CN109044576A - Aortic blood pressure controlled release carried stent and controlling of blood pressure drug delivery system - Google Patents
Aortic blood pressure controlled release carried stent and controlling of blood pressure drug delivery system Download PDFInfo
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- CN109044576A CN109044576A CN201810977492.8A CN201810977492A CN109044576A CN 109044576 A CN109044576 A CN 109044576A CN 201810977492 A CN201810977492 A CN 201810977492A CN 109044576 A CN109044576 A CN 109044576A
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- China
- Prior art keywords
- blood pressure
- controlled release
- aortic blood
- overlay film
- rack body
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Abstract
The present invention provides a kind of aortic blood pressure controlled release carried stent and controlling of blood pressure drug delivery systems, belong to endoluminal vascular technical field.Wherein, aortic blood pressure controlled release carried stent includes rack body, liner overlay film, conductive load medicine overlay film, varistor and power supply；Liner overlay film is coated on the inner surface of rack body, and conduction carries medicine overlay film and is coated on the outer surface of rack body；Power supply, varistor, rack body connection forming circuit, when the pressure suffered by the varistor is greater than threshold value, resistance value reduces, and there are micro-current in circuit, conduction, which carries medicine overlay film, will promote drug release and micro-current is promoted to be transmitted to body surface.The aortic blood pressure controlled release carried stent system can carry out non-invasive monitoring to the aortic blood pressure of patient, be assessed the therapeutic effect of dissection of aorta and carried out Risk-warning, while can carry out the preventative accuracy drug therapy of local lesion.
Description
Technical field
The present invention relates to aortic blood pressure monitoring technology fields, carry medicine in particular to a kind of aortic blood pressure controlled release
Bracket and controlling of blood pressure drug delivery system.
Background technique
Dissection of aorta refers to that arterial blood enters aorta wall by the cut on aortic tunica intima, makes aortic tunica media
It is removed with aortic tunica adventitia, causes the arotic disease of false chamber.Currently, the treatment of dissection of aorta can pass through aortic stents
Aorta, while blocking or part blocks vacation chamber blood flow are remolded, to play the role for the treatment of dissection of aorta.
But the generation of adverse events may seriously affect dissection of aorta intracavitary therapeutic effect and prognosis, such as exist and move
Plant and tube wall mismatch and lead to breach closing not exclusively, in whole body or local blood system exception or have special dynamics
Under the blood flow impact of feature (such as fluctuation of blood pressure), then will lead to false chamber cannot thrombosis (or even without thrombus), and then possibility completely
Occur: 1) true chamber blood flow cannot restore, false chamber progressive Ectasia；2) by distal end breach blood supply, new hair drives in the wrong direction to be torn false chamber
Fragility interlayer；3) the false chamber thrombosis of specific form can lead to the mechanical strength differentiation of tube wall, local vulnerable areas etc. occurs.
Since non-invasive monitoring can not be carried out to patient sustainer blood pressure, it is difficult to dissection of aorta endovascular graft
Prognosis and complication risk are assessed；Meanwhile lacking the preventative accurate of the fragile vascular wall in the part in patient's hypertension
Property treatment means.
Summary of the invention
For above-mentioned problems of the prior art, the present invention provides a kind of aortic blood pressure controlled release carried stent and
Controlling of blood pressure drug delivery system can carry out non-invasive monitoring to the aortic blood pressure of patient, imitate to the treatment of dissection of aorta
Fruit is assessed and carries out Risk-warning, at the same provide a kind of local lesion it is high-risk when preventative accuracy treatment means.
In a first aspect, the embodiment of the invention provides a kind of aortic blood pressure controlled release carried stent, including rack body, lead
Electricity carries medicine overlay film, varistor and power supply；The liner overlay film is coated on the inner surface of the rack body, and conduction carries medicine and covers
Film is coated on the outer surface of the rack body；
The power supply, the varistor and the rack body form circuit, the pressure suffered by the varistor
When greater than threshold value, resistance value reduces, and there are micro-current in the circuit, the conductive medicine overlay film that carries will promote drug release and rush
Body surface is transmitted into the micro-current.
