CN103690808B - A kind of medicinal liquid for mouth care after Operation on Esophageal Cancer - Google Patents
A kind of medicinal liquid for mouth care after Operation on Esophageal Cancer Download PDFInfo
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- CN103690808B CN103690808B CN201310711182.9A CN201310711182A CN103690808B CN 103690808 B CN103690808 B CN 103690808B CN 201310711182 A CN201310711182 A CN 201310711182A CN 103690808 B CN103690808 B CN 103690808B
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Abstract
The invention discloses a kind of medicinal liquid for mouth care after Operation on Esophageal Cancer, this medicinal liquid is prepared from by traditional Chinese medicinal material raw materials and excipient, by weight, described Chinese crude drug comprises Folium Bambusae 28-36 part, Flos Rosae Chinensis 28-36 part, Flos Lonicerae 12-20 part, Fructus Gardeniae 12-20 part, Spica Prunellae 12-20 part, Fructus Momordicae charantiae 55-70 part.Medicinal liquid of the present invention is used for the mouth care after Operation on Esophageal Cancer, can promote the wound healing that festers fast, determined curative effect.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of medicinal liquid for mouth care after Operation on Esophageal Cancer.
Background technology
The esophageal carcinoma means the malignant change formed by esophagus squameous epithelium or epithelioglandular paraplasm.The esophageal carcinoma emphasizes early diagnosis and early treatment, the first-selected operative treatment of the esophageal carcinoma.Oral ulcer symptom may be there is, in cyclic recurrence after Thoracic esophageal carcinoma and radiotherapy.Patient with esophageal carcinoma is postoperative, because the state of an illness needs, there is the fasting phase.During this period, due to operation plane wound, patient's resistance declines, add that patient with esophageal carcinoma needs fasting to prohibit water, salivation reduces, and more reduces the bacteriostasis in oral cavity, patient with esophageal carcinoma is not if noted oral hygiene, intraoral antibacterial likely along with saliva enters esophagus, and stops breeding in wound location, causes wound infection.If use stomach tube in patient treatment, pharynx rear wall will become clean dead angle, and all factors all can cause postoperative patient with esophageal carcinoma generation oral ulcer, and then affect postoperative rehabilitation.
Summary of the invention
The object of the present invention is to provide a kind of medicinal liquid for mouth care after Operation on Esophageal Cancer.
The object of the present invention is achieved like this: a kind of medicinal liquid for mouth care after Operation on Esophageal Cancer, be prepared from by Chinese crude drug and excipient, by weight, described Chinese crude drug comprises: Folium Bambusae 28-36 part, Flos Rosae Chinensis 28-36 part, Flos Lonicerae 12-20 part, Fructus Gardeniae 12-20 part, Spica Prunellae 12-20 part, Fructus Momordicae charantiae 55-70 part.
Preferably, as mentioned above for the medicinal liquid of mouth care after Operation on Esophageal Cancer, by weight, described traditional Chinese medicinal material raw materials is made up of Folium Bambusae 30-34 part, Flos Rosae Chinensis 30-34 part, Flos Lonicerae 15-17 part, Fructus Gardeniae 15-17 part, Spica Prunellae 15-17 part and Fructus Momordicae charantiae 60-66 part.
In a most preferred embodiment of the present invention, as mentioned above for the medicinal liquid of mouth care after Operation on Esophageal Cancer, by weight, described traditional Chinese medicinal material raw materials is made up of 32 parts, Folium Bambusae, Flos Rosae Chinensis 32 parts, Flos Lonicerae 16 parts, Fructus Gardeniae 16 parts, Spica Prunellae 16 parts and 63 parts, Fructus Momordicae charantiae.
Further preferably, as mentioned above for the medicinal liquid of mouth care after Operation on Esophageal Cancer, excipient wherein comprises antiseptic, and described antiseptic is preferably ethyl hydroxybenzoate.
The preparation method of the oral solutions that the present invention relates to comprises the steps: to take Folium Bambusae 28-36 part, Flos Rosae Chinensis 28-36 part, Flos Lonicerae 12-20 part, Fructus Gardeniae 12-20 part, Spica Prunellae 12-20 part and Fructus Momordicae charantiae 55-70 part, cleans roguing, dries, be ground into granule, with bundle it, put into container, add 15-18 times of water, soaking after 30 minutes decocts to boiling, continues 25-40 minute, filters to get filtrate, be concentrated into paste, lyophilization evacuation, obtains extract, for subsequent use; Take extract, the ratio being 1:2-4 in mass volume ratio adds 25-35%(v/v) glycerine water solution, and add appropriate antiseptic ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30-60min.
