CN108936636A - It is a kind of with the protection composition of liver function, health food and preparation method thereof - Google Patents
It is a kind of with the protection composition of liver function, health food and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to technical field of health care food, specifically disclose a kind of with composition, the health food and preparation method thereof of protecting liver function.The composition, the raw material including following mass fraction: 30-50 parts of pueraria lobata, 30-50 parts of Radix Salviae Miltiorrhizae, 20-40 parts of hoveniae semoveniae semen, 20-40 parts of dandelion, 10-30 parts of turmeric, 5-15 parts of Schisandra chinensis.Composition provided by the invention, after plurality of Chinese compounds, interaction; by different protect liver mechanism, enhancing protection liver effect, there is preferable auxiliary protection function to chemical damage; especially there is good protective effect to the hepatic injury as caused by alcohol, promotes liver function normalization.The preparation method of the present composition, according to the special nature of composition material pharmaceutically active ingredient, using different extraction processes, simple process is easy to operate, environmentally protective, securely and reliably, is convenient for industrialized production.
Description
Technical field
The present invention relates to technical field of health care food more particularly to a kind of compositions with protection liver function, health care
Food and preparation method thereof.
Background technique
Chemical damage is the hepatic injury as caused by chemically Hepatoxic substance.These chemical substances include alcohol,
Chemical toxic substances and some drugs in environment.Alcohol is a kind of dangerous substance for liver, because of the wine drunk into
95% or more essence will carry out catabolism by liver, and when decomposition, the hepatotoxicity wind agitation of intermediate product acetaldehyde is very big, long-term a large amount of drinks
When wine, when the concentration of acetaldehyde has been more than metabolic detoxification ability of the liver to acetaldehyde, it will lead to the accumulation of intrahepatic metabolism product, draw
The direct toxic effect to liver cell is played, lipid peroxidation is caused, destroys cell membrane, promotes hepatic injury.In addition, ethyl alcohol is thin to liver
The toxicity of born of the same parents can make liver cell that obstacle occur to the decomposition of fatty acid and metabolism, cause intrahepatic fat to deposit, cause fatty liver.Wine
Essence can also induce liver fibrosis, cause cirrhosis while causing fatty liver.
Currently, as the improvement of people's living standards, the accelerating rhythm of life, the crowd that drinks is also more and more, therewith
The case of the chemical damage come also gradually increases.Therefore, the production that there is assistant protection function for chemical liver is developed
Grade has market value.
Summary of the invention
Aiming at the problem that case of existing chemical damage gradually increases, the present invention provides a kind of with protection liver function
Can composition, health food and preparation method thereof.
To achieve the above object of the invention, present invention employs the following technical solutions:
A kind of composition with protection liver function, the raw material including following mass fraction: 30-50 parts of pueraria lobata, Radix Salviae Miltiorrhizae
30-50 parts, 20-40 parts of hoveniae semoveniae semen, 20-40 parts of dandelion, 10-30 parts of turmeric, 5-15 parts of Schisandra chinensis.
Preferably, the composition with protection liver function, the raw material including following mass fraction: pueraria lobata 32-
48 parts, 32-48 parts of Radix Salviae Miltiorrhizae, 24-36 parts of hoveniae semoveniae semen, 24-36 parts of dandelion, 16-24 parts of turmeric, 8-12 parts of Schisandra chinensis.
Preferably, the composition with protection liver function, the raw material including following mass fraction: pueraria lobata 40
Part, 40 parts of Radix Salviae Miltiorrhizae, 30 parts of hoveniae semoveniae semen, 30 parts of dandelion, 20 parts of turmeric, 10 parts of Schisandra chinensis.
The present invention also provides the preparation methods of the above-mentioned composition with protection liver function, comprising the following steps:
(1) each component is weighed according to the composition material proportion with protection liver function；
(2) by the hoveniae semoveniae semen, pueraria lobata, dandelion, processing is extracted, combined extract obtains Aqueous extracts；
(3) Schisandra chinensis is crushed, after sieving processing, with turmeric, Radix Salviae Miltiorrhizae, extracts processing, combined extract obtains
Alcohol extract；
(4) Aqueous extracts are subjected to concentration, obtain the first thick paste, be dried, obtains the first dry cream；By institute
It states alcohol extract and carries out concentration, obtain the second thick paste, be dried, obtain the second dry cream；
(5) first dry cream, the second dry cream are crushed, after sieving processing, carries out mixing treatment, it is dry obtains mixing
Cream powder.
