CN109044576B - Aortic blood pressure controlled drug delivery stent and blood pressure controlled drug delivery system - Google Patents
Aortic blood pressure controlled drug delivery stent and blood pressure controlled drug delivery system Download PDFInfo
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- CN109044576B CN109044576B CN201810977492.8A CN201810977492A CN109044576B CN 109044576 B CN109044576 B CN 109044576B CN 201810977492 A CN201810977492 A CN 201810977492A CN 109044576 B CN109044576 B CN 109044576B
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- blood pressure
- stent
- drug delivery
- aortic blood
- pressure controlled
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Abstract
The invention provides an aortic blood pressure control drug-loaded stent and a blood pressure control drug release system, belonging to the technical field of intracavity angiography. The aortic blood pressure controlled drug-delivery stent comprises a stent main body, a lining tectorial membrane, a conductive drug-delivery tectorial membrane, a piezoresistor and a power supply; the inner lining coating film is coated on the inner surface of the bracket main body, and the conductive medicine carrying coating film is coated on the outer surface of the bracket main body; when the pressure borne by the piezoresistor is larger than a threshold value, the resistance value is reduced, micro-current exists in the circuit, and the conductive medicine carrying film can promote medicine release and micro-current conduction to the body surface. The aortic blood pressure control drug-delivery stent system can perform noninvasive monitoring on the aortic blood pressure of a patient, evaluate the treatment effect of aortic dissection and perform risk early warning, and can perform preventive accurate drug treatment of local focus.
Description
Technical Field
The invention relates to the technical field of aortic blood pressure monitoring, in particular to an aortic blood pressure controlled drug delivery stent and a blood pressure controlled drug delivery system.
Background
Aortic dissection refers to aortic disease in which arterial blood enters the aortic wall through a breach in the intima of the aorta, causing the media in the aorta to delaminate from the adventitia of the aorta, resulting in a false lumen. At present, aortic dissection treatment can be performed by remodelling the aorta through an aortic stent, and simultaneously blocking or partially blocking the blood flow of a false cavity, thereby playing a role in treating aortic dissection.
However, the occurrence of adverse events may seriously affect the therapeutic effect and prognosis in the aortic dissection cavity, such as incomplete breach closure due to mismatching of the graft and the vessel wall, and incomplete thrombosis (even no thrombosis) of the prosthetic cavity may occur due to abnormal systemic or local blood system or blood flow impact with special dynamic characteristics (such as blood pressure fluctuation): 1) True lumen blood flow cannot be restored, false lumen progressive tumor-like dilation; 2) The false cavity is supplied with blood from the far-end breaking crack, and a retrograde tearing interlayer is newly generated; 3) Special forms of false cavity thrombosis can lead to the variation of mechanical strength of the tube wall, local fragile areas and the like.
Because the aortic blood pressure of a patient cannot be monitored noninvasively, prognosis and complication risk of aortic dissection intracavity isolation are difficult to evaluate; meanwhile, a preventive and accurate treatment means for locally fragile vessel walls during hypertension of patients is lacking.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides the aortic blood pressure control drug delivery stent and the blood pressure control drug delivery system, which can perform noninvasive monitoring on the aortic blood pressure of a patient, evaluate the treatment effect of aortic dissection and perform risk early warning, and simultaneously provide a preventive and accurate treatment means when local focus is at high risk.
In a first aspect, an embodiment of the present invention provides an aortic blood pressure controlled drug delivery stent, including a stent main body, a conductive drug delivery coating, a piezoresistor and a power supply; the lining coating film is coated on the inner surface of the bracket main body, and the conductive medicine carrying coating film is coated on the outer surface of the bracket main body;
the power supply, the piezoresistor and the bracket main body form a loop, when the pressure borne by the piezoresistor is larger than a threshold value, the resistance value is reduced, micro-current exists in the loop, and the conductive medicine carrying film can promote medicine release and micro-current conduction to the body surface.
With reference to the first aspect, an embodiment of the present invention provides a first possible implementation manner of the first aspect, where the support main body is provided with a support wire, and the piezoresistor and the power supply are embedded on the support main body and connected through the support main body to form a loop.
With reference to the first possible implementation manner of the first aspect, the present embodiment provides a second possible implementation manner of the first aspect, wherein the support stent wire is disposed along a length direction of the stent body and around a circumferential direction of the stent body.
