) 2025-05-28
CA3022878C (en) 2024-04-30
JP2019514993A (ja) 2019-06-06
JP2022116234A (ja) 2022-08-09

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