CN108969575A - A kind of pharmaceutical composition and its preparation method and application for treating canker sore and exanthemv - Google Patents
A kind of pharmaceutical composition and its preparation method and application for treating canker sore and exanthemv Download PDFInfo
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- CN108969575A CN108969575A CN201811171719.6A CN201811171719A CN108969575A CN 108969575 A CN108969575 A CN 108969575A CN 201811171719 A CN201811171719 A CN 201811171719A CN 108969575 A CN108969575 A CN 108969575A
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- exanthemv
- pharmaceutical composition
- canker sore
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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Abstract
The present invention relates to a kind of pharmaceutical compositions and preparation method thereof for treating canker sore and exanthemv, the treatment canker sore and the pharmaceutical composition of exanthemv are by using copper sulphate, talcum powder and indigo naturalis powder are raw material and carry out being suitble to weight proportion, when preparation, it first prepares and obtains copper-bath, talcum powder is added into copper-bath again, so that talcum powder is well-dispersed in copper-bath, realize that a small amount of copper sulphate is mixed with the uniform of a large amount of talcum powder, mixed material is obtained after evaporating moisture, mixed material and indigo naturalis powder are sufficiently mixed later, the composition being finally prepared, each component is able to be sufficiently mixed uniformly, analgesic can be played, hypnosis, help the function of raw saliva and hematopoiesis, with the curative effect for curing canker sore and other exanthemvs.
Description
Technical field
The invention belongs to technical field of Chinese medicine, and in particular to a kind of pharmaceutical composition for treating canker sore and exanthemv
Object and preparation method thereof.
Background technique
Canker sore is commonly called as " aphtha ", is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, is more common in
The positions such as lip inside, tongue, tongue abdomen, cheek mucous membrane, vestibular ditch, soft palate, the mucous membrane at these positions lack keratinization layer or angling compared with
Difference.Tongue ulcer refers to the canker sore for betiding tongue, tongue abdomen position.Sharp ache when canker sore is broken out, local cusalgia are bright
Aobvious, serious person also will affect diet, speak, and cause very big inconvenience to daily life；It can concurrent halitosis, chronic pharyngitis, constipation, head
Bitterly, the constitutional symptoms such as dizzy, nauseous, out of strength, irritated, fever, enlargement of lymph nodes.
Exanthemv, usually by wound, microorganism infection, tumour, dyshaemia and neurological dysfunction, immune function
Limitation Skin preparation caused by abnormal or congenital defect of skin etc..Exanthemv is secondary lesion, all skin injuries,
Infection or the damage of tubercle ulceration up to certain depth can lead to the generation of exanthemv.
Canker sore is treated now and there are many drug treatment of exanthemv, and treatment with western effect is clear, rises
It is short to imitate the time, but adverse reaction is larger.Traditional chinese medicine medicament treatment adverse reaction is small, highly-safe, but lacks unified effective Chinese medicine
Preparation.
Summary of the invention
In order to solve the above problems existing in the present technology, canker sore and exanthemv are treated the present invention provides a kind of
Pharmaceutical composition and preparation method thereof, the composition can play analgesic, hypnosis, the function of helping raw saliva and hematopoiesis, tool
There is the curative effect for curing canker sore and other exanthemvs.
The technical scheme adopted by the invention is as follows:
A kind of pharmaceutical composition for treating canker sore and exanthemv, raw material components include:
Copper sulphate 1-3 parts by weight, talcum powder 100-200 parts by weight, indigo naturalis powder 200-300 parts by weight.
The raw material components of pharmaceutical composition of the further preferably described treatment canker sore and exanthemv include:
Copper sulphate 1.5-2.5 parts by weight, talcum powder 130-170 parts by weight, indigo naturalis powder 230-270 parts by weight.
The raw material components of pharmaceutical composition of the further preferably described treatment canker sore and exanthemv include:
2 parts by weight of copper sulphate, 150 parts by weight of talcum powder, 250 parts by weight of indigo naturalis powder.