With reference to the first possible implementation manner of the first aspect, the embodiment of the present invention provides a third possible implementation manner of the first aspect, where the support bracket wire, the piezoresistor and the power supply are connected to form a plurality of loops, and at least one piezoresistor is connected to each loop.
With reference to the first aspect, an embodiment of the present invention provides a fourth possible implementation manner of the first aspect, where the conductive drug-carrying film includes a drug release layer, a nanosphere storage layer, and a conductive film layer that are sequentially arranged; drug release micropores are formed on the drug release layer; the nanosphere storage layer contains medicine-carrying nanospheres.
With reference to the fourth possible implementation manner of the first aspect, the embodiment of the present invention provides a fifth possible implementation manner of the first aspect, where the conductive film layer includes a thin film layer and a metal sheet inlaid on the thin film layer, and the metal sheet is connected to the varistor.
With reference to the fourth possible implementation manner of the first aspect, the present embodiment provides a sixth possible implementation manner of the first aspect, wherein the diameter of the drug-loaded nanospheres is 101nm-999nm, and the diameter of drug release micropores is less than 100nm.
With reference to the sixth possible implementation manner of the first aspect, the present embodiment provides a seventh possible implementation manner of the first aspect, wherein the drug-loaded nanospheres load one of the following drugs: antihypertensives, procoagulants, glucocorticoids, non-steroidal anti-inflammatory drugs, vasoactive drugs, and pro-endothelial repair drugs.
With reference to the first aspect, an embodiment of the present invention provides an eighth possible implementation manner of the first aspect, wherein the inner liner covering film and the conductive drug-carrying covering film are made of expanded polytetrafluoroethylene materials.
In a second aspect, an embodiment of the present invention further provides a blood pressure control drug release system, including a monitoring device and the aortic blood pressure control drug delivery stent according to any one of the first aspect; the aortic blood pressure control drug delivery stent is used for being placed in a blood vessel, and the monitoring equipment is used for being connected to the body surface.
The embodiment of the invention has the following beneficial effects:
the aortic blood pressure control drug-delivery stent and the aortic blood pressure monitoring system provided by the embodiment of the invention comprise a stent main body, an inner lining coating, a conductive drug-delivery coating, a piezoresistor and a power supply; the inner lining coating film is coated on the inner surface of the bracket main body, and the conductive medicine carrying coating film is coated on the outer surface of the bracket main body; the power supply, the piezoresistor and the bracket main body are connected to form a loop, when the pressure borne by the piezoresistor is greater than a threshold value, the resistance value is reduced, micro-current exists in the loop, and the conductive medicine carrying coating film conducts the micro-current to the body surface, so that the monitoring equipment connected to the body surface can detect the change of the aortic blood pressure; the micro-current can break down the drug-carrying nanospheres in the conductive drug-carrying film at the same time, so that the aortic blood pressure can control the release of the loaded drugs. The aortic blood pressure control drug-delivery stent can perform noninvasive monitoring on the aortic blood pressure of a patient, evaluate the treatment effect of aortic dissection and perform risk early warning, and simultaneously provides a preventive accurate treatment means when local focus is at high risk.
Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The objectives and other advantages of the invention will be realized and attained by the structure particularly pointed out in the written description and claims hereof as well as the appended drawings.
In order to make the above objects, features and advantages of the present invention more comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural diagram of an aortic blood pressure controlled drug delivery stent according to an embodiment of the present invention;
FIG. 2 is a schematic circuit diagram of an aortic blood pressure controlled drug delivery stent according to an embodiment of the present invention;
FIG. 3 is a schematic view of the inner surface structure of a conductive drug-loaded film according to an embodiment of the present invention;
FIG. 4 is a schematic view of the structure of the outer surface of a conductive drug-loaded film according to an embodiment of the present invention;
fig. 5 is a schematic structural view of a bracket body according to an embodiment of the present invention;
fig. 6 is a schematic longitudinal section structure of a conductive drug-loading film according to an embodiment of the present invention.
Icon: 10-a stent body; 11-a power supply; 12-piezoresistor; 13-supporting a stent wire; 20-a conductive drug-carrying coating; 21-sheet metal; 30-lining coating; 210-a drug release layer; 220-drug release microwells; 230-drug-loaded nanospheres; 240-nanosphere storage layer; 250-conductive coating layer.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. The components of the embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Aiming at the problems that the aortic blood pressure of a patient cannot be monitored in a noninvasive way at present and a preventive accurate treatment means for local fragile vessel walls during hypertension of the patient is lacking, the embodiment of the invention provides the aortic blood pressure controlled drug delivery stent and the blood pressure controlled drug delivery system, which can monitor the aortic blood pressure of the patient in a noninvasive way, evaluate the treatment effect of aortic dissection and perform risk early warning, and simultaneously provide the preventive accurate treatment means during high risk of local focus. The aortic blood pressure controlled drug delivery stent of the present invention will be described in detail first.
Example 1
The present embodiment provides an aortic blood pressure controlled drug delivery stent, as shown in fig. 1 to 6, which comprises a stent body 10, a conductive drug delivery coating 20, a piezoresistor 12 and a power supply 11. The conductive medicine-carrying film 20 is coated on the outer surface of the bracket main body 10. The piezoresistor 12 is connected with the power supply 11 to form a loop, when the pressure born by the piezoresistor 12 is larger than a threshold value, the resistance value is reduced, micro-current exists in the loop, and the conductive medicine carrying coating film 20 conducts the micro-current in the loop to the body surface. The maximum micro-current in the loop is less than 10mA.
As shown in fig. 5, the stent body 10 may be made of a nickel-titanium alloy wire, and the nickel-titanium alloy wire has a shape memory property and can automatically restore its plastic deformation to its original shape at a specific temperature. The expansion rate is above 20%, the fatigue life is up to 107 times, the damping characteristic is 10 times higher than that of a common spring, the wear resistance and corrosion resistance of the spring are superior to those of the medical stainless steel which is the best at present, and the spring is a high-quality functional material. The stent body 10 is in a continuous spiral sine wave configuration, and can also be in a grid shape, a woven mesh, a Z-shaped wave or other mesh shapes. The nickel-titanium alloy processing technology can be realized by adopting metal wires to weave, heat and shape, and then welding, binding and sleeving or laser cutting metal pipes to shape.
The support body 10 is provided with a support wire 13, the piezoresistor 12 and the power supply 11 are embedded on the support body, and the piezoresistor and the power supply 11 are connected through the support wire 13 to form a loop. A part of the support wire 13 is disposed along the length direction of the stent body, and the other part of the support wire 13 is disposed around the circumferential direction of the stent body 10 in a ring shape, which may be called a stent ring.
As shown in fig. 2, the support bracket wire 13 is connected with the power supply 11 to form a plurality of loops, and at least one piezoresistor 12 is connected to each loop, so that the circuits cannot be shorted. It can also be said that the varistor 12 is arranged at least one between every two carrier rings. The varistor 12 is a resistor of a pressure sensitive material embedded in the body of the support, which is small when the blood pressure is higher than a threshold value, which may be set to any value in the range of 50-200 mmHg.
As shown in fig. 3, 4 and 6, the conductive drug-loaded coating 20 includes a drug release layer 210, a nanosphere storage layer 240 and a conductive coating layer 250, which are sequentially arranged. Drug release layer 210 has drug release micropores 220 formed thereon, and the diameter of drug release micropores 220 is less than 100nm. The nanosphere storage layer 240 contains drug-loaded nanospheres 230. The diameter of the drug-loaded nanospheres 230 is between 101nm and 999 nm. Drug-loaded nanospheres 230 carry one of the following drugs: antihypertensives, procoagulants, glucocorticoids, non-steroidal anti-inflammatory drugs, vasoactive drugs, and pro-endothelial repair drugs. The principle of drug-loaded nanospheres 230 releasing drugs is that human body safety micro-currents are formed in the circuit to break down the drug-loaded nanospheres so that the drugs can smoothly pass through drug-releasing micropores 220. The conductive coating layer 250 comprises a film layer and a metal sheet 21 embedded on the film layer, and the metal sheet 21 is connected with the piezoresistor 12 to conduct micro-current in the loop to the body surface. Specifically, the varistor 12 has a certain thickness, the metal sheets 21 are tightly attached to the varistor 12, the film layer is made of expanded polytetrafluoroethylene (expanded Poly tetra fluoroethylene, ePTFE) which is an ideal insulating material and has good biocompatibility, and the metal sheets are not conducted, so that the aortic blood pressure controlled release drug delivery stent can be prevented from forming a short circuit in vivo.