With reference to first aspect, the embodiment of the invention provides the first possible embodiments of first aspect, wherein institute
It states and is provided with supporting support silk on rack body, the varistor and the power supply are embedded on the rack body, are passed through
Rack body connection forming circuit.
The possible embodiment of with reference to first aspect the first, the embodiment of the invention provides second of first aspect
Possible embodiment, wherein the supporting support silk is along the length direction of the rack body and around the rack body
Circumferencial direction setting.
The possible embodiment of with reference to first aspect the first, the embodiment of the invention provides the third of first aspect
Possible embodiment, wherein the supporting support silk, varistor connect to form multiple circuits with the power supply, each to return
A varistor has been at least connected in road.
With reference to first aspect, the embodiment of the invention provides the 4th kind of possible embodiments of first aspect, wherein institute
Stating the conductive medicine overlay film that carries includes the drug release layer being arranged successively, nanosphere storage layer and conductive coating layer；The drug release
Drug release micropore is formed on layer；It include medicine-carried nanospheres in the nanosphere storage layer.
The 4th kind of possible embodiment with reference to first aspect, the embodiment of the invention provides the 5th kind of first aspect
Possible embodiment, wherein the sheet metal that the conduction coating layer includes film layer and is embedded in the film layer, it is described
Sheet metal is connect with the varistor.
The 4th kind of possible embodiment with reference to first aspect, the embodiment of the invention provides the 6th kind of first aspect
Possible embodiment, the medicament-carried nano bulb diameter are less than 100nm in 101nm-999nm, drug release micro-pore diameter.
The 6th kind of possible embodiment with reference to first aspect, the embodiment of the invention provides the 7th kind of first aspect
Possible embodiment, wherein the medicine-carried nanospheres load one of following drug: depressor, promote solidifying medicine, glucocorticoid,
Non-steroidal anti-inflammatory drugs, promotees endothelium repair medicine at vasoactive agent.
With reference to first aspect, the embodiment of the invention provides the 8th kind of possible embodiments of first aspect, wherein institute
It states liner overlay film and the conductive medicine overlay film that carries is made of expanded PTFE material.
Second aspect, the embodiment of the invention also provides a kind of controlling of blood pressure drug delivery system, including monitoring device and
Aortic blood pressure controlled release carried stent described in any one of above-mentioned first aspect；The aortic blood pressure controlled release carried stent is used
In placing in the blood vessels, the monitoring device is for being connected to body surface.
The embodiment of the present invention bring it is following the utility model has the advantages that
Aortic blood pressure controlled release carried stent provided in an embodiment of the present invention and aortic blood pressure monitoring system, wherein main
Arterial pressure controlled release carried stent includes rack body, liner overlay film, conductive load medicine overlay film, varistor and power supply；Interior lining
Film is coated on the inner surface of the rack body, and conduction carries medicine overlay film and is coated on the outer surface of rack body；It is power supply, pressure-sensitive
Resistance, rack body connection forming circuit, when the pressure suffered by the varistor is greater than threshold value, resistance value reduces, and exists in circuit
Micro-current, conduction carry medicine overlay film and micro-current are transmitted to body surface, and the monitoring device for being connected to body surface is made to can detecte aortic blood
The variation of pressure；Meeting disruptive conduction carries the medicine-carried nanospheres in medicine overlay film to micro-current simultaneously, accomplishes that aortic blood pressure control is loaded
The release of drug.The aortic blood pressure controlled release carried stent can carry out non-invasive monitoring to the aortic blood pressure of patient, to actively
The therapeutic effect of arteries and veins interlayer is assessed and carries out Risk-warning, at the same provide a kind of local lesion it is high-risk when preventative essence
Parasexuality treatment means.
