CN109069385B - Hair pigment enhancer - Google Patents
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- CN109069385B CN109069385B CN201780028545.5A CN201780028545A CN109069385B CN 109069385 B CN109069385 B CN 109069385B CN 201780028545 A CN201780028545 A CN 201780028545A CN 109069385 B CN109069385 B CN 109069385B
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Abstract
Disclosed is a hair dye enhancer which acts on cells involved in hair dye formation to promote the production of hair dye and can prevent/improve white hair. It is a single-dose hair dye enhancer comprising at least one of gallic acid and gallic acid derivatives as an active ingredient. The gallic acid derivative is preferably hydrolyzed tannin such as tara tannin and gallnut tannin, and further preferably contains saccharides, amino acids, vitamins, coenzymes, minerals, saponins such as quillaja saponin, and seed extract of plant of genus elaeagnus of family Papilionaceae.
Description
Technical Field
The present invention relates to a hair dye enhancer which activates cells involved in hair dye formation to promote hair dye formation.
Background
Conventionally, hair dyeing has been mainly used as a method for blackening hair, in order to whiten hair with aging (aging). However, in recent years, it has been known that the whitening of hair is caused by the functional deterioration of hair pigment cells in hair follicles of the scalp due to aging and stress. Furthermore, regarding hair whitening, a component that promotes melanin production in hair pigment cells has been found, and a composition for preventing white hair using this component has been proposed (see patent documents 1 to 5).
For example, patent document 1 describes a melanin production promoter containing one or more plant extracts selected from ginseng, notoginseng, salvia miltiorrhiza, yucca, loquat, and honeysuckle as a main component, and a white hair improving agent containing the same.
Patent document 2 describes a composition for promoting tyrosinase activity or a composition for preventing canities, which contains a plant extract as an active ingredient, wherein the active ingredient is composed of at least one extract derived from a plant belonging to a genus selected from the group consisting of Salvia (savia), Anemarrhena (Anemarrhena), and Ipomoea (Ipomoea).
Patent document 3 describes that 6-benzylaminopurine and a corn silk extract containing the same are useful as active ingredients of external preparations for preventing gray hair.
Patent document 4 describes that 7-O-methyl eriodictyol and artemisia capillaris thunb extracts containing the same are useful for preventing and improving white hair.
Patent document 5 describes that paeonol and a moutan cortex bark extract containing the same have melanin production ability, and that an external preparation having an excellent effect of preventing and improving gray hair is provided by blending the paeonol and the moutan cortex bark extract.
Documents of the prior art
Patent document
Patent document 1: japanese laid-open patent application No. 2001 and 288098
Patent document 2: japanese laid-open patent publication No. 9-263540
Patent document 3: japanese patent laid-open publication No. 2013-159592
Patent document 4: japanese patent laid-open publication No. 2013-147491
Patent document 5: japanese patent laid-open publication No. 2005-015472
Disclosure of Invention
Technical problem to be solved by the invention
However, although the melanin production-promoting agents and the white hair-preventing compositions described in the above patent documents have a certain effect such as a melanin production-promoting effect, the prevention and improvement of white hair is still insufficient, and a material having a more excellent white hair-preventing/improving effect is desired.
The present invention has been made in view of the above circumstances, and an object thereof is to provide a hair dye enhancer that acts on cells involved in hair dye formation to promote hair dye production and can exhibit more excellent ability to prevent/improve white hair than conventional melanin production promoters and white hair prevention compositions.
Means for solving the problems
Conventionally, the use of gallic acid and its derivatives as agents for dyeing hair by forming black complexes with iron salts and the like (see Japanese patent laid-open No. 2001-270812), as hair-care agents (Japanese patent laid-open No. 7-206644, and 2003-321330), or as anti-plaque (whitening) agents (Japanese patent publication No. 5-28203, and 2004-175688) has been reported, but no specific report has been made on the effect of preventing white hair caused only by gallic acid and its derivatives. Although the above-mentioned Japanese patent laid-open No. 2003-321330 generally describes the effect of improving white hair, the examples and the like do not describe the effect.
The present inventors have conducted intensive studies on polyphenol compounds containing gallic acid using a test system using a three-dimensional human skin culture model, and as a result of a test that gallic acid or a derivative thereof is a drug that activates cells involved in hair pigmentation to promote hair pigmentation as a part of the present search for a drug having a high hair pigmentation-enhancing ability. Further, the present inventors have conducted a human body test and then obtained a finding that the composition has a white hair prevention/improvement effect, and thus completed the present invention.