The power supply 11 can adopt a miniature lithium-iodine battery, and can generate and output electric pulses, and the maximum voltage is less than 36V.
The aortic blood pressure controlled drug delivery stent also comprises a liner coating 30. The lining film 30 is attached to the inner surface of the stent body 10, preventing the circuit from contacting the blood. The inner liner membrane 30 is also made of expanded polytetrafluoroethylene material.
The varistor 12 and the power supply 11 are both disposed between the lining film 30 and the conductive drug-carrying film 20. The circuit formed by the power supply, the piezoresistor and the bracket main body can not be short-circuited.
The aortic blood pressure controlled drug-loaded stent provided by the embodiment of the invention has the advantages that the stent main body is placed in a blood vessel and acts on the interlayer breach, so that the interlayer breach can be plugged, the blood vessel intima can be supported, and the blood flow of a true cavity can be restored, thereby achieving the purpose of operation. The power supply and the piezoresistor are arranged in the bracket main body, and when the pressure born by the piezoresistor is smaller than a threshold value under the premise of not affecting the mechanical property of the bracket main body, the loop current is basically 0. When the pressure of the piezoresistor is larger than a threshold (for example, 140mmHg, a hypertension threshold and the risk of aortic dissection, the resistance value of the piezoresistor is greatly reduced, so that micro-current exists in a loop. Through the metal sheet on the conductive medicine carrying film, micro-current can break down the medicine carrying nanospheres, so that various optional medicines can reach focus through medicine release micropores, and a preventive and accurate treatment effect is achieved when the local focus is at high risk; meanwhile, different potentials detected at different body surface positions can be reflected, the monitoring equipment is connected to the body surface, the change of potential signals of the body surface can be detected, and the intra-aortic blood pressure can be obtained according to the change of the potential signals, so that the intra-aortic blood pressure of a patient during or after an operation can be monitored simply and accurately, and a valuable risk assessment index is provided for the field of intracavity angiography.
Furthermore, before the power supply fails and the medicine is exhausted, the aortic blood pressure controlled drug delivery stent can release the medicine to a local focus according to the aortic blood pressure and accurately reflect the specific numerical value of the aortic blood pressure, so that the preventive and accurate treatment and the evaluation of the aortic dissection recurrence or rupture risk are realized, and particularly, the preventive and accurate treatment and the monitoring of the aortic blood pressure of a lesion part have great clinical values in a high risk period of 3 months after a perioperative period and an operation. After the power supply is disabled and the medicine is exhausted, the aortic blood pressure controlled drug delivery stent can still play the role of an aortic tectorial membrane stent.
The aortic blood pressure measured by the aortic blood pressure controlled drug delivery stent provided by the embodiment of the invention can be used for guiding a patient to control the blood pressure for drug taking in a preventive and accurate way, and the drug taking experience of a doctor is not relied on alone; not only can control the peak value of blood pressure, but also can control the fluctuation of blood pressure. Meanwhile, when the aortic blood pressure is higher than a high-risk threshold value, preventive and accurate drug treatment can be performed on local lesions.
In summary, the aortic blood pressure control drug-delivery stent provided by the embodiment of the invention comprises a stent main body, an inner lining coating, a conductive drug-delivery coating, a piezoresistor and a power supply; the inner lining coating film is coated on the inner surface of the bracket main body, and the conductive medicine carrying coating film is coated on the outer surface of the bracket main body; the power supply, the piezoresistor and the bracket main body are connected to form a loop, when the pressure borne by the piezoresistor is greater than a threshold value, the resistance value is reduced, micro-current exists in the loop, and the conductive medicine carrying coating film conducts the micro-current to the body surface, so that the monitoring equipment connected to the body surface can monitor the change of the aortic blood pressure; meanwhile, the micro-current breaks down the drug-carrying nanospheres, so that the drug can smoothly act on the focus through the drug release micropores. The aortic blood pressure control drug delivery stent and the blood pressure control drug delivery system can perform noninvasive monitoring on the aortic blood pressure of a patient, evaluate the treatment effect of aortic dissection and perform risk early warning, and simultaneously provide a preventive accurate treatment means when local focus is at high risk.
Example two
The embodiment of the invention also provides an aortic blood pressure monitoring system which comprises monitoring equipment and an aortic blood pressure control drug delivery support. The aortic blood pressure controlled drug delivery stent provided in the first embodiment can be placed in a blood vessel. The monitoring equipment is used for being connected to the body surface and detecting potential signals of the body surface.
In particular, the monitoring device may comprise a plurality of contact electrodes for connection to the body surface, a host computer connected to the contact electrodes by lead wires or wirelessly, for detecting the body surface potential, similar to an electrocardiograph.
When the pressure born by the piezoresistor in the aortic blood pressure controlled drug delivery stent is greater than a threshold value, the resistance value of the piezoresistor is greatly reduced, so that micro-current exists in a loop. Through the metal sheet on the conductive medicine carrying film, the micro-current can show different potentials detected at different body surface positions. The contact electrode of the monitoring equipment is connected to the body surface, the monitoring equipment can detect the change of the potential signal of the body surface, and the intra-aortic blood pressure can be obtained according to the change of the potential signal.
The aortic blood pressure controlled drug delivery stent and the blood pressure controlled drug delivery system provided by the embodiment of the invention have the same technical characteristics, so that the same technical problems can be solved, and the same technical effects can be achieved.
It should be noted that, in the description of the embodiments of the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
In the description of the present invention, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Finally, it should be noted that: the above examples are only specific embodiments of the present invention, and are not intended to limit the scope of the present invention, but it should be understood by those skilled in the art that the present invention is not limited thereto, and that the present invention is described in detail with reference to the foregoing examples: any person skilled in the art may modify or easily conceive of the technical solution described in the foregoing embodiments, or perform equivalent substitution of some of the technical features, while remaining within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention, and are intended to be included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (8)
1. The aortic blood pressure controlled drug-delivery stent is characterized by comprising a stent main body, an inner lining coating, a conductive drug-delivery coating, a piezoresistor and a power supply; the inner lining coating film is coated on the inner surface of the bracket main body, and the conductive medicine carrying coating film is coated on the outer surface of the bracket main body;
the power supply, the piezoresistor and the bracket main body form a loop, when the pressure born by the piezoresistor is larger than a threshold value, the resistance value is reduced, micro-current exists in the loop, and the conductive medicine carrying film can promote medicine release and the micro-current conduction to the body surface;
the support main body is provided with a support wire, the piezoresistor and the power supply are embedded on the support main body, and the piezoresistor and the power supply are connected through the support wire to form a loop;
the conductive medicine carrying coating comprises a medicine release layer, a nanosphere storage layer and a conductive coating layer which are sequentially arranged; drug release micropores are formed on the drug release layer; the nanosphere storage layer contains medicine-carrying nanospheres.
2. The aortic blood pressure controlled drug delivery stent of claim 1, wherein the support stent wire is disposed along a length direction of the stent body and around a circumferential direction of the stent body.
3. The aortic blood pressure controlled drug delivery stent of claim 1, wherein the support stent wire, the piezoresistor and the power supply are connected to form a plurality of loops, and at least one piezoresistor is connected to each loop.
4. The aortic blood pressure controlled drug delivery stent of claim 1, wherein the conductive coating comprises a thin film layer and a metal sheet embedded on the thin film layer, the metal sheet being connected with the piezoresistor.
5. The aortic blood pressure controlled drug delivery stent of claim 1, wherein the diameter of the drug delivery nanospheres is between 101nm and 999nm, and the diameter of the drug delivery micropores is less than 100nm.
6. The aortic blood pressure controlled release drug delivery stent of claim 5, wherein the drug delivery nanospheres are loaded with one of the following drugs: antihypertensives, procoagulants, glucocorticoids, non-steroidal anti-inflammatory drugs, vasoactive drugs, and pro-endothelial repair drugs.
7. The aortic blood pressure controlled drug delivery stent of claim 1 wherein the inner liner cover and the conductive drug delivery cover are made of expanded polytetrafluoroethylene material.
8. A blood pressure controlled drug delivery system comprising a monitoring device and an aortic blood pressure controlled drug delivery stent as defined in any one of claims 1 to 7; the aortic blood pressure controlled drug delivery stent is used for being placed in a body, and the monitoring equipment is used for being connected to the body surface.
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| CN110353867A (en) * | 2019-08-06 | 2019-10-22 | 谢恩泽华 | A kind of intelligence initiative pulse support blood vessel and its control method |
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| CN109044576A (en) | 2018-12-21 |
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