KR101856549B1

KR101856549B1 - Stent capable of heart disease early detection and heart disease early warning system using it

Info

Publication number: KR101856549B1
Application number: KR1020160029471A
Authority: KR
Inventors: 노주환; 최수범
Original assignee: 연세대학교 산학협력단
Priority date: 2016-03-11
Filing date: 2016-03-11
Publication date: 2018-05-10
Also published as: KR20170105982A

Abstract

The present invention relates to a stent capable of early detection of heart diseases such as myocardial infarction and arrhythmia due to vascular occlusion using a piezoelectric sensor and an electrocardiogram sensor, and a heart disease early warning system including the stent.
A stent capable of early detection of heart disease according to an embodiment of the present invention is a stent for expanding a cardiovascular tube installed inside a cardiovascular vessel, An inner circumferential cell spaced apart from the outer circumferential cell and contacting blood flow; And a heart disease sensing unit formed between the peripheral cell and the inner cell and acquiring state information of blood flowing inside the cardiovascular vessel and transmitting the acquired state information to an external device.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a stent for early detection of heart disease,

The present invention relates to a stent capable of early detection of heart disease and an early warning system for heart disease including the stent. More specifically, the present invention relates to a stent for early detection of heart disease such as myocardial infarction due to occlusion of blood vessels, And an early warning system for heart disease including the stent.

The heart is largely oxygenated and nutritious by three cardiac vessels (coronary arteries). If any of these three coronary arteries is acutely clogged by thrombosis or rapid constriction of the blood vessels, oxygen or nutrient supply to all or part of the heart may be abruptly reduced, resulting in death of the heart muscle tissue or cells (necrosis ) The condition is called myocardial infarction.

Myocardial infarction can be divided into anterior myocardial infarction, infarct wall myocardial infarction, transmural myocardial infarction (myocardial infarction), and subendocardial infarction (myocardial infarction) Based on the electrocardiographic findings, ST segment elevation myocardial infarction and non ST segment elevation myocardial infarction can be categorized.

If such myocardial infarction is found at an early stage, it can be diagnosed promptly by going to a hospital to prevent deepening of myocardial infarction. However, the general public will not be able to receive proper initial treatment because the heart is already deeply intensified if the pain is felt in the chest. Therefore, it is urgent to develop a technique capable of early detection of heart disease such as myocardial infarction.

Korean Utility Model Registration No. 20-0464309 discloses a hollow cylindrical body portion to be inserted into a lumen of a human body, a distal end portion positioned at the lower end of the body portion and having an outer diameter larger than that of the body portion, Discloses a stent comprising a head having an outer diameter greater than the distal end.

According to the utility model, the size of the outer diameter of the head portion of the stent is dramatically increased so that the stent inserted into the gastrointestinal tract can be securely fixed by the head portion, thereby preventing the stent from moving in the direction of flow of the fluid such as food , Heart disease such as myocardial infarction can not be detected early.

Korean Registered Utility Model 20-0464309

An object of the present invention is to provide a stent capable of early detection of heart diseases such as myocardial infarction and arrhythmia caused by vascular occlusion using a piezoelectric sensor and an electrocardiogram sensor, and a heart disease early warning system including the stent.

A stent capable of early detection of heart disease according to an embodiment of the present invention includes:

A stent for expanding a cardiovascular tube installed inside the cardiovascular vessel, the outer tube being in contact with the tissue inside the cardiovascular system; An inner circumferential cell spaced apart from the outer circumferential cell and contacting blood flow; And a heart disease sensing unit formed between the peripheral cell and the inner cell and acquiring state information of blood flowing inside the cardiovascular vessel and transmitting the acquired state information to an external device.

According to one aspect of the present invention, the heart disease detection unit includes: a cylindrical tube having an inner space formed therein; A piezoelectric sensor formed in the inner space and sensing a pressure due to blood flow inside the cardiovascular system; An electrocardiogram sensor formed in the inner space and sensing a waveform of an electric signal flowing in the heart; A transmission unit formed in the internal space, for transmitting sensed values of the piezoelectric sensor and the electrocardiogram sensor to the external device; And a microprocessor formed in the internal space and controlling the operation of the piezoelectric sensor, the electrocardiograph sensor, and the transmitting unit.

According to one aspect of the present invention, the piezoelectric sensor may be formed in at least two or more spaces in the internal space, or may be formed in a cylindrical shape corresponding to the tube in the internal space.