The hair color enhancer of the present invention is a single-dose hair color enhancer containing at least one of gallic acid and gallic acid derivatives as an active ingredient. The hair color enhancer of the present invention contains the above active ingredient, and can provide a white hair preventing/improving effect by applying the hair color enhancer to the scalp.
More specifically, the gallic acid derivative is preferably a compound represented by the following general formula (I) or a hydrolyzable tannin. The hydrolyzed tannin is preferably one or more hydrolyzed tannins selected from the group consisting of tara tannin, chestnut tannin, myrobalan tannin, gallnut tannin (tannic acid), oak tannin, and tea tannin.
[ CHEM 1 ]
The hair color enhancer of the present invention preferably further comprises at least one of saponins. Inclusion of saponins can further enhance the canities prevention/improvement effect.
The hair color enhancer of the present invention preferably further comprises at least one of a saccharide and/or an amino acid. By containing these saccharides or amino acids, the canities prevention/improvement effect can be further improved.
The hair colorant-enhancing agent of the present invention preferably further comprises at least one of vitamins and/or coenzymes. By including these vitamins or coenzymes, the canities prevention/improvement effect can be further improved.
The hair color enhancer of the present invention preferably further comprises at least one of minerals. By including minerals, the canities prevention/improvement effect can be further improved.
The hair color enhancer of the present invention preferably further comprises a plant extract of a plant of the genus Sesamum of the family Papilionaceae. The canities prevention/improvement effect can be further enhanced by containing a plant extract of a plant of the genus elaeagnus of the family Papilionaceae.
In the hair dye enhancer of the present invention, gallic acid or a gallic acid derivative acts on cells such as dye stem cells, hair follicle stem cells, melanocytes, hair mother cells, hair papilla cells, melanosomes, and the like, which are involved in melanin formation, and thereby the production of hair dye is promoted, and an excellent composition for preventing/improving white hair in the form of a single preparation such as a solution, gel, mousse, cream, and the like, containing the same can be provided.
Drawings
FIG. 1 is a photograph of a three-dimensional human skin culture model MEL-300A manufactured by MatTek corporation in examples 4, 6, 7, 8, and 11 and comparative examples 1 and 3.
Detailed Description
The present invention is not limited to the embodiments described below, and can be carried out with appropriate modifications within the scope of the object of the present invention.
First, the action and effect of the hair color enhancer of the present invention will be described. Among hair pigments, two kinds of melanin, dark brown eumelanin (eumelanin) and yellow orange melanoid (brown melanin), are mainly present. The hair is black hair, chestnut hair, golden hair and red hair according to the proportion and the amount. The two kinds of cells involved in melanin formation are cells such as pigment stem cells, hair follicle stem cells, melanocytes, hair mother cells, hair papilla cells, melanosomes, and the like, and the hair dye enhancer of the present invention can act on these cells to promote the production of hair dye, that is, the enhancement of hair dye. This can prevent white hair and improve the white hair condition. In the present specification, the prevention and improvement of white hair is the same as understood by those skilled in the art, and specifically, the prevention means preventive application to, for example, hair in a state of black hair, chestnut hair, gold hair, red hair, etc., or scalp thereof, and the prevention of the hair in a state of white hair, further fading, etc., and the improvement means application to, for example, hair in a state of white hair, fading, etc., or scalp thereof, and the hair in a state of original black hair, chestnut hair, gold hair, red hair, etc., or colored hair, etc.
Therefore, the active ingredient in the present invention is a component capable of exerting the above-mentioned hair dye-enhancing function, and is a component which acts on any cell related to hair dye, such as dye stem cells, hair follicle stem cells, melanocytes, hair papilla cells, melanosomes, and promotes the production of the hair dye.
In the present invention, the hair color enhancer is used in the form of a single dosage form such as a solution, a gel, a mousse, a cream, etc., but is preferably used in the form of a single dosage form (e.g., a tonic or a lotion) of a solution (including a dispersion). The form of a single formulation is to use a single agent containing the hair dye enhancer of the present invention in the form of a solution, gel, mousse, cream, or the like, and does not exert its effect by applying a plurality of agents to the scalp.
The active ingredient in the present invention is at least one of gallic acid and gallic acid derivatives, and the description thereof is given. Gallic acid is 3, 4, 5-trihydroxybenzoic acid or a salt thereof, and is a compound having the structure of the following (1). Hydrogen cation (H)+) X other than+Is an organic or inorganic cation. Representative ions are ammonium ions or alkali metal ions.
