CN108904609A - A kind of RADIX ACONITILATERALIS PREPARATA processing procedure and products thereof and application - Google Patents
A kind of RADIX ACONITILATERALIS PREPARATA processing procedure and products thereof and application Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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Abstract
The invention discloses a kind of RADIX ACONITILATERALIS PREPARATA processing procedure and products thereof and application, RADIX ACONITILATERALIS PREPARATA processing procedure includes the following steps：Step that the step of slice, moisturizing heating the step of steaming, ginger Radix Glycyrrhizae are decocted altogether, the step of drying are to get RADIX ACONITILATERALIS PREPARATA.RADIX ACONITILATERALIS PREPARATA processing procedure of the invention, on the one hand exists《Pharmacopeia》Under the guidance of preparation method, the step of optimizing RADIX ACONITILATERALIS PREPARATA production process, eliminate gallbladder bar, using method is gradually warmed up, technical process is steamed by changing, controls steaming temperature and steaming time, while guaranteeing detoxification effect, it is ensured that the content of effective component meets statutory standards；Product appearance and inherent quality are promoted, and ensure that the stability and reproducibility of kind technique.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation technologies more particularly to a kind of RADIX ACONITILATERALIS PREPARATA processing procedure and products thereof and application.
Background technique
Monkshood is the processed goods of the sub- root of ranunculaceae plant rhizome of Chinese monkshood Aconitum carmichaelii Debx., is had back
Sun is rescued inverse, the effect of mends fire supporing yang, eliminating cold to stop pain, collapses for yang depletion, cold weak pulse of limb, impotence palace cold, institute's abdomen crymodynia, and the cold of insufficiency type is spat
It rushes down, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness, is a kind of important Chinese medicine.Monkshood contains aconitine, and aconitine is then right
Heart, blood pressure, heart rate suffer from wide influence, may occur in which salivation, nausea,vomiting,diarrhea dizziness, tongue four limbs hair after poisoning
Fiber crops, tetany, expiratory dyspnea, arrhythmia etc. performance.Since the toxicity of monkshood is big, the processing of monkshood just seems especially
It is important.
《Chinese Pharmacopoeia》The preparation method that RADIX ACONITILATERALIS PREPARATA is recorded in 2015 editions is as follows：Mud monkshood of uniform size is selected, is cleaned, is immersed
A few days in the aqueous solution of gallbladder bar boils to the saturating heart together with immersion liquid, pulls out, peels off crust, and the piece of longitudinal sectional Cheng Houyue 0.3cm uses water logging
Drift is taken out, and is steamed thoroughly, is dried, and is practised and is claimed " RADIX ACONITILATERALIS PREPARATA ".RADIX ACONITILATERALIS PREPARATA exists《Pharmacopeia》Preparation method is more general, without specific crucial control ginseng
Number；Conventionally employed normal pressure water proof steams, and amount of water, feeding quantity, temperature, time etc. are without detailed standard；And it is time-consuming, it produces
Measure lower, reproducibility is poor.Monkshood is after the processing of above-mentioned manufacturing procedure, although toxicity is eased, due to monkshood
Effective component alkaloid be easy to happen hydrolysis, impregnating can be such that effective component is also largely lost for a long time, and gallbladder bar (mainly at
Divide includes calcium chloride, magnesium chloride) it impregnates, calcium and magnesium ion too high levels can have an adverse effect to human body.Therefore, monkshood exists
While considering to process detoxification, also to pay attention to the content of effective component, how to achieve the purpose that attenuation synergistic, be still one
Problem.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of RADIX ACONITILATERALIS PREPARATA processing procedures.This
The RADIX ACONITILATERALIS PREPARATA processing procedure of invention, on the one hand exists《Pharmacopeia》Under the guidance of preparation method, RADIX ACONITILATERALIS PREPARATA production process is optimized, is removed from
The step of gallbladder bar, steams technical process by changing, controls steaming temperature and steaming time, guaranteeing using method is gradually warmed up
While detoxification effect, it is ensured that the content of effective component meets statutory standards；Product appearance and inherent quality are promoted, and ensure that product
The stability and reproducibility of kind technique.