According to one aspect of the present invention, the piezoelectric sensor can convert the pressure caused by the blood flow into electric energy, and supply power to the electrocardiogram sensor, the transmission unit, and the microprocessor.

According to an aspect of the present invention, the outer circumferential cell is formed of a plurality of nodes which are connected to the inner wall of the cardiovascular tube and connected to each other in a zigzag manner so that the stent is interlocked with the inner wall of the cardiovascular tube, So that the thickness of the nodule increases from both ends to the both ends.

According to an aspect of the present invention, a coating for preventing the penetration of cardiovascular tissues is formed between the peripheral cell and the heart disease sensing unit.

In addition, the heart disease early warning system according to the embodiment of the present invention includes the stent and a mobile terminal for determining whether or not a heart disease has occurred using the sensed value transmitted from the stent.

Other specific embodiments of various aspects of the present invention are included in the detailed description below.

According to the embodiments of the present invention, it is possible to provide a stent capable of early detection of heart diseases such as myocardial infarction and arrhythmia due to vascular occlusion using a piezoelectric sensor and an electrocardiogram sensor, and a heart disease early warning system including the stent .

The user can know early that there is an abnormality related to his / her heart, and can take quick measures such as going to a hospital and receiving a precise diagnosis.

1 is a block diagram illustrating a heart disease early warning system in accordance with an embodiment of the present invention.
2 is a view showing a stent capable of early detection of heart disease according to an embodiment of the present invention.
3 is a development view showing a stent capable of early detection of heart disease according to an embodiment of the present invention.
FIG. 4 is a block diagram showing a heart disease sensing unit of a stent capable of early detection of a heart disease according to an embodiment of the present invention.
5 is a block diagram illustrating a configuration of a mobile terminal according to an embodiment of the present invention.
6 is an exemplary view illustrating an installation position of a stent according to an embodiment of the present invention.

The present invention is capable of various modifications and various embodiments and is intended to illustrate and describe the specific embodiments in detail. It should be understood, however, that the invention is not intended to be limited to the particular embodiments, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In the present invention, terms such as "comprises" or "having" are used to designate the presence of stated features, integers, steps, operations, elements, components, or combinations thereof, But do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, or combinations thereof. Hereinafter, a stent capable of early detection of heart disease according to an embodiment of the present invention and a heart disease early warning system including the stent will be described with reference to the drawings.

As shown in the drawing, the heart disease early warning system according to an embodiment of the present invention includes a stent 100 capable of early detection of a heart disease, And a mobile terminal (200) for determining whether the mobile terminal

In the present specification, the term " early detection " means a time when a symptom of disease occurrence is detected, and specifically includes " before a user feels a symptom of a heart attack ".

The stent 100 includes an outer circumferential cell 110, a capsule 120, a heart disease sensing unit 130 and an inner circumferential cell 140. As the outer circumferential cell 110 moves to the inner circumferential cell 140 The outer diameter of the capsule is small so that the capsule 120 is formed on the inner side of the outer shell 110. The heart disease detection unit 130 is formed inside the capsule 120 and the inner cell 140 are formed.

The outer circumference cell 110 is located at the outermost portion of the stent 100 and contacts the tissue inside the cardiovascular system. The outer circumference cell 110 is formed of a plurality of nodes connected to the stent 100 in a zigzag manner so that the stent 100 is inserted into the cardiovascular system and entangled with the cardiovascular tissue so that the stent 100 can be fixed inside the cardiovascular system.

When the stent 100 is fixed to the inside of the cardiovascular system, pressure is applied to the entire surface of the outer circumference cell 110 by the cardiovascular system. Since both ends of the outer circumference cell 110 are not formed with adjoining outer sides, The holding force against the pressure is weak and the holding force of the stenosed region is relatively lowered. Therefore, it is preferable to form the outer circumferential cell so that the thickness of the node increases from the center of the outer circumferential cell toward both ends. That is, the nodes located at the center of the outer circumference cell 110 are formed to be thinnest, and the nodes located at both ends of the outer circumference cell 110 are formed to be thickest.

The inner circumference cell 140 is located at the innermost portion of the stent 100 and contacts blood flow inside the cardiovascular system. The inner peripheral cell 140 is formed for ensuring the vascular passage.