According to Chinese medicine Historical Data Data About, pharmacologically active and the source of above-mentioned Chinese crude drug are as follows:
Folium Bambusae: clearing heat and relieving fidgetness, diuresis of promoting the production of body fluid.Control calentura excessive thirst, pediatric epilepsy scared, cough with dyspnea tells nosebleed, flushed complexion, oliguria also, erosion of the oral mucosa tongue boil.Select the leaf of grass phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.
Flos Rosae Chinensis: promoting blood flow to regulate menstruation, dispersing the stagnated live-QI to relieve the stagnation of QI, subduing swelling and detoxicating.Cure mainly: stagnation of liver-QI stasis, menoxenia, dysmenorrhea, amenorrhea and distending pain in the chest and hypochondrium; Traumatic injury, pain caused by ecchymoma, swollen ulcer drug, scrofula.Select the dried floral for rosaceous plant Chinese rose.
Flos Lonicerae: heat-clearing and toxic substances removing.Epidemic febrile disease is generated heat; Toxic-heat and blood stasis; Carbuncle furuncle; Sore throat and multi-infection disease.Be selected from the dry flower of caprifoliaceae plant Radix Ophiopogonis (Lonicera japonica Thunb).
Fructus Gardeniae: pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body; Fructus Gardeniae Preparatus: cooling blood for hemostasis.Be used for the treatment of calentura vexed; Liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.Select the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis.
Spica Prunellae: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, and goiter, swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension, hyperglycemia, hyperlipidemia and high blood viscosity.Select the dry fruit ear of labiate Spica Prunellae Prunella vulgaris L..
Fructus Momordicae charantiae: there is clearing summer heat, improving eyesight removing toxic substances, reducing pressure and sugar, diuresis removing heat from blood, separate that labor clears away heart-fire, effect of QI invigorating tonifying YANG.Cure mainly the disease such as heatstroke, summer-heat excessive thirst, summer boil, miliaria is too much, dysentery, skin ulcer are swollen, conjunctivitis, conjunctival congestion and swelling pain, carbuncle erysipelas, burn and scald, oliguria.Select the dry fruit of cucurbitaceous plant Fructus Momordicae charantiae Momordica charantia.
Oral ulcer is the modal complication of Thoracic esophageal carcinoma, postoperative mouth care to promote operative incision healing, gastrointestinal function recovery, prevent and treat every complication and all play vital effect.Medicinal liquid of the present invention is used for the mouth care after Operation on Esophageal Cancer, can promote the wound healing that festers fast, determined curative effect, significantly be better than nitrofural.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Take 32 parts, Folium Bambusae, Flos Rosae Chinensis 32 parts, Flos Lonicerae 16 parts, Fructus Gardeniae 16 parts, Spica Prunellae 16 parts, 63 parts, Fructus Momordicae charantiae, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 16 times of water, soaking after 30 minutes decocts to boiling, continues 40 minutes, filters to get filtrate, be concentrated into paste, lyophilization evacuation, obtains extract, for subsequent use; Take extract, the ratio being 1:3 in mass volume ratio adds 33%(v/v) glycerine water solution, and add appropriate antiseptic ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 2
Take 30 parts, Folium Bambusae, Flos Rosae Chinensis 30 parts, Flos Lonicerae 20 parts, Fructus Gardeniae 12 parts, Spica Prunellae 20 parts, 60 parts, Fructus Momordicae charantiae, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 16 times of water, soaking after 30 minutes decocts to boiling, continues 30 minutes, filters to get filtrate, be concentrated into paste, lyophilization evacuation, obtains extract, for subsequent use; Take extract, the ratio being 1:2 in mass volume ratio adds 25%(v/v) glycerine water solution, and add appropriate antiseptic ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 3
Take 35 parts, Folium Bambusae, Flos Rosae Chinensis 35 parts, Flos Lonicerae 15 parts, Fructus Gardeniae 15 parts, Spica Prunellae 12 parts, 70 parts, Fructus Momordicae charantiae, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 18 times of water, soaking after 30 minutes decocts to boiling, continues 40 minutes, filters to get filtrate, be concentrated into paste, lyophilization evacuation, obtains extract, for subsequent use; Take extract, the ratio being 1:4 in mass volume ratio adds 33%(v/v) glycerine water solution, and add appropriate antiseptic ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 4 medicinal liquid is to the effectiveness study of patient's mouth care after Operation on Esophageal Cancer
Patient 42 example after Operation on Esophageal Cancer, wherein male 23 example, women 19 example; Age 50-76 year, average 68.3 ± 5.1 years old.Be divided into treatment group (21 example) and matched group (21 example) at random.Two groups in sex, age and disease degree without significantly lower difference, there is comparability.