Other features and advantages of the present invention will illustrate in the following description, also, partly become from specification
It obtains it is clear that understand through the implementation of the invention.The objectives and other advantages of the invention are in specification, claims
And specifically noted structure is achieved and obtained in attached drawing.
To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment is cited below particularly, and cooperate
Appended attached drawing, is described in detail below.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is a kind of structural schematic diagram of aortic blood pressure controlled release carried stent provided by one embodiment of the invention；
Fig. 2 is the circuit theory figure of aortic blood pressure controlled release carried stent provided by one embodiment of the invention；
Fig. 3 is the inner surface structure schematic diagram that conduction provided by one embodiment of the invention carries medicine overlay film；
Fig. 4 is the outer surface structure schematic diagram that conduction provided by one embodiment of the invention carries medicine overlay film；
Fig. 5 is the structural schematic diagram of rack body provided by one embodiment of the invention；
Fig. 6 is the vertical section structure schematic diagram that conduction provided by one embodiment of the invention carries medicine overlay film.
Icon: 10- rack body；11- power supply；12- varistor；13- supporting support silk；20- conduction carries medicine overlay film；
21- sheet metal；30- liner overlay film；210- drug release layer；220- drug release micropore；230- medicine-carried nanospheres；240- nanometers
Ball storage layer；250- conduction coating layer.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with attached drawing to the present invention
Technical solution be clearly and completely described, it is clear that described embodiments are some of the embodiments of the present invention, rather than
Whole embodiments.The component of embodiments of the present invention, which are generally described and illustrated herein in the accompanying drawings can be matched with a variety of different
It sets to arrange and design.Therefore, the detailed description of the embodiment of the present invention provided in the accompanying drawings is not intended to limit below
The range of claimed invention, but it is merely representative of selected embodiment of the invention.Based on the embodiments of the present invention, originally
Field those of ordinary skill every other embodiment obtained without making creative work, belongs to the present invention
The range of protection.
For to patient sustainer blood pressure can not non-invasive monitoring and lack locally crisp in patient's hypertension at present
The problem of preventative accuracy treatment means of weak vascular wall, the embodiment of the invention provides a kind of aortic blood pressure controlled release loads
Medicine bracket and controlling of blood pressure drug delivery system can carry out non-invasive monitoring to the aortic blood pressure of patient, to dissection of aorta
Therapeutic effect assessed and carry out Risk-warning, while provide a kind of local lesion it is high-risk when preventative accuracy control
Treatment means.It describes in detail first to aortic blood pressure controlled release carried stent of the invention below.
Embodiment one
Present embodiments provide a kind of aortic blood pressure controlled release carried stent, as shown in Figures 1 to 6, the aortic blood pressure
Controlled release carried stent includes rack body 10, conductive load medicine overlay film 20, varistor 12 and power supply 11.Conduction carries medicine overlay film 20 and wraps
It is overlying on the outer surface of rack body 10.Varistor 12 connect forming circuit with power supply 11, the pressure suffered by the varistor 12
When power is greater than threshold value, resistance value reduces, and there are micro-current in circuit, conduction carries medicine overlay film 20 and the micro-current in circuit is transmitted to body
Table.Maximum micro-current in circuit is less than 10mA.
Wherein, as shown in figure 5, rack body 10 can be made of nitinol alloy wire, Nitinol has shape memory
The plastic deformation of itself can be automatically restored to original-shape under a certain specific temperature by characteristic.Its expansion and contraction 20% with
On, fatigue life, damping characteristic was 10 times higher than common spring up to 107 times, and wear resistance and corrosion resistance are better than at present most
Good medical stainless steel, is a kind of good functional material.Rack body 10 is in continuous helical shape sine wave configuration, can also be in
Latticed, mesh grid, Z-shaped wave or other net type.It, can be fixed using metal wire knitted heat for the processing technology of Nitinol
After type through welding, bundle, be socketed to form or laser cut metal pipe is formed.
