CN102553065A - Controllable drug releasing method on basis of surface tension drive controlled by electric field - Google Patents
Controllable drug releasing method on basis of surface tension drive controlled by electric field Download PDFInfo
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- CN102553065A CN102553065A CN2011103422410A CN201110342241A CN102553065A CN 102553065 A CN102553065 A CN 102553065A CN 2011103422410 A CN2011103422410 A CN 2011103422410A CN 201110342241 A CN201110342241 A CN 201110342241A CN 102553065 A CN102553065 A CN 102553065A
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Abstract
The invention discloses a controllable drug releasing method on the basis of surface tension drive controlled by an electric field, which includes applying electric charge to liquid medicine, packaging the charged liquid medicine into liquid medicine drops coated with a film layer respectively, applying the electric field with certain voltage to the charged liquid medicine drops coated with the film layers, and pressing the liquid medicine drops to a support object under action of the electric field so as to open the film layers. The external electric field is applied to the charged liquid medicine drops coated with the film layers, the film layers coated on the liquid medicine drops can be opened when the electric field applied externally is strong enough, so that drug can be released and controllable releasing of the drug under control of the electric field is realized.
Description
Technical field
The present invention relates to a kind of drug controllable release method based on the electric field controls surface tension driving.
Background technology
Threaten modern's life, the key factor of quality of life along with major diseases such as cancer become gradually, countries in the world government, scientific research personnel and non-government organization have all dropped into a large amount of manpowers, financial resources are used to capture this " incurable disease ".
Under various countries scientist's effort, on clinical medicine front, various countries, brought into play great function to the medicine of cancer, also played good effect.But it is enough not capture this major disease of cancer that medicine is only arranged, because existing medicine not only plays intensive lethal effect to cancer, can kill a lot of normal body cells simultaneously.Therefore, no matter radiotherapy or chemotherapy all cause very serious adverse to human body itself.
In order to overcome this difficult problem; The World Science man has carried out a large amount of effort aspect the controllable release of medicine; Hope and can reach: " medicine only and the affected part discharges, metabolism, and reduce in a large number in other position concentration of health " effect, thereby reach the purpose of slowing down side effect.Scientist attempts through drug molecule being modified at the magnetic-particle surface now, and when treatment, through external magnetic pole drug particles is guided to the sufferer place, reaches the effect of drug targeting and controllable release.Also have scientist through modified antigen albumen on drug molecule, carry out specific immune response, make medicine assemble the purpose that reaches controllable release in the affected part through antigen and cancerous cell.
But all there is following problem in these methods: medicine can only slowly discharge along with the time.That is to say that medicine is in fact always in uncontrolled release, only more a high proportion of drug molecule is fixed on the affected part and carries out slow release.Therefore, side effect has just been alleviated by part, on principle, can not avoid side effect.
Summary of the invention
The object of the present invention is to provide a kind of drug controllable release method, can control the release of medicine well based on the electric field controls surface tension driving.
A kind of drug controllable release method based on the electric field controls surface tension driving provided by the invention is:
Make electric charge on the liquid medicine band, charged liquid medicine is packaged into the medicine drop that is coated with thin film;
The charged medicine drop that is coated with thin film is applied the electric field of certain voltage, and the medicine drop is pressed towards under effect of electric field and presses thing, thereby thin film is opened.
Preferably, the method for packing of said charged medicine comprises the steps:
1) the hydrophilic fexible film is placed the surface of the substrate of processing by the material of low adhesion;
2) said thin film is carried out graphical treatment, make it become the monolithic thin film of a plurality of small sizes;
3) liquid medicine to be packaged is sprayed on the monolithic thin film surface;
4) liquid medicine gathers into the medicine drop on the surface of monolithic thin film, and said monolithic thin film coats drop through surface tension.
Preferably, said thin film is processed by silicon dioxide or polydimethylsiloxane (PDMS) material.
The present invention is through applying extra electric field to charged and medicine drop that be coated with thin film, and when extra electric field was enough big, the thin film that medicine coats will be strutted, thereby discharges medicine, realizes the controllable release of the medicine under the electric field controls.
Description of drawings
Fig. 1 a～e is the coating process sketch map of medicine drop of the present invention;
Fig. 2 a, b are the process sketch map of controllable release of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is done further detailed explanation.
The principle of the invention is through after charged drop is coated, and around drop, applies electric field, and the medicine drop will be opened the coating of thin film under electric field action so.If comprise ingredient in the drop, can realize the complete controllable release of medicine so, promptly discharge medicine fully, and do not having the intact coating of the packed material of electric field place medicine at the electric field place.Specific as follows:
At first, the charged liquid medicine is encapsulated, encapsulation can be adopted following mode:
The hydrophilic fexible film 1 (like silica membrane or the polydimethylsiloxane PDMS material that prepares completion) that will be used to coat liquid medicine is placed on the surface of the substrate 2 of being processed by the material (like super hydrophobic material) of low adhesion, shown in Fig. 1 a, b.2 pairs of thin film 1 of substrate have lower adhesion.The low adhesion here is meant and is lower than ...
Then, thin film 1 is carried out graphically making it to become the free film 3 of the very little monolithic of a lot of areas, shown in Fig. 1 c.
Afterwards, through the mode of spraying medicine is sprayed the surface that is attached to free film 3, medicine forms medicine drop 4 at the surface aggregation of free film 3, shown in Fig. 1 d.
