CN108926644A - A kind of antibacterial cream of nasal cavity - Google Patents
A kind of antibacterial cream of nasal cavity Download PDFInfo
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- CN108926644A CN108926644A CN201810932153.8A CN201810932153A CN108926644A CN 108926644 A CN108926644 A CN 108926644A CN 201810932153 A CN201810932153 A CN 201810932153A CN 108926644 A CN108926644 A CN 108926644A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
The invention discloses a kind of antibacterial cream of nasal cavity, it is related to treatment of rhinitis technical field of pharmaceuticals, the antibacterial cream includes following weight item raw material: 5 parts of the achene of Siberian cocklebur, 5 parts of the flower bud of lily magnolia, 10 parts of the root of Dahurain angelica, 5 parts of honeysuckle, 10 parts of chrysanthemum, 10 parts of radix scutellariae, 10 parts of the coptis, 5 parts of the root of gansui, 10 parts of campanulaceae, 10 parts of viola mandshurica, 10 parts of rhizoma acori graminei, 5 parts of peppermint, 10 parts of safflower, 10 parts of Prunella vulgaris, 10 parts of oyster, 10 parts of pangolin.This antibacterial cream system Chinese medicine succession, the secret recipe of potentiality research and development, such antibacterial cream is in the nasal cavity topical application of drug, have effects that convergence and toxin expelling, unobstructed mechanism of qi, YIN and YANG balance regulating adjust viscera function, until sinus cavities inflammation absorbs, and cell migration, the effect of reaching healing, suitable for rhinitis, nasosinusitis, allergic rhinitis, acute or chronic rhinitis has the effect of antibacterial reparation, and all Chinese materia medica preparations for schneiderian membrance, have no toxic side effect, can effectively antipruritic, ventilation, keep nasal cavity moistening, cure rate is high.
Description
Technical field
The present invention relates to a kind of antibacterial cream of nasal cavity, specially treatment of rhinitis technical field of pharmaceuticals.
Background technique
Rhinitis, that is, nasal cavity inflammatory disease is virus, bacterium, allergen, various physical and chemical factors and certain systemic diseases
The inflammation of caused bronchia mucosal.The main pathological change of rhinitis is bronchia mucosal hyperemia, swelling, exudation, hyperplasia, atrophy or bad
It waits indefinitely.The symptom of rhinitis often shows as nasal obstruction, sneezing, more tears, smell decline, and majority are also often accompanied by headache, giddy, appetite
Depressed, the easy symptoms such as tired, failure of memory and insomnia.
When rhinitis breaking-out, the symptoms such as nasal obstruction, continuous sneezing, runny nose and headache are often seriously affecting people just
Normal work and life.Since the cause of rhinitis is more complicated, patient is treated the symptoms when using some western medicines without effecting a permanent cure,
Its therapeutic effect is all less desirable.And at present some Western medicine the ephedrine of 0 .5%~1% is for example used for a long time can
Damage schneiderian membrance ciliary structures, it is easier to aggravate rhinitis;Naphazoline has confirmed that it can cause rhinitis medicamentosa.Therefore it needs
Study Chinese materia medica preparation that is a kind of significant in efficacy and having no toxic side effect.
Summary of the invention
The purpose of the present invention is to provide a kind of antibacterial cream of nasal cavity.
To achieve the above object, the invention provides the following technical scheme: a kind of antibacterial cream of nasal cavity includes following weight item
Raw material: 3-8 parts of the achene of Siberian cocklebur, 3-8 parts of the flower bud of lily magnolia, 8-12 parts of the root of Dahurain angelica, 3-8 parts of honeysuckle, 8-12 parts of chrysanthemum, 8-12 parts of radix scutellariae, the coptis
8-12 parts, 3-8 parts of the root of gansui, 8-12 parts of campanulaceae, 8-12 parts of viola mandshurica, 8-12 parts of rhizoma acori graminei, 3-8 parts of peppermint, 8-12 parts of safflower,
8-12 parts of Prunella vulgaris, 8-12 parts of oyster, 8-12 parts of pangolin.