Further, the dosage form of the pharmaceutical composition is appointing in tablet, granule, syrup, pill and effervescent tablet
It is a kind of.
The preparation method of the treatment canker sore and the pharmaceutical composition of exanthemv, comprising the following steps:
(1) after taking copper sulphate to be dissolved in water, copper-bath is obtained；
(2) talcum powder is added into the copper-bath, is sufficiently mixed uniformly, obtains suspension；It evaporates described outstanding
Moisture in turbid, obtains mixed material；
(3) indigo naturalis powder is added into mixed material obtained by step (2), is sufficiently mixed and uniformly bursts to get the treatment oral cavity
The pharmaceutical composition of ulcer and exanthemv.
Further, it in step (1), after being dissolved in water, is also filtered.
Further, in step (1), the mass ratio of the copper sulphate and addition water is 1:70-1:90.
Further, in step (2), the nature that is evaporated to of moisture is dried or is dried in the suspension.
Further, in step (2), the partial size of the talcum powder is 1000-1500 mesh；In step (3), the indigo naturalis powder
Partial size be 1200-1500 mesh.
It underdraws below to raw material essential information in the present invention.
Copper sulphate, inorganic compound, chemical formula CuSO4.For white or pale powder.Aqueous solution is weakly acidic, shows indigo plant
Color.But when crystallizing from aqueous solution, the cupric sulfate pentahydrate (CuSO of blue is generated4·5H2O, also known as blue stone).It is heated to lose crystallization
It is decomposed after water, it is very stable at normal temperatures and pressures, it does not deliquesce, it can gradually weathering in dry air.
Talcum powder, white or off-white color, fine, without grittiness powder, hand touches with greasy feeling, odorless, tasteless.With relieving inflammation or internal heat
The effect of resolving sputum, inducing diuresis for treating strangurtia, clearing away summerheat, hygroscopic sore.This product has absorption and astriction, for oral administration to protect intestinal wall.It is sliding
Mountain flour dispenses the surface of a wound and forms envelope, there is the protection surface of a wound, absorbs secretion, promotes the effect of incrustation.In vitro, 10% talcum powder pair
Typhoid bacillus, paratyphoid bacillus A have inhibiting effect.
Indigo naturalis powder, property is salty, cold, return liver warp.Effect: clearing heat and detoxicating, blood cooling and ecchymoses removing, purging intense heat arresting convulsion, primary treatment temperature
Malicious macular eruption, blood-head tells nosebleed, pectoralgia hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.
The invention has the benefit that
The pharmaceutical composition for the treatment of canker sore and exanthemv of the present invention, by using copper sulphate, talcum powder
It is raw material with indigo naturalis powder and carries out being suitble to weight proportion, when preparation, first prepares and obtain copper-bath, then into copper-bath
Talcum powder is added, so that talcum powder is well-dispersed in copper-bath, realizes the uniform of a small amount of copper sulphate and a large amount of talcum powder
Mixing, obtains mixed material after evaporating moisture, is later sufficiently mixed mixed material and indigo naturalis powder, is finally prepared
Composition, each component is able to be sufficiently mixed uniformly, can play analgesic, hypnosis, the function of helping raw saliva and hematopoiesis, have and control
More the curative effect of canker sore and other exanthemvs.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiment is only a part of the embodiments of the present invention, instead of all the embodiments.
Based on the embodiments of the present invention, those of ordinary skill in the art obtained institute without making creative work
There is other embodiment, belongs to the range that the present invention is protected.
Embodiment 1
The present embodiment provides a kind of pharmaceutical composition for treating canker sore and exanthemv, raw material components include:
Copper sulphate 1g, talcum powder 100g, indigo naturalis powder 200g.