Explanation is further explained to above-mentioned preparation method below:
Preferably, step (2), in (3), the extraction process number is 1-3 times, extraction time 1.5-2.5h.
Preferably, temperature≤70 DEG C that processing is concentrated under reduced pressure, vacuum degree are -0.05~-0.07MPa.
The present invention also provides the health foods with protection liver function, including the above-mentioned group with protection liver function
Close object.
Preferably, the described health food with protection liver function, dosage form be powder, tablet, capsule or
Granula.
The present invention also provides the particles with protection liver function, including the above-mentioned combination with protection liver function
Object further includes 9.425-28.275 parts of dextrin, 0.75-2.25 parts of glycine betaine, 0.075-0.225 parts of Sucralose, coffee aroma
0.05-0.15 parts.
Specifically, it is anti-to mitigate lipid peroxidation by correcting methionine cycle and turning the exception of sulfenyl access for glycine betaine
It answers, mitigates immune response, mitigate alcoholic liver damage.There is preferable protective effect to alcoholic liver injury, with pueraria lobata, trifoliate orange
Dulcis, turmeric, Radix Salviae Miltiorrhizae and Schisandra chinensis collective effect, promote liver function normalization.
The present invention also provides the preparation methods of the above-mentioned particle with protection liver function, comprising the following steps:
(1) by the hoveniae semoveniae semen, pueraria lobata, dandelion, processing is extracted, combined extract obtains Aqueous extracts；By the five tastes
Son is crushed, after sieving processing, with turmeric, Radix Salviae Miltiorrhizae, extracts processing, combined extract obtains alcohol extract；
(2) Aqueous extracts are subjected to concentration, obtain the first thick paste, be dried, obtains the first dry cream；By institute
It states alcohol extract and carries out concentration, obtain the second thick paste, be dried, obtain the second dry cream；By first dry cream, second
Dry cream is crushed, after sieving processing, and mixing treatment is carried out, and obtains mixing dried cream powder；
(3) glycine betaine is crushed, after sieving processing, and through sieving treated dextrin, Sucralose and mixed
It closes dried cream powder and carries out mixing treatment, obtain mixed powder；
(4) mixed powder is granulated, then carries out mixing treatment with the coffee aroma through sieving processing, granulation is had
There is the particle of protection liver function.
The main component and pharmacological property pharmacology of Chinese medicine used in the present invention are as follows:
Pueraria lobata, it is sweet in flavor, pungent, it is cool in nature, it attaches to the lung and stomach meridians, expelling pathogenic factors from muscles and skin is brought down a fever, and promoting eruption promotes the production of body fluid to quench thirst, Shengyang Zhixie.It is rich in pueraria lobata
The nutriments such as starch-containing, dietary fiber, flavone compound, wherein the Puerarin being rich in is in the stomach absorption of ethyl alcohol and generation
It thanks to removing toxic substances to play a role, to make ethyl alcohol in blood, acetaldehyde concentration decline, to play antialcoholism action, Puerarin is to acute alcohol
Hepatic injury caused by being poisoned has protective effect, and with hoveniae semoveniae semen, turmeric collective effect, further accelerating alcohol metabolism, enhances
Alcohol dehydrogenase activity, shortening sober up the time, especially play a protective role to alcoholic liver disease.
Radix Salviae Miltiorrhizae, bitter are slightly cold.Converge to heart and liver channels.Promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness, cool blood to disappear carbuncle.Chemical component
It is broadly divided into two classes: fat-soluble diterpene quinone and water-soluble liposoluble ingredient.Radix Salviae Miltiorrhizae can protect liver cell, lead to
It crosses the regeneration for promoting liver cell, anti-hepatic fibrosis and improves the therapeutic effect that hepatic blood recycles to reach it to liver fibrosis.It is red
Denaturation, the necrosis of liver cell when ginseng is able to suppress and mitigates acute and chronic liver injury, protect liver plasma membrane and organelle, promote liver thin
Born of the same parents DNA synthesis, plasma fiber joint albumen can also be improved by reducing NSC 334200 transaminase, anti peroxidation of lipid etc., while Radix Salviae Miltiorrhizae
(PFN) horizontal, enhance reticuloendothelial system phagocytic function and conditioner activity, avoids Liver immunity from damaging, to play protection
Liver cell and the palingenesis for promoting liver cell, act synergistically with hoveniae semoveniae semen and Schisandra chinensis, further improve liver cell survival
And proliferation rate, so that liver cell is restored and is regenerated；In addition, further improving anti-grease matter under the synergistic effect of dandelion
Peroxidation capacity avoids hepatic lipid peroxidation from damaging.
