CN108938491A - With instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix and preparation method and application - Google Patents
With instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix and preparation method and application Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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Abstract
The invention discloses a kind of with instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix and preparation method and application.The skin matrix includes following components: butanediol 5~15%, tapioca 20~40%, decarboxylation carnosine HCL 5~15%, purslane extract 5~15%, dipropylene glycol 0.1~5%, Sodium Hyaluronate 1~2%, polysorbate -20 0.1~5%, boswellia serrata resin extract 0.01~0.5%.The skin matrix to skin it is instant it is compact, long-acting compact and antiphlogistic effects are significant；Each ingredient can be degraded by skin, be absorbed in matrix, provide nutrition for skin；The matrix can make cosmetics have the elastic loss of the generation and skin that reduce wrinkle for cosmetics, improve skin microgroove, anti-oxidant, inhibit the generation of melanin, prevent the photo-aging and damage of skin, enhance the barrier action of skin.
Description
Technical field
It is the present invention relates to cosmetic field, in particular to a kind of with instant compact, long-acting anti-ageing and anti-inflammatory efficacy shield
Skin matrix and preparation method and application.
Background technique
With the development of science and technology, anti-ageing product also has been to be concerned by more and more people.Skin be one be easy to be in
The organ of existing aging.With the increase at age, the feature of skin aging also occurs therewith: wrinkle increases, cutis laxa, flavescence,
Gloss, smoothness reduce, and dermatoglyph is thicker, and pigmentation color spot increases.Improve to skin relaxed state is people
The demand the most urgent in face of ageing skin.
In addition to aging, there is the phenomenon that inflammation also more and more frequently in skin.Inflammation is that have the living body group of vascular system
Knit the defense reaction to damage factor, it is generally the case that inflammation is a kind of defense reaction that is beneficial, making body to stimulation.But
Be, when the regulatory function of body is unbalance, a large amount of inflammatory mediator can to machine nocuousness, including make local organization denaturation, exudation and
Hyperplasia.Scytitis be caused by undesirable living habit, such as: with the water face-washing of overheat, frequently using perfumed soap, face cleaning etc.
Skin cleaner does not pay attention to the protection etc. to ultraviolet light usually, these reasons, change stimulation can all change or damage the protection screen of skin
The regulatory function of barrier and blood vessel.The clinical manifestation of dermatitis is varied, and inflammation can be by acute to chronic, recurrent exerbation, acutely
Itch.
Currently, it is also fewer on the market at present to have compact and anti-inflammatory cosmetics concurrently, therefore exploitation is a has both two kinds
The skin care item of function are very necessary.
Summary of the invention
The primary purpose of the present invention is that the shortcomings that overcoming the prior art and deficiency, provide a kind of with immediately compact, long
Imitate anti-ageing and anti-inflammatory efficacy skin matrix.
Another object of the present invention is to provide the preparation methods of above-mentioned skin matrix.
A further object of the present invention is to provide the applications of above-mentioned skin matrix.
The purpose of the invention is achieved by the following technical solution: one kind having instant compact, long-acting anti-ageing and anti-inflammatory efficacy
Skin matrix, mainly include following component as mass fraction: butanediol 5~15%, tapioca 20~40%, decarboxylation
Carnosine HCL 5~15%, purslane extract 5~15%, dipropylene glycol 0.1~5%, Sodium Hyaluronate 1~2%, poly- sorb
Alcohol ester -20 (Tween-20) 0.1~5%, boswellia serrata resin extract 0.01~0.5%；Preferably, main comprising pressing below
The component of mass fraction meter: butanediol 7~15%, tapioca 25~40%, decarboxylation carnosine HCL 7~15%, purslane mention
Take object 7~15%, dipropylene glycol 0.1~5%, Sodium Hyaluronate 1~2%, polysorbate -20 0.1~5%, boswellia serrata
Resin extract 0.01~0.4%；It is highly preferred that mainly including following component as mass fraction: butanediol 10~15%,
It is tapioca 25~35%, decarboxylation carnosine HCL 7~15%, purslane extract 7~15%, dipropylene glycol 1~5%, transparent
Matter acid sodium 1~2%, polysorbate -20 1~5%, boswellia serrata resin extract 0.1~0.4%.
It is described that have instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix also may include water；Or also include it
At least one of his functional skin care substance, preservative, pigment and essence ingredient and water.
The other function skin care substance includes moisturizing materials, whitening material, anti-wrinkle substance etc..
The dosage of the preservative, pigment and essence be it is appropriate, meet the relevant regulations such as country, industry.
The dosage of the water is surplus.
The Sodium Hyaluronate is preferably that molecular weight is 0.2 × 106~0.4 × 106The Sodium Hyaluronate of Da.
The preparation method for having instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix, includes following step
It is rapid: to be added to the water after the dipropylene glycol of formula ratio, polysorbate -20 and boswellia serrata resin extract are mixed, be added saturating
Bright matter acid sodium, butanediol, tapioca, decarboxylation carnosine HCL and purslane extract mix, and obtain having immediately compact, long-acting
Anti-ageing and anti-inflammatory efficacy skin matrix；Preferably, specifically comprise the following steps:
(a) prefabricated: the dipropylene glycol of formula ratio, polysorbate -20 and boswellia serrata resin extract are dissolved by heating,
Clear solution is obtained, it is spare；
(b) Sodium Hyaluronate, butanediol are added to the water, heating mixes；
(c) prefabricated ingredient, the tapioca, decarboxylation flesh of step (a) preparation are added after the mixture cooling that step (b) obtains
Peptide HCL and purslane extract, stir and evenly mix, and obtain having instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix.
In step (a):
The temperature of the heating is preferably 70~90 DEG C；More preferably 85 DEG C.
The mode of the heating is preferably to heat under stirring.
The speed of the stirring is preferably 30~60r/min；More preferably 50r/min.
The time of the stirring is preferably 2~10min；More preferably 5min.