Supporting support silk 13 is provided on rack body 10, varistor 12 and power supply 11 are embedded on rack body, are led to
Cross the connection forming circuit of supporting support silk 13.A part of supporting support silk 13 is arranged along the length direction of rack body, another portion
Sub-support scaffolding thread 13 is arranged around the circumferencial direction of rack body 10, in a ring, is properly termed as support ring.
As shown in Fig. 2, supporting support silk 13 connect to form multiple circuits with power supply 11, one is at least connected on each circuit
A varistor 12, can not short circuit.It may also be said that varistor 12 is at least arranged one between every two support ring.It is pressure-sensitive
Resistance 12 is the pressure sensitive resistance for being embedded in rack body, and when blood pressure is higher than threshold value, resistance is smaller, and the threshold value can be set
Any value being set within the scope of 50-200mmHg.
As shown in Fig. 3, Fig. 4 and Fig. 6, it includes the drug release layer 210 being arranged successively, nanosphere storage that conduction, which carries medicine overlay film 20,
Deposit layer 240 and conductive coating layer 250.Drug release micropore 220 is formed on drug release layer 210, drug release micropore 220
Diameter is less than 100nm.It include medicine-carried nanospheres 230 in nanosphere storage layer 240.The diameter of medicine-carried nanospheres 230 exists
Between 101nm-999nm.Medicine-carried nanospheres 230 load one of following drug: depressor promotees solidifying medicine, glucocorticoid, non-steroidal
Anti-inflammatory agent, promotees endothelium repair medicine at vasoactive agent.Medicine-carried nanospheres 230 discharge drug principle and are, people is formed in circuit
The safe micro-current of body punctures medicine-carried nanospheres, and drug is allow to pass through drug release micropore 220.Conductive coating layer 250 wraps
The sheet metal 21 for including film layer and being embedded in film layer, sheet metal 21 are connect with varistor 12, by the micro-current in circuit
It is transmitted to body surface.Specifically, varistor 12 has certain thickness, sheet metal 21 is fitted closely with varistor 12, thin
Film layer is made of expanded PTFE (expanded Poly tetra fluoroethylene, ePTFE) material, varicosity
Polytetrafluoroethylene (PTFE) is ideal insulating materials and possesses good biocompatibility, is not turned between each sheet metal, can be to prevent
Only aortic blood pressure controlled release carried stent forms short circuit in vivo.
Power supply 11 can use miniature lithium-iodine battery, can produce and export electric pulse, and maximum voltage is less than 36V.
Aortic blood pressure controlled release carried stent further includes liner overlay film 30.Liner overlay film 30 is attached at the interior of rack body 10
On surface, circuit and contacting blood are prevented.Liner overlay film 30 is also made of expanded PTFE material.
Varistor 12 and power supply 11 are all set between liner overlay film 30 and conductive load medicine overlay film 20.Power supply, pressure-sensitive electricity
Resistance, rack body are formed by circuit can not short circuit.
Aortic blood pressure controlled release carried stent provided in an embodiment of the present invention, rack body are placed in intravascular, act on
At interlayer cut, interlayer cut and support blood vessels inner membrance can be blocked, restores true chamber blood flow, to realize operation purpose.Bracket
Power supply and varistor are provided in main body, under the premise of not influencing rack body mechanical property, when varistor is pressurized
When power is less than threshold value, loop current is essentially 0.It is greater than threshold value (such as 140mmHg, hypertension threshold in varistor pressure
Value, there is the risk for sending out dissection of aorta again), the resistance value of varistor is greatly lowered, and makes in circuit that there are micro-currents.By leading
Electricity carries the sheet metal on medicine overlay film, and micro-current can puncture medicine-carried nanospheres, and plurality of optional drug is made to pass through drug release micropore
Reach lesion, play local lesion it is high-risk when preventative accuracy therapeutic effect；It can be embodied in different sites simultaneously
Monitoring device is connected to body surface by the different potentials detected, be can be detected the electric potential signal variation of body surface, is believed according to current potential
Number variation, blood pressure in available aorta accurately monitors in art or the aorta of postoperative patient so as to simplicity
Blood pressure provides valuable risk assessment index for endoluminal vascular field.