The preparation method of the treatment canker sore and the pharmaceutical composition of exanthemv, comprising the following steps:
(1) copper sulphate is taken to be dissolved in water, the mass ratio of the copper sulphate and addition water is 1:70-1:90, obtains copper sulphate
Solution, and be filtered；
(2) talcum powder that partial size is 1000-1500 mesh is added into the copper-bath, is sufficiently mixed uniformly, obtains
Suspension；By drying naturally or the mode of drying evaporates moisture in the suspension, mixed material is obtained；
(3) the indigo naturalis powder that partial size is 1200-1500 mesh is added into mixed material obtained by step (2), is sufficiently mixed uniformly,
Up to the pharmaceutical composition of the treatment canker sore and exanthemv.
Embodiment 2
The present embodiment provides a kind of pharmaceutical composition for treating canker sore and exanthemv, raw material components include:
Copper sulphate 3g, talcum powder 200g, indigo naturalis powder 300g.
The preparation method of the treatment canker sore and the pharmaceutical composition of exanthemv, comprising the following steps:
(1) copper sulphate is taken to be dissolved in water, the mass ratio of the copper sulphate and addition water is 1:70-1:90, obtains copper sulphate
Solution, and be filtered；
(2) talcum powder that partial size is 1000-1500 mesh is added into the copper-bath, is sufficiently mixed uniformly, obtains
Suspension；By drying naturally or the mode of drying evaporates moisture in the suspension, mixed material is obtained；
(3) the indigo naturalis powder that partial size is 1200-1500 mesh is added into mixed material obtained by step (2), is sufficiently mixed uniformly,
Up to the drug of the treatment canker sore and exanthemv.
Embodiment 3
The present embodiment provides a kind of pharmaceutical composition for treating canker sore and exanthemv, raw material components include:
Copper sulphate 2g, talcum powder 150g, indigo naturalis powder 250g.
The preparation method of the treatment canker sore and the pharmaceutical composition of exanthemv, comprising the following steps:
(1) copper sulphate is taken to be dissolved in water, the mass ratio of the copper sulphate and addition water is 1:70-1:90, obtains copper sulphate
Solution, and be filtered；
(2) talcum powder that partial size is 1000-1500 mesh is added into the copper-bath, is sufficiently mixed uniformly, obtains
Suspension；By drying naturally or the mode of drying evaporates moisture in the suspension, mixed material is obtained；
(3) the indigo naturalis powder that partial size is 1200-1500 mesh is added into mixed material obtained by step (2), is sufficiently mixed uniformly,
Up to the pharmaceutical composition of the treatment canker sore and exanthemv.
Experimental example
Effect test is carried out to treatment canker sore obtained by embodiment 3 and the pharmaceutical composition of exanthemv
1, subjects: suffering from 68 people of oral ulcer, and the regardless of sex and age is divided into two groups, and every group of 34 people order respectively
Entitled experimental group and control group.
2, test process: experimental group patient takes pharmaceutical composition produced by the present invention orally, and control group patient is for oral administration a kind of non-
Drug made from the method for the present invention.It allows subject using one day respectively, then inquires that subject takes effect.
3, test result judgment criteria: (1) effective: original symptom disappears, and restores normal at ulcer；(2) effectively: original each
Symptom mitigates, and function is improved；(3) invalid: symptom is unchanged.
4, test result: it is shown in Table 1.
1 test result of table
| Group | Number | It is effective | Effectively | In vain | Efficient (%) |
| Experimental group | 34 | 30 | 4 | 0 | 100 |
| Control group | 34 | 17 | 11 | 6 | 82.4 |
From table 1 it follows that treatment canker sore of the present invention and the pharmaceutical composition of exanthemv burst to oral cavity
Ulcer has good therapeutic effect, works rapidly, cure rate 100%.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of pharmaceutical composition for treating canker sore and exanthemv, which is characterized in that raw material components include:
Copper sulphate 1-3 parts by weight, talcum powder 100-200 parts by weight, indigo naturalis powder 200-300 parts by weight.
2. the pharmaceutical composition for the treatment of canker sore and exanthemv according to claim 1, which is characterized in that raw material group
Divide and includes:
Copper sulphate 1.5-2.5 parts by weight, talcum powder 130-170 parts by weight, indigo naturalis powder 230-270 parts by weight.
3. the pharmaceutical composition for the treatment of canker sore and exanthemv according to claim 1, which is characterized in that raw material group
Divide and includes:
2 parts by weight of copper sulphate, 150 parts by weight of talcum powder, 250 parts by weight of indigo naturalis powder.
4. pharmaceutical composition according to claim 1-3, which is characterized in that the dosage form of described pharmaceutical composition is
Any one of tablet, granule, syrup, pill and effervescent tablet.
5. the preparation method of a kind of any one of claim 1-3 treatment canker sore and the pharmaceutical composition of exanthemv,
Characterized by comprising the following steps:
(1) after taking copper sulphate to be dissolved in water, copper-bath is obtained；
(2) talcum powder is added into the copper-bath, is sufficiently mixed uniformly, obtains suspension；Evaporate the suspension
In moisture, obtain mixed material；
(3) indigo naturalis powder is added into mixed material obtained by step (2), be sufficiently mixed uniformly to get the treatment canker sore with
The pharmaceutical composition of exanthemv.
6. treating the preparation method of the pharmaceutical composition of canker sore and exanthemv according to claim 5, feature exists
In after being dissolved in water, being also filtered in step (1).
7. treating the preparation method of the pharmaceutical composition of canker sore and exanthemv according to claim 5, feature exists
In in step (1), the mass ratio of the copper sulphate and addition water is 1:70-1:90.
8. treating the preparation method of the pharmaceutical composition of canker sore and exanthemv according to claim 5, feature exists
In in step (2), the nature that is evaporated to of moisture is dried or dried in the suspension.
9. treating the preparation method of the pharmaceutical composition of canker sore and exanthemv according to claim 5, feature exists
In in step (2), the partial size of the talcum powder is 1000-1500 mesh；In step (3), the partial size of the indigo naturalis powder is 1200-
1500 mesh.
10. the described in any item compositions of claim 1-4 are in preparation treatment canker sore and exanthemv pharmaceutical composition
Application.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811171719.6A CN108969575A (en) | 2018-10-09 | 2018-10-09 | A kind of pharmaceutical composition and its preparation method and application for treating canker sore and exanthemv |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811171719.6A CN108969575A (en) | 2018-10-09 | 2018-10-09 | A kind of pharmaceutical composition and its preparation method and application for treating canker sore and exanthemv |
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| CN108969575A true CN108969575A (en) | 2018-12-11 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112138043A (en) * | 2020-10-09 | 2020-12-29 | 沧州爱农生物科技有限公司 | Dai tea ice boron effervescent granule, preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308220A (en) * | 2017-07-07 | 2017-11-03 | 许典粤 | A kind of composition for treating the disease of cari oris mucosa |
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2018
- 2018-10-09 CN CN201811171719.6A patent/CN108969575A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308220A (en) * | 2017-07-07 | 2017-11-03 | 许典粤 | A kind of composition for treating the disease of cari oris mucosa |
Non-Patent Citations (3)
| Title |
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| SISTER-D等: "有什么好的方法能使两种粉末混合均匀？（http://muchong.com/html/201112/3920742.html）", 《小木虫》 * |
| 张秀平等: "硫酸铜治疗口腔溃疡163例", 《中国民间疗法》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112138043A (en) * | 2020-10-09 | 2020-12-29 | 沧州爱农生物科技有限公司 | Dai tea ice boron effervescent granule, preparation method and application thereof |
| CN112138043B (en) * | 2020-10-09 | 2022-04-15 | 沧州爱农生物科技有限公司 | Dai tea ice boron effervescent granule, preparation method and application thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20190701 Address after: 530000 Shangcun 52, Dalu Village Committee, Baihe Town, Hengxian County, Guangxi Applicant after: Liang Wenyuan Address before: No. 52 Shangcun, Dalu Village Committee, Baihe Town, Hengxian County, Nanning City, Guangxi Zhuang Autonomous Region Applicant before: Liang Wanlai |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181211 |