CN108994447A - A kind of medical instrument on-line monitoring preparation system and method based on femtosecond laser - Google Patents

A kind of medical instrument on-line monitoring preparation system and method based on femtosecond laser Download PDF

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Publication number
CN108994447A
CN108994447A CN201811062102.0A CN201811062102A CN108994447A CN 108994447 A CN108994447 A CN 108994447A CN 201811062102 A CN201811062102 A CN 201811062102A CN 108994447 A CN108994447 A CN 108994447A
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China
Prior art keywords
femtosecond laser
medical instrument
chirped pulse
amplification device
reflective mirror
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CN201811062102.0A
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Chinese (zh)
Inventor
于志浩
杨骐戎
匡传富
张勇浩
郑俊荣
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Beijing Qingmuzi Science And Technology Development Co Ltd
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Beijing Qingmuzi Science And Technology Development Co Ltd
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Priority to CN201811062102.0A priority Critical patent/CN108994447A/en
Publication of CN108994447A publication Critical patent/CN108994447A/en
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B23MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23KSOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00Working by laser beam, e.g. welding, cutting or boring
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B23MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23KSOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00Working by laser beam, e.g. welding, cutting or boring
    • B23K26/70Auxiliary operations or equipment
    • B23K26/702Auxiliary equipment

Abstract

The invention discloses a kind of, and the medical instrument based on femtosecond laser monitors preparation system and method on-line, and system includes: multistage femtosecond laser regenerative amplification system, focuses micro imaging system, Ultra-precision Turning digital Platform and computer.Device and method provided by the present invention prepares medical instrument using femtosecond laser technology and is especially degradable angiocarpy bracket, and technique is advanced, reliable and stable, processing precise, high yield rate;The system integration optical electromechanical module, using computer software control, it can be achieved that the ultraprecise Digital manufacturing of arbitrary graphic pattern, high degree of automation, guaranteed efficiency and quality;The system includes micro imaging system, can monitor femtosecond laser machine process and effect on-line, and real-time perfoming parameter adjusts, and great convenience applies to the system to process other field accurate device.

Description

A kind of medical instrument on-line monitoring preparation system and method based on femtosecond laser
Technical field
The present invention relates to femtosecond laser applied technical fields, and in particular to a kind of medical instrument based on femtosecond laser is online Monitor preparation system and method.
Background technique
Angiocarpy bracket is that common medical instrument, traditional metallic support itself have thrombus in cardiovascular interventional operation Source property, late result are unsatisfactory.Degradable angiocarpy bracket can voluntarily be dissolved after acute stage in vivo, avoid part The adverse consequences such as inflammatory reaction.Degradable angiocarpy bracket common at present mainly has braiding-winding bracket, plane photoetching coiling welded Bracket, three-dimensional laser engraving bracket etc..That there are intensity is poor for braiding-winding bracket, deforms non-uniform problem;Plane photoetching volume The bracket of soldering method preparation is difficult to meet forming requirements;Traditional three-dimensional laser engraving technology be inevitably present fuel factor and Workpiece deformation, uneven cutting will lead to bracket and the phenomenon that partial denaturization and stress concentration occur, it is caused to make blood vessel At damage local mechanical performance decline, and it is difficult to be degraded.
Femtosecond laser is with characteristics such as its extremely short pulse width, high instantaneous power and apparent nonlinear effects.When Femto-second laser pulse and when matter interaction, whole energy are injected into the zone of action in a very short period of time, when pulse persistance Between be much smaller than material internal excited electron relaxation time, thermal diffusion is inherently eliminated, so that femtosecond laser processing technology exists Field of micro-Na manufacture embodies the advantages that machining accuracy is high, damage threshold is low, non-contact pollution-free, navigates in biologic medical, aviation It, the key areas such as electronic communication there is boundless application prospect.Therefore, there is an urgent need to a kind of femtosecond laser processing technologies Degradable angiocarpy bracket is especially preferably to prepare medical instrument.