So will spontaneous medicine drop 4 have been coated under capillary effect by graphical good free film 3, and form the medicine drop 4 that is coated with free film 3, shown in Fig. 1 e.
At last, only need carry out simple collection, just can obtain by the packaged medicine of free film 3.
Packaged medicine is because the 4 capillary effects of medicine drop, is used for the coating that the free film 3 of coating medicine drop will be spontaneous and keeps the state that coats drop.Because medicine commonly used all is a macromolecular compound, and when the solution pH value is under the macromole isoelectric point, IP, drug molecule meeting positively charged; And when pH value was on isoelectric point, IP, drug molecule can be electronegative.That is to say that the pH value through the adjustment drug solution can make drug molecule charged, promptly forms charged molecule.
Then, the medicine that has coated free film 3 is placed under the effect of extra electric field, shown in Fig. 2 a, b; When medicine liquid droplet charged molecule positively charged; When extra electric field 6 was directed downwards, drug molecule will move basad 5 aspects, and the extruding medicine coats free film 3.When extra electric field 6 was enough big, medicine coated free film 3 and will be strutted, thereby discharged medicine, realized the controllable release of the medicine under the electric field controls.When in human body, matrix 5 is just with respect to the tissue of human body.
Because in whole system, only need apply extra electric field just can realize the release for drug particles, and as long as no breakdown current produces, even strong again extra electric field also is harmless for human existence.Therefore this mode that causes drug particles to discharge medicine through extra electric field control drip gauge surface tension is fully harmless for human body.Extra electric field can be introduced through the mode of implantation or additional electrodes in the human body affected part; And be that the mode that mode or the external part of implant electrode applies electric field all is the ripe clinical technology that has earlier, therefore controllable release method of the present invention can be applied in the clinical use well.
Claims (3)
1. drug controllable release method based on the electric field controls surface tension driving, this method is:
Make electric charge on the liquid medicine band, charged liquid medicine is packaged into the medicine drop that is coated with thin film;
The charged medicine drop that is coated with thin film is applied the electric field of certain voltage, and the medicine drop is pressed towards under effect of electric field and presses thing, thereby thin film is opened.
2. the method for claim 1 is characterized in that, the method for packing of said charged medicine comprises the steps:
1) the hydrophilic fexible film is placed the surface of the substrate of processing by the material of low adhesion;
2) said thin film is carried out graphical treatment, make it become the monolithic thin film of a plurality of small sizes;
3) liquid medicine to be packaged is sprayed on the monolithic thin film surface;
4) liquid medicine gathers into the medicine drop on the surface of monolithic thin film, and said monolithic thin film coats drop through surface tension.
3. according to claim 1 or claim 2 method is characterized in that said thin film is processed by silicon dioxide or polydimethylsiloxane (PDMS) material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103422410A CN102553065A (en) | 2011-11-02 | 2011-11-02 | Controllable drug releasing method on basis of surface tension drive controlled by electric field |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103422410A CN102553065A (en) | 2011-11-02 | 2011-11-02 | Controllable drug releasing method on basis of surface tension drive controlled by electric field |
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| CN102553065A true CN102553065A (en) | 2012-07-11 |
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| CN2011103422410A Pending CN102553065A (en) | 2011-11-02 | 2011-11-02 | Controllable drug releasing method on basis of surface tension drive controlled by electric field |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109044576A (en) * | 2018-08-24 | 2018-12-21 | 上海长海医院 | Aortic blood pressure controlled release carried stent and controlling of blood pressure drug delivery system |
| CN109046483A (en) * | 2018-08-28 | 2018-12-21 | 京东方科技集团股份有限公司 | Fluid fine particle and preparation method, microfluidic system and preparation method, control method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009123242A1 (en) * | 2008-03-31 | 2009-10-08 | 東レエンジニアリング株式会社 | Method for manufacturing unsymmetric laminated preparation |
-
2011
- 2011-11-02 CN CN2011103422410A patent/CN102553065A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009123242A1 (en) * | 2008-03-31 | 2009-10-08 | 東レエンジニアリング株式会社 | Method for manufacturing unsymmetric laminated preparation |
Non-Patent Citations (1)
| Title |
|---|
| 王子千: "Experimental study of Electro-elasto-capillarity: Electric field driven unwrapping of water drop with elastic film", 《2010年第四届微纳米海峡两岸科技暨纳微米系统与加工制备中的力学问题研讨会摘要集》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109044576A (en) * | 2018-08-24 | 2018-12-21 | 上海长海医院 | Aortic blood pressure controlled release carried stent and controlling of blood pressure drug delivery system |
| CN109044576B (en) * | 2018-08-24 | 2023-09-19 | 上海长海医院 | Aortic blood pressure controlled drug delivery stent and blood pressure controlled drug delivery system |
| CN109046483A (en) * | 2018-08-28 | 2018-12-21 | 京东方科技集团股份有限公司 | Fluid fine particle and preparation method, microfluidic system and preparation method, control method |
| US11278899B2 (en) | 2018-08-28 | 2022-03-22 | Beijing Boe Optoelectronics Technology Co., Ltd. | Microfluidic particle and manufacturing method thereof, microfluidic system, manufacturing method and control method thereof |
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Application publication date: 20120711 |