CN108938874A - Containing callicarpa nudiflora sow perfusion liquid and its preparation method and application - Google Patents
Containing callicarpa nudiflora sow perfusion liquid and its preparation method and application Download PDFInfo
- Publication number
- CN108938874A CN108938874A CN201810828824.6A CN201810828824A CN108938874A CN 108938874 A CN108938874 A CN 108938874A CN 201810828824 A CN201810828824 A CN 201810828824A CN 108938874 A CN108938874 A CN 108938874A
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- China
- Prior art keywords
- parts
- sow
- dry powder
- perfusion liquid
- chinese
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
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Abstract
The present invention is disclosed containing callicarpa nudiflora sow perfusion liquid and its preparation method and application, it can promote sow postpartum afterbirth, lochia discharge, accelerate the recovery in uterus, prevent and treat pathogen (staphylococcus aureus, Escherichia coli, salmonella, pseudomonas aeruginosa) caused Gilt Uterus inflammation is infected, treat hysteritis intimitis, and it can promote sow postpartum, ensure the fertility of sow, lasting medicine, the harm such as, medicament residue nonirritant to Gilt Uterus mucous membrane.
Description
Technical field
The invention belongs to animal feed additive fields, and in particular to containing callicarpa nudiflora sow perfusion liquid and its preparation side
Method and application.
Background technique
Callicarpa nudiflora is Verenaceae Callicarpa bodinieri Levl. platymiscium, and be used as medicine part root, leaf, has antibacterial anti-inflammatory, eliminating stasis to subdue swelling, receipts
The effect of holding back hemostasis.It is callicarpa nudiflora can be used for treating wound hemorrhage, influenza, burn, suppurative skin ulcer, cervix erosion,
The diseases such as traumatic injury, rheumatalgia.Modern pharmacological studies have shown that callicarpa nudiflora have broad-spectrum antibacterial action, to staphylococcus, green pus
Bacillus, Escherichia coli, streptococcus etc. cause hysteritis the main pathogenic fungi to all have a strong inhibitory effect.
Gilt Uterus inflammation is the inflammation that sow postpartum uterine mucosa occurs, and is common Sow Genital Organs disease.Sow
In childbirth, midwifery, disinfection is stringent, injury of birth canal, retention of afterbirth, Abwehrkraft des Koepers decline etc., leads to bacterial invasion and numerous
It grows, to induce hysteritis.Sow postpartum suffers from hysteritis, it may appear that lactation reduction or agalasisa, breast matter decline influence piglet
Growth and development；Sow can also unmatch repeatly after or heat out of heat because of inflammation, reproductive capability declines, and service life shortens, and mention
It is preceding to eliminate.Therefore, the generation for preventing this disease reduces cost to pig breeding industry, increases benefit important in inhibiting.
Currently used for treat hysteritis drug be mainly antibiotics, however the uterine perfusion of long-term, high-dose or
Vein, intramuscular injection do not only result in generation and the medicament residue of antibody-resistant bacterium, more seriously destroy micro- life in Gilt Uterus
State balance, increases treatment difficulty.Meanwhile antibiotic also passes through breast milk and enters in piglet body, causes under grice diarrhoea, immunity
The problems such as drop.Hysteritis is also clinically treated using Acu-Dyne, action principle is the stronger oxidation of iodine to thin
Bacterium plays killing effect, has preferable therapeutic effect.But povidone iodine also has certain harmfulness, and excessive povidone iodine is unfavorable
In the recovery of uterine mucosa, and can be concentrated in milk by mucosa absorption.For current situation, it is special to develop a broad sow
Mild drug is extremely urgent way.
Summary of the invention
The primary purpose of the present invention is that providing containing callicarpa nudiflora sow perfusion liquid.
A further object of the present invention is to provide liquid and preparation method thereof is perfused containing callicarpa nudiflora sow.
Another object of the present invention is to provide the applications containing callicarpa nudiflora sow perfusion liquid.
The technical solution used in the present invention is:
One broad sow perfusion liquid, the perfusion liquid contain Chinese herbal medicine Aqueous extracts, and the Chinese herbal medicine Aqueous extracts are callicarpa nudiflora, snake
Machine tool, radix paeoniae rubra, wild chrysanthemum, Herba Andrographitis, safflower, Herba Epimedii, Chinese yam and Radix Angelicae Sinensis Chinese herbal medicine Aqueous extracts.
Further, which contains 25~35 parts of Chinese herbal medicine Aqueous extracts, 0.1~1 part of Pfansteihl, 1~5 part of richness
Horse acid, 1~5 part of beta glucan, 1~5 part of glycerine and 0.1~0.3 part of sodium benzoate；The number is mass fraction.
Further, which it is poly- to contain 35 parts of medium-height grass Aqueous extracts, 1 part of Pfansteihl, 5 parts of fumaric acid, 5 parts of β-Portugals
Sugar, 5 parts of glycerine and 0.1 part of sodium benzoate.
Further, which also contains 40~65 parts of physiological saline.
Further, the Chinese herbal medicine Aqueous extracts are callicarpa nudiflora by 10~20 parts, 5~10 parts of frutus cnidiis, 5~10 parts it is red
Chinese herbaceous peony, 5~15 parts of wild chrysanthemums, 5~10 parts of Herba Andrographitis, 5~15 parts of safflowers, 5~15 parts of Herba Epimedii, 5~10 portions of Chinese yams and 5~10 parts
Radix Angelicae Sinensis is made.
Further, the specific extracting method of the Chinese traditional medicine water extract are as follows: weigh callicarpa nudiflora dry powder, frutus cnidii by formula
Dry powder, radix paeoniae rubra dry powder, wild chrysanthemum dry powder, Herba Andrographitis dry powder, safflower dry powder, Herba Epimedii dry powder, Chinese yam dry powder and Radix Angelicae Sinensis dry powder, add
Enter water, solid-liquid ratio is 1kg:6~10L, decocts 2~4 filterings and merging filtrate, is condensed into Chinese traditional medicine water extract.
Further, every milliliter of extracting solution 0.8~1.2g containing crude drug in Chinese traditional medicine water extract.
Further, the sow perfusion liquid preparation method the following steps are included:
(1) each raw material is weighed according to formula described above and Chinese traditional medicine water extract is made；
(2) 1~5 part of glycerine, the heating of 40~65 parts of physiological saline are slowly stirred evenly, add Chinese traditional medicine water extract, 0.1~
1 part of Pfansteihl, 1~5 part of fumaric acid, 1~5 part of beta glucan, add 0.1~0.3 part of sodium benzoate, filter to take filtrate, i.e.,
Obtain perfusion liquid.
Further, 45~60 DEG C are heated in step (1).
The callicarpa nudiflora application in the feed or feed addictive of preparation prevention and/or treatment hysteritis intimitis.
The callicarpa nudiflora application in the feed or feed addictive that preparation promotes sow Recovery.
The beneficial effects of the present invention are:
The present invention promotes sow postpartum afterbirth, lochia discharge, accelerates the recovery in uterus, prevents and treats mother caused by pathogenic bacterial infection
Pig hysteritis promotes sow post-partum estrus；Lasting medicine endangers uterus, the nonirritant, medicament residue of vagina mucosa etc..This
Invention facilitates the recovery in sow postpartum uterus, ensures that the fertility of sow, lasting medicine are non-stimulated to Gilt Uterus mucous membrane
Property, the harm such as medicament residue.The callicarpa nudiflora dual regulation that can also play Chinese herbal medicine maintains the Tiny ecosystem in Gilt Uterus
Balance, comprehensive coordinate body function improve sow immunity, premunition.
Specific embodiment
One broad sow perfusion liquid, the perfusion liquid contain Chinese herbal medicine Aqueous extracts, and the Chinese herbal medicine Aqueous extracts are callicarpa nudiflora, snake
Machine tool, radix paeoniae rubra, wild chrysanthemum, Herba Andrographitis, safflower, Herba Epimedii, Chinese yam and Radix Angelicae Sinensis Chinese herbal medicine Aqueous extracts.
Preferably, which contains 25~35 parts of Chinese herbal medicine Aqueous extracts, 0.1~1 part of Pfansteihl, 1~5 part of rich horse
Acid, 1~5 part of beta glucan, 1~5 part of glycerine and 0.1~0.3 part of sodium benzoate；The number is mass fraction.
Preferably, which it is poly- to contain 35 parts of medium-height grass Aqueous extracts, 1 part of Pfansteihl, 5 parts of fumaric acid, 5 parts of β-Portugals
Sugar, 5 parts of glycerine and 0.1 part of sodium benzoate.
Preferably, which also contains 40~65 parts of physiological saline.
Preferably, the Chinese herbal medicine Aqueous extracts are callicarpa nudiflora by 10~20 parts, 5~10 parts of frutus cnidiis, 5~10 parts it is red
Chinese herbaceous peony, 5~15 parts of wild chrysanthemums, 5~10 parts of Herba Andrographitis, 5~15 parts of safflowers, 5~15 parts of Herba Epimedii, 5~10 portions of Chinese yams and 5~10 parts
Radix Angelicae Sinensis is made.
Preferably, the specific extracting method of the Chinese traditional medicine water extract are as follows: it is dry to weigh callicarpa nudiflora dry powder, frutus cnidii by formula
Powder, radix paeoniae rubra dry powder, wild chrysanthemum dry powder, Herba Andrographitis dry powder, safflower dry powder, Herba Epimedii dry powder, Chinese yam dry powder and Radix Angelicae Sinensis dry powder,
Water is added, solid-liquid ratio is 1kg:6~10L, decocts 2~4 filterings and merging filtrate, is condensed into Chinese traditional medicine water extract.
Preferably, every milliliter of extracting solution 0.8~1.2g containing crude drug in Chinese traditional medicine water extract.
The preparation method of one broad sow perfusion liquid, it is shown that steps are as follows:
(1) 1~5 part of glycerine, 40~65 parts of physiological saline heating are slowly stirred evenly；
(2) by step (1) preparation stir evenly object be added to Chinese traditional medicine water extract described above, 0.1~1 part of Pfansteihl, 1~
5 parts of fumaric acid, 1~5 part of beta glucan, add 0.1~0.3 part of sodium benzoate, filter to take filtrate to get perfusion liquid.
Preferably, 45~60 DEG C are heated in step (1).
The callicarpa nudiflora application in the feed or feed addictive of preparation prevention and/or treatment hysteritis intimitis.
The callicarpa nudiflora application in the feed or feed addictive that preparation promotes sow Recovery.
The present invention is further illustrated combined with specific embodiments below.
A kind of animal feed additive of embodiment 1 and preparation method thereof
(1) 20 parts of callicarpa nudiflora dry powder, 10 parts of frutus cnidii dry powder, 10 parts of radix paeoniae rubra dry powder, 15 parts of wild chrysanthemum dry powder, 10 are weighed
Water, material is added in part Herba Andrographitis dry powder, 15 parts of safflower dry powder, 15 parts of Herba Epimedii dry powder, 10 parts of Chinese yam dry powder and 10 parts of Radix Angelicae Sinensis dry powder
Liquor ratio is 1kg:6L, decocts 3 filterings and merging filtrate, is condensed into the Chinese traditional medicine water extract of the 1.03g/ml containing crude drug；
(2) 5 parts of glycerine, 40 parts of physiological saline heating are stirred evenly, 35 parts of Chinese traditional medicine water extracts, 1 part of Pfansteihl, 5 parts is added
0.1 part of sodium benzoate is added in fumaric acid, 5 parts of beta glucans, stirring, filters to get perfusion liquid.
A kind of animal feed additive of embodiment 2 and preparation method thereof
(1) 15 parts of callicarpa nudiflora dry powder, 7 parts of frutus cnidii dry powder, 8 parts of radix paeoniae rubra dry powder, 10 parts of wild chrysanthemum dry powder, 8 parts are weighed
Water, solid-liquid ratio is added in Herba Andrographitis dry powder, 10 parts of safflower dry powder, 10 parts of Herba Epimedii dry powder, 8 parts of Chinese yam dry powder and 7 parts of Radix Angelicae Sinensis dry powder
For 1kg:6L, 3 filterings and merging filtrate are decocted, the Chinese traditional medicine water extract of the 1.02g/ml containing crude drug is condensed into；
(2) 2.5 parts of glycerine, 65 parts of physiological saline heating are stirred evenly, Chinese traditional medicine water extract, 0.5 part of L- of step (2) is added
0.2 part of sodium benzoate is added in lactic acid, 2.5 parts of fumaric acid, 2.5 parts of beta glucans, stirring, filters to get perfusion liquid.
A kind of animal feed additive of embodiment 3 and preparation method thereof
(1) weigh 10 parts of callicarpa nudiflora dry powder, 5 parts of frutus cnidii dry powder, 5 parts of radix paeoniae rubra dry powder, 5 parts of wild chrysanthemum dry powder, 5 parts wear
Heart lotus dry powder, 5 parts of safflower dry powder, 5 parts of Herba Epimedii dry powder, 5 parts of Chinese yam dry powder and 5 parts of Radix Angelicae Sinensis dry powder, water is added, solid-liquid ratio is
1kg:8L decocts 2 filterings and merging filtrate, is condensed into the Chinese traditional medicine water extract of 1.04g/ml containing crude drug；
(2) 1 part of glycerine, 56 parts of physiological saline heating are stirred evenly, 35 parts of Chinese traditional medicine water extracts, 0.1 part of Pfansteihl, 1 is added
0.1 part of sodium benzoate is added in part fumaric acid, 1 part of beta glucan, stirring, filters to get perfusion liquid.
A kind of animal feed additive of embodiment 4 and preparation method thereof
(1) 18 parts of callicarpa nudiflora dry powder, 7 parts of frutus cnidii dry powder, 7 parts of radix paeoniae rubra dry powder, 13 parts of wild chrysanthemum dry powder, 7 parts are weighed
Herba Andrographitis dry powder, 9 parts of safflower dry powder, 9 parts of Herba Epimedii dry powder, 7 parts of Chinese yam dry powder and 7 parts of Radix Angelicae Sinensis dry powder, are added water, and solid-liquid ratio is
1kg:10L decocts 4 filterings and merging filtrate, is condensed into the Chinese traditional medicine water extract of 1.03g/ml containing crude drug；
(2) 5 parts of glycerine, 49 parts of physiological saline heating are stirred evenly, 25 parts of Chinese traditional medicine water extracts, 1 part of Pfansteihl, 5 parts is added
0.3 part of sodium benzoate is added in fumaric acid, 5 parts of beta glucans, stirring, filters to get perfusion liquid.
The callicarpa nudiflora In vitro Bactericidal Experiments of embodiment 5
(1) test medical fluid: callicarpa nudiflora removal of impurities is cleaned, chopping, is crushed, and is crossed 80 meshes into powder, is taken the callicarpa nudiflora end 25g
100mL deionized water is added to mix, it is spare after autoclave sterilization.
(2) test strain: staphylococcus aureus (ATCC25923), salmonella (ATCC14028), Escherichia coli
(ATCC25922), pseudomonas aeruginosa (ATCC27853) is purchased from China Veterinery Drug Inspection Office.
Method:
The preparation of bacterium solution: test strain LB agar medium plate culture 18h~for 24 hours selects colonies typical and is inoculated in
In meat soup, then after 37 DEG C of culture 18h, bacterium solution is diluted to 105~106A/mL is spare.
The doubling dilution of medical fluid: taking the test tube of 10 sterilization zone tampons, is one group, number 1~10.On the super-clean bench by 1
LB broth bouillon 1.0mL is separately added into~No. 9 test tubes, No. 1 pipe adds 1mL preparating liquid, and it is dilute to make two times of decreasing concentrations
Release to No. 8 pipes (i.e. liquor strength in 1~No. 8 pipe is respectively 0.125g/mL, 0.0625g/mL, 0.03125g/mL,
0.016g/mL, 0.008g/mL, 0.004g/mL, 0.002g/mL, 0.001g/mL), 1.0mL mixed liquor is sucked out from No. 8 pipes and abandons
It goes.
It is separately added into bacterium solution 0.1mL in No. 1~No. 8 every pipes of test tube, No. 9 test tube adds meat soup and medical fluid 1mL, bacterium is not added
Liquid observes whether drug pollutes as control, and No. 10 test tube adds LB broth bouillon 1.0mL, bacterium solution 0.1mL, as bacterium
Control, observation bacterium whether normal growth.Then developmental tube and control tube are set to cultivate in 37 DEG C of incubator and are taken out afterwards for 24 hours,
The minimum inhibitory concentration (MIC) observed and determine drug to this bacterial strain.Since the liquid of high concentration medicine group is not easy to see whether
There is muddiness, draws in 50 μ L to 1.0mL LB broth bouillons and cultivated for 24 hours from No. 1 pipe to No. 4 pipes, whether observation liquid is muddy.
As a result:
The discovery of bacterium colony upgrowth situation is observed, in blank control pipe, bacterial growth is vigorous.In meat soup+medical fluid control group pipe
In, no bacterial growth.In callicarpa nudiflora last experimental group, four kinds of bacteriums are 0.125g/mL in concentration, 0.0625g/mL,
In the test tube of 0.03125g/mL, without bacterial growth；As drug concentration reduces, other each drug test tubes become muddy, show have
Bacterial growth.The experimental results showed that callicarpa nudiflora foot couple standard bacteria staphylococcus aureus, Escherichia coli, salmonella, verdigris
Pseudomonad has bacteriostasis.
Therapeutic effect of the callicarpa nudiflora perfusion liquid of embodiment 6 to Gilt Uterus inflammation
(1) trial drug: callicarpa nudiflora perfusion liquid；10% terramycin injectant.
(2) case load and case selection standard: hysteritis sow 50, body temperature increases, lassitude, appetite stimulator, nose
Mirror is dry, exerts duty, and intravaginal flows out white slimy or with stink, contaminated bronzing liquid or purulent secretion；Root of the tail,
Vaginal orifice nearby has thick secretions or incrustation, and when sleeping ground easily flows out.
(3) test grouping: 40 sows with hysteritis are randomly divided into 5 groups, every group 10,4 purple for nakedflower
Pearl perfusion liquid test group, 1 drug control group, 10% terramycin injectant of control group medicament selection.
(4) efficacy determination method and standard:
1. curing and (restoring completely): the state of mind, body temperature and the appetite of sow are all restored normally, and intravaginal is without rheuminess
Object and fester discharge, secretion transparent clear, after wean 7 days or so can heat on schedule, normal breeding person is judged to cure.
Effective 2. (being clearly better): the state of mind, body temperature and the appetite of sow return to normal, though there is certain secretion
It flows out but more transparent limpid, no fester or inflammatory object discharge person are judged to effectively.
Invalid 3. (without being clearly better): the state of mind, body temperature and the appetite of sow are not all restored normally, and intravaginal still has inflammation
Property fester discharge person is judged in vain.
Method: tested sow first uses normal saline flushing uterus.Callicarpa nudiflora perfusion is perfused in every sow of test group every time
Liquid 60ml is used in conjunction 3 days 1 time a day；Drug control group injects 10% terramycin injectant, one time a day, is used in conjunction 3 days.
As a result:
The callicarpa nudiflora perfusion liquid of table 1 is compared with the effect of 10% terramycin injectant treatment hysteritis
Find out from the result of table 1: callicarpa nudiflora perfusion liquid has preferable therapeutic effect, cure rate point to Gilt Uterus inflammation
Not Wei 100%, 80%, 70% and 90%, therapeutic effect is suitable with 10% terramycin injectant effect.
Influence of the callicarpa nudiflora perfusion liquid of embodiment 7 to sow Recovery
(1) trial drug: callicarpa nudiflora perfusion liquid
(2) test sow: selection clinical health has produced 2 tires, and breeding is normal, the breeding phase it is almost the same (front and back be separated by 5d with
It is interior) Suprapubic arch sling 50, be in the postpartum breastfeeding stage.
(3) test grouping: 50 postpartum sows are randomly divided into 5 groups, every group 10,4 callicarpa nudiflora perfusion liquids are tried
Test group, 1 blank control group.
Method: tested sow first uses normal saline flushing vagina.For test group from day of farrowing, every sow of test group is each
Callicarpa nudiflora perfusion liquid 30ml is perfused, one time a day, is used in conjunction 5 days；Control group does not add drug.Index determining: observation sow lochia
The time to take a turn for the better；Observation sow postpartum is inflamed situation；Estrus time after recording sow wean.