Summary of the invention
In view of the deficiencies in the prior art, the purpose of the present invention is to provide a kind of Medical treatment devices based on femtosecond laser Tool monitors preparation system and method on-line, prepares medical instrument using femtosecond laser technology and is especially degradable angiocarpy bracket, Technique is advanced, reliable and stable, processing precise, high yield rate.
To achieve the above object, The technical solution adopted by the invention is as follows:
A kind of medical instrument on-line monitoring preparation system based on femtosecond laser, comprising: multistage femtosecond laser regenerative amplification System focuses micro imaging system, Ultra-precision Turning digital Platform and computer;
It is described multistage femtosecond laser regenerative amplification system be used for by the femtosecond laser of generation export to it is described focus it is micro- at As system, the machined parameters of the computer medical instrument for receiving input and according to the machined parameters to the superfinishing Close manufacturing digitally platform sends control instruction, and the Ultra-precision Turning digital Platform is used to be aligned according to the control instruction It is moved in the target sample of machining area, the femtosecond laser pair for focusing micro imaging system and being used to pass through input The target sample of the machining area carries out laser engraving.
Further, a kind of medical instrument based on femtosecond laser as described above monitors preparation system, the multistage on-line Femtosecond laser regenerative amplification system includes: horizontally arranged oscillator and chirped pulse amplification device, and the oscillator goes out Optical port is opposite with the light inlet of the chirped pulse amplification device;
The oscillator is for generating femtosecond laser and exporting to the chirped pulse amplification device, the chirped pulse amplification It exports after the femtosecond laser amplification that device is used to input to the focusing micro imaging system.
Further, a kind of medical instrument based on femtosecond laser as described above monitors preparation system, the focusing on-line Micro imaging system includes: lighting source, spectroscope, high reflective mirror and the microcobjective that vertical direction is set gradually from top to bottom, And horizontally arranged CCD camera, the camera lens of the lighting source and the CCD camera is opposite with the spectroscope, The light-emitting window of the chirped pulse amplification device is opposite with the high reflective mirror, and the high reflective mirror is also opposite with the microcobjective, institute CCD camera is stated to connect with the computer;
The femtosecond laser of the oscillator output is irradiated on the high reflective mirror through the chirped pulse amplification device, passes through institute It states high reflective mirror to be reflected on the microcobjective, the Ultra-precision Turning digital Platform is focused on by the microcobjective Machining area;
The light that the lighting source issues is irradiated on the microcobjective through the spectroscope and the high reflective mirror, is passed through The microcobjective focuses on the machining area of the Ultra-precision Turning digital Platform.
Further, a kind of medical instrument based on femtosecond laser as described above monitors preparation system, the superfinishing on-line Close manufacturing digitally platform includes: the linear displacement platform connecting with the computer and turntable and sample clamp, the sample Product fixture is located at the focusing of the microcobjective and is fixed on the rotation translation stage by adapter, and the turntable is solid It is scheduled on the linear displacement platform;The sample clamp is for clamping the target sample;
The linear displacement platform and the turntable are used for according to the control instruction to the institute for being located at the machining area The target sample for stating sample clamp clamping is moved.
Further, a kind of medical instrument based on femtosecond laser as described above monitors preparation system, the superfinishing on-line Close manufacturing digitally platform further include: automatically controlled optical shutter, the automatically controlled optical shutter are located at the light out of the chirped pulse amplification device Between mouth and the high reflective mirror;
The automatically controlled optical shutter is used to adjust the brightness of the femtosecond laser of the chirped pulse amplification device output.
Further, a kind of medical instrument based on femtosecond laser as described above monitors preparation system on-line, described high anti- The angle between laser optical path that the mirror surface of mirror and the chirped pulse amplification device issue is the first predetermined angle, the spectroscope Mirror surface and horizontal direction between angle be the second predetermined angle.