Further preferably, the antibacterial cream of the nasal cavity includes following weight item raw material: 5 parts of the achene of Siberian cocklebur, 5 parts of the flower bud of lily magnolia, white
10 parts of the root of Dahurian angelica, 5 parts of honeysuckle, 10 parts of chrysanthemum, 10 parts of radix scutellariae, 10 parts of the coptis, 5 parts of the root of gansui, 10 parts of campanulaceae, 10 parts of viola mandshurica,
10 parts of rhizoma acori graminei, 5 parts of peppermint, 10 parts of safflower, 10 parts of Prunella vulgaris, 10 parts of oyster, 10 parts of pangolin.
A kind of antibacterial cream of nasal cavity is prepared the preparation method comprises the following steps: the raw material of the antibacterial cream of nasal cavity is matched according to weight item, will
It is smashed after all raw materials are baked and is ground into 300 mesh medicinal powder;
Appropriate crab oil is added after traditional Chinese medicine powder is mixed, stirs evenly and is configured to ointment, high-temperature sterilization is filling, and quality inspection personnel is taken out
It tests;Qualified semi-finished product are evacuated to bottling, loading amount and sealing;It is packed by this product specification requirement, and is put into a specification, covered
Upper box cover seals mouth label, after filling, is put into area to be checked;It examines, storage.
Compared with prior art, beneficial effects of the present invention are as follows: this antibacterial cream has convergence and toxin expelling in the nasal cavity topical application of drug
The effect of, unobstructed mechanism of qi, YIN and YANG balance regulating adjusts viscera function, is conducive to the absorption of sinus cavities inflammation, cell migration reaches healing
Effect is suitable for rhinitis, and nasosinusitis, allergic rhinitis, acute or chronic rhinitis has the effect of antibacterial reparation for schneiderian membrance, and
All Chinese materia medica preparations, have no toxic side effect, and effectively antipruritic, ventilation and can keep for a long time nasal cavity moistening, cure rate is high.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction in the embodiment of the present invention, it is clear that institute
The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention,
Every other embodiment obtained by those of ordinary skill in the art without making creative efforts, belongs to this hair
The range of bright protection.
Embodiment: a kind of antibacterial cream of nasal cavity the preparation method comprises the following steps: the raw material of the antibacterial cream of nasal cavity is matched according to weight item
It prepares, by 3-8 parts all of the raw material achenes of Siberian cocklebur, 3-8 parts of the flower bud of lily magnolia, 8-12 parts of the root of Dahurain angelica, 3-8 parts of honeysuckle, 8-12 parts of chrysanthemum, radix scutellariae
8-12 parts, it is 8-12 parts of the coptis, 3-8 parts of the root of gansui, 8-12 parts of campanulaceae, 8-12 parts of viola mandshurica, 8-12 parts of rhizoma acori graminei, peppermint 3-8, red
8-12 parts of flower, 8-12 parts of Prunella vulgaris, 8-12 parts of oyster, 8-12 parts of pangolin it is baked after smash and be ground into 300 mesh medicinal powder;
Appropriate crab oil is added after traditional Chinese medicine powder is mixed, stirs evenly and is configured to ointment, high-temperature sterilization is filling, and quality inspection personnel is taken out
It tests;Qualified semi-finished product are evacuated to bottling, loading amount and sealing;It is packed by this product specification requirement, and is put into a specification, covered
Upper box cover seals mouth label, after filling, is put into area to be checked;It examines, storage.
Case: Mr. Wang, male, 50 years old, firmly Anhui Province's Fuyang City, suffered from chronic paranasal rhinitis for many years, does not hear perfume (or spice) and smell, and 2013
2 month first time was put into meatus nasi inferior using the antibacterial cream of monarch side's nasal cavity, and secondary further consultation sees below the half that concha holds back chamber, and nasal obstruction disappears
It loses, ventilation improves, and restrains middle nasal meatus immediately, and patient is micro- swollen without significant discomfort, alleviates after 2 minutes.Further consultation three times, endoscopy
It looks into, concha nasalis inferior and concha nasalis media restore normal, give the antibacterial cream of this nasal cavity, and more purulent secretion is flowed out in the drainage of middle nasal meatus opening
Object, four further consultations, headache and dizzy and nasal obstruction symptom all disappear, and physiology sea water spray mist, twice daily, smell restore normal, and four
Zhou Kangfu achieves the desired results.