Treatment group patient oral cavity first after furacillin solution is gargled, with dry cotton swab pick the appropriate medicinal liquid (being prepared from according to the prescription of the embodiment of the present invention 1 and technique) got ready gently be applied to oral mucosa affection position.Remain silent after coating 10min.Can not gargle immediately, drinking-water and feed.Medication twice every day 5 days is a course for the treatment of.Matched group only gives furacillin solution and directly to gargle treatment.Treat after 5 days, contrast two groups of curative effects.
Therapeutic outcome statistics is carried out by following curative effect judging standard:
Recovery from illness: ulcer surface heals, pain disappears;
Effective: ulcer surface reduces 2/3, pain relief;
Invalid: ulcer surface is without reducing or expanding gradually, and pain has no to be alleviated or increase the weight of.
Two groups of comparitive study, in table 1, can be found out by table 1, adopt medicinal liquid of the present invention to be significantly better than nitrofural for the mouth care after Operation on Esophageal Cancer, have better curative effect.
Table 1 liang group comparitive study
Claims (3)
1. the medicinal liquid for mouth care after Operation on Esophageal Cancer, it is characterized in that: be prepared from by traditional Chinese medicinal material raw materials and excipient, traditional Chinese medicinal material raw materials described is by weight made up of Folium Bambusae 30-34 part, Flos Rosae Chinensis 30-34 part, Flos Lonicerae 15-17 part, Fructus Gardeniae 15-17 part, Spica Prunellae 15-17 part and Fructus Momordicae charantiae 60-66 part.
2. according to claim 1 for the medicinal liquid of mouth care after Operation on Esophageal Cancer, it is characterized in that: traditional Chinese medicinal material raw materials described is by weight made up of 32 parts, Folium Bambusae, Flos Rosae Chinensis 32 parts, Flos Lonicerae 16 parts, Fructus Gardeniae 16 parts, Spica Prunellae 16 parts and 63 parts, Fructus Momordicae charantiae.
3. according to claim 1 or 2 for the medicinal liquid of mouth care after Operation on Esophageal Cancer, it is characterized in that: described excipient comprises antiseptic, described antiseptic is ethyl hydroxybenzoate.
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| CN201310711182.9A CN103690808B (en) | 2013-12-23 | 2013-12-23 | A kind of medicinal liquid for mouth care after Operation on Esophageal Cancer |
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| CN103690808B true CN103690808B (en) | 2015-08-05 |
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| CN104667238A (en) * | 2015-02-04 | 2015-06-03 | 滨州职业学院 | Traditional Chinese medicinal composition for oral care after gastrointestinal surgery and preparation method of composition |
| CN108567907A (en) * | 2018-07-15 | 2018-09-25 | 张晓莉 | A kind of conditioning liquid for Patients Receiving Chemotherapy oral care |
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| CN102370897A (en) * | 2010-08-09 | 2012-03-14 | 王辉 | Drug composition for treating mouth ulcer |
| CN102266500B (en) * | 2011-07-20 | 2013-04-10 | 丽水职业技术学院 | Chinese medicinal preparation for treating dental ulcer |
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Effective date of registration: 20170428 Address after: 226200 Jiangsu province Nantong Jiulong Zhen Yuan Dong Cun highstar Chemical Co. Ltd. in Patentee after: Qidong Su Xing carbon dioxide Co., Ltd. Address before: 266200 Jimo, Qingdao, the Yellow River, No. two, No. Road, building 25, building 182 Patentee before: Wang Xueyan |