Further, a kind of medical instrument on-line monitoring preparation system based on femtosecond laser as described above, described first Predetermined angle is 45 degree, and second predetermined angle is 45 degree, and the medical instrument is degradable angiocarpy bracket.
Further, a kind of medical instrument based on femtosecond laser as described above monitors preparation system, the light splitting on-line Mirror is Transflective spectroscope, and the high reflective mirror is high to femtosecond laser anti-and to the high saturating eyeglass of imaging.
The embodiment of the present invention also provides a kind of medical instrument based on femtosecond laser and is especially degradable angiocarpy bracket Monitor preparation method on-line, comprising:
S1, the target sample that sample is cut into default size, the target sample is fixed on sample clamp, by institute Sample clamp is stated to be fixed in the rotary shaft of turntable by adapter;
S2, the power supply for connecting oscillator and chirped pulse amplification device, start the oscillator, carry out mode locking, measure and remember The laser parameter for recording the light-emitting window of the oscillator starts the chirped pulse amplification device, is broadened, multistage is amplified and pressure Contracting generates femtosecond pulse, measures and records the laser parameter of the light-emitting window of the chirped pulse amplification device;
S3, the light-emitting window of the chirped pulse amplification device is directed at high reflective mirror, the high reflective mirror is directed at microcobjective, it will Lighting source is directed at spectroscope, spectroscope described in the alignment lens by CCD camera, by the mirror surface of the high reflective mirror and the chirp The angle between laser optical path that pulse amplifier issues is adjusted to the first predetermined angle, by spectroscopical mirror surface and level Angle between direction is adjusted to the second predetermined angle;
S4, starting computer, import the processing graphic pattern of the target sample, input customized processing according to different demands Parameter checks the quality condition of the CCD camera imaging contexts and the target sample, adjusts the position of the microcobjective, Until being imaged clear;
S5, the computer are sent according to the processing graphic pattern and the machined parameters to Ultra-precision Turning digital Platform Control instruction, the Ultra-precision Turning digital Platform are started to work, until be more than preset time, remove the sample clamp and The target sample, processes at one time.
Further, a kind of medical instrument on-line monitoring preparation method based on femtosecond laser as described above, described first Predetermined angle is 45 degree, and second predetermined angle is 45 degree, and the medical instrument is degradable angiocarpy bracket.
The beneficial effects of the present invention are: system and method provided by the present invention is prepared using femtosecond laser technology and is cured It treats instrument and is especially degradable angiocarpy bracket, technique is advanced, reliable and stable, processing precise, high yield rate;The system integration light Electromechanical module is learned, using computer software control, it can be achieved that the ultraprecise Digital manufacturing of arbitrary graphic pattern, high degree of automation, Guaranteed efficiency and quality;The system includes micro imaging system, can monitor femtosecond laser machine process and effect on-line, and in real time Parameter adjustment is carried out, great convenience applies to the system to process other field accurate device.
Detailed description of the invention
Fig. 1 is that a kind of medical instrument based on femtosecond laser provided in the embodiment of the present invention monitors preparation system on-line Structural schematic diagram;
Fig. 2 is that a kind of medical instrument based on femtosecond laser provided in the embodiment of the present invention monitors preparation method on-line Flow diagram;
Fig. 3 is the finished product signal of the degradable angiocarpy bracket prepared using system shown in FIG. 1 and method shown in Fig. 2 Figure.
Specific embodiment
The present invention is described in further detail with specific embodiment with reference to the accompanying drawings of the specification.