[ CHEM 2 ]
The gallic acid derivatives are compounds derived from gallic acid, and they may be chemically synthesized derivatives or derivatives isolated from natural substances. The gallic acid derivative of the present invention is preferably a compound capable of releasing gallic acid by hydrolysis. Preferred compounds of the present invention which can be derived by chemical synthesis are represented by the following general formula (I).
[ CHEM 3 ]
Ar in the general formula (I) represents a substituted or unsubstituted aryl group, preferably a substituted or unsubstituted phenyl group. In the case of a substituted aryl group, the substituent which may be present is not particularly limited, but a substituted aryl group in which phenol generated by hydrolysis does not adversely affect the organism is preferable. Preferred examples of the substituent which may be contained include an alkyl group, an aryl group, a hydroxyl group, a carboxylic acid group and an ester group, and a particularly preferred group is a hydroxyl group or a carboxylic acid group. The substituents may be the same or different and may be multiple substituents on the aryl group.
Specific examples of preferred compounds represented by the general formula (I) are shown below, but the compounds are not limited thereto. [ CHEM 4 ]
Among gallic acid derivatives isolated from natural substances, a particularly preferred compound in the present invention is a hydrolyzed tannin. The source of tannin comes from "tanning". The tanning effect from hide to leather is based on the interaction of the collagen of the hide with tannin (formation of a poorly soluble complex coating on the surface). Tannin is a natural polyphenol group which exhibits strong affinity for high molecular compounds such as proteins and polysaccharides, basic compounds such as alkaloids, heavy metals, and the like, and which retains a property of easily forming a complex with them. The tannin includes condensed tannin and hydrolyzed tannin. Among these, the hydrolyzed tannins release gallic acid by hydrolysis, and are preferred tannins in the present invention. (see: journal of the society of organic Synthesis chemistry, 2004, 62, 94-101)
The hydrolysis type tannins preferred in the present invention are tara tannins, chestnut tannins, myrobalan tannins, gallnut tannins (tannins), oak tannins, tea tannins and the like, and particularly preferred hydrolysis type tannins are tara tannins and gallnut tannins (tannins). Tara tannin is a hydrolyzed tannin extracted from the pod (pod) of a leguminous plant called Tara spinosa, grown in peru, south america (academic name: Caesalpinia spinosa kuntze, english: Tara spanish: Tara), and galltannic acid is a hydrolyzed tannin obtained from a substance obtained by drying gallnut resulting from the formation of a puncture wound by an insect of the aphid family (rhus chinensis) on the deciduous tree rhus chinensis of the anadaceae family, and plants of the same genus. Both of them are a mixture of a plurality of compounds (the schematic structure is shown below), and both of them are characterized by containing gallic acid sites bonded in the form of aryl esters.
[ CHEM 5 ]
The content of gallic acid and gallic acid derivatives (tara tannin, tannic acid, etc.) in the hair dye enhancer of the present invention is not particularly limited, and is preferably 0.01 to 20% by mass, and more preferably 0.1 to 10% by mass when the gallic acid and gallic acid derivatives are in the form of a solution (e.g., tonic or lotion). In the case of gel or cream form, the content is preferably 0.05 to 50% by mass, and particularly preferably 0.1 to 30% by mass, although a higher content can be achieved because there is no problem such as precipitation.
When the hair color enhancer of the present invention is used in the form of a one-part solution (including a dispersion), a gel, a mousse, a cream, or the like, it preferably contains at least one of saponins for the purpose of enhancing the canities prevention/improvement effect. Saponins are a generic term for glycosides composed of sapogenins and sugars, and are roughly classified into oleanane-based, dammarane-based, and steroid-based saponins.
The oleanane-type saponin includes saponin such as polygala tenuifolia, akebia stem, platycodon grandiflorum, radix bupleuri, senega, licorice, achyranthes bidentata, panax japonicus V, and quillaja saponaria, the dammarane-type saponin includes saponin such as ginseng, jujube, panax japonicus III, tragacanth, and astragalus root, and the steroid-type saponin includes saponin such as yam, rhizoma anemarrhenae, ophiopogon root, rehmannia glutinosa, and smilax.
In the present invention, preferred saponins are saikosaponin, quillajasaponin, panax japonicus saponin and sarsasaponin, and quillajasaponin and sarsasaponin are particularly preferred. The amount of the saponin to be added is preferably 0.05 to 10% by mass, and particularly preferably 0.1 to 8% by mass.