Hoveniae semoveniae semen, it is sweet in flavor, it is mild-natured.Enter stomach meridian.Relieving alcoholism, relieving restlessness of quenching the thirst, preventing or arresting vomiting, sharp stool and urine.Chemical component is mainly wrapped
Include saponin(e and glucosides, alkaloid, flavone compound, fatty acid etc..Hoveniae semoveniae semen can enhance alcohol dehydrogenase with accelerating alcohol metabolism
Enzymatic activity, shortening are sobered up the time, have inhibiting effect to alcohol induced Muscle relaxation, in addition, hoveniae semoveniae semen can resist lipid peroxy
Change, Semen Hoveniae (Fructus Hoveniae) aqueous extract can improve liver cell survival and proliferation rate, have growth promoting activity to liver cell.
Dandelion, bitter sweet tremble with fear, enter liver, stomach meridian.It is clearing heat and detoxicating, diuresis dissipating bind.Control acute mastitis, adenolymphitis, scrofula
Scrofula, boil poisonous soreness, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urine
Road feel dye.Chemical component mainly contain taraxasterol, taraxerol, stigmasterol, sitosterol, choline, organic acid, synanthrin,
Rubber etc..Taraxacum Polysaccharides can fight Cell membrane lipids peroxidating caused by chloromethyl free radical, protect liver cell and subcellular
It is injury-free,
Turmeric is worked hard, and temperature enters spleen, Liver Channel.Blood-breaking, promoting the circulation of qi, promoting menstruation, analgesic.Control trusted subordinate's feeling of fullness distending pain, brachialgia, abdominal mass,
Women's blood stasis, the postpartum stasis of blood stop abdominal pain, injury from falling down, carbuncle swells.Chemical component is mainly curcumin and volatile oil two major classes,
In addition, still having carbohydrate, sterol etc..Curcumin can improve network phagocytic power, adjust immunity of organisms, while also having benefit
Gallbladder, hepatoprotective effect, especially play a protective role to alcoholic liver disease, act synergistically with Radix Salviae Miltiorrhizae, by improving hepatic blood circulation
With enhancing reticuloendothelial system phagocytic function, phagocytic activity is further improved, enhances immunity of organisms, Liver immunity is avoided to damage
Wound.
Schisandra chinensis, astringing lung-QI, nourshing kidney are promoted the production of body fluid, and sweat, arresting seminal emission are received.It controls the deficiency syndrome of the lung to breath with cough, thirst, spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin
It is thin, emission, protracted dysentery and diarrhea.Schisandra chinensis and its main chemical compositions schizandrin A, B prime, C prime, alcohol first, alcohol second, five
Taste phenol has apparent function for protecting liver and reducing enzyme activity, and Schisandra chinensis facilitates the synthesis of Hepatocyte matter, liver cell is enable to restore
And regeneration.
Compared with the existing technology, the composition with protection liver function provided by the invention, it is reasonable using plurality of Chinese
Compatibility has effects that liver-protective well.Wherein, Radix Salviae Miltiorrhizae and Schisandra chinensis synergistic effect, promote the power of regeneration of liver cell,
Hoveniae semoveniae semen is added, further improves liver cell survival and proliferation rate, liver cell is enable preferably to restore and regenerate；In pellet
Under ginseng, Schisandra chinensis and the synergistic effect of dandelion, the anti peroxidation of lipid ability of body is further improved, the rouge of liver is avoided
Matter peroxide injury；Turmeric and Radix Salviae Miltiorrhizae collective effect, by improving hepatic blood circulation and enhancing reticuloendothelial system phagocytic function,
The phagocytic activity of body is further improved, enhances immunity of organisms, Liver immunity is avoided to damage；Pueraria lobata and hoveniae semoveniae semen, turmeric
Collective effect, further accelerating alcohol metabolism, shortening sober up the time, play a protective role to alcoholic liver disease, among the above
After medicine compounding, interaction promotes liver cell regeneration by different protect liver mechanism, improves anti peroxidation of lipid ability, enhances machine
Body immunity, enhancing protection liver effect, has preferable auxiliary protection function to chemical damage, especially to by alcohol
Caused hepatic injury has good protective effect, promotes liver function normalization, facilitate control chemical damage case by
It is cumulative more.
Compared with the existing technology, the preparation method of the composition with protection liver function provided by the invention, according to group
The special nature for closing raw material pharmaceutically active ingredient passes through extraction, concentration, centrifugation, mixing and preparation using different extraction processes
Processing obtains health food, and simple process is easy to operate, environmentally protective, securely and reliably, is convenient for industrialized production.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Embodiment 1
A kind of particle with protection liver function, the raw material components including following mass fraction are prepared:
Pueraria lobata 400g；
Radix Salviae Miltiorrhizae 400g；
Hoveniae semoveniae semen 300g；
Dandelion 300g；
Turmeric 200g；
Schisandra chinensis 100g；
Dextrin 188.5g；
Glycine betaine 15g；
Sucralose 1.5g；
Coffee aroma 1g.
The preparation method of the above-mentioned health food with protection liver function, includes the following steps:
(1) each component is weighed according to the composition material proportion with protection liver function；
(2) decocting method is respectively adopted in the hoveniae semoveniae semen, pueraria lobata, dandelion and extracts processing 2 times, water consumption is Chinese medicine
8 times of quality, extraction time 1.5h, combined extract obtains Aqueous extracts；
(3) after being crushed Schisandra chinensis, crossing the processing of 60 meshes, circumfluence method is respectively adopted with turmeric, Radix Salviae Miltiorrhizae and extracts place
Reason 2 times, with 8 times that amount of alcohol is traditional Chinese medicine quality, extraction time 1.5h, combined extract obtains alcohol extract；
(4) by the Aqueous extracts in temperature≤70 DEG C, vacuum degree carries out concentration under the conditions of being -0.05MPa, obtains the
One thick paste is dried, and the first dry cream is obtained；By the alcohol extract in temperature≤70 DEG C, vacuum degree is -0.05MPa condition
Lower carry out concentration, obtains the second thick paste, is dried, obtain the second dry cream；
(5) after being crushed first dry cream, the second dry cream, crossing the processing of 60 meshes, mixing treatment is carried out, is mixed
Close dried cream powder；
(6) after being crushed the glycine betaine, crossing the processing of 60 meshes, and by 60 meshes treated dextrin, trichlorine
Sucrose and mixing dried cream powder carry out mixing treatment 50min, obtain mixed powder；
(7) mixed powder is granulated, then carries out mixing treatment with the coffee aroma through sieving processing, conventionally
Granule is made, obtains the particle with protection liver function.
Embodiment 2
A kind of powder with protection liver function, the raw material components including following mass fraction are prepared:
Pueraria lobata 500g；
Radix Salviae Miltiorrhizae 500g；
Hoveniae semoveniae semen 400g；
Dandelion 400g；
Turmeric 300g；
Schisandra chinensis 150g；
Glycine betaine 22.5g.
The preparation method of the above-mentioned powder with protection liver function, includes the following steps:
(1) each component is weighed according to the powder raw material proportioning with protection liver function；
(2) decocting method is respectively adopted in the hoveniae semoveniae semen, pueraria lobata, dandelion and extracts processing 2 times, water consumption is Chinese medicine
7 times of quality, extraction time 2h, combined extract obtains Aqueous extracts；
(3) after being crushed Schisandra chinensis, crossing the processing of 60 meshes, circumfluence method is respectively adopted with turmeric, Radix Salviae Miltiorrhizae and extracts place
Reason 2 times, with 8 times that amount of alcohol is traditional Chinese medicine quality, extraction time 1.5h, combined extract obtains alcohol extract；
(4) by the Aqueous extracts in temperature≤70 DEG C, vacuum degree carries out concentration under the conditions of being -0.07MPa, obtains the
One thick paste is dried, and the first dry cream is obtained；By the alcohol extract in temperature≤70 DEG C, vacuum degree is -0.07MPa condition
Lower carry out concentration, obtains the second thick paste, is dried, obtain the second dry cream；
(5) after being crushed first dry cream, the second dry cream, crossing the processing of 60 meshes, mixing treatment is carried out, is mixed
Close dried cream powder；
(6) after being crushed the glycine betaine, crossing the processing of 60 meshes, mixing treatment 45min is carried out with dried cream powder is mixed,
Obtain mixed powder；
(7) customary adjuvant of powder is added into the mixed powder, powder is conventionally made, obtains that there is protection
The powder of liver function.
Embodiment 3
A kind of tablet with protection liver function, the raw material components including following mass fraction are prepared:
Pueraria lobata 300g；
Radix Salviae Miltiorrhizae 300g；
Hoveniae semoveniae semen 200g；
Dandelion 200g；
Turmeric 100g；
Schisandra chinensis 50g；
Glycine betaine 7.5g.
The preparation method of the above-mentioned tablet with protection liver function, includes the following steps:
(1) each component is weighed according to the tablet material proportion with protection liver function；
(2) decocting method is respectively adopted in the hoveniae semoveniae semen, pueraria lobata, dandelion and extracts processing 2 times, water consumption is Chinese medicine
9 times of quality, extraction time 1h, combined extract obtains Aqueous extracts；
(3) after being crushed Schisandra chinensis, crossing the processing of 60 meshes, circumfluence method is respectively adopted with turmeric, Radix Salviae Miltiorrhizae and extracts place
Reason 2 times, with 7 times that amount of alcohol is traditional Chinese medicine quality, extraction time 2h, combined extract obtains alcohol extract；
(4) by the Aqueous extracts in temperature≤70 DEG C, vacuum degree carries out concentration under the conditions of being -0.05MPa, obtains the
One thick paste is dried, and the first dry cream is obtained；By the alcohol extract in temperature≤70 DEG C, vacuum degree is -0.05MPa condition
Lower carry out concentration, obtains the second thick paste, is dried, obtain the second dry cream；
(5) after being crushed first dry cream, the second dry cream, crossing the processing of 60 meshes, mixing treatment is carried out, is mixed
Close dried cream powder；
(6) after being crushed the glycine betaine, crossing the processing of 60 meshes, mixing treatment 45min is carried out with dried cream powder is mixed,
Obtain mixed powder；
(7) customary adjuvant of tablet is added into the mixed powder, tablet is conventionally made, obtains that there is protection
The tablet of liver function.
Embodiment 4
A kind of capsule with protection liver function, the raw material components including following mass fraction are prepared:
Pueraria lobata 450g；
Radix Salviae Miltiorrhizae 450g；
Hoveniae semoveniae semen 400g；
Dandelion 200g；
Turmeric 200g；
Schisandra chinensis 100g；
Glycine betaine 22.5g.
The preparation method of the above-mentioned capsule with protection liver function, includes the following steps:
(1) each component is weighed according to the capsule raw material proportioning with protection liver function；
(2) decocting method is respectively adopted in the hoveniae semoveniae semen, pueraria lobata, dandelion and extracts processing 2 times, water consumption is Chinese medicine
7 times of quality, extraction time 2h, combined extract obtains Aqueous extracts；
(3) after being crushed Schisandra chinensis, crossing the processing of 60 meshes, circumfluence method is respectively adopted with turmeric, Radix Salviae Miltiorrhizae and extracts place
Reason 2 times, with 8 times that amount of alcohol is traditional Chinese medicine quality, extraction time 1.5h, combined extract obtains alcohol extract；
(4) by the Aqueous extracts in temperature≤70 DEG C, vacuum degree carries out concentration under the conditions of being -0.06MPa, obtains the
One thick paste is dried, and the first dry cream is obtained；By the alcohol extract in temperature≤70 DEG C, vacuum degree is -0.06MPa condition
Lower carry out concentration, obtains the second thick paste, is dried, obtain the second dry cream；
(5) after being crushed first dry cream, the second dry cream, crossing the processing of 60 meshes, mixing treatment is carried out, is mixed
Close dried cream powder；
(6) after being crushed the glycine betaine, crossing the processing of 60 meshes, mixing treatment 45min is carried out with dried cream powder is mixed,
Obtain mixed powder；
(7) customary adjuvant of capsule is added into the mixed powder, capsule is conventionally made, is had
Protect the capsule of liver function.