As shown in Figure 1, a kind of medical instrument based on femtosecond laser is especially the on-line monitoring of degradable angiocarpy bracket Preparation system, comprising: multistage femtosecond laser regenerative amplification system focuses micro imaging system, Ultra-precision Turning digital Platform With computer 12;
Multistage femtosecond laser regenerative amplification system is used to export the femtosecond laser of generation to micro imaging system is focused, and counts The machined parameters of the medical instrument for receiving input of calculation machine 12 are simultaneously sent out according to machined parameters to Ultra-precision Turning digital Platform Control instruction is sent, and Ultra-precision Turning digital Platform is used to the target sample for being located at machining area is moved according to control instruction It is dynamic, it focuses micro imaging system and is used to carry out laser engraving to the target sample of machining area by the femtosecond laser of input.
Multistage femtosecond laser regenerative amplification system includes: horizontally arranged oscillator 1 and chirped pulse amplification device 2, The light-emitting window of oscillator 1 is opposite with the light inlet of chirped pulse amplification device 2;
For oscillator 1 for generating femtosecond laser and exporting to chirped pulse amplification device 2, chirped pulse amplification device 2 is used for will Output extremely focuses micro imaging system after the femtosecond laser amplification of input.
Focusing micro imaging system includes: the lighting source 6, spectroscope 5, high anti-that vertical direction is set gradually from top to bottom The camera lens of mirror 4 and microcobjective 8 and horizontally arranged CCD camera 7, lighting source 6 and CCD camera 7 is and spectroscope 5 is opposite, and the light-emitting window and high reflective mirror 4 of chirped pulse amplification device 2 are opposite, and high reflective mirror 4 is also opposite with microcobjective 8, CCD camera 7 It is connect with computer 12;
The femtosecond laser that oscillator 1 exports is irradiated on high reflective mirror 4 through chirped pulse amplification device 2, is reflected by high reflective mirror 4 Onto microcobjective 8, the machining area of Ultra-precision Turning digital Platform is focused on by microcobjective 8;
The light that lighting source 6 issues is irradiated on microcobjective 8 through spectroscope 5 and high reflective mirror 4, poly- by microcobjective 8 Coke arrives the machining area of Ultra-precision Turning digital Platform.
Ultra-precision Turning digital Platform includes: the linear displacement platform 11 and turntable 10 connecting with computer 12, and Sample clamp 9, sample clamp 9 are located at the focusing of microcobjective 8 and are fixed on rotation translation stage 10 by adapter, rotation Platform 10 is fixed on linear displacement platform 11;Sample clamp 9 is for clamping target sample;
What linear displacement platform 11 and turntable 10 were used to clamp the sample clamp 9 for being located at machining area according to control instruction Target sample is moved.
Ultra-precision Turning digital Platform further include: automatically controlled optical shutter 3, automatically controlled optical shutter 3 are located at chirped pulse amplification device 2 Light-emitting window and high reflective mirror 4 between;
Automatically controlled optical shutter 3 is used to adjust the brightness of the femtosecond laser of the output of chirped pulse amplification device 2.
The angle between laser optical path that the mirror surface and chirped pulse amplification device 2 of high reflective mirror 4 issue is the first predetermined angle, Angle between the mirror surface and horizontal direction of spectroscope 5 is the second predetermined angle.
First predetermined angle is 45 degree, and the second predetermined angle is 45 degree.First predetermined angle is not limited to 45 degree, and second is pre- If angle is not limited to 45 degree, other angles can also, only in practical operation, which is optimized angle, can make imaging more Clearly.
Spectroscope 5 is Transflective spectroscope, and high reflective mirror 4 is high to femtosecond laser anti-and to the high saturating mirror of imaging Piece.
