CN108992575A - A kind of rhizoma polygonati piece production method - Google Patents

A kind of rhizoma polygonati piece production method Download PDF

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Publication number
CN108992575A
CN108992575A CN201811131424.6A CN201811131424A CN108992575A CN 108992575 A CN108992575 A CN 108992575A CN 201811131424 A CN201811131424 A CN 201811131424A CN 108992575 A CN108992575 A CN 108992575A
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China
Prior art keywords
rhizoma polygonati
powder
production method
dandelion
impurity
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Pending
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CN201811131424.6A
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Chinese (zh)
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文华
何华君
奉欢
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Peng'an Dasheng Agricultural Co Ltd
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Peng'an Dasheng Agricultural Co Ltd
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Priority to CN201811131424.6A priority Critical patent/CN108992575A/en
Publication of CN108992575A publication Critical patent/CN108992575A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
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  • Microbiology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a kind of rhizoma polygonati piece production method, pre-treatment: rhizoma polygonati (1/2 amount): being cleaned, 100 mesh of pulverized powder, and rhizoma polygonati powder is made in sterilizing;Rhizoma polygonati (1/2 amount): impurity is removed;Dandelion: impurity is removed;It extracts: by the rhizoma polygonati of decontamination, dandelion, adding 10-12 times of water to measure, decoction is secondary, and it is 2-3 hours each, it filters respectively, merging filtrate, the thick paste for being concentrated into relative density 1.30 is spare;Granulation: will be ground into the rhizoma polygonati powder of fine powder, puts into clean trough-type mixture machine, thickens the soup cream mixing 20-40 minutes, is allowed to uniformly, softwood be made, crosses 16 mesh screens, pelletizes and dry, moisture≤8%;Total mix: the particle made is put into two-dimensional mixing machine, is allowed to uniformly mixed;Tabletting: the test running, debugging plus lubricant of equipment: inner packing, outer packing, storage are first carried out before tabletting.Rhizoma polygonati slice prescription of the present invention is obtained by experiment repeatedly, then by its production method, extracts the effective component in raw material as far as possible, raw material is adequately used.

Description

A kind of rhizoma polygonati piece production method
Technical field
The present invention relates to technical field of traditional Chinese medicines, in particular to a kind of rhizoma polygonati piece production method.
Background technique
Rhizoma polygonati also known as tendrilleaf solomonseal rhizome, chicken head ginseng.Liliaceae herbaceous plant rhizoma polygonati, polygonatum kingianurn, polygonatum cyrtonema rhizome.Once by Li Shizhen (1518-1593 A.D.) is described as " precious medicine ", can treat a variety of diseases and men and women, old and young's health food suitable for four seasons.It being capable of tonifying spleen profit Lung, promotes the production of body fluid to quench thirst at supplementing qi and nourishing yin, and sweet in flavor, it is mild-natured and, person in poor health is also acceptant, and it is tired to be suitable for deficiency-cold in spleen and stomach, body Out of strength, tired spirit, dryness of the lung dry cough are quenched one's thirst and the edible for patients such as impotence.It is very effective in cure for diabetes.Pharmacological research hair Existing, rhizoma polygonati has blood pressure lowering, inhibits hyperglycemia, and the prevention and treatment pharmacological actions such as atherosclerosis and liver fatty infiltration.According to money Material introduce, be main ingredient with rhizoma polygonati, be equipped with other Chinese medicines, to treatment hemoptysis of pulmonary tuberculosis, coronary heart diseases and angina pectoris, dryness of the lung dry cough and Pertussis etc. has significant curative effect.The work rhythm of modern society is getting faster, and life stress is on the rise, many male compatriot by It is sat in an office in long-term, is easy to appear that soreness and weakness of waist and knees, dysphoria in chestpalms-soles, chilly is cold, underbelly is uncomfortable, difficult urination, impotence Premature ejaculation and the symptoms such as infertile, are unfavorable for the health of the people.
Currently, the type of the rhizoma polygonati piece of the prior art has certain limitation, when preparing, not by the effective of medicinal material Ingredient adequately utilizes, and keeps its curative effect bad.
Summary of the invention
Object of the present invention is to overcome the deficiencies of the prior art and provide a kind of to produce simple, the apparent rhizoma polygonati piece of effect life Production method.
A kind of rhizoma polygonati piece production method of the present invention, comprising the following steps:
1, pre-treatment:
Rhizoma polygonati (1/2 amount): cleaning, 100 mesh of pulverized powder, and rhizoma polygonati powder is made in sterilizing;
Rhizoma polygonati (1/2 amount): impurity is removed;
Dandelion: impurity is removed;
2, it extracts: by the rhizoma polygonati of decontamination, dandelion, adding 10-12 times of water to measure, decoction is secondary, and it is 2-3 hours each, it filters respectively, Merging filtrate is concentrated into relative density 1.30(600C) thick paste it is spare;
3, it pelletizes: the rhizoma polygonati powder of fine powder will be ground into, put into clean trough-type mixture machine, thicken the soup cream mixing 20-40 minutes, make It is that softwood uniformly is made, 16 mesh screens are crossed, are pelletized and dry, moisture≤8%;
4, total mix: the particle made is put into two-dimensional mixing machine, is allowed to uniformly mixed;
5, the test running, debugging plus lubricant of equipment first tabletting: are carried out before tabletting;
6, inner packing, outer packing;
7, it is put in storage.
Rhizoma polygonati slice prescription of the present invention is obtained by experiment repeatedly, then by its production method, makes the effective component in raw material It extracts as far as possible, raw material is adequately used.And by compatibility, the pharmacological property of rhizoma polygonati is improved, to people's waist and knee acid The symptoms good effects such as soft, chilly is cold, difficult urination, impotence and premature ejaculation.
Specific embodiment
A kind of embodiment 1: rhizoma polygonati piece production method, comprising the following steps:
1, pre-treatment:
Rhizoma polygonati (1/2 amount): cleaning, 100 mesh of pulverized powder, and rhizoma polygonati powder is made in sterilizing;
Rhizoma polygonati (1/2 amount): impurity is removed;
Dandelion: impurity is removed;
2, it extracts: by the rhizoma polygonati of decontamination, dandelion, adding 12 times of water amounts, decoction is secondary, 2 hours every time, filters respectively, merges Filtrate is concentrated into relative density 1.30(600C) thick paste it is spare;
3, it pelletizes: the rhizoma polygonati powder of fine powder will be ground into, put into clean trough-type mixture machine, the cream that thickens the soup mixes 30 minutes, is allowed to Uniformly, softwood is made, crosses 16 mesh screens, pelletizes and dry, moisture≤8%;
4, total mix: the particle made is put into two-dimensional mixing machine, is allowed to uniformly mixed;
5, the test running, debugging plus lubricant of equipment first tabletting: are carried out before tabletting;
6, inner packing, outer packing;
7, it is put in storage.
A kind of embodiment 2: rhizoma polygonati piece production method, comprising the following steps:
1, pre-treatment:
Rhizoma polygonati (1/2 amount): cleaning, 100 mesh of pulverized powder, and rhizoma polygonati powder is made in sterilizing;
Rhizoma polygonati (1/2 amount): impurity is removed;
Dandelion: impurity is removed;
2, it extracts: by the rhizoma polygonati of decontamination, dandelion, adding 10 times of water amounts, decoction is secondary, 3 hours every time, filters respectively, merges Filtrate is concentrated into relative density 1.30(600C) thick paste it is spare;
3, it pelletizes: the rhizoma polygonati powder of fine powder will be ground into, put into clean trough-type mixture machine, the cream that thickens the soup mixes 40 minutes, is allowed to Uniformly, softwood is made, crosses 16 mesh screens, pelletizes and dry, moisture≤8%;
4, total mix: the particle made is put into two-dimensional mixing machine, is allowed to uniformly mixed;
5, the test running, debugging plus lubricant of equipment first tabletting: are carried out before tabletting;
6, inner packing, outer packing;
7, it is put in storage.