Ms Zhang, female, 30 years old, Shandong Province Qufu citizen suffered from chronic paranasal rhinitis for many years, and thin nasal discharge is uninterrupted, paper handkerchief
It carries, need to be wiped every five minutes once, influence image to work and life and bring inconvenience, worries can't bear, with this
The antibacterial cream of nasal cavity improves five times, and symptom disappears, and checks after 1 year, no relapse.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (3)
1. a kind of antibacterial cream of nasal cavity, it is characterised in that: the antibacterial cream includes following weight item raw material: 3-8 parts of the achene of Siberian cocklebur,
3-8 parts of the flower bud of lily magnolia, 8-12 parts of the root of Dahurain angelica, 3-8 parts of honeysuckle, 8-12 parts of chrysanthemum, 8-12 parts of radix scutellariae, 8-12 parts of the coptis, 3-8 parts of the root of gansui,
8-12 parts of campanulaceae, 8-12 parts of viola mandshurica, 8-12 parts of rhizoma acori graminei, 3-8 parts of peppermint, 8-12 parts of safflower, 8-12 parts of Prunella vulgaris, oyster
8-12 parts, 8-12 parts of pangolin.
2. a kind of antibacterial cream of nasal cavity according to claim, it is characterised in that: the antibacterial cream of the nasal cavity includes following heavy
Measure component materials: 5 parts of the achene of Siberian cocklebur, 5 parts of the flower bud of lily magnolia, 10 parts of the root of Dahurain angelica, 5 parts of honeysuckle, 10 parts of chrysanthemum, 10 parts of radix scutellariae, 10 parts of the coptis, sweet
Then 5 parts, 10 parts of campanulaceae, 10 parts of viola mandshurica, 10 parts of rhizoma acori graminei, 5 parts of peppermint, 10 parts of safflower, 10 parts of Prunella vulgaris, oyster 10
Part, 10 parts of pangolin.
3. a kind of preparation method of the antibacterial cream of nasal cavity, it is characterised in that: the antibacterial cream is specific the preparation method comprises the following steps: nasal cavity is pressed down
The raw material of bacterium cream is matched according to weight item and is prepared, by all raw materials it is baked after smash and be ground into 300 mesh medicinal powder;
Appropriate crab oil is added after traditional Chinese medicine powder is mixed, stirs evenly and is configured to ointment, then filling using high-temperature sterilization, quality inspection
Personnel's examination at random;Qualified semi-finished product are evacuated to bottling, loading amount and sealing;It is packed by this product specification requirement, and is put into one and says
Bright book covers box cover, seals mouth label, after filling, is put into area to be checked;It examines, storage.
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CN201810932153.8A CN108926644A (en) | 2018-08-16 | 2018-08-16 | A kind of antibacterial cream of nasal cavity |
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CN201810932153.8A CN108926644A (en) | 2018-08-16 | 2018-08-16 | A kind of antibacterial cream of nasal cavity |
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CN108926644A true CN108926644A (en) | 2018-12-04 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111281948A (en) * | 2020-04-22 | 2020-06-16 | 辽宁宝一堂科技发展有限公司 | Preparation method of Baicao antibacterial cream |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102258650A (en) * | 2011-08-28 | 2011-11-30 | 陈晓阳 | External rhinitis paste |
CN107050140A (en) * | 2017-05-17 | 2017-08-18 | 河南陈氏中医研究院有限公司 | Treat nasosinusitis, the Chinese medicine of allergic rhinitis, application method and production technology |
-
2018
- 2018-08-16 CN CN201810932153.8A patent/CN108926644A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102258650A (en) * | 2011-08-28 | 2011-11-30 | 陈晓阳 | External rhinitis paste |
CN107050140A (en) * | 2017-05-17 | 2017-08-18 | 河南陈氏中医研究院有限公司 | Treat nasosinusitis, the Chinese medicine of allergic rhinitis, application method and production technology |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111281948A (en) * | 2020-04-22 | 2020-06-16 | 辽宁宝一堂科技发展有限公司 | Preparation method of Baicao antibacterial cream |
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Application publication date: 20181204 |