It further says, before power-fail and drug depletion, which can basis
Aortic blood pressure is to local lesion's release drug and accurately reflects the specific value of aortic blood pressure, and then accomplishes preventative and smart
The treatment of parasexuality and assessment dissection of aorta is sent out again or risk of rupture, the high risk especially in perioperative and 3 months after operation
The aortic blood pressure of phase, preventative accuracy treatment and monitoring diseased region will have great clinical value.In power-fail and
After drug depletion, which is remained to take the initiative the effect of arteries and veins overlay film frame.
The aortic blood pressure that the aortic blood pressure controlled release carried stent provided through the embodiment of the present invention measures, can prevent
Property accuracy instructs Patients' rights blood pressure medication, and no longer relies solely on the medication experience of doctor pharmacist；It can not only accomplish to control
Blood pressure peak value processed can also be accomplished to control fluctuation of blood pressure.It simultaneously can be when aortic blood pressure be higher than high-risk threshold value, to part
Lesion plays preventative and accuracy drug therapy.
In conclusion aortic blood pressure controlled release carried stent provided in an embodiment of the present invention, including rack body, interior lining
Film, conductive load medicine overlay film, varistor and power supply；Liner overlay film is coated on the inner surface of the rack body, and conduction carries medicine
Overlay film is coated on the outer surface of rack body；Power supply, varistor, rack body connection forming circuit, when varistor institute
When the pressure received is greater than threshold value, resistance value reduces, and there are micro-current in circuit, conduction carries medicine overlay film and micro-current is transmitted to body surface,
The monitoring device for being connected to body surface is set to monitor the variation of aortic blood pressure；Meanwhile micro-current punctures medicine-carried nanospheres, makes medicine
Object can pass through drug release micropore and act on lesion.The aortic blood pressure controlled release carried stent and controlling of blood pressure drug are released
Place system can carry out non-invasive monitoring to the aortic blood pressure of patient, assessed the therapeutic effect of dissection of aorta and carried out
Risk-warning, at the same provide a kind of local lesion it is high-risk when preventative accuracy treatment means.
Embodiment two
The embodiment of the invention also provides a kind of aortic blood pressure monitoring system, including monitoring device and aortic blood it is voltage-controlled
Release carried stent.Aortic blood pressure controlled release carried stent can be carried using aortic blood pressure controlled release provided by above-described embodiment one
Medicine bracket is placed in the blood vessels.Monitoring device detects the electric potential signal of body surface for being connected to body surface.
Specifically, be similar to electrocardiograph, monitoring device may include for be connected to multiple contact electrodes of body surface,
With contact electrode by conducting wire or the host of wireless connection, for detecting body surface potential.
When the varistor pressure in aortic blood pressure controlled release carried stent is greater than threshold value, the resistance value of varistor
It is greatly lowered, makes in circuit that there are micro-currents.By the conductive sheet metal carried on medicine overlay film, micro-current can be embodied in difference
The different potentials that sites detect.The contact electrode of monitoring device is connected to body surface, monitoring device can be detected
The electric potential signal of body surface changes, according to the variation of electric potential signal, blood pressure in available aorta.
Aortic blood pressure controlled release carried stent and controlling of blood pressure drug delivery system provided in an embodiment of the present invention have phase
Same technical characteristic reaches identical technical effect so also can solve identical technical problem.
It should be noted that in the description of the embodiment of the present invention unless specifically defined or limited otherwise, term " peace
Dress ", " connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integrally
Connection；It can be mechanical connection, be also possible to be electrically connected；Can be directly connected, can also indirectly connected through an intermediary,
It can be the connection inside two elements.For the ordinary skill in the art, above-mentioned art can be understood with concrete condition
The concrete meaning of language in the present invention.