In order to further enhance the effect of the hair color enhancer of the present invention, it is preferable to contain saccharides, amino acids, vitamins and coenzymes, minerals, pyruvic acid, and the like. Here, among the saccharides, there are monosaccharides, disaccharides, and polysaccharides, but monosaccharides and disaccharides are preferable, and glucose, lactose, galactose, mannose, sucrose, maltose, and the like are particularly preferable. Further, the amino acids include essential amino acids and nonessential amino acids, and preferable examples of the amino acids include glycine, L-histidine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-valine, L-arginine, L-cystine, L-glutamine, L-serine, and L-tyrosine. The amount of these substances added is preferably 0.05 to 20% by mass, and particularly preferably 0.1 to 10% by mass.
Examples of vitamins and coenzymes include vitamin a, vitamin D, vitamin E, vitamin B1 (thiamine), B2 (riboflavin), B3 (nicotinic acid), B5 (pantothenic acid), B6 (pyridoxine), B8 (folic acid), B12 (cobalamin), biotin, choline, lipoic acid, inositol, and preferred examples of vitamins and coenzymes include vitamin B1 (thiamine), B2 (riboflavin), B3 (nicotinic acid), B5 (pantothenic acid), B6 (pyridoxine), B8 (folic acid), biotin, choline, lipoic acid, inositol, and meso-inositol. The amount of these substances added is preferably 0.01 to 2% by mass, and particularly preferably 0.05 to 1% by mass.
Examples of the minerals include chlorides, hydrochlorides, carbonates, bicarbonates, nitrates, sulfates, monohydrogen phosphates, and dihydrogen phosphates of calcium, sodium, potassium, magnesium, zinc, and aluminum. Among these minerals, calcium is particularly important, and is preferably 50ppm or more, and more preferably 100 to 500 ppm. The total content of minerals is preferably 0.3 to 12% by mass, and particularly preferably 0.5 to 8% by mass.
In order to further enhance the effect of the hair color enhancer of the present invention, it is preferable to contain a plant extract of a plant of the genus spatholobus of the subfamily Papilionaceae. Among them, plants of the genus Mucuna of the subfamily Papiloideae are preferably plants of the genus Mucuna, and particularly, are preferably plants of the genus Chenopodium, such as Chenopodium album (academic name: Mucuna pruriens, Japanese name: ビロード beans), Chenopodium album (academic name: Stizolobium hassjoo), Stizolobium janthinellum (academic name: Mucuna cochinchinensis), and Mucuna henryi (academic name: Mucuna japonica). The plant extract can be obtained from all parts such as flower, leaf, stem, and root, but the seed extract is most effective. The extraction for preparing the plant extract can be suitably carried out according to a method known to those skilled in the art, and examples thereof include a method of pulverizing an undried or dried seed, adding water, alcohols (methanol, ethanol, isopropanol, etc.), glycols (propylene glycol, butylene glycol, etc.) or a mixed solvent thereof to the pulverized seed, and after the extraction treatment, distilling off the solvent. The amount of the plant extract of the plant of the genus Metaplexis varies depending on the amount of the active ingredient in the extract, and is preferably 0.05 to 10% by mass, and more preferably 0.1 to 3% by mass.
Other components such as surfactants, penetration enhancers, moisturizers, blood circulation enhancers, anti-inflammatory agents, antioxidants, ultraviolet ray inhibitors, antibacterial agents, cell proliferation enhancers, cell differentiation inducers, perfumes, oils, enzymes, cooling agents, and the like may be further added to the present invention as necessary. Examples thereof include blood circulation promoters such as piperine and capsaicin, cell proliferation promoters such as naringenin, cell differentiation inducers such as forskolin, oils such as camellia oil and squalane, and enzymes such as tyrosinase. The amount of other components added is preferably 0.01 to 10 mass%. Preferably 0.1 to 5 mass%.
In the case where the hair color enhancer of the present invention is a solution (including a dispersion), the main solvent used is water, but in the case where the additive is hardly dissolved in water, an organic solvent approved for addition to cosmetics may be used. An organic solvent such as ethanol, isopropyl alcohol, propylene glycol, butylene glycol, or glycerin may be used, and the amount thereof is preferably less than 20% by mass.
The effect of the hair dye enhancer of the present invention is inhibited by the presence of heavy metal ions, particularly iron ions. It is considered that this is because, when heavy metal ions are present, the iron ions form a colored complex, so that gallic acid and gallic acid derivatives are insolubilized, and absorption through pores is inhibited. In the form of the solution (including dispersion liquid), gel, mousse, cream, etc. of the present invention, it is preferable that heavy metal ions are not substantially contained.