Working principle is as follows:
Laser along the oscillator 1 output is input to chirped pulse amplification device 2, flies along what chirped pulse amplification device 2 exported Second laser passes sequentially through automatically controlled optical shutter 3, reflects on high reflective mirror 4, the processing district of sample clamp 9 is focused on by microcobjective 8 Domain, sample clamp 9 are fixed on turntable 10, and turntable 10 is fixed on linear displacement platform 11, high reflective mirror 4 and femtosecond laser light Road is in 45 degree angles, and the height of sample clamp 9 makes the focus of microcobjective 8 be located at the inside of processing object, in the vertical of high reflective mirror 4 Histogram is to setting spectroscope 5 and lighting source 6, and spectroscope 5 and horizontal direction are in 45 degree of angles, in the horizontal direction of spectroscope 5 Upper setting CCD camera 7, the light that lighting source 6 is issued focus on sample by microcobjective 8 again after spectroscope 5 and high reflective mirror 4 The machining area of product fixture 9 provides illumination for whole process, Gold Films Irradiated by Femtosecond Laser area by microcobjective 8, spectroscope 5 at Picture simultaneously receives image by CCD camera 7, and CCD camera 7, turntable 10 are connected with linear displacement platform 11 with computer 12, CCD camera 7 Received image input computer 12 simultaneously shows, the motion control of turntable 10 and linear displacement platform 11 by computer 12 program Software, i.e. control module and drive module are completed, and control module internal processor, drive module carries out feedback control by grating scale System is to improve repetitive positioning accuracy.
As shown in Fig. 2, additionally providing a kind of on-line monitoring preparation side of degradable angiocarpy bracket in the embodiment of the present invention Method, comprising:
S1, the target sample that sample is cut into default size, target sample are fixed on sample clamp, by specimen holder Tool is fixed in the rotary shaft of turntable by adapter;
S2, the power supply for connecting oscillator and chirped pulse amplification device start oscillator, carry out mode locking, measure and record vibration The laser parameter of the light-emitting window of device is swung, chirped pulse amplification device is started, is broadened, multistage is amplified and compression, generation femtosecond arteries and veins Impulse light measures and records the laser parameter of the light-emitting window of chirped pulse amplification device;
S3, the light-emitting window of chirped pulse amplification device is directed at high reflective mirror, high reflective mirror is directed at microcobjective, by lighting source It is directed at spectroscope, by the alignment lens spectroscope of CCD camera, the laser that the mirror surface of high reflective mirror and chirped pulse amplification device are issued Angle between optical path is adjusted to the first predetermined angle, and the angle between spectroscopical mirror surface and horizontal direction is adjusted to second Predetermined angle;
S4, starting computer, import the processing graphic pattern of target sample, input customized processing according to different demands and join Number checks the quality condition of CCD camera imaging contexts and target sample, adjusts the position of microcobjective, until being imaged clear;
S5, computer send control instruction to Ultra-precision Turning digital Platform according to processing graphic pattern and machined parameters, surpass Precision Machining digital Platform is started to work, until being more than preset time, removes sample clamp and target sample, time processing is complete At.
After step S5, further includes:
S6, step S1 to step S5 progress batch machining is repeated;
It after S7, process finishing, shuts down computer, oscillator and chirped pulse amplification device.
First predetermined angle is 45 degree, and the second predetermined angle is 45 degree.First predetermined angle is not limited to 45 degree, and second is pre- If angle is not limited to 45 degree, other angles can also, only in practical operation, which is optimized angle, can make imaging more Clearly.
Fig. 3 is the finished product of the degradable angiocarpy bracket prepared using system shown in FIG. 1 and method shown in Fig. 2.
It should be noted that the laser of the light-emitting window of the laser parameter and chirped pulse amplification device of the light-emitting window of oscillator is joined Number includes power and pulsewidth etc., belongs to the prior art.Machined parameters include auto-focusing, processing graphic pattern ratio, xyz translation stage Fast revolving speed, repeat patterns setting are moved, galvanometer position etc. further includes preset time, and computer is by automation control to ultraprecise The linear displacement platform and turntable of manufacturing digitally platform are controlled.Specifically, self-developing can be installed on computers Programming software and computer aided design software, and control femtosecond laser system of processing program, programming software can be real Now process intellectual monitoring is controlled, computer aided design software can carry out precise laser for complex figure structure and add The program of work, control femtosecond laser system of processing can directly control linear displacement platform and turntable.Oscillator mentioned above, The equipment such as chirped pulse amplification device, automatically controlled optical shutter, spectroscope, high reflective mirror, microcobjective are state of the art.Step In S3, the angle between the mirror surface of high reflective mirror and the laser optical path of chirped pulse amplification device sending is adjusted to the first preset angle Degree, is adjusted to the second predetermined angle for the angle between spectroscopical mirror surface and horizontal direction, can in order to be more clear imaging The first predetermined angle and the second predetermined angle are set as 45 degree.High reflective mirror is high to the light of 800nm 400nm wavelength Instead, high to visible light saturating, it is also possible to other wavelength such as 801nm or 802nm.