In step (b):
The temperature of the heating is preferably 70~90 DEG C；More preferably 85 DEG C.
The mode of the heating is preferably to heat under stirring.
The speed of the stirring is preferably 800~1000r/min；More preferably 1000r/min.
The time of the stirring is preferably 10~30min；More preferably 20min.
In step (c):
Temperature after the cooling is preferably 35~45 DEG C；More preferably 45 DEG C.
The speed of the stirring is preferably 800~1000r/min；More preferably 1000r/min.
The time of the stirring is preferably 10~30min；More preferably 20min.
Step (c) is preferred are as follows: prefabricated ingredient, the cassava of step (a) preparation are added after the mixture cooling that step (b) obtains
Starch, decarboxylation carnosine HCL and purslane extract, stir and evenly mix, separation, obtain having immediately compact, long-acting anti-ageing and anti-inflammatory
The skin matrix of effect.
By the way of filtering, filtering mesh number is preferably 150~250 mesh for the separation.
It is described that there is instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix to prepare the application in cosmetics.
The cosmetics include Moisturizer, crease-resistant skin care item, whitening skin lightening skin care item or anti-acne skin care item.
It is a kind of with instant compact, long-acting anti-ageing and anti-inflammatory efficacy cosmetics, including it is described have it is immediately compact, long-acting
Anti-ageing and anti-inflammatory efficacy skin matrix.
The type of the cosmetics includes lotion, cream, toner or Essence.
Content of the skin matrix in the cosmetics is mass percent 20~30%.
The cosmetics mainly include following component according to mass percentage:
Component A: hydrolecithin 1~2.5%, stearine/PEG-100 stearate 1~2%, poly dimethyl
Siloxanes 1~4%, docosyl alcohol 1~2%, jojoba seed oil 2~5%, ethylhexyl palmitate 3~8%；
B component: glycerol 4~10%, propylene glycol 4~10%, 1,2- pentanediol 2~5%, carbomer 0.1~0.5%, water；
Component C: triethanolamine 0.1~0.5%；
D component: the skin matrix 20~30%, essence 0~appropriate；
Preferably, mainly include following component:
Component A: hydrolecithin 1~1.5%, stearine/PEG-100 stearate 1~1.5%, poly- diformazan
Radical siloxane 3%, docosyl alcohol 1.5%, jojoba seed oil 4%, ethylhexyl palmitate 5%；
B component: glycerol 6%, propylene glycol 6%, 1,2- pentanediol 4%, carbomer 0.3%, water；
Component C: triethanolamine 0.18%；
D component: the skin matrix 20~30%, essence 0~appropriate.
Described is to meet the relevant regulations such as country, industry in right amount.
Content of the essence in the cosmetics is preferably mass percent 0.01~0.03%.
The water is preferably deionized water.
The dosage of the water is surplus.
The preparation method of above-mentioned cosmetics includes the following steps: to mix ingredient each in component A, obtains oily phase；By B group
Each ingredient mixes in point, obtains water phase；It is mutually mixed oily with water phase, carries out homogeneous；It is subsequently added into component C, homogeneous；Add D
Component, homogeneous obtain cosmetics；Preferably, specifically comprise the following steps:
(1) oily phase pot is added in each ingredient in component A, stirring is warming up to 85~90 DEG C, and heat preservation obtains oily phase；
(2) water phase pot is added in each substance in B component, stirring is warming up to 85~90 DEG C, and heat preservation obtains water phase；
(3) water phase sucking emulsion pot is mutually sucked into emulsion pot for oily again after mixing evenly, keeps vacuum and mixing speed not
Become, homogeneous；
(4) component C, homogeneous are added after the completion of homogeneous；
(5) 40~45 DEG C are cooled to after the completion of homogeneous, are stirred and evenly mixed after adding D component, homogeneous obtains cosmetics.
The speed of stirring described in step (1) is 800~1000r/min；Preferably 1000r/min.
The temperature of heating described in step (1) is preferably 85 DEG C.
The time of heat preservation described in step (1) is 5~10min；Preferably 10min.
The speed of stirring described in step (2) is 800~1000r/min；Preferably 1000r/min.
The temperature of heating described in step (2) is 85~90 DEG C；Preferably 85 DEG C.
The time of heat preservation described in step (2) is 10~20min；Preferably 20min.
The speed of stirring described in step (3) is 600~800r/min；Preferably 600r/min.
The pressure of vacuum described in step (3) is -0.05~-0.08MPa；Preferably -0.05MPa.
The time of homogeneous described in step (3) is 3~5min；Preferably 5min.
The speed of homogeneous described in step (3) is 2000~3000r/min；Preferably 3000r/min.
The time of homogeneous described in step (4) is 3~5min；Preferably 3min.
The speed of homogeneous described in step (4) is 1000~2000r/min；Preferably 2000r/min.
The temperature of cooling described in step (5) is preferably 45 DEG C.
The time of stirring described in step (5) is 3~5min；Preferably 5min.
The speed of stirring described in step (5) is 600~800r/min；Preferably 600r/min.
The time of homogeneous described in step (5) is 1~3min；Preferably 1min.
The speed of homogeneous described in step (5) is 1000~2000r/min；Preferably 2000r/min.
Above-mentioned component A is oil phase and emulsifier, is water phase after B component mixing, component C is neutralizer, can effectively neutralize A
Component and B component realize the effect mixed well, simultaneously as D group is divided into low temperature component, therefore need in the preparation last
D component is added after cooling, can guarantee that the effective component of D component and remaining ingredient are sufficiently mixed uniformly, reduce effective component
Loss, finally obtains property stable homogeneous and the preferable cosmetics of quality.
Water herein is surplus, is to be equal to mass percent 100% after water is added with other components.
The present invention has the following advantages and effects with respect to the prior art:
1. skin matrix of the invention passes through tapioca, decarboxylation carnosine, purslane extract, Sodium Hyaluronate and tingia
Five kinds of functional components of olibanum resin extract, and the reasonable compatibility with butanediol, dipropylene glycol, polysorbate -20 and water,
It can be realized synergistic effect, effectively reduce the generation of wrinkle and the elastic loss of skin, improve skin microgroove, antioxygen
Change, inhibits the generation of melanin, reduce the photo-aging and damage of skin, enhance the barrier action of skin, finally realize skin care
Matrix provides nutrition by the effective Transdermal absorption of skin and for skin, has both instant compact, long-acting anti-ageing and anti-inflammatory effect.
2. the preparation method of skin matrix of the invention is simple, easy to operate, by heating, stirring and separation, can make each
It is mixed well between the effective component of component, is conducive to active constituent and sufficiently discharges, the skin matrix uniform properties of acquisition, quality
Stablize, is suitable for standardized production and popularization and application.
3. skin matrix of the invention can be added to the cosmetics such as lotion, cream, toner or Essence as raw material
In, nutrition is supplied for skin, has both instant compact, long-acting anti-ageing and anti-inflammatory effect.
4. cosmetics of the invention can not only make cosmetics transdermal by skin by the skin matrix of addition certain content
It absorbs, provides nutrition for skin, moreover it is possible to cosmetics be made to have both instant compact, long-acting anti-ageing and anti-inflammatory effect.
5. the preparation method of cosmetics of the invention is simple, easy to operate, it can guarantee finally to obtain that property is uniform and matter
Stable cosmetics are measured, standardized production and popularization and application are suitable for.
Specific embodiment
Below in conjunction with embodiment, the present invention will be described in detail, it will be appreciated by those skilled in the art that following
Embodiment is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.The person that is not specified actual conditions, according to conventional strip
The condition that part or manufacturer suggest carries out.Reagents or instruments used without specified manufacturer, being can be by commercially available purchase
The conventional products of acquisition.
In the formula for the skin matrix that embodiment of the present invention provides:
Sodium Hyaluronate: white or off-white color particle or powder, characteristic odor, pH:6.0-7.5, effective content are
>=91%, loss on drying :≤10%, molecular weight: 0.2 × 106~0.4 × 106Da.Effect is to constitute iuntercellular in the present invention
The main component of matrix and extracellular matrix plays an important role to the normal configuration and function that maintain cell.Intelligent moisturizing is made
With can be according to the humidity regulation moisture content of environment.A variety of effects to cell such as influence movement, hyperplasia and the differentiation of cell,
Enhance skin barrier function.Sodium Hyaluronate in the present invention is purchased from the prosperous Fu Ruida of China, and product name is low molecular weight hyaluronic acid
Sodium (HA-TLM20-40).
Tapioca: yellow transparent liquid, characteristic odor, pH 3.0-4.0.Effect is immediately compact in the present invention.This
Tapioca in invention is purchased from Qian Laibo, and product name is INSTENSYL.
Decarboxylation carnosine HCL: colourless to light yellow clear liquid, characteristic odor, relative density (20 DEG C) 1.025-1.045,
The amount of dry matter is 9.0-11.0%, pH 4.0-6.0.Effect is in the present invention: 1, anti-oxidant anti-saccharification；2, protection DNA is resisted
Color spot；3, anti-light aging, anti-UVB injury；4, increase cell metabolism and restore cell viability, increase collagen and generate；5,
The compact effect of extracellular matrix；6, skin is smooth；7, inhibit inflammatory factor overreaction.Decarboxylation carnosine HCL purchase in the present invention
In EXSYMOL company, product name is ALISTIN.
Purslane extract: colourless to light yellow clear liquid, characteristic odor, index of refraction 1.35-1.40, relative density
(20 DEG C) 1.000-1.040, pH (1 → 10) 4.0-6.0, the amount of dry matter are 0.2-0.6%.Effect is in the present invention: stimulation
Reduction is damaged as caused by UVA, has anti-inflammatory, anti-irritant, anti-light toxicity effect.Purslane extract in the present invention is purchased from
BIOLAND company, product name are purslane extract portulaca extract.
Boswellia serrata resin extract: white to micro-yellow powder, characteristic odor are dissolved in alcohol but not soluble in water.
Effect is in the present invention: Shu Min, anti-inflammatory and anti-aging.Boswellia serrata resin extract in the present invention is purchased from nine peak companies, quotient
The name of an article claimsOlibanum extract.
Optionally, the mass percent of butanediol it is typical but non-limiting be 5%, 7%, 9%, 10%, 11%, 13% or
15%.
Optionally, it is 20%, 25%, 30%, 35% or 40% that the mass percent of tapioca is typical but non-limiting.
Optionally, the mass percent of decarboxylation carnosine HCL it is typical but non-limiting be 5%, 7%, 9%, 11%, 13% or
15%.
Optionally, it is 5%, 7%, 9%, 11%, 13% that the mass percent of purslane extract is typical but non-limiting
Or 15%.
Optionally, it is 1%, 1.25%, 1.5%, 1.75% that the mass percent of Sodium Hyaluronate is typical but non-limiting
Or 2%.
Optionally, the mass percent of dipropylene glycol it is typical but non-limiting be 0.1%, 1%, 2%, 3%, 4% or
5%.
Optionally, it is 0.1%, 1%, 2%, 3%, 4% that the mass percent of polysorbate -20 is typical but non-limiting
Or 5%.
Optionally, it is 0.01% that the mass percent of boswellia serrata resin extract is typical but non-limiting, 0.1%,
0.2%, 0.3%, 0.4% or 0.5%.
In the present invention, water used is preferably deionized water.
In the preparation method for the skin matrix that embodiment of the present invention provides:
Optionally, in step (a), heating temperature is typical but non-limiting be 70 DEG C, 75 DEG C, 80 DEG C, 85 DEG C, 89 DEG C or
90℃；Typical but non-limiting soaking time is 2min, 3min, 4min, 5min, 6min, 7min, 8min, 9min or 10min.
Optionally, step (a) neutralize/or, mixing speed be 30r/min, 35r/min, 40r/min, 45r/min,
50r/min, 55r/min or 60r/min.
Optionally, in step (b), heating temperature is 70~90 DEG C；And/or mixing speed is 800~1000r/min, is stirred
Mixing the time is 10~30min.
Optionally, in step (b), heating temperature is typical but non-limiting be 70 DEG C, 75 DEG C, 80 DEG C, 85 DEG C, 89 DEG C or
90℃；Typical but non-limiting soaking time is 10min, 12min, 14min, 16min, 18min, 20min, 25min, 27min
Or 30min.
Optionally, in step (b), and/or, mixing speed 800r/min, 825r/min, 850r/min, 875r/
Min, 900r/min, 825r/min, 950r/min, 975r/min or 1000r/min.
Optionally, in step (c), temperature is 35~45 DEG C after cooling；And/or mixing speed is 800~1000r/min,
Mixing time is 10~30min；And/or separation, by the way of filtering, filtering mesh number is 150~250 mesh.
Optionally, in step (c), after cooling temperature it is typical but it is non-limiting be 35 DEG C, 36 DEG C, 37 DEG C, 38 DEG C, 39 DEG C,
40 DEG C, 41 DEG C, 42,43,44 DEG C or 45 DEG C；Soaking time it is typical but it is non-limiting for 10min, 12min, 14min, 16min,
18min, 20min, 25min, 27min or 30min.
Optionally, in step (c), and/or, mixing speed 800r/min, 825r/min, 850r/min, 875r/min,
900r/min, 825r/min, 950r/min, 975r/min or 1000r/min.
Optionally, in step (c), and/or, separation using filtering by the way of, filtering mesh number be 150~250 mesh, 160 mesh,
170 mesh, 180 mesh, 190 mesh, 200 mesh, 210 mesh, 220 mesh, 230 mesh, 240 mesh or 250 mesh.
In the cosmetics that embodiment of the present invention provides:
Optionally, it is 20% that mass percent of the skin matrix in cosmetics is typical but non-limiting, 21%, 22%,
23%, 24%, 25%, 26%, 27%, 28%, 29% or 30%.
Jojoba (SIMMONDSIA CHINENSIS) seed oil, the commercial goods of purchase have and moisten, tighten skin, is soft
The effect of changing fat and anti-inflammatory.
Optionally, it is 1% that the mass percent of hydrolecithin is typical but non-limiting, 1.2%, 1.5%, 1.6%,
1.8%, 2%, 2.2% or 2.5%.
It is 1% that optionally, stearine/PEG-100 stearate mass percent is typical but non-limiting,
1.2%, 1.5%, 1.6%, 1.8% or 2%.
Optionally, it is 2%, 2.5%, 3%, 3.5% that the mass percent of dimethyl silicone polymer is typical but non-limiting
Or 4%.
Optionally, it is 1%, 1.2%, 1.5%, 1.6%, 1.8% that the mass percent of docosyl alcohol is typical but non-limiting
Or 2%.
Optionally, it is 2% that the mass percent of jojoba seed oil is typical but non-limiting, 2.5%, 3%, 3.5%, 4%,
4.5% or 5%.
Optionally, it is 3%, 4%, 5%, 6%, 7% that the mass percent of ethylhexyl palmitate is typical but non-limiting
Or 8%.
Optionally, it is 6%, 7%, 8%, 9% or 10% that the mass percent of glycerol is typical but non-limiting.
Optionally, it is 4%, 5%, 6%, 7% or 8% that the mass percent of dipropylene glycol is typical but non-limiting.
Optionally, it is 4%, 5%, 6%, 7%, 8%, 9% or 10% that the mass percent of glycerol is typical but non-limiting.
Optionally, the mass percent of propylene glycol it is typical but non-limiting be 4%, 5%, 6%, 7%, 8%, 9% or
10%.
Optionally, it is 2% that the mass percent of 1,2- pentanediol is typical but unrestricted, 2.5%, 3%, 3.5%, 4%,
4.5% or 5%.
Optionally, the mass percent of carbomer it is typical but non-limiting be 0.1%, 0.2%, 0.3%, 0.4% or
0.5%.
Optionally, the mass percent of triethanolamine it is typical but non-limiting be 0.1%, 0.2%, 0.3%, 0.4% or
0.5%.
Optionally, it is 0.01%, 0.02% or 0.03% that the mass percent of essence is typical but non-limiting.
In the preparation method for the cosmetics that embodiment of the present invention provides:
Homogeneous is also referred to as homogenized, be make dispersion micronized in suspension (or emulsion) system, homogenization it is processed
Journey, it is this to handle while plaing a part of to reduce dispersion scale and improving dispersion distributing homogeneity.
By sequentially adding each component and by operations such as heating, stirring and homogeneous, can make to fill between each effective component
Divide mixing, is conducive to active constituent and sufficiently discharges, obtain the cosmetics of stable homogeneous.
Optionally, in step (1), mixing speed is 800~1000r/min；Mixing speed it is typical but it is non-limiting can
Think 800r/min, 850r/min, 900r/min, 950r/min or 1000r/min.
Optionally, in step (1), warming temperature is typical but non-limiting be 85 DEG C, 86 DEG C, 87 DEG C, 88 DEG C, 89 DEG C or
90℃。
Optionally, in step (1), soaking time is 5~10min；Soaking time it is typical but it is non-limiting for 5min,
6min, 7min, 8min, 9min or 10min.
Optionally, in step (2), mixing speed is 800~1000r/min；Mixing speed it is typical but it is non-limiting can
Think 800r/min, 850r/min, 900r/min, 950r/min or 1000r/min.
Optionally, in step (2), warming temperature is typical but non-limiting be 85 DEG C, 86 DEG C, 87 DEG C, 88 DEG C, 89 DEG C or
90℃。
Optionally, in step (2), soaking time is 10~20min；Soaking time it is typical but it is non-limiting for 10min,
11min, 12min, 13min, 14min, 15min, 16min, 17min, 18min, 19min or 20min.
Optionally, in step (3), mixing speed is 600~800r/min；Mixing speed is typical but non-limiting to be
600r/min, 650r/min, 700r/min, 750r/min or 800r/min.
Optionally, in step (3), pressure is -0.05~-0.08MPa under vacuum；Pressure is typical but unrestricted under vacuum
Property be -0.05MPa, -0.06MPa, -0.07MPa or -0.08MPa.
Optionally, in step (3), the typical but non-limiting time of homogeneous is 3min, 4min or 5min；Homogeneous speed
For 2000~3000r/min；Typical but non-limiting homogeneous speed is 2000r/min, 2500r/min or 3000r/min.
Optionally, in step (4), the typical but non-limiting time of homogeneous is 3min, 4min or 5min；Homogeneous speed
For 1000~2000r/min；Homogeneous speed it is typical but it is non-limiting for 1000r/min, 1200r/min, 1500r/min,
1800r/min or 2000r/min.
Optionally, in step (5), the mode of cooling can be cooled down using cold water, and temperature is typical but unrestricted after cooling
Property be 40 DEG C, 41 DEG C, 42 DEG C, 43 DEG C, 44 DEG C or 45 DEG C.
Optionally, in step (5), mixing time typical case but non-limiting 3min, 4min or 5min；Mixing speed is
600~800r/min, typical but non-limiting mixing speed is 600min, 650min, 700min, 750min or 800r/min.
Optionally, in step (5), typical but non-limiting homogenizing time is 1min, 2min or 3min；Homogeneous speed is
1000~2000r/min；Typical but non-limiting homogeneous speed is 1000r/min, 1200r/min, 1500r/min, 1800r/
Min or 2000r/min.
By selecting specific mixing speed, mixing time, homogeneous speed and homogenizing time, each component can effectively ensure that
Be sufficiently mixed uniformly, avoid influence cosmetics using effect, be finally prepared property stable homogeneous and have both immediately it is compact,
Long-acting anti-ageing and anti-inflammatory effect cosmetics.
In order to further appreciate that the present invention, combined with specific embodiments below with comparative example to product of the present invention method and effect
It elaborates.Each raw material component of the present invention can be obtained by purchase.
Embodiment 1
A kind of skin matrix is mainly grouped as by following group by mass percentage: butanediol 10%, tapioca
25%, decarboxylation carnosine HCL7%, purslane extract 7%, dipropylene glycol 1%, Sodium Hyaluronate 1%, polysorbate -20
1%, boswellia serrata resin extract 0.1%, water are mended to 100%.
The preparation method of skin matrix, includes the following steps:
(1) prefabricated: the dipropylene glycol of formula ratio, polysorbate -20, boswellia serrata resin extract are heated to 85 DEG C
Dissolution, mixing speed 50r/min, mixing time 5min are spare.
(2) Sodium Hyaluronate, butanediol are added to the water, are heated to 85 DEG C, 1000r/min stirs 20min.
(3) 45 DEG C are cooled to, prefabricated ingredient, tapioca, decarboxylation carnosine HCL and the purslane being added in step (1) mention
Object, mixing speed 1000r/min are taken, mixing time 20min obtains skin matrix.
Embodiment 2
A kind of skin matrix is mainly grouped as by following group by mass percentage: butanediol 10%, tapioca
35%, decarboxylation carnosine HCL 7%, purslane extract 7%, dipropylene glycol 1%, Sodium Hyaluronate 1%, polysorbate -20
1%, boswellia serrata resin extract 0.1%, water are mended to 100%.
The preparation method of skin matrix, with embodiment 1.
Embodiment 3
A kind of skin matrix is mainly grouped as by following group by mass percentage: butanediol 10%, tapioca
35%, decarboxylation carnosine HCL 10%, purslane extract 7%, dipropylene glycol 1%, Sodium Hyaluronate 1%, polysorbate -20
1%, boswellia serrata resin extract 0.1%, water are mended to 100%.
The preparation method of skin matrix, with embodiment 1.
Embodiment 4
A kind of skin matrix is mainly grouped as by following group by mass percentage: butanediol 10%, tapioca
35%, decarboxylation carnosine HCL 15%, purslane extract 10%, dipropylene glycol 1%, Sodium Hyaluronate 1%, polysorbate-
20 1%, boswellia serrata resin extract 0.1%, water are mended to 100%.
The preparation method of skin matrix, with embodiment 1.
Embodiment 5
A kind of skin matrix is mainly grouped as by following group by mass percentage: butanediol 10%, tapioca
35%, decarboxylation carnosine HCL 15%, purslane extract 10%, dipropylene glycol 3%, Sodium Hyaluronate 1%, polysorbate-
20 3%, boswellia serrata resin extract 0.3%, water are mended to 100%.
The preparation method of skin matrix, with embodiment 1.
Embodiment 6
A kind of skin matrix is mainly grouped as by following group by mass percentage: butanediol 10%, tapioca
35%, decarboxylation carnosine HCL 15%, purslane extract 15%, dipropylene glycol 5%, Sodium Hyaluronate 2%, polysorbate-
20 5%, boswellia serrata resin extract 0.4%, water are mended to 100%.
The preparation method of skin matrix, with embodiment 1.
Embodiment 7
A kind of skin care cream is mainly grouped as by following group by mass percentage:
Component A: hydrolecithin 1.5%, stearine/PEG-100 stearate 1.5%, polydimethylsiloxanes
Alkane 3%, docosyl alcohol 1.5%, jojoba seed oil 4%, ethylhexyl palmitate 5%.
B component: glycerol 6%, propylene glycol 6%, 1,2- pentanediol 4%, carbomer 0.3%, water are mended to 100%.
Component C: triethanolamine 0.18%.
D component: the skin matrix of 30% embodiment 1 preparation, essence 0.02%.
The preparation method of skin care cream, includes the following steps:
(1) component A is sequentially added into oily phase pot, opens and stirs and be warming up to 85 DEG C, mixing speed 1000r/min, protected
Warm 10min, obtains oil-phase component；
(2) water phase pot is added in B component, opens and stirs and be warming up to 85 DEG C, mixing speed 1000r/min, heat preservation
20min obtains water-phase component；
(3) after water-phase component being sucked emulsion pot, emulsion pot stirring, mixing speed 600r/min are opened, then slowly will
Oil-phase component sucks emulsion pot, and then holding -0.05MPa vacuum and mixing speed are constant, opens outer circulation homogenizer immediately
Homogeneous, homogenizing time 5min are carried out, homogeneous speed is 3000r/min；
(4) component C is added after the completion of homogeneous, and opens outer circulation homogenizer and carries out homogeneous, homogenizing time 3min,
Matter speed is 2000r/min；
(5) temperature lowering water being opened after the completion of homogeneous and being cooled to 45 DEG C, D component is added and stirs 5min, mixing speed 600r/
Min is then turned on interior circulation homogenizer homogeneous 1min, and homogeneous speed is 2000r/min, obtains skin care cream.
Embodiment 8
A kind of skin care cream is mainly grouped as by following group by mass percentage:
Component A: hydrolecithin 1%, stearine/PEG-100 stearate 1%, dimethyl silicone polymer
3%, docosyl alcohol 1.5%, jojoba seed oil 4%, ethylhexyl palmitate 5%.
B component: glycerol 6%, propylene glycol 6%, 1,2- pentanediol 4%, carbomer 0.3%, water are mended to 100%.
Component C: triethanolamine 0.18%.
D component: the skin matrix of 30% embodiment 2 preparation, essence 0.02%.
The preparation method of skin care cream, with embodiment 7.
Embodiment 9
A kind of skin care cream, according to mass percentage, except the skin matrix in D component is made from 30% embodiment 3
Outside skin matrix, other components and content are the same as embodiment 7.
The preparation method of skin care cream is the same as embodiment 7.
Embodiment 10
A kind of skin care cream, according to mass percentage, except the skin matrix in D component is made from 30% embodiment 4
Outside skin matrix, other components and content are the same as embodiment 7.
The preparation method of skin care cream is the same as embodiment 7.
Embodiment 11
A kind of skin care cream, according to mass percentage, except the skin matrix in D component is made from 30% embodiment 5
Outside skin matrix, other components and content are the same as embodiment 7.
The preparation method of skin care cream is the same as embodiment 7.
Embodiment 12
A kind of skin care cream, according to mass percentage, except the skin matrix in D component is made from 30% embodiment 6
Outside skin matrix, other components and content are the same as embodiment 7.
The preparation method of skin care cream is the same as embodiment 7.
Comparative example 1
A kind of skin matrix, according to mass percentage, in addition to without tapioca, other components and content are the same as implementation
Example 6, and be adaptively adjusted, i.e., the content of tapioca is supplied with water.
The preparation method is the same as that of Example 1 for skin matrix.
Comparative example 2
A kind of skin matrix, according to mass percentage, in addition to without decarboxylation carnosine HCL, other components and content are same
Embodiment 6, and be adaptively adjusted, i.e., the content of decarboxylation carnosine HCL is supplied with water.
The preparation method is the same as that of Example 1 for skin matrix.
Comparative example 3
A kind of skin matrix, according to mass percentage, in addition to without purslane extract, other components and content are same
Embodiment 6, and be adaptively adjusted, i.e., the content of purslane extract is supplied with water.
The preparation method is the same as that of Example 1 for skin matrix.
Comparative example 4
A kind of skin matrix in addition to without boswellia serrata resin extract, other components and contains according to mass percentage
Amount is adaptively adjusted with embodiment 6, i.e., the content of boswellia serrata resin extract is supplied with water.
The preparation method is the same as that of Example 1 for skin matrix.
Comparative example 5
A kind of skin matrix, according to mass percentage, in addition to without Sodium Hyaluronate, other components and content are the same as real
Example 6 is applied, and is adaptively adjusted, i.e., supplies the content of Sodium Hyaluronate with water.
The preparation method is the same as that of Example 1 for skin matrix.
Comparative example 6
A kind of skin care cream, according to mass percentage, except the skin matrix in D component is made from 30% comparative example 1
Outside skin matrix, other components and content are the same as embodiment 7.
The preparation method of skin care cream, with embodiment 7.
Comparative example 7
A kind of skin care cream, according to mass percentage, except the skin matrix in D component is made from 30% comparative example 2
Outside skin matrix, other components and content are the same as embodiment 7.
The preparation method of skin care cream, with embodiment 7.
Comparative example 8
A kind of skin care cream, according to mass percentage, except the skin matrix in D component is made from 30% comparative example 3
Outside skin matrix, other components and content are the same as embodiment 7.
The preparation method of skin care cream, with embodiment 7.
Comparative example 9
A kind of skin care cream, according to mass percentage, except the skin matrix in D component is made from 30% comparative example 4
Outside skin matrix, other components and content are the same as embodiment 7.
The preparation method of skin care cream, with embodiment 7.
Comparative example 10
A kind of skin care cream, according to mass percentage, except the skin matrix in D component is made from 30% comparative example 5
Outside skin matrix, other components and content are the same as embodiment 7.
The preparation method of skin care cream, with embodiment 7.
