CN109045247A - 一种铁皮石斛复方制剂及其制备方法与用途 - Google Patents

一种铁皮石斛复方制剂及其制备方法与用途 Download PDF

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CN109045247A
CN109045247A CN201811263039.7A CN201811263039A CN109045247A CN 109045247 A CN109045247 A CN 109045247A CN 201811263039 A CN201811263039 A CN 201811263039A CN 109045247 A CN109045247 A CN 109045247A
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dendrobium candidum
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杨志波
曾昭武
肖人钟
孙政祥
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Hunan Huihao Biomedical Technology Co Ltd
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Abstract

本发明属于中药制剂技术领域，具体涉及一种铁皮石斛复方制剂及其制备方法与用途。本发明铁皮石斛复方制剂，其原料按照重量份数计，包括铁皮石斛5‑30份、马齿苋20‑40份、金银花15‑25份、苦参15‑25份、白鲜皮15‑25份、牡丹皮15‑25份、薄荷15‑25份、迷迭香提取物0.5‑10份、水飞蓟提取物1‑15份、莪术油3‑15份、茶油3‑25份、薄荷脑0.5‑10份、聚六亚甲基胍盐酸盐1‑5份、苯扎溴铵1‑5份、醋酸氯己定1‑5份，卡波姆1～5份。本发明的铁皮石斛复方制剂配方合理，疗效高，见效快，抗菌、抑菌、止痒效果显著。

Description

一种铁皮石斛复方制剂及其制备方法与用途
技术领域
本发明属于中药制剂技术领域，具体涉及一种铁皮石斛复方制剂及其制备方法与用途。
背景技术
皮肤病是有关皮肤的疾病，是严重影响人民健康的常见病、多发病之一，如麻风、疥疮、真菌病、皮肤细菌感染等。引起皮肤病的原因很多，常见的外在原因有物理、化学刺激及细菌病毒侵袭，内在原因有饮食不当、代谢障碍、内分泌紊乱、遗传等。皮肤病常见的自觉症状有瘙痒、疼痛、麻木或蚁行、烧灼感。他觉症状有红斑、红疹、水疱、脓疱、抓痕、溃烂、结节、囊肿、肿瘤等。
生活中常见的皮肤病有痱子、脚癣、痤疮、丘疹、过敏性皮肤病、病毒性皮肤病等，这些虽不是重大疾病，但时刻困扰着病患者。
发明内容
为了广大皮肤病患者的需求，本发明提供一种铁皮石斛复方制剂及其制备方法与用途，目的是提供一种配方合理、疗效高、见效快、抗菌、抑菌、止痒效果显著的铁皮石斛复方制剂。
本发明铁皮石斛复方制剂，其原料按照重量份数计，包括铁皮石斛5-30份、马齿苋20-40份、金银花15-25份、苦参15-25份、白鲜皮15-25份、牡丹皮15-25份、薄荷15-25份、迷迭香提取物0.5-10份、水飞蓟提取物1-15份、莪术油3-15份、茶油3-25份、薄荷脑0.5-10份、聚六亚甲基胍盐酸盐1-5份、苯扎溴铵1-5份、醋酸氯己定1-5份，卡波姆1～5份。
其中，所述的原料中，铁皮石斛、马齿苋、金银花、苦参、白鲜皮、牡丹皮、薄荷的重量比为3-8:15-40:5-15:5-15：5-15:5-15:5-15。
上述原料按照重量份计：铁皮石斛6份、马齿苋36份、金银花12份、苦参12份、白鲜皮12份、牡丹皮12份、薄荷12份。
本发明的铁皮石斛复方制剂的制备方法，包括如下步骤：
(1)按重量分计，铁皮石斛5-30份、马齿苋20-40份、金银花15-25份、苦参15-25份、白鲜皮15-25份、牡丹皮15-25份、薄荷15-25份粉碎，加10％-70％乙醇煎煮1-3h，过滤，得到煎煮液，浓缩干燥后粉碎得到提取物粉末；
(2)取卡波姆1-5份，加水溶胀3h，加入步骤(1)所得提取物粉末、迷迭香提取物0.5-10份、水飞蓟提取物1-15份、莪术油3-15份、茶油3-25份、薄荷脑0.5-10份、聚六亚甲基胍盐酸盐1-5份、苯扎溴铵1-5份、醋酸氯己定1-5份，高速搅拌后，加入三乙醇胺，高速搅拌后即得铁皮石斛复方制剂。
一种铁皮石斛复方制剂用于制备与治疗皮肤疾病有关的药物。
与现有技术相比，本发明的特点和有益效果是：
本发明的铁皮石斛复方制剂以中药为主要原料，经科学合理配比采用多组配比，祛风止痒、养血润肤、清热解毒的功效，治疗效果明显且所用时间较短。本发明中铁皮石斛、马齿苋、金银花、苦参、白鲜皮、牡丹皮、薄荷具有抑菌、消炎、止痒的功能，让治疗作用进一步增强，从而达到彻底治愈的目的。
具体实施方式
下面结合实施例对本发明进一步说明。
实施例1
本实施例铁皮石斛复方制剂，其原料按照重量份数计，包括铁皮石斛6份、马齿苋36份、金银花12份、苦参12份、白鲜皮12份、牡丹皮12份、薄荷12份，迷迭香提取物5份、水飞蓟提取物15份、莪术油3份、茶油25份、薄荷脑10份、聚六亚甲基胍盐酸盐1份、苯扎溴铵2份、醋酸氯己定3份，卡波姆1～5份。
本实施例的铁皮石斛复方制剂的制备方法，包括如下步骤：
(1)按重量分计，铁皮石斛6份、马齿苋36份、金银花12份、苦参12份、白鲜皮12份、牡丹皮12份、薄荷12份粉碎，加10％-70％乙醇煎煮1-3h，过滤，得到煎煮液，浓缩干燥后粉碎得到提取物粉末。
(2)取卡波姆1-5份，加水溶胀3h，加入步骤(1)所得提取物粉末、迷迭香提取物5份、水飞蓟提取物15份、莪术油3份、茶油25份、薄荷脑10份、聚六亚甲基胍盐酸盐1份、苯扎溴铵2份、醋酸氯己定3份，高速搅拌后，加入三乙醇胺，高速搅拌后即得铁皮石斛复方制剂。
本实施例的临床实验及结果：
实验一：
采用实例1进行临床观察100例，观察前皮肤临床主要表现为皮肤蚊虫叮咬、皮肤瘙痒、湿疹、痤疮、炎症性皮炎、脂溢性皮炎的不适。
1.方法：用在肌肤上和易发部位涂抹实施例1制备的铁皮石斛复方制剂适量，早中晚各一次或感觉瘙痒时涂抹。
2.疗效标准：治疗前、治疗1周后，观察患者的自觉症状(痰痒)和客观症状(包括红斑、丘疹、糜烂、渗液、苔鲜化、抓痕血痴、干燥脱屑等)、全身情况(食欲、睡眠)进行客观评分，按4级评分法进行评分，无：0分；轻度：l分；中度：2分；重度：3分。具体计算方法：疗效指数＝(治疗前总积分-治疗后总积分)/治疗前总积分×100％。痊愈：疗效指数≥95％；显效：疗效指数70％-94％；好转：疗效指数50％-69％；无效：疗效指数＜50％。痊愈与显效合计为治愈率，痊愈、显效和好转合计为有效率。
类型 例数 痊愈 显效 好转 无效 治愈率％ 有效率％
Ⅱ级痤疮 50 44 2 2 2 92.0 96.0
Ⅲ级痤疮 50 43 3 1 3 92.0 94.0
Ⅳ级痤疮 30 27 1 1 1 93.3 96.7
湿疹 80 68 8 4 0 95.0 100
蚊虫叮咬 80 78 2 0 0 100 100
皮肤瘙痒 100 82 9 9 0 91.0 100
炎症性皮炎 50 43 4 1 2 94.0 96.0
脂溢性皮炎 40 34 3 1 2 92.5 95.0
实施例2
本实施例的铁皮石斛复方制剂，其原料按照重量份数计，包括铁皮石斛8份、马齿苋30份、金银花10份、苦参15份、白鲜皮5份、牡丹皮5份、薄荷15份、迷迭香提取物0.5份、水飞蓟提取物1份、莪术油10份、茶油25份、薄荷脑0.5份、聚六亚甲基胍盐酸盐5份、苯扎溴铵1份、醋酸氯己定1份，卡波姆1～5份。
本实施例的铁皮石斛复方制剂的制备方法，包括如下步骤：
(1)按重量分计，铁皮石斛8份、马齿苋30份、金银花10份、苦参15份、白鲜皮5份、牡丹皮5份、薄荷15份粉碎，加10％-70％乙醇煎煮1-3h，过滤，得到煎煮液，浓缩干燥后粉碎得到提取物粉末；
(2)取卡波姆1-5份，加水溶胀3h，加入步骤(1)所得提取物粉末迷迭香提取物0.5份、水飞蓟提取物1份、莪术油10份、茶油25份、薄荷脑0.5份、聚六亚甲基胍盐酸盐5份、苯扎溴铵1份、醋酸氯己定1份，高速搅拌后，加入三乙醇胺，高速搅拌后即得铁皮石斛复方制剂。
本实施例的铁皮石斛复方制剂经临床验证具有优异疗效。
实施例3
本实施例的铁皮石斛复方制剂，其原料按照重量份数计，包括铁皮石斛3份、马齿苋15份、金银花5份、苦参5份、白鲜皮15份、牡丹皮15份、薄荷5份、迷迭香提取物8份、水飞蓟提取物15份、莪术油3份、茶油3份、薄荷脑10份、聚六亚甲基胍盐酸盐5份、苯扎溴铵5份、醋酸氯己定5份，卡波姆1～5份。
本实施例的铁皮石斛复方制剂的制备方法，包括如下步骤：
(1)按重量分计，铁皮石斛3份、马齿苋15份、金银花5份、苦参5份、白鲜皮15份、牡丹皮15份、薄荷5份粉碎，加10％-70％乙醇煎煮1-3h，过滤，得到煎煮液，浓缩干燥后粉碎得到提取物粉末。
(2)取卡波姆1-5份，加水溶胀3h，加入步骤(1)所得提取物粉末迷迭香提取物8份、水飞蓟提取物15份、莪术油3份、茶油3份、薄荷脑10份、聚六亚甲基胍盐酸盐5份、苯扎溴铵5份、醋酸氯己定5份，高速搅拌后，加入三乙醇胺，高速搅拌后即得铁皮石斛复方制剂。
本实施例的铁皮石斛复方制剂经临床验证具有优异疗效。