It can be seen from above-described embodiment that compared with prior art, the invention has the following outstanding advantages:
(1) this method innovatively prepares medical instrument using femtosecond laser technology and is especially degradable angiocarpy bracket, Technique is advanced, reliable and stable, processing precise, high yield rate;
(2) system integration optical electromechanical module, using computer software control, it can be achieved that the ultraprecise number of arbitrary graphic pattern Wordization processing, high degree of automation, guaranteed efficiency and quality;
(3) system includes micro imaging system, can monitor femtosecond laser machine process and effect, and real-time perfoming on-line Parameter adjustment, great convenience apply to the system to process other field accurate device.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technology Within, then the present invention is also intended to include these modifications and variations.

Claims (10)

1. a kind of medical instrument based on femtosecond laser monitors preparation system on-line characterized by comprising multistage femtosecond laser Regenerative amplification system focuses micro imaging system, Ultra-precision Turning digital Platform and computer;
The multistage femtosecond laser regenerative amplification system is for exporting the femtosecond laser of generation to the focusing micro-imaging system System, the machined parameters of the computer medical instrument for receiving input simultaneously add according to the machined parameters to the ultraprecise Work digital Platform send control instruction, the Ultra-precision Turning digital Platform be used for according to the control instruction to be located at plus The target sample in work area domain is moved, and the micro imaging system that focuses is used for the femtosecond laser by input to described The target sample of machining area carries out laser engraving.
2. a kind of medical instrument based on femtosecond laser according to claim 1 monitors preparation system on-line, feature exists In the multistage femtosecond laser regenerative amplification system includes: horizontally arranged oscillator and chirped pulse amplification device, described The light-emitting window of oscillator is opposite with the light inlet of the chirped pulse amplification device;
The oscillator for generating femtosecond laser and exporting to the chirped pulse amplification device, use by the chirped pulse amplification device It exports after the femtosecond laser amplification that will be inputted to the focusing micro imaging system.
3. a kind of medical instrument based on femtosecond laser according to claim 2 monitors preparation system on-line, feature exists In the micro imaging system that focuses includes: lighting source, spectroscope, the high reflective mirror that vertical direction is set gradually from top to bottom And microcobjective and horizontally arranged CCD camera, the camera lens of the lighting source and the CCD camera with it is described Spectroscope is opposite, and the light-emitting window of the chirped pulse amplification device is opposite with the high reflective mirror, the high reflective mirror also with it is described micro- Object lens are opposite, and the CCD camera is connect with the computer;
The femtosecond laser of the oscillator output is irradiated on the high reflective mirror through the chirped pulse amplification device, passes through the height Anti- mirror is reflected on the microcobjective, and the processing of the Ultra-precision Turning digital Platform is focused on by the microcobjective Region;
The light that the lighting source issues is irradiated on the microcobjective through the spectroscope and the high reflective mirror, by described Microcobjective focuses on the machining area of the Ultra-precision Turning digital Platform.
4. a kind of medical instrument based on femtosecond laser according to claim 1 monitors preparation system on-line, feature exists In the Ultra-precision Turning digital Platform includes: the linear displacement platform connecting with the computer and turntable and sample Fixture, the sample clamp are located at the focusing of the microcobjective and are fixed on the rotation translation stage by adapter, The turntable is fixed on the linear displacement platform;The sample clamp is for clamping the target sample;
The linear displacement platform and the turntable are used for according to the control instruction to the sample for being located at the machining area The target sample of product fixture clamping is moved.