Antiphlogistic effects verification test
Test method: be respectively adopted 0.3% sldium lauryl sulfate of 0.1g (SLS), 0.3% sldium lauryl sulfate of 0.1g+
0.1g sample to be tested processing 3D artificial skin (is made of, the limited public affairs of Guangdong Bo Xi biotechnology I-type collagen and human body cell
Department), every group of setting 3 it is parallel (concrete operations see " Test No.439:In Vitro Skin Irritation:
Reconstructed Human Epidermis Test Method[S].OECD Guidelines for the Testing
of Chemicals,2010,1(4:)1-18")；Then enzyme linked immunosorbent assay (ELISA) is (fixed using human interleukin-11 (IL-1)
Amount ELISA detection kit) measure the burst size for inspiring the interleukin-11-α of inflammation.Sample to be tested is respectively Examples 1 to 6 system
Standby skin matrix, sample A (10% butanediol, 5% dipropylene glycol, 5% polysorbate -20, water surplus), sample B (10%
Butanediol, 5% dipropylene glycol, 5% polysorbate -20,35% tapioca, 15% decarboxylation peptide HCL, 2% hyaluronic acid
Sodium, water surplus), sample C (10% butanediol, 5% dipropylene glycol, 5% polysorbate -20,0.4% boswellia serrata resin, water
Surplus), sample D (10% butanediol, 5% dipropylene glycol, 5% polysorbate -20,15% purslane extract, water surplus),
Sample E (10% butanediol, 5% dipropylene glycol, 5% polysorbate -20,35% tapioca, 15% decarboxylation peptide HCL,
2% Sodium Hyaluronate, 0.4% boswellia serrata resin, water surplus), sample F (10% butanediol, 5% dipropylene glycol, 5% poly- mountain
Pears alcohol ester -20,35% tapioca, 15% decarboxylation peptide HCL, 2% Sodium Hyaluronate, 15% purslane extract, more than water
Amount).Antiphlogistic effects are indicated by inspiring the release inhibiting rate of the interleukin-11-α of inflammation.Its calculation formula is as follows:
And the average value of each group result is calculated, test result is as shown in table 1.
1 test result of table
| Group | Source | The release inhibiting rate of interleukin-11-α |
| 1 | Embodiment 1 | 25.28% |
| 2 | Embodiment 2 | 25.34% |
| 3 | Embodiment 3 | 25.38% |
| 4 | Embodiment 4 | 30.14% |
| 5 | Embodiment 5 | 30.46% |
| 6 | Embodiment 6 | 38.75% |
| 7 | Sample A | 0.15% |
| 8 | Sample B | 0.78% |
| 9 | Sample C | 0.95% |
| 10 | Sample D | 24.95% |
| 11 | Sample E | 2.14% |
| 12 | Sample F | 27.38% |
As can be known from the results of Table 1, embodiment 6 is compared with sample E and sample F, it is seen that embodiment 6 is mentioned containing purslane simultaneously
Object and boswellia serrata extract are taken, the effect for reducing the release for the interleukin-11-α that SLS causes is obviously more preferable, also illustrates tool
There are the cosmetics of the skin matrix to have the effect of anti-inflammatory.
Instant wrinkle improvement effect verification test
Test method: 220 female volunteers (age is 40-50 years old, average age 45 years old) stochastic averagina is selected to be divided into
22 groups.After 22 groups of volunteer's face cleanings, eye crow's feet area wrinkle area, wrinkle quantity and wrinkle depth are detected with VISIA instrument,
It is then coated with corresponding using skin matrix, embodiment 7-12 system made from skin matrix made from embodiment 1-6, comparative example 1-5
Skin care cream and comparative example 6-10 made from skin care cream, every group of amount used every time is all the same, using using after 30min
The detection of VISIA instrument detects crow's feet area wrinkle area, wrinkle quantity and wrinkle depth again.Assess canthus fishtail line area wrinkle
The reduction amount of area, wrinkle quantity and wrinkle depth, test result are as shown in table 2.
2 test result of table
In instant wrinkle improvement effect test, compared with Example 6, the skin matrix of embodiment 2-6 preparation is instant by comparative example 1-5
Wrinkle improvement effect is preferable, wherein the instant wrinkle improvement effect of skin matrix prepared by embodiment 6 is best；Comparative example 1-5 is in addition to respectively lacking
A kind of functional materials, remaining substance and content are same as Example 6, but wrinkle improvement effect is not so good as embodiment 6, explanation immediately
In skin matrix of the present invention each component have the function of mutually cooperateing in terms of anti-aging and resultant effect more preferably.With comparative example
6-10 is compared, due to including the skin matrix in embodiment 1-6 in the skin care cream of embodiment 7-12, skin care cream tool
There is better instant tightening effect.The data of comparative example 1-5 are shown, when lacking tapioca, wrinkle area is reduced after 30min
Amount, wrinkle quantity reduction amount and wrinkle depth reduction amount are 0.03%, other 4 kinds of functional components are single when lacking with
Upper data are not much different, and also gap is little for effect compared with embodiment 1-6, illustrate that tapioca plays the reduction of wrinkle and determine
Property effect.
Anti-ageing compliance test result test
Test method: 110 female volunteers (age is 40-50 years old, average age 45 years old) is selected, stochastic averagina is divided into
22 groups, skin care made from skin matrix made from embodiment 1-6, comparative example 1-5 is used eye is corresponding after daily morning and evening face cleaning
Skin care cream made from skin care cream made from matrix, embodiment 7-12 and comparative example 6-10, every group of amount used every time are homogeneous
Together, it is detected after being used continuously 8 weeks with VISIA instrument, assesses canthus fishtail line area wrinkle area, wrinkle quantity and wrinkle depth
Reduction degree, test result are as shown in table 3.
3 test result of table
In long-acting smoothing wrinkle test, compared with comparative example 1-5, on the whole, the skin matrix better effect of embodiment 1-6,
Wherein, 6 effect of embodiment is best；Comparative example 1-5 in addition to respectively lacking a kind of functional materials, remaining substance and content with implementation
Example 6 is identical, but long-acting wrinkle improvement effect is not so good as embodiment 6, illustrates that each component has in terms of anti-aging in skin matrix of the present invention
Play the role of mutually cooperateing with and resultant effect more preferably.Compared with comparative example 5-10, due in the skin care cream of embodiment 6-12
Including the skin matrix in embodiment 1-6, therefore there are better anti-aging effects accordingly.The data of comparative example 1-5 show,
When lacking decarboxylation carnosine HCL, after 8 weeks, wrinkle area reduction, wrinkle quantity reduction amount and wrinkle depth reduction amount difference
It is 3.40%, 4.60% and 5.61%, illustrates that decarboxylation carnosine HCL plays a decisive role to long-acting smoothing wrinkle.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of with instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix, it is characterised in that main comprising pressing below
The component of mass fraction meter: butanediol 5~15%, tapioca 20~40%, decarboxylation carnosine HCL 5~15%, purslane mention
Take object 5~15%, dipropylene glycol 0.1~5%, Sodium Hyaluronate 1~2%, polysorbate -20 0.1~5%, boswellia serrata
Resin extract 0.01~0.5%.