Claims (5)

1.一种铁皮石斛复方制剂，其特征在于原料按照重量份数计，包括铁皮石斛5-30份、马齿苋20-40份、金银花15-25份、苦参15-25份、白鲜皮15-25份、牡丹皮15-25份、薄荷15-25份、迷迭香提取物0.5-10份、水飞蓟提取物1-15份、莪术油3-15份、茶油3-25份、薄荷脑0.5-10份、聚六亚甲基胍盐酸盐1-5份、苯扎溴铵1-5份、醋酸氯己定1-5份，卡波姆1～5份。
2.根据权利要求1所述的一种铁皮石斛复方制剂，其特征在于所述的原料中，铁皮石斛、马齿苋、金银花、苦参、白鲜皮、牡丹皮、薄荷的重量比为3-8:15-40:5-15:5-15：5-15:5-15:5-15。
3.根据权利要求2所述的一种铁皮石斛复方制剂，其特征在于原料按照重量份计：铁皮石斛6份、马齿苋36份、金银花12份、苦参12份、白鲜皮12份、牡丹皮12份、薄荷12份。
4.如权利要求1所述的铁皮石斛复方制剂的制备方法，其特征在于包括如下步骤：
(1)按重量份计，铁皮石斛5-30份、马齿苋20-40份、金银花15-25份、苦参15-25份、白鲜皮15-25份、牡丹皮15-25份、薄荷15-25份粉碎，加10％-70％乙醇煎煮1-3h，过滤，得到煎煮液，浓缩干燥后粉碎得到提取物粉末；
(2)取卡波姆1-5份，加水溶胀3h，加入步骤(1)所得提取物粉末、迷迭香提取物0.5-10份、水飞蓟提取物1-15份、莪术油3-15份、茶油3-25份、薄荷脑0.5-10份、聚六亚甲基胍盐酸盐1-5份、苯扎溴铵1-5份、醋酸氯己定1-5份，高速搅拌后，加入三乙醇胺，高速搅拌后即得铁皮石斛复方制剂。
5.一种如权利要求1所述的铁皮石斛复方制剂用于制备与治疗皮肤疾病有关的药物。
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