In the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" be based on the orientation or positional relationship shown in the drawings, merely to
Convenient for description the present invention and simplify description, rather than the device or element of indication or suggestion meaning must have a particular orientation,
It is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.In addition, term " first ", " second ",
" third " is used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance.
Finally, it should be noted that embodiment described above, only a specific embodiment of the invention, to illustrate the present invention
Technical solution, rather than its limitations, scope of protection of the present invention is not limited thereto, although with reference to the foregoing embodiments to this hair
It is bright to be described in detail, those skilled in the art should understand that: anyone skilled in the art
In the technical scope disclosed by the present invention, it can still modify to technical solution documented by previous embodiment or can be light
It is readily conceivable that variation or equivalent replacement of some of the technical features；And these modifications, variation or replacement, do not make
The essence of corresponding technical solution is detached from the spirit and scope of technical solution of the embodiment of the present invention, should all cover in protection of the invention
Within the scope of.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. a kind of aortic blood pressure controlled release carried stent, which is characterized in that covered including rack body, liner overlay film, the conductive medicine that carries
Film, varistor and power supply；Liner overlay film is coated on the inner surface of the rack body, and conduction load medicine overlay film is coated on described
On the outer surface of rack body；
The power supply, the varistor and the rack body form circuit, and the pressure suffered by the varistor is greater than
When threshold value, resistance value reduces, and there are micro-current in the circuit, the conductive medicine overlay film that carries will promote drug release and promote institute
It states micro-current and is transmitted to body surface.
2. aortic blood pressure controlled release carried stent according to claim 1, which is characterized in that be arranged on the rack body
There is supporting support silk, the varistor and the power supply are embedded on the rack body, are connected by the supporting support silk
Connect forming circuit.
3. aortic blood pressure controlled release carried stent according to claim 2, which is characterized in that the supporting support silk is along institute
It states the length direction of rack body and is arranged around the circumferencial direction of the rack body.
4. aortic blood pressure controlled release carried stent according to claim 2, which is characterized in that the supporting support silk, pressure
Quick resistance connect to form multiple circuits with the power supply, and a varistor has been at least connected in each circuit.
5. aortic blood pressure controlled release carried stent according to claim 1, which is characterized in that the conductive load medicine overlay film packet
Include the drug release layer being arranged successively, nanosphere storage layer and conductive coating layer；Drug is formed on the drug release layer to release
Put micropore；It include medicine-carried nanospheres in the nanosphere storage layer.
6. aortic blood pressure controlled release carried stent according to claim 5, which is characterized in that it is described conduction coating layer include
Film layer and the sheet metal being embedded in the film layer, the sheet metal are connect with the varistor.
7. aortic blood pressure controlled release carried stent according to claim 5, which is characterized in that the medicine-carried nanospheres it is straight
For diameter between 101nm-999nm, the diameter of the drug release micropore is less than 100nm.
8. aortic blood pressure controlled release carried stent according to claim 7, which is characterized in that the medicine-carried nanospheres load
One of following drug: depressor promotees solidifying medicine, glucocorticoid, non-steroidal anti-inflammatory drugs, vasoactive agent, promotees endothelium reparation medicine
Object.
9. aortic blood pressure controlled release carried stent according to claim 1, which is characterized in that the liner overlay film and described
Conduction is carried medicine overlay film and is made of expanded PTFE material.
10. a kind of controlling of blood pressure drug delivery system, which is characterized in that including any in monitoring device and such as claim 1~9
Aortic blood pressure controlled release carried stent described in；The aortic blood pressure controlled release carried stent is described for placing in vivo
Monitoring device is for being connected to body surface.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110353867A (en) * | 2019-08-06 | 2019-10-22 | 谢恩泽华 | A kind of intelligence initiative pulse support blood vessel and its control method |
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| CN110353867A (en) * | 2019-08-06 | 2019-10-22 | 谢恩泽华 | A kind of intelligence initiative pulse support blood vessel and its control method |
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