Claims (1)

1. a kind of rhizoma polygonati piece production method, it is characterised in that: the following steps are included:
(1) pre-treatment:
Rhizoma polygonati (1/2 amount): cleaning, 100 mesh of pulverized powder, and rhizoma polygonati powder is made in sterilizing;
Rhizoma polygonati (1/2 amount): impurity is removed;
Dandelion: impurity is removed;
(2) it extracts: by the rhizoma polygonati of decontamination, dandelion, adding 10-12 times of water to measure, decoction is secondary, and it is 2-3 hours each, it filters respectively It crosses, merging filtrate, the thick paste for being concentrated into relative density 1.30 is spare;
(3) it pelletizes: the rhizoma polygonati powder of fine powder will be ground into, put into clean trough-type mixture machine, thicken the soup cream mixing 20-40 minutes, It is allowed to uniformly, softwood be made, crosses 16 mesh screens, pelletize and dry, moisture≤8%;
(4) total mix: the particle made is put into two-dimensional mixing machine, is allowed to uniformly mixed;
(5) test running, debugging plus lubricant of equipment first tabletting: are carried out before tabletting;
(6) inner packing, outer packing;
(7) it is put in storage.
CN201811131424.6A 2018-09-27 2018-09-27 A kind of rhizoma polygonati piece production method Pending CN108992575A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811131424.6A CN108992575A (en) 2018-09-27 2018-09-27 A kind of rhizoma polygonati piece production method

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Application Number Priority Date Filing Date Title
CN201811131424.6A CN108992575A (en) 2018-09-27 2018-09-27 A kind of rhizoma polygonati piece production method

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103623222A (en) * 2013-11-27 2014-03-12 泸州百草堂健康产品有限公司 Food, health-care product or medicinal composition with liver-protecting effect
CN106620349A (en) * 2017-01-11 2017-05-10 成都中医药大学 Medicine composition for nourishing yin of lung and kidney, cooling blood and realizing hemostasis and preparation method of medicine composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103623222A (en) * 2013-11-27 2014-03-12 泸州百草堂健康产品有限公司 Food, health-care product or medicinal composition with liver-protecting effect
CN106620349A (en) * 2017-01-11 2017-05-10 成都中医药大学 Medicine composition for nourishing yin of lung and kidney, cooling blood and realizing hemostasis and preparation method of medicine composition

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
岳桂华: "《名老中医用药心得 第2辑》", 28 February 2013, 人民军医出版社 *
青海省卫生局: "《青海省药品标准 1976》", 31 December 1976 *

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Application publication date: 20181214