The coating 120 is formed between the peripheral cell 110 and the heart disease sensing part 130 to prevent the penetration of cardiovascular tissues. That is, the cardiovascular tissue that is entangled with the outer circumference cell 110 to prevent the cardiovascular tissue that fixes the stent 100 to the inside of the cardiovascular can be prevented from penetrating into the inner space, so that the heart disease detection unit 130 and the inner circumference cell 140 are separated from the outer circumference cell 110 In order to secure a space that can be maintained within the space.

The material of the coating 120 is preferably a flexible polymer film used for medical use. For example, a medical silicone film, polyurethane, PTFE, or the like can be used.

The heart disease detection unit 130 is formed between the outer circumference cell 110 and the inner circumference cell 140 to acquire status information of the blood flowing inside the cardiovascular tube and transmit it to the outside. More preferably, the heart disease detection unit 130 is formed between the peripheral cell 110 and the coating 120. Here, the blood status information may be, for example, pressure information due to blood flow inside the cardiovascular system, an electrocardiogram signal, which is a waveform of an electric signal flowing in the heart, and the like.

4, the heart disease detection unit 130 includes a tube T, a piezoelectric sensor 131, an electrocardiogram sensor 132, a transmission unit 133, a microprocessor 135 ).

The tube T is formed in a cylindrical shape having an internal space. The piezoelectric sensor 131, the electrocardiogram sensor 132, the transmitting unit 133, and the microprocessor 135 are formed in the inner space of the tube T. [ Thus, it is possible to prevent the piezoelectric sensor 131 or the like from malfunctioning due to blood flow, or to prevent components such as the piezoelectric sensor 131 from being swept into the bloodstream and flowing out to the human body.

The piezoelectric sensor 131 senses pressure due to blood flow inside the cardiovascular system. The piezoelectric sensor 131 may be formed at least two spaces in the inner space of the tube T. [ That is, a plurality of piezoelectric sensors 131 may be uniformly spaced apart from each other in the inner space to obtain a sensed value according to a position in a cardiovascular region, and an average value thereof may be calculated as a pressure due to blood flow.

In addition, the piezoelectric sensor 131 may be formed in a cylindrical shape corresponding to the tube in the inner space of the tube T. In the case of a cylindrical shape, it is possible to obtain a sensed value according to the entire cardiovascular position, so that a more precise pressure can be calculated and a stable position can be maintained in the inner space of the tube T.

The piezoelectric sensor 131 can convert the pressure caused by the blood flow into electrical energy and supply power to the electrocardiograph sensor 132, the transmission unit 133 and the microprocessor 135.

The electrocardiogram sensor 132 senses the waveform of the electric signal flowing in the heart. Normally, the electrocardiogram sensor is recorded by an electrode attached to the skin and equipment external to the body. However, in the present invention, since the electrical signal waveform of the heart is detected by being positioned in the cardiovascular system of the human body, a more accurate electric signal can be obtained.

The transmission unit 133 transmits the detection values of the piezoelectric sensor and the electrocardiogram sensor to the external device. Here, the external device may be any one of a mobile communication terminal, a personal digital assistant (PDA), a tablet, a notebook, and the like. The external device may include a memory and a program for storing a program for transmitting / And a microprocessor for performing operations and controlling and controlling the mobile terminal 200.

Since the heart disease early warning system of the present invention sends a detection value to a mobile terminal 200 carried by a user to alert the user in real time whether or not a heart disease has occurred, the transmission unit 133 transmits the detection result to the mobile terminal 200, And a short range wireless communication module for performing communication.

The stent according to the embodiment of the present invention configured as described above may be inserted into at least one of right and left coronary arteries as shown in FIG. Patients with left coronary artery occlusion should be inserted into the left side, patients with right coronary artery occlusion should be inserted to the right side, and patients with both left and right occlusion should be inserted into both sides.

In practice, the stent of the present invention is not inserted to monitor the occurrence of heart disease in a normal person. When the artery of a patient who has already developed heart disease is occluded, the stent is inserted. Depending on the occluded portion of the blood vessel, You can choose whether to insert a stent or an existing stent.

The difference from the conventional stent is that the existing stent only functions to maintain the blood vessels and has no sensing function. On the other hand, the stent of the present invention has a function of retaining and detecting the blood vessels, and the complication due to myocardial infarction or recurrence of asymptomatic myocardial infarction Can be helpful for early detection of

According to the stent of the present invention, in the case of a patient having a cardiac-related event, it is possible to prevent the progress and deterioration (secondary prevention) by making it possible to judge and respond to the condition before the examination and the response, Can help.

5 is a block diagram illustrating a configuration of a mobile terminal according to an embodiment of the present invention. 5, the mobile terminal 200 includes a control unit 210, an input unit 220, a display unit 230, a storage unit 240, a heart disease determination unit 250, and a communication unit 260.

The input unit 220 receives various information such as numbers and character information and transmits various signals to the controller 210 in order to set various functions and control the functions of the mobile terminal 200. In addition, the input unit 220 may include at least one of a keypad and a touchpad that generates an input signal according to a user's touch or operation. The input unit 220 may be configured as a touch panel or a touch screen together with the display unit 230 to simultaneously perform input and display functions. In addition to input devices such as keypads, mice, joysticks, etc., any type of input means that can be developed in the future can be used.

The display unit 230 displays information on a series of operation states, operation results, and the like that occur during the performance of the function of the mobile terminal 200.

In addition, the display unit 230 may display a menu of the mobile terminal 200 and user data input by the user. The display unit 230 may be a liquid crystal display (LCD), a thin film transistor LCD (TFT-LCD), a light emitting diode (LED), an organic light emitting diode LEDs, active matrix organic light emitting diodes (AMOLED), active matrix OLEDs, retina displays, flexible displays, and three-dimensional displays. In this case, when the display unit 230 is configured as a touch screen, the display unit 230 may perform some or all of the functions of the input unit 220. [

The storage unit 240 is a device for storing data. The storage unit 240 includes a main storage device and an auxiliary storage device, and stores an application program required for the functional operation of the mobile terminal 200. The storage unit 240 may include a program area and a data area. Here, when the mobile terminal 200 activates each function according to the request of the user, the mobile terminal 200 executes the corresponding application programs under the control of the controller 210 to provide each function.

The heart disease determination unit 250 determines whether or not a heart disease has occurred using the sensing value transmitted from the stent 100.

The heart disease judgment unit 250 compares the pressure value sensed by the piezoelectric sensor with a preset normal pattern and judges that the myocardial infarction is progressing when the pressure change pattern of the blood flow is out of a predetermined range, And transmits the generated signal to the control unit 210.

The heart disease determination unit 250 collects the pressure value sensed by the piezoelectric sensor, the blood flow velocity and change sensed by the LED and the optical sensor, and the electrocardiogram information sensed by the electrocardiographic sensor for a predetermined period after the stent is inserted.

The heart disease judgment unit 250 detects a pressure change pattern of blood flow in various situations such as lying, sitting, speaking, and running in daily life.

The heart disease judgment unit 250 compares the pressure value sensed by the piezoelectric sensor with a preset reference pattern, and when the pattern is distinctly different, the user confirms the state of the current situation. If the detected blood flow velocity is high and the blood pressure is low, it is determined that the myocardial infarction is progressing, and a heart disease alert signal is generated and transmitted to the control unit 210.

In addition, the heart disease judgment unit 250 compares the sensed waveform of the electrocardiogram sensor with a normal waveform, and when the sensed waveform is out of a predetermined range, it is judged that the arrhythmia is proceeding to generate a heart disease alarm signal, 210).

Upon receiving the heart disease alert signal, the control unit 210 controls the display unit 230 to output an alarm message or an alarm sound to inform the user of the occurrence of heart disease.

The communication unit 260 includes a short-range communication module capable of performing data communication with the transmission unit 133 through short-range communication.

The control unit 210 controls the mobile terminal 200 to process all operations. That is, the control unit 210 controls the operation of the input unit 220, the display unit 230, the storage unit 240, the heart disease determination unit 250, and the communication unit 260, respectively.

Next, the operation procedure of the stent and the heart disease early warning system including the stent capable of early detection of the heart disease will be described.

If the user does not have any indication of the occurrence of heart disease, that is, if there is no abnormality such as cardiovascular occlusion, the detection values of the piezoelectric sensor 131 and the electrocardiograph sensor 132 are within a predetermined normal range. When the detection value is transmitted from the stent 100 to the mobile terminal 200, the heart disease determination unit 250 of the mobile terminal determines that the heart disease is not present and does not indicate normal or generate a separate notification message.