5. a kind of medical instrument based on femtosecond laser according to claim 1 monitors preparation system on-line, feature exists In the Ultra-precision Turning digital Platform further include: automatically controlled optical shutter, the automatically controlled optical shutter are located at the chirped pulse and put Between the light-emitting window and the high reflective mirror of big device;
The automatically controlled optical shutter is used to adjust the brightness of the femtosecond laser of the chirped pulse amplification device output.
6. a kind of medical instrument based on femtosecond laser according to claim 2 monitors preparation system on-line, feature exists In the angle between laser optical path that the mirror surface of the high reflective mirror and the chirped pulse amplification device issue is the first preset angle Degree, the angle between spectroscopical mirror surface and horizontal direction is the second predetermined angle.
7. a kind of medical instrument based on femtosecond laser according to claim 6 monitors preparation system on-line, feature exists In first predetermined angle is 45 degree, and second predetermined angle is 45 degree, and the medical instrument is degradable cardiovascular branch Frame.
8. a kind of medical instrument based on femtosecond laser according to claim 1 monitors preparation system on-line, feature exists In the spectroscope is Transflective spectroscope, and the high reflective mirror is high to femtosecond laser anti-and to the high saturating mirror of imaging Piece.
9. based on a kind of described in any item medical instrument on-line monitoring preparation systems based on femtosecond laser of claim 1-8 A kind of medical instrument on-line monitoring preparation method based on femtosecond laser characterized by comprising
S1, the target sample that sample is cut into default size, the target sample is fixed on sample clamp, by the sample Product fixture is fixed in the rotary shaft of turntable by adapter;
S2, the power supply for connecting oscillator and chirped pulse amplification device, start the oscillator, carry out mode locking, measure and record institute The laser parameter for stating the light-emitting window of oscillator starts the chirped pulse amplification device, is broadened, multistage is amplified and compression, production Raw femtosecond pulse, measures and records the laser parameter of the light-emitting window of the chirped pulse amplification device;
S3, the light-emitting window of the chirped pulse amplification device is directed at high reflective mirror, the high reflective mirror is directed at microcobjective, will be illuminated Source alignment spectroscope, spectroscope described in the alignment lens by CCD camera, by the mirror surface of the high reflective mirror and the chirped pulse The angle between laser optical path that amplifier issues is adjusted to the first predetermined angle, by spectroscopical mirror surface and horizontal direction Between angle be adjusted to the second predetermined angle;
S4, starting computer, import the processing graphic pattern of the target sample, input customized processing according to different demands and join Number, checks the quality condition of the CCD camera imaging contexts and the target sample, adjusts the position of the microcobjective, directly It is clear to being imaged;
S5, the computer send to Ultra-precision Turning digital Platform according to the processing graphic pattern and the machined parameters and control Instruction, the Ultra-precision Turning digital Platform are started to work, until be more than preset time, remove the sample clamp and described Target sample processes at one time.
10. a kind of medical instrument based on femtosecond laser according to claim 9 monitors preparation method on-line, feature exists In first predetermined angle is 45 degree, and second predetermined angle is 45 degree, and the medical instrument is degradable cardiovascular branch Frame.
CN201811062102.0A 2018-09-12 2018-09-12 A kind of medical instrument on-line monitoring preparation system and method based on femtosecond laser Pending CN108994447A (en)

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CN107335923A (en) * 2017-06-09 2017-11-10 中国科学院上海光学精密机械研究所 Femtosecond laser space-time focuses on metal surface high throughput processes apparatus and method
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CN111257301A (en) * 2020-03-13 2020-06-09 北京青木子科技发展有限公司 Raman spectrometer system based on low-cost refrigeration type CMOS detector
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