As a result:
The effect of the callicarpa nudiflora perfusion liquid of table 2 promotion sow Recovery
Find out from the result of table 2: callicarpa nudiflora perfusion liquid can promote the discharge of sow lochia, and prevention sow postpartum is scorching
Disease promotes sow Recovery and postweaning estrus, ensures the reproductive performance of sow.
In conclusion callicarpa nudiflora perfusion liquid of the invention can effectively prevent Gilt Uterus inflammation, promote sow Recovery
And heat.
The above is the preferable embodiment of the present invention, but embodiments of the present invention are not by the limit of above-described embodiment
System, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a broad sow perfusion liquid, which is characterized in that the perfusion liquid contains Chinese herbal medicine Aqueous extracts, and the Chinese herbal medicine Aqueous extracts are naked
Spend the Chinese herbal medicine Aqueous extracts of Callicarpa bodinieri Levl., frutus cnidii, radix paeoniae rubra, wild chrysanthemum, Herba Andrographitis, safflower, Herba Epimedii, Chinese yam and Radix Angelicae Sinensis.
2. sow perfusion liquid according to claim 1, which is characterized in that the sow perfusion liquid contains 25~35 parts of Chinese herbal medicines
Aqueous extracts, 0.1~1 part of Pfansteihl, 1~5 part of fumaric acid, 1~5 part of beta glucan, 1~5 part of glycerine and 0.1~0.3 part
Sodium benzoate；The number is mass fraction.
3. sow perfusion liquid according to claim 2, which is characterized in that the sow perfusion liquid contains 35 parts of medium-height grass water and mentions
Liquid, 1 part of Pfansteihl, 5 parts of fumaric acid, 5 parts of beta glucans, 5 parts of glycerine and 0.1 part of sodium benzoate.
4. sow perfusion liquid according to claim 2 or 3, which is characterized in that the sow perfusion liquid also contains 40~65 parts
Physiological saline.
5. sow perfusion liquid according to claim 2, which is characterized in that the Chinese herbal medicine Aqueous extracts are naked by 10~20 parts
Flower Callicarpa bodinieri Levl., 5~10 parts of frutus cnidiis, 5~10 parts of radix paeoniae rubras, 5~15 parts of wild chrysanthemums, 5~10 parts of Herba Andrographitis, 5~15 parts of safflowers, 5~
15 parts of Herba Epimedii, 5~10 portions of Chinese yams and 5~10 parts of Radix Angelicae Sinensis are made.
6. sow perfusion liquid according to claim 5, which is characterized in that the specific extracting method of the Chinese traditional medicine water extract
Are as follows: by formula weigh callicarpa nudiflora dry powder, frutus cnidii dry powder, radix paeoniae rubra dry powder, wild chrysanthemum dry powder, Herba Andrographitis dry powder, safflower dry powder,
Water is added in Herba Epimedii dry powder, Chinese yam dry powder and Radix Angelicae Sinensis dry powder, and solid-liquid ratio is 1kg:6~10L, decocts 2~4 times and filters and merge
Filtrate is condensed into Chinese traditional medicine water extract.
7. sow perfusion liquid according to claim 6, which is characterized in that every milliliter of extracting solution contains crude drug in Chinese traditional medicine water extract
0.8~1.2g.
8. sow perfusion liquid according to claim 1, which is characterized in that the preparation method of the sow perfusion liquid includes
Following steps:
(1) formula according to claim 5 weighs each raw material and Chinese traditional medicine water extract is made；
(2) 1~5 part of glycerine, 40~65 parts of physiological saline heating are slowly stirred evenly, adds Chinese traditional medicine water extract, 0.1~1 part
Pfansteihl, 1~5 part of fumaric acid, 1~5 part of beta glucan, add 0.1~0.3 part of sodium benzoate, filter to take filtrate to get filling
Fluid injection.
9. the callicarpa nudiflora application in the feed or feed addictive of preparation prevention and/or treatment hysteritis intimitis.
10. the callicarpa nudiflora application in the feed or feed addictive that preparation promotes sow Recovery.
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