Embodiment 5
A kind of particle with protection liver function, the raw material components including following mass fraction are prepared:
Pueraria lobata 666.67g；
Radix Salviae Miltiorrhizae 666.67g；
Hoveniae semoveniae semen 500g；
Dandelion 500g；
Turmeric 333.33g；
Schisandra chinensis 166.67g；
Dextrin 314.17g；
Glycine betaine 25g；
Sucralose 2.5g；
Coffee aroma 1.67g.
The preparation method of the above-mentioned particle with protection liver function, includes the following steps:
(1) each component is weighed according to the particulate material proportion with protection liver function；
(2) decocting method is respectively adopted in the hoveniae semoveniae semen, pueraria lobata, dandelion and extracts processing 2 times, water consumption is Chinese medicine
8 times of quality, extraction time 1.5h, combined extract obtains Aqueous extracts；
(3) after being crushed Schisandra chinensis, crossing the processing of 60 meshes, circumfluence method is respectively adopted with turmeric, Radix Salviae Miltiorrhizae and extracts place
Reason 2 times, with 8 times that amount of alcohol is traditional Chinese medicine quality, extraction time 1.5h, combined extract obtains alcohol extract；
(4) by the Aqueous extracts in temperature≤70 DEG C, vacuum degree carries out concentration under the conditions of being -0.06MPa, obtains the
One thick paste is dried, and the first dry cream is obtained；By the alcohol extract in temperature≤70 DEG C, vacuum degree is -0.06MPa condition
Lower carry out concentration, obtains the second thick paste, is dried, obtain the second dry cream；
(5) after being crushed first dry cream, the second dry cream, crossing the processing of 60 meshes, mixing treatment is carried out, is mixed
Close dried cream powder；
(6) after being crushed the glycine betaine, crossing the processing of 60 meshes, and by 60 meshes treated dextrin, trichlorine
Sucrose and mixing dried cream powder carry out mixing treatment 50min, obtain mixed powder；
(7) mixed powder is subjected to granulation processing, then carries out mixing treatment with the coffee aroma through sieving processing, according to
Granule is made in conventional method, obtains the particle with protection liver function.
Comparative example 1
Danshen component in embodiment 1 is changed to Radix Notoginseng, the preparation method is the same as that of Example 1, obtains comparative example 1.
Comparative example 2
Hoveniae semoveniae semen component in embodiment 1 is changed to Radix Glycyrrhizae, the preparation method is the same as that of Example 1, obtains comparative example 2.
Experimental example 1
The characteristic with the health food for protecting liver function that embodiment provides in order to better illustrate the present invention, below
The health food with protection liver function prepared by embodiment 1-5 and comparative example 1-2 carries out mouse experiment.
Blank group: giving distilled water, according to 0.2mL/10g weight to intragastric administration on mice；
Experimental group: the health food with protection liver function of Example 1-5 and comparative example 1-2 preparation respectively is pressed
The standard that 3g is given according to every 10kg mouse weight, is configured to solution with distilled water respectively, equally by 0.2mL/10g weight to mouse
Stomach-filling, i.e. respectively experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, experimental group 6, experimental group 7.
The healthy ICR mouse that weight is about 25g is divided into 8 groups, every group 10 by randomly assigne.Fasting (can't help water) 12h
Afterwards, it weighs, blank group stomach-filling distilled water, experimental group stomach-filling has the solution of the health food of protection liver function, is spaced 25min
Afterwards, 8 groups of equal stomach-filling 12.5mL/ (kgmb) wine.Close observation records and counts the average drunk time of every group of mouse (from stomach-filling
The time that alcohol to righting reflex completely disappears) and averagely sober up the time (time from righting reflex loss to recovery), as a result
As shown in table 1.
Table 1
| Group | The drunk time/min | Sober up the time/min |
| Blank group | 6.67±8.52 | 356.87±30.12 |
| Experimental group 1 | 36.85±4.52 | 158.21±41.32 |
| Experimental group 2 | 30.47±11.36 | 163.35±36.21 |
| Experimental group 3 | 30.14±7.59 | 165.41±35.21 |
| Experimental group 4 | 33.14±6.13 | 162.59±57.12 |
| Experimental group 5 | 32.25±10.37 | 160.47±42.67 |
| Experimental group 6 | 29.12±20.51 | 170.41±33.19 |
| Experimental group 7 | 27.49±5.27 | 192.57±36.24 |
It can be obtained by above data, compared with blank group and comparative example group (experimental group 6,7), (experiment of group of the embodiment of the present invention
Group 1-6) sobering up the time for mouse can be shortened, suitable health food energy with protection liver function is drunk before drinking
It is enough effectively to extend the drunk time, shorten and sober up the time, thus play the role of it is anti-intoxication, relieve the effect of alcohol, effectively avoid or mitigate alcohol
Caused by acute hepatic injury.
Experimental example 2
Blank group: giving distilled water, according to 0.2mL/10g weight to intragastric administration on mice；
Model group: giving distilled water, according to 0.2mL/10g weight to intragastric administration on mice；
Experimental group: the health food with protection liver function of Example 1-5 and comparative example 1-2 preparation respectively is pressed
The standard that 3g is given according to every 10kg mouse weight, is configured to solution with distilled water respectively, equally by 0.2mL/10g weight to mouse
Stomach-filling, i.e. respectively experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, experimental group 6, experimental group 7.
The healthy ICR mouse that weight is about 25g is divided into 9 groups, every group 10 by randomly assigne.Blank group and model group fill
Stomach distilled water, experimental group stomach-filling have the solution of the health food of protection liver function, and interval is after 25 days, each group mouse taboo overnight
Eat 12h, model group and equal 0.5% carbon tetrachloride 10mL/kg weight (the i.e. CCl of stomach-filling of experimental group4Metering is 80mg/kg weight),
Blank group stomach-filling vegetable oil, after being spaced 6h, experimental group continues to give health food to experiment and terminate, stomach-filling carbon tetrachloride for 24 hours after
Put to death mouse, take blood system from serum, measure serum glutamic pyruvic transminase (ALT), glutamic-oxalacetic transaminease (AST), blank group, model group and
The experimental result of experimental group is shown in Table 2.
Table 2
Compared with blank group:+P < 0.05++P < 0.01
Compared with model group: * P < 0.05**P < 0.01
As seen from the data in Table 2, after 0.5% carbon tetrachloride of stomach-filling of mouse, compared with blank group, model group mice serum
Middle ALT and AST is horizontal significantly raised；Compared with model group and comparative example group (experimental group 6-7), embodiment 1-5's has protection
The health food of liver function can significantly reduce ALT and AST, show provided in an embodiment of the present invention with protection liver function
Health food to chemical damage have good alleviation effect.
In addition, appointing the health food with protection liver function prepared in Example 1-5, according to every 10kg Mice Body
The standard for giving 3g again, is configured to solution with distilled water respectively, equally by 0.2mL/10g weight carbon tetrachloride hepatic injury mouse and
Normal mouse stomach-filling, the results show that the health food with protection liver function provided in the embodiment of the present invention can make four
The SGPT of chlorination carbon hepatic injury mouse rising tune is remarkably decreased, and liver glycogen content significantly increases, and to the mda content in liver
There is apparent reduction to act on；Meanwhile, it is capable to inhibit mouse liver even slurry peroxidatic reaction of lipid, promote the bile secretion of normal mouse
With the regeneration of liver after partially hepatectomized.Illustrate that is provided in the embodiment of the present invention has the health food of protection liver function, it is right
Chemical damage has preferable auxiliary protection function, promotes liver function normalization.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. a kind of composition with protection liver function, it is characterised in that the raw material including following mass fraction: pueraria lobata 30-50
Part, 30-50 parts of Radix Salviae Miltiorrhizae, 20-40 parts of hoveniae semoveniae semen, 20-40 parts of dandelion, 10-30 parts of turmeric, 5-15 parts of Schisandra chinensis.
2. the composition with protection liver function as described in claim 1, it is characterised in that including following mass fraction
Raw material: 32-48 parts of pueraria lobata, 32-48 parts of Radix Salviae Miltiorrhizae, 24-36 parts of hoveniae semoveniae semen, 24-36 parts of dandelion, 16-24 parts of turmeric, Schisandra chinensis 8-
12 parts.
3. the composition with protection liver function as claimed in claim 2, it is characterised in that including following mass fraction
Raw material: 40 parts of pueraria lobata, 40 parts of Radix Salviae Miltiorrhizae, 30 parts of hoveniae semoveniae semen, 30 parts of dandelion, 20 parts of turmeric, 10 parts of Schisandra chinensis.
4. the preparation method of the described in any item compositions with protection liver function of claims 1 to 3, it is characterised in that packet
Include following steps:
(1) each component is weighed according to the composition material proportion with protection liver function；
(2) by the hoveniae semoveniae semen, pueraria lobata, dandelion, processing is extracted, combined extract obtains Aqueous extracts；
(3) Schisandra chinensis is crushed, after sieving processing, with turmeric, Radix Salviae Miltiorrhizae, extracts processing, combined extract obtains alcohol extracting
Liquid；
(4) Aqueous extracts are subjected to concentration, obtain the first thick paste, be dried, obtains the first dry cream；By the alcohol
Extract carries out concentration, obtains the second thick paste, is dried, obtains the second dry cream；
(5) first dry cream, the second dry cream are crushed, after sieving processing, carries out mixing treatment, obtain mixing dry cream
Powder.
5. the preparation method of the composition with protection liver function as claimed in claim 4, it is characterised in that: step (2),
(3) in, the extraction process number is 1-3 times, extraction time 1.5-2.5h.
6. the preparation method of the composition with protection liver function as claimed in claim 4, it is characterised in that: the decompression
Temperature≤70 DEG C of concentration, vacuum degree are -0.05~-0.07MPa.
7. a kind of health food with protection liver function, it is characterised in that including the described in any item tools of claims 1 to 3
There is the composition of protection liver function.
8. the health food with protection liver function as claimed in claim 7, it is characterised in that: its dosage form is powder, piece
Agent, capsule or granule.
9. a kind of particle with protection liver function, it is characterised in that described in any item with guarantor including claims 1 to 3
The composition for protecting liver function, further includes 9.425-28.275 parts of dextrin, 0.75-2.25 parts of glycine betaine, Sucralose 0.075-
0.225 part, 0.05-0.15 parts of coffee aroma.
10. the preparation method of the particle with protection liver function as claimed in claim 9, it is characterised in that including following step
It is rapid:
(1) by the hoveniae semoveniae semen, pueraria lobata, dandelion, processing is extracted, combined extract obtains Aqueous extracts；Schisandra chinensis is passed through
It crushes, after sieving processing, with turmeric, Radix Salviae Miltiorrhizae, extracts processing, combined extract obtains alcohol extract；
(2) Aqueous extracts are subjected to concentration, obtain the first thick paste, be dried, obtains the first dry cream；By the alcohol
Extract carries out concentration, obtains the second thick paste, is dried, obtains the second dry cream；By first dry cream, the second dry cream
It is crushed, after sieving processing, carries out mixing treatment, obtain mixing dried cream powder；
(3) glycine betaine is crushed, after sieving processing, is done with through sieving treated dextrin, Sucralose and mix
Cream powder carries out mixing treatment, obtains mixed powder；
(4) mixed powder is granulated, then carries out mixing treatment with the coffee aroma through sieving processing, granulation is obtained having and be protected
Protect the particle of liver function.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810968275.2A CN108936636A (en) | 2018-08-23 | 2018-08-23 | It is a kind of with the protection composition of liver function, health food and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810968275.2A CN108936636A (en) | 2018-08-23 | 2018-08-23 | It is a kind of with the protection composition of liver function, health food and preparation method thereof |
Publications (1)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113694104A (en) * | 2021-07-23 | 2021-11-26 | 江苏大学 | Traditional Chinese medicine composition with protection effect on chemical liver injury and liver regeneration promotion function, preparation method and application thereof |
| CN115337376A (en) * | 2022-08-24 | 2022-11-15 | 辽宁泰阳医药科技开发有限公司 | Traditional Chinese medicine composition with liver protecting and toxin expelling effects, preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214773A (en) * | 2016-07-29 | 2016-12-14 | 神威药业集团有限公司 | A kind of to chemical liver injury compositions having assistant protection function and preparation method thereof |
-
2018
- 2018-08-23 CN CN201810968275.2A patent/CN108936636A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214773A (en) * | 2016-07-29 | 2016-12-14 | 神威药业集团有限公司 | A kind of to chemical liver injury compositions having assistant protection function and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113694104A (en) * | 2021-07-23 | 2021-11-26 | 江苏大学 | Traditional Chinese medicine composition with protection effect on chemical liver injury and liver regeneration promotion function, preparation method and application thereof |
| CN115337376A (en) * | 2022-08-24 | 2022-11-15 | 辽宁泰阳医药科技开发有限公司 | Traditional Chinese medicine composition with liver protecting and toxin expelling effects, preparation method and application thereof |
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