2. according to claim 1 have instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix, it is characterised in that
Mainly include following component as mass fraction: mainly including following component as mass fraction: butanediol 10~15%,
It is tapioca 25~35%, decarboxylation carnosine HCL 7~15%, purslane extract 7~15%, dipropylene glycol 1~5%, transparent
Matter acid sodium 1~2%, polysorbate -20 1~5%, boswellia serrata resin extract 0.1~0.4%.
3. according to claim 1 or 2 have instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix, feature
It is: also comprising water；Or also comprising at least one of other function skin care substance, preservative, pigment and essence ingredient
With water.
4. the described in any item preparations with instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix of claims 1 to 3
Method, characterized by comprising the steps of:
(a) prefabricated: the dipropylene glycol of formula ratio, polysorbate -20 and boswellia serrata resin extract being dissolved by heating, obtained
Clear solution, it is spare；
(b) Sodium Hyaluronate, butanediol are added to the water, heating mixes；
(c) prefabricated ingredient, the tapioca, decarboxylation carnosine of step (a) preparation are added after the mixture cooling that step (b) obtains
HCL and purslane extract, stir and evenly mix, and obtain having instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix.
5. the preparation method with instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix according to claim 4,
It is characterized by:
The temperature of heating described in step (a) is 70~90 DEG C；
The mode of heating described in step (a) is to heat under stirring；
The temperature of heating described in step (b) is 70~90 DEG C；
The mode of heating described in step (b) is to heat under stirring；
Temperature after cooling described in step (c) is 35~45 DEG C.
6. the preparation method with instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix according to claim 5,
It is characterized by:
The temperature of heating described in step (a) is 85 DEG C；
The temperature of heating described in step (b) is 85 DEG C；
Temperature after cooling described in step (c) is 45 DEG C.
7. of any of claims 1 or 2 there is instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix to prepare cosmetics
In application.
8. a kind of with instant compact, long-acting anti-ageing and anti-inflammatory efficacy cosmetics, it is characterised in that: including claims 1 or 2
It is described that there is instant compact, long-acting anti-ageing and anti-inflammatory efficacy skin matrix.
9. according to claim 8 have instant compact, long-acting anti-ageing and anti-inflammatory efficacy cosmetics, which is characterized in that
Mainly include following component according to mass percentage:
Component A: hydrolecithin 1~2.5%, stearine/PEG-100 stearate 1~2%, polydimethylsiloxanes
Alkane 1~4%, docosyl alcohol 1~2%, jojoba seed oil 2~5%, ethylhexyl palmitate 3~8%；
B component: glycerol 4~10%, propylene glycol 4~10%, 1,2- pentanediol 2~5%, carbomer 0.1~0.5%, water；
Component C: triethanolamine 0.1~0.5%；
D component: the skin matrix 20~30%, essence 0~appropriate.
10. the preparation method with instant compact, long-acting anti-ageing and anti-inflammatory efficacy cosmetics as claimed in claim 9, special
Sign is to include the following steps:
(1) oily phase pot is added in each ingredient in component A, stirring is warming up to 85~90 DEG C, and heat preservation obtains oily phase；
(2) water phase pot is added in each substance in B component, stirring is warming up to 85~90 DEG C, and heat preservation obtains water phase；
(3) water phase sucking emulsion pot is mutually sucked into emulsion pot for oily again after mixing evenly, keeps vacuum and mixing speed constant,
Matter；
(4) component C, homogeneous are added after the completion of homogeneous；
(5) 40~45 DEG C are cooled to after the completion of homogeneous, are stirred and evenly mixed after adding D component, homogeneous, obtain having it is immediately compact,
Long-acting anti-ageing and anti-inflammatory efficacy cosmetics.
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| IT202100017528A1 (en) * | 2021-07-02 | 2023-01-02 | Ezio Abbiati | IMPROVED COMPOSITION FOR THE TREATMENT OF CUTANEOUS, MUCOSAL AND CARTILAGE LESIONS IN GENERAL |
| BE1029955B1 (en) * | 2022-05-16 | 2023-06-16 | Dyna S A R L | Composition comprising at least one boswellic acid and/or at least one plant extract comprising at least one boswellic acid for topical use in the treatment of skin aging |
| WO2024061476A1 (en) * | 2022-09-19 | 2024-03-28 | Symrise Ag | A method for preventing, mitigating and/or treating ptgs2-induced skin disorders and related dysfunctions |
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| IT202100017528A1 (en) * | 2021-07-02 | 2023-01-02 | Ezio Abbiati | IMPROVED COMPOSITION FOR THE TREATMENT OF CUTANEOUS, MUCOSAL AND CARTILAGE LESIONS IN GENERAL |
| CN113616541A (en) * | 2021-08-27 | 2021-11-09 | 广东丸美生物技术股份有限公司 | Double-layer essence and preparation method thereof |
| CN113616541B (en) * | 2021-08-27 | 2022-04-12 | 广东丸美生物技术股份有限公司 | Double-layer essence and preparation method thereof |
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| WO2024061476A1 (en) * | 2022-09-19 | 2024-03-28 | Symrise Ag | A method for preventing, mitigating and/or treating ptgs2-induced skin disorders and related dysfunctions |
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