If the user has signs of heart disease, that is, if the cardiovascular occlusion begins to progress, the cardiovascular passageway becomes narrower so that blood flow in the cardiovascular blood becomes faster and the pressure sensed by the piezoelectric sensor placed in the tube is lowered.

When the sensed pressure value is transmitted from the stent 100 to the mobile terminal 200, the heart disease determination unit 250 of the mobile terminal compares the pressure value sensed by the piezoelectric sensor with a preset normal pattern, If the change pattern is out of the preset range, it is determined that the myocardial infarction is progressing, and a heart disease alert signal is generated and transmitted to the control unit 210.

The control unit 210 receiving the heart disease alert signal controls the display unit 230 to output an alarm message or an alarm sound informing the user of the occurrence of heart disease.

Also, the controller 210 may transmit the heart disease alert signal to the mobile terminal of the pre-registered primary care physician.

A user who has confirmed such an alarm message or an alarm sound can quickly know that there is an abnormality related to his / her heart, and can take quick measures such as going to a hospital and receiving a precise diagnosis.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit of the invention as set forth in the appended claims. The present invention can be variously modified and changed by those skilled in the art, and it is also within the scope of the present invention.

100: stent 200: mobile terminal
110: Outer cell 120: Coating
130: Heart disease detection unit 131: Piezoelectric sensor
132: Electrocardiogram sensor 133: Transmitting unit
135: Microprocessor
T: tube 140: inner peripheral cell
210: control unit 220: input unit
230: Display unit 240:
250: heart disease judgment section 260: communication section

Claims

A stent for expanding a cardiovascular tube installed inside the cardiovascular vessel, the outer tube being in contact with the tissue inside the cardiovascular system; An inner circumferential cell spaced apart from the outer circumferential cell and contacting blood flow; And a heart disease sensing unit formed between the outer peripheral cell and the inner peripheral cell and acquiring state information of blood flowing inside the cardiovascular vessel and transmitting the acquired state information to an external device,
The heart disease detection unit includes: a cylindrical tube having an internal space formed therein; A piezoelectric sensor formed in the inner space and sensing a pressure due to blood flow inside the cardiovascular system; And an electrocardiogram sensor formed in the inner space and sensing a waveform of an electric signal flowing in the heart,
The piezoelectric sensor may be formed by arranging two or more piezoelectric sensors spaced equally distantly from each other in the internal space so as to obtain a sensed pressure value according to a position in the cardiovascular space or to have a cylindrical shape corresponding to the tube in the internal space To obtain a sensed pressure value according to the entire cardiovascular location,
The heart disease judgment unit compares a pressure value sensed by the piezoelectric sensor with a predetermined normal pattern to generate a heart disease alert signal when the pressure value is lower than a predetermined range,
Wherein the heart disease judgment unit compares a sensed waveform of the electrocardiogram sensor with a normal waveform and generates a heart disease alert signal when the sensed waveform exceeds a preset range.

[2] The method according to claim 1,
A transmission unit formed in the internal space, for transmitting sensed values of the piezoelectric sensor and the electrocardiogram sensor to the external device; And a microprocessor formed in the inner space, the microprocessor controlling the operation of the piezoelectric sensor, the electrocardiogram sensor, and the transmitting unit.

The method according to claim 1,
Wherein when the plurality of piezoelectric sensors are spaced apart from each other, an average value of sensed values according to positions in the cardiovascular system is calculated as pressure due to blood flow.

The method according to claim 1,
The piezoelectric sensor includes:
Wherein the electrocardiographic sensor, the transmission unit, and the microprocessor are capable of supplying power to the electrocardiogram sensor, the transmission unit, and the microprocessor by converting the pressure due to the blood flow into electrical energy.

The method according to claim 1,
Wherein,
And a plurality of nodes connected to the cardiovascular tissue and connected in a zigzag manner so that the stent can be fixed inside the cardiovascular system,
Wherein a thickness of the nodule increases from the center of the outer circumference cell toward both ends of the outer circumference cell.

The method according to claim 1,
Wherein a coating for preventing cardiovascular tissue penetration is formed between the outer circumference cell and the heart disease sensing unit.

The stent of any one of claims 1 to 6,
And a mobile terminal for determining whether or not a heart disease has occurred using the sensed value transmitted from the stent, and displaying the heart disease.