When the additive to be added to the hair dye enhancer of the present invention is a compound that is extremely insoluble in water, it is necessary to form a solution by nano-dispersion in water. When the volume average particle diameter of the nano-dispersion is 200nm or less, the permeability from the scalp to the hair root is improved, and the function thereof can be used appropriately. From the viewpoint of enhancing permeability, the volume average particle diameter is more preferably 100nm or less.
Examples
The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to the following examples.
[ examples 1 to 14, comparative examples 1 to 4 ] Melanin pigment production test E
(1) Preparation of skin external preparation for melanin pigment generation
Sample solutions of examples and comparative examples were prepared with the following compositions (see table 1).
The amounts of the effective components listed in Table 1
5% by mass of propylene glycol
The total amount of water is adjusted to 100 mass%
Tara tannin was manufactured by kamura corporation.
Quillajanin D-100 manufactured by Wanshan pharmaceutical company is used as Quillajanin, and Sarakeep ALS manufactured by Wanshan pharmaceutical company is used as sarsasaponin. In addition, Quillajanin D-100 is prepared from Quillajanin: 25 mass%, propylene glycol: 15 mass%, and water: 60% by mass, Sarakeep ALS is a derivative of sarsasaponin: 7.5 mass%, water: 42.5 mass%, ethanol: 50% by mass, and therefore converted in terms of purity.
Further, commercially available reagents were used as the other active ingredients.
[ culture of human skin three-dimensional culture model ]
Using a three-dimensional human skin culture model MEL-300A (8mm) manufactured by MatTek, and EPI-100NMM113 as a culture medium, the culture was carried out at 37 ℃ for 3 weeks under an atmosphere of 5% carbon dioxide. Meanwhile, 50. mu.l of the sample solution was added every 1 day from day 1 while the medium was changed.
[ measurement of Absorbance ]
After culturing the human skin three-dimensional culture model for 3 weeks, the membrane in the culture cup is punched, 0.5ml of 1N-sodium hydroxide aqueous solution is added, and the cells are decomposed by vigorous shaking in a hot water bath at 90 ℃ for 3 hours. The mixture was filtered through a 0.45 μ filter, and the absorbance of the filtrate was measured by a microplate reader (wavelength: 405 nm).
[ TABLE 1 ]
As shown in table 1, tara tannin and tannic acid showed high absorbance and developed color at high concentration. In particular, the example using tara tannin and quillajasaponin together showed higher absorbance. In addition, gallic acid and phenyl gallate also showed relatively high absorbance.
On the other hand, as shown in FIG. 1, it is clear from the results of the MEL-300A cup photographs of the three-dimensional human skin culture models in examples 4, 6, 7, 8, and 11 and comparative examples 1 and 3 that the color development concentrations in examples 4, 6, 7, 8, and 11 are extremely high as compared with comparative examples 1 and 3.
[ examples 15 to 18, comparative examples 5 to 6 ] human body test &
Preparation of hair conditioner "
(1) Hair conditioner A (1% by mass solution based on tara tannin) was prepared by diluting 2g of tara tannin with 200ml of water.
(2) Conditioner B (1% by mass solution based on tara tannin and Quillajanin) was prepared by diluting 2g of tara tannin and 8g of Quillajanin D-100 solution (25% by mass of Quillajanin saponin, 60% by mass of water, 15% by mass of propylene glycol aqueous solution, manufactured by Wanshan pharmaceutical Co.) with 200ml of water.
(3) Hair conditioner C was prepared using an aqueous solution not employing active ingredients.
[ human body test ]
15 men and women of 40-60 years old, whose hair had been whitened at 1/5-1/4, were divided into 3 groups of 10 (each group consisting of 5 men and 5 women). The conditioner a was used in 5 men in example 15 and 5 women in example 16. In addition, the conditioner B was used for 5 men in example 17 and 5 women in example 18. Further, the hair conditioner C was used for 5 men in comparative example 5 and for 5 women in comparative example 6.
In each of examples and comparative examples, 1ml of each conditioner was applied to the top of the head for 3 months every day before going to bed after bathing and 2 times/day after getting up, and the applied part was massaged to permeate into the scalp.
The judgment of the effect was made by taking photographs of the part near the hair root (3 cm from the scalp) before and after the test, measuring the ratio of blackening of white hair, and was excellent when 80% or more was blackened, good when 30 to 80% was blackened, and x when less than 30% was used.
[ TABLE 2 ]
| Hair conditioner | Active ingredient | Sex of the subject | Effect | |
| Example 15 | A | Tara tannin | Male sex | 4 and 1 |
| Example 16 | A | Tara tannin | Female with a view to preventing the formation of wrinkles | Very good 5 |
| Example 17 | B | Tara tannin/Quillaja Saponaria Molina saponin | Male sex | Very good 5 |
| Example 18 | B | Tara tannin/Quillaja Saponaria Molina saponin | Female with a view to preventing the formation of wrinkles | Very good 5 |
| Comparative example 5 | C | Is free of | Male sex | X 5 name |
| Comparative example 6 | C | Is free of | Female with a view to preventing the formation of wrinkles | X 5 name |
As a result, as shown in table 2, a clear difference was observed between the tara tannin and the tara tannin/quillaja saponin according to the present invention, and it was found that the tara tannin of the present invention has a white hair improving effect. In particular, when quillajasaponins are used together with tala tannins, a significant effect of improving canities can be seen. In addition, no significant difference was seen between men and women.
[ example 19 ] preparation of Hair dye enhancer Dispersion and human body test
After 0.1g of talaronin and 0.1g of forskolin (cell differentiation inducer) which is extremely insoluble in water were dissolved in 5g of ethanol, the mixture was passed through a 0.45 μm microfilter (manufactured by Sartorius corporation) to remove impurities such as dust, thereby preparing solution Ia (6.1 g). Next, 1.0g of quillaja saponin (saponin manufactured by tokyo chemical corporation) as a nonionic surfactant was dissolved in distilled water (92.9g), and then impurities such as dust were removed by passing through a 0.45 μm microfilter (manufactured by Sartorius corporation), thereby obtaining an Ib solution (93.9 g). The solution Ia and the solution Ib were subjected to nano-dispersion using a T-shaped micromixer in the following order. Specifically, 1/16-inch teflon (registered trademark) tubes were connected to both inlets of a T-shaped micromixer having an equivalent diameter of 250 μm, and syringes containing the Ia solution and the Ib solution were connected to the tubes and set in the syringe pump. An 1/16-inch Teflon tube was connected to the outlet, and a sample bottle for trapping was provided at the outlet. The solution Ia was fed at a feed rate of 0.20g/min and the solution Ib at a feed rate of 3.12g/min for 20 minutes. The transparent dispersion collected in the sample bottle was used as sample 15. The concentration of tara tannin, the concentration of forskolin, the concentration of quillaja saponin, and the concentration of ethanol in sample 15 were 1.0 mass%, 0.1 mass%, 1.0 mass%, and 5.0 mass%, respectively. When the particle size of sample 15 was measured, the volume average particle size Mv was 28nm, and the ratio of the volume average particle size Mv/number average particle size Mn, which is an indicator of monodispersity, was 1.25.
[ COMPARATIVE EXAMPLE 7 ]
In the same manner as above except that talarotan was removed from the Ia liquid, Ia' liquid (5.1g) was prepared as an ethanol solution containing forskolin. Further, Ib' solution (94.9g) containing quillaja saponin was prepared in the same manner except that the amount of water was increased by 1 g. These were placed in a T-shaped micromixer in the same manner as described above, and the solution Ia 'and Ib' were fed at a feed rate of 0.17g/min and 3.15g/min for 20 minutes. The transparent dispersion collected in the sample bottle was used as comparative sample 5. The concentration of forskolin in comparative sample 5 was 0.1 mass%, the concentration of quillaja saponin was 1.0 mass%, and the concentration of ethanol was 5.0 mass%. When the particle size of comparative sample 5 was measured, the volume average particle size Mv was 27nm, and the ratio of the volume average particle size Mv/number average particle size Mn, which is an indicator of monodispersity, was 1.26.
[ human body test ]
Human body tests were carried out in the same manner as in examples 15 to 18 using sample 15 of example 19 and comparative sample 5 of comparative example 7. As a result, 90% blackening was observed in the case of using the sample 15, and the effect was evaluated as "excellent", whereas the effect stayed in 65% blackening in the case of using the comparative sample 5, and the effect was evaluated as "o". From these results, it was found that the ability to prevent white hair was enhanced by adding talarone.
[ examples 20-32 ] and comparative example 8 ] to Medium-Scale human body test (test period of 3 months) & E & gt
(1) Preparation of hair conditioner
The respective active ingredients shown in Table 3 were appropriately selected and dissolved in 150ml of purified water and 50ml of butanediol so as to give the contents of the respective ingredients shown in the table, to prepare conditioners A ', B', D to N shown in Table 4 below. In tables 3 and 4, tara tannin is labeled TT, quillaja saponin is labeled QS, saccharides is labeled S, amino acids is labeled AA, vitamins and coenzymes are labeled V, minerals are labeled M, and chenopodium spinosum seed extract is labeled MP.
(2) Preparation of comparative solution
A mixture of 150ml of purified water and 50ml of butylene glycol was prepared as conditioner C'.
[ TABLE 3 ]
[ human body test ]
140 women aged 50-65 who had whitened hair, 1/3-2/3, were divided into 14 groups of 10. In examples 20 to 32, conditioners A ', B ' and D to N shown in Table 4 were used, and in comparative example 8, conditioner C ' containing no active ingredient was used.
In each of examples and comparative examples, 1ml of each conditioner was applied to the white hair part for 3 months every day before going to bed after bathing and 2 times/day after getting up, and the applied part was massaged to permeate into the scalp.
The judgment of the effect was made by taking photographs of the part near the hair root (3 cm from the scalp) before and after the test, measuring the ratio of blackening of white hair, and was excellent when blackening was 50% or more, good when blackening was 20 to 50%, and x when blackening was less than 20%.
[ TABLE 4 ]
| Hair conditioner | Active ingredient | Effect | |
| Example 20 | A’ | TT | 2, 5, and 3 |
| Example 21 | B’ | TT/QS | 4, and 2 |
| Example 22 | D | TT/QS/S | 4, 5, and x 1 |
| Example 23 | E | TT/QS/AA | 4, 5, and x 1 |
| Example 24 | F | TT/QS/S/AA | 5, 4, and x 1 |
| Example 25 | G | TT/QS/S/AA/V | 6, 3, and x 1 |
| Example 26 | H | TT/QS/S/AA/M | 7, 2, and x 1 |
| Example 27 | I | TT/QS/S/AA/V/M | 7, 2, and x 1 |
| Example 28 | J | TT/QS/S/AA/ME | 6, 3, and x 1 |
| Example 29 | K | TT/QS/AA/V/M | 6, 3, and x 1 |
| Example 30 | L | TT/QS/AA/M | 5, 4, and x 1 |
| Example 31 | M | TT/QS/AA/M/ME | 7, 2, and x 1 |
| Example 32 | N | TT/QS/AA/V/M/ME | 8, 1, and x 1 |
| Comparative example 8 | C’ | Is free of | 0, and 10 |
As a result, as shown in table 4, it was found that tara tannin of the present invention has a clear effect of improving white hair even in elderly women with a high white hair ratio. In addition, it is found that the effect of improving canities is improved by adding quillaja saponin, saccharides, amino acids, vitamins, coenzymes, minerals and the like. Further, when a seed extract of chenopodium album which is a plant of the genus elaeagnus of the subfamily Papilionaceae is used together, it is found that the effect of improving white hair is further enhanced.
Claims (7)
1. Use of tara tannin in the manufacture of a hair colour enhancer.
2. Use of tannic acid in the manufacture of a hair colour enhancer.
3. Use of talaronin and tannic acid in the manufacture of a hair colour enhancer.
4. The use according to claim 1 or 2, wherein the hair color enhancer further comprises one or more than two hydrolyzed tannins selected from the group consisting of chestnut tannin, myrobalan tannin, oak tannin and tea tannin.
5. Use according to claim 1 or 2, characterized in that the hair pigment enhancing agent comprises at least one of the saponins.
6. The use according to claim 1 or 2, wherein the hair color enhancer comprises at least one selected from the group consisting of saccharides, amino acids, vitamins, coenzymes and minerals.
7. Use according to claim 1 or 2, wherein the hair colour enhancer comprises a plant extract of a plant of the genus Metaplexis of the family Papilionaceae.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016097220 | 2016-05-13 | ||
| JP2016-097220 | 2016-05-13 | ||
| JP2017-074040 | 2017-04-03 | ||
| JP2017074040A JP6562469B2 (en) | 2016-05-13 | 2017-04-03 | Hair pigment enhancer |
| PCT/JP2017/017756 WO2017195841A1 (en) | 2016-05-13 | 2017-05-10 | Hair pigment enhancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109069385A CN109069385A (en) | 2018-12-21 |
| CN109069385B true CN109069385B (en) | 2021-11-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780028545.5A Active CN109069385B (en) | 2016-05-13 | 2017-05-10 | Hair pigment enhancer |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6562469B2 (en) |
| CN (1) | CN109069385B (en) |
| TW (1) | TWI780048B (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300409A (en) * | 2022-09-13 | 2022-11-08 | 浙江熙正霖生物科技有限公司 | Component for preventing and improving white hair and alopecia and application thereof |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5899417A (en) * | 1981-12-08 | 1983-06-13 | Rooto Seiyaku Kk | Remedy for poliosis |
| JPS6038314A (en) * | 1983-08-10 | 1985-02-27 | Osaka Chem Lab | Hair tonic |
| CN1079142A (en) * | 1992-02-17 | 1993-12-08 | 野村学 | Hair grower |
| JPH0665031A (en) * | 1991-12-04 | 1994-03-08 | Wella Ag | Application of inactivating substance to radical catcher and/or non-radical active oxygen for preventing or suppressing of |
| JPH06192053A (en) * | 1992-12-25 | 1994-07-12 | Hoyu Co Ltd | Autoxidation-type hair dye |
| JP2005281760A (en) * | 2004-03-29 | 2005-10-13 | Kurita Water Ind Ltd | High-temperature aqueous water treatment agent composition and treatment method for the same |
| JP2007326813A (en) * | 2006-06-07 | 2007-12-20 | Kao Corp | Hair cosmetic |
| CN102697793A (en) * | 2012-06-11 | 2012-10-03 | 中国人民解放军第四军医大学 | Medicament for inhibiting oral bacterial plaque and preparation method thereof |
| CN102948426A (en) * | 2012-11-01 | 2013-03-06 | 云南华韵科技开发有限公司 | Novel food safety grade disinfection solution and preparation method thereof |
| JP2014024766A (en) * | 2012-07-25 | 2014-02-06 | Riaru Kagaku Kk | External preparation with unstable dye being stably admixed, for coloring skin and hair |
| JP2015533169A (en) * | 2012-10-12 | 2015-11-19 | ロレアル | Cosmetic composition comprising at least one flavonoid and ferulic acid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60152408A (en) * | 1984-01-18 | 1985-08-10 | Yanagiya Honten:Kk | Hair dye composition |
| JPH08337516A (en) * | 1995-06-13 | 1996-12-24 | Lion Corp | One pot-type hair dyeing composition |
| ITMI991896A1 (en) * | 1999-09-09 | 2001-03-09 | Carlo Ghisalberti | MELANINES AND VEGETABLE PIGMENTS |
| JP4133785B2 (en) * | 2003-12-16 | 2008-08-13 | ホーユー株式会社 | Semi-permanent hair dye composition |
-
2017
- 2017-04-03 JP JP2017074040A patent/JP6562469B2/en active Active
- 2017-05-10 CN CN201780028545.5A patent/CN109069385B/en active Active
- 2017-05-12 TW TW106115841A patent/TWI780048B/en active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5899417A (en) * | 1981-12-08 | 1983-06-13 | Rooto Seiyaku Kk | Remedy for poliosis |
| JPS6038314A (en) * | 1983-08-10 | 1985-02-27 | Osaka Chem Lab | Hair tonic |
| JPH0665031A (en) * | 1991-12-04 | 1994-03-08 | Wella Ag | Application of inactivating substance to radical catcher and/or non-radical active oxygen for preventing or suppressing of |
| CN1079142A (en) * | 1992-02-17 | 1993-12-08 | 野村学 | Hair grower |
| JPH06192053A (en) * | 1992-12-25 | 1994-07-12 | Hoyu Co Ltd | Autoxidation-type hair dye |
| JP2005281760A (en) * | 2004-03-29 | 2005-10-13 | Kurita Water Ind Ltd | High-temperature aqueous water treatment agent composition and treatment method for the same |
| JP2007326813A (en) * | 2006-06-07 | 2007-12-20 | Kao Corp | Hair cosmetic |
| CN102697793A (en) * | 2012-06-11 | 2012-10-03 | 中国人民解放军第四军医大学 | Medicament for inhibiting oral bacterial plaque and preparation method thereof |
| JP2014024766A (en) * | 2012-07-25 | 2014-02-06 | Riaru Kagaku Kk | External preparation with unstable dye being stably admixed, for coloring skin and hair |
| JP2015533169A (en) * | 2012-10-12 | 2015-11-19 | ロレアル | Cosmetic composition comprising at least one flavonoid and ferulic acid |
| CN102948426A (en) * | 2012-11-01 | 2013-03-06 | 云南华韵科技开发有限公司 | Novel food safety grade disinfection solution and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6562469B2 (en) | 2019-08-21 |
| CN109069385A (en) | 2018-12-21 |
| TWI780048B (en) | 2022-10-11 |
| TW201808259A (en) | 2018-03-16 |
| JP2017206497A (en) | 2017-11-24 |
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