The second object of the present invention is to provide a kind of RADIX ACONITILATERALIS PREPARATA medicine materical crude slice, which processes as described above
Technique is made.
The third object of the present invention is to provide a kind of RADIX ACONITILATERALIS PREPARATA medicine materical crude slice as described above in preparation for treating kidney
YANG deficiency, aversion to cold and cold limbs, wind-cold-dampness arthralgia pharmaceutical composition in application.
An object of the present invention adopts the following technical scheme that realization：A kind of RADIX ACONITILATERALIS PREPARATA processing procedure, includes the following steps：
The step of slice：Monkshood is thinly sliced；
The step of moisturizing heating steams：Monkshood piece is placed in boiler, using the method that is gradually warmed up, and controls humidity in boiler
For 60-70%, water proof steams 1-2h；
The step that ginger Radix Glycyrrhizae is decocted altogether：Monkshood piece after steaming be placed in ginger and the decocting liquid of Radix Glycyrrhizae decoct altogether to receive juice it is complete
Finish；
Dry step：Monkshood piece after decocting altogether is put in a drying box and is dried to get RADIX ACONITILATERALIS PREPARATA.
Further, slice the step of in, the monkshood with a thickness of 0.4-0.6cm.
Further, in the step of moisturizing heating steams, the condition for being gradually warmed up method is as follows：It is 90- in temperature
105 DEG C, steam pressure be 0.02Mpa under conditions of steam 8-12min；Temperature is 105-115 DEG C, steam pressure is
20-40min is steamed under conditions of 0.04Mpa；20- is steamed under conditions of temperature is 120-130 DEG C, steam pressure is 0.1Mpa
40min。
Further, the condition for being gradually warmed up method is as follows：In the item that temperature is 105 DEG C, steam pressure is 0.02Mpa
10min is steamed under part；30min is steamed under conditions of temperature is 110 DEG C, steam pressure is 0.04Mpa；Temperature be 120 DEG C,
Steam pressure steams 30min under conditions of being 0.1Mpa.
Further, in the step that ginger Radix Glycyrrhizae is decocted altogether, preparing for the decocting liquid of the ginger and Radix Glycyrrhizae is as follows：Take weight
Than for (1-3)：1 ginger, Radix Glycyrrhizae are added water, are once decocted, decocting time 0.5-1h, separating filtrate and filter residue；Filter residue
Water is added, carries out secondary decoction, decocting time 0.5h, filtering；Merge filtrate twice, obtains decocting liquid.
Further, the amount of water once decocted is 5-6 times of ginger and Radix Glycyrrhizae weight, decocts temperature and is maintained at 75-85
℃；The amount of water of secondary decoction is 3-4 times of ginger and Radix Glycyrrhizae weight, decocts temperature and is maintained at 80-85 DEG C.
Further, the weight ratio of the ginger and Radix Glycyrrhizae is 2:1.
Further, in dry step, the condition of the drying is that initial temperature is 100-120 DEG C, keeps 2-3h.
The second object of the present invention adopts the following technical scheme that realization：A kind of RADIX ACONITILATERALIS PREPARATA medicine materical crude slice, the RADIX ACONITILATERALIS PREPARATA medicine materical crude slice according to
Processing procedure as described above is made.
The third object of the present invention adopts the following technical scheme that realization：RADIX ACONITILATERALIS PREPARATA medicine materical crude slice is used in preparation as described above
In treatment the insufficiency of the kidney yang, aversion to cold and cold limbs, wind-cold-dampness arthralgia pharmaceutical composition in application.
Compared with prior art, the beneficial effects of the present invention are：
(1) RADIX ACONITILATERALIS PREPARATA processing procedure of the invention, on the one hand exists《Pharmacopeia》Under the guidance of preparation method, RADIX ACONITILATERALIS PREPARATA production is optimized
Technical process, the step of eliminating gallbladder bar, steam technical process by changing using method is gradually warmed up, and control steaming temperature and steam
Time processed, while guaranteeing detoxification effect, it is ensured that the content of effective component meets statutory standards；Product appearance and inherent quality
It is promoted, ensure that the stability and reproducibility of kind technique.
(2) due in concocting process without be added gallbladder bar, therefore processed product of the invention compared with traditional RADIX ACONITILATERALIS PREPARATA significantly
The concentration for reducing wherein magnesium ion, calcium ion, chloride ion plasma reduces side effect of the residual saltwater brine to human body.
(3) it present invention also reduces impregnating, avoids effective component from hydrolyzing, is effectively retained ingredient, avoids into
It shunts and loses.
(4) present invention can be improved diester-type alkaloids and be converted to nontoxic monoester type life by decocting altogether with ginger Radix Glycyrrhizae
The conversion ratio of alkaloids to more effectively reduce the toxicity of RADIX ACONITILATERALIS PREPARATA, and can preferably save the content of diester-type alkaloids,
That is can preferably achieve the effect that be attenuated sustainability.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
In the present invention, if not refering in particular to, all parts, percentage are unit of weight, used equipment and raw material etc.
It is commercially available or commonly used in the art.Method in following embodiments is unless otherwise instructed the normal of this field
Rule method.
A kind of RADIX ACONITILATERALIS PREPARATA processing procedure, includes the following steps：
The step of slice：Monkshood is thinly sliced；Preferably, the monkshood with a thickness of 0.4-0.6cm.
The step of moisturizing heating steams：Monkshood piece is placed in boiler, using the method that is gradually warmed up, and controls humidity in boiler
For 60-70%, water proof steams 1-2h；The condition for being gradually warmed up method is as follows：Temperature is 90-105 DEG C, steam pressure is
8-12min is steamed under conditions of 0.02Mpa；20- is steamed under conditions of temperature is 105-115 DEG C, steam pressure is 0.04Mpa
40min；20-40min is steamed under conditions of temperature is 120-130 DEG C, steam pressure is 0.1Mpa.As further preferred side
Case, the condition for being gradually warmed up method are as follows：10min is steamed under conditions of temperature is 105 DEG C, steam pressure is 0.02Mpa；
30min is steamed under conditions of temperature is 110 DEG C, steam pressure is 0.04Mpa；Temperature is 120 DEG C, steam pressure is
30min is steamed under conditions of 0.1Mpa.Another advantage for being gradually warmed up method is：Under saturated vapor effect, steam by it is outer and in,
Material is gradually penetrated, " half-cooked " and " pattern piece " are avoided, medicine materical crude slice appearance character is uniform, and inherent quality reaches " system is saturating " and " subtracts
The processing purpose of malicious synergy ".
The step that ginger Radix Glycyrrhizae is decocted altogether：Monkshood piece after steaming be placed in ginger and the decocting liquid of Radix Glycyrrhizae decoct altogether to receive juice it is complete
Finish；Wherein, the ginger and the decocting liquid of Radix Glycyrrhizae prepare it is as follows：Taking weight ratio is (1-3)：Water is added in 1 ginger, Radix Glycyrrhizae, carries out
Primary decoction, decocting time 0.5-1h, separating filtrate and filter residue；Water is added in filter residue, carries out secondary decoction, decocting time is
0.5h, filtering；Merge filtrate twice, obtains decocting liquid.As further preferred scheme, the amount of water that once decocts be ginger with it is sweet
5-6 times of careless weight decocts temperature and is maintained at 75-85 DEG C；The amount of water of secondary decoction is 3-4 times of ginger and Radix Glycyrrhizae weight,
It decocts temperature and is maintained at 80-85 DEG C.As most preferably scheme, the weight ratio of the ginger and Radix Glycyrrhizae is 2:1.
Dry step：Monkshood piece after decocting altogether is put in a drying box and is dried to get RADIX ACONITILATERALIS PREPARATA.As further
Preferred embodiment, the condition of the drying are that initial temperature is 100-120 DEG C, keep 2-3h.
The present invention also provides a kind of RADIX ACONITILATERALIS PREPARATA medicine materical crude slice, processing procedure is made the RADIX ACONITILATERALIS PREPARATA medicine materical crude slice as described above.
In addition, RADIX ACONITILATERALIS PREPARATA medicine materical crude slice is in preparation for treating the insufficiency of the kidney yang, aversion to cold and cold limbs, wind-cold-dampness arthralgia as described above
Pharmaceutical composition in application.
It is specific embodiment of the present invention below, used raw material, equipment etc. remove special limit in the following embodiments
It can be obtained by buying pattern outside fixed.
Embodiment 1
A kind of RADIX ACONITILATERALIS PREPARATA processing procedure, includes the following steps：
The step of slice：Monkshood is cut into the thin slice with a thickness of 0.4cm；
The step of moisturizing heating steams：Monkshood piece is placed in boiler, using method is gradually warmed up, is 90 DEG C, steams in temperature
Steam pressure steams 8min under conditions of being 0.02Mpa；It is steamed under conditions of temperature is 105 DEG C, steam pressure is 0.04Mpa
20min；20min is steamed under conditions of temperature is 120 DEG C, steam pressure is 0.1Mpa；And controlling humidity in boiler is 60%,
Water proof is carried out to steam；
The step that ginger Radix Glycyrrhizae is decocted altogether：Monkshood piece after steaming be placed in ginger and the decocting liquid of Radix Glycyrrhizae decoct altogether to receive juice it is complete
Finish；Wherein, the ginger and the decocting liquid of Radix Glycyrrhizae prepare it is as follows：Taking weight ratio is 1：Ginger and Radix Glycyrrhizae is added in 1 ginger, Radix Glycyrrhizae
The water that 5 times of weight, is once decocted, and is decocted temperature and is maintained at 75 DEG C, decocting time 0.5h, separating filtrate and filter residue；Filter
The water of ginger with 3 times of Radix Glycyrrhizae weight is added in slag, carries out secondary decoction, decocts temperature and is maintained at 80 DEG C, decocting time 0.5h, mistake
Filter；Merge filtrate twice, obtains decocting liquid.
Dry step：Monkshood piece after decocting altogether is put in a drying box and is dried, dry condition is initial temperature
It is 100 DEG C, keeps 2h to get RADIX ACONITILATERALIS PREPARATA.
Embodiment 2
A kind of RADIX ACONITILATERALIS PREPARATA processing procedure, includes the following steps：
The step of slice：Monkshood is cut into the thin slice with a thickness of 0.5cm；
The step of moisturizing heating steams：Monkshood piece is placed in boiler, using method is gradually warmed up, is 105 DEG C, steams in temperature
Steam pressure steams 10min under conditions of being 0.02Mpa；It is steamed under conditions of temperature is 110 DEG C, steam pressure is 0.04Mpa
30min；30min is steamed under conditions of temperature is 120 DEG C, steam pressure is 0.1Mpa；And controlling humidity in boiler is 65%,
Water proof is carried out to steam；
The step that ginger Radix Glycyrrhizae is decocted altogether：Monkshood piece after steaming be placed in ginger and the decocting liquid of Radix Glycyrrhizae decoct altogether to receive juice it is complete
Finish；Wherein, the ginger and the decocting liquid of Radix Glycyrrhizae prepare it is as follows：Taking weight ratio is 2：Ginger and Radix Glycyrrhizae is added in 1 ginger, Radix Glycyrrhizae
5.5 times of water of weight, is once decocted, and is decocted temperature and is maintained at 80 DEG C, decocting time 45min, separating filtrate and filter
Slag；3.5 times of water of ginger and Radix Glycyrrhizae weight is added in filter residue, carries out secondary decoction, decocts temperature and is maintained at 80 DEG C, decocting time
For 0.5h, filtering；Merge filtrate twice, obtains decocting liquid；
Dry step：Monkshood piece after decocting altogether is put in a drying box and is dried, dry condition is initial temperature
It is 110 DEG C, keeps 2.5h to get RADIX ACONITILATERALIS PREPARATA.
Embodiment 3
A kind of RADIX ACONITILATERALIS PREPARATA processing procedure, includes the following steps：
The step of slice：Monkshood is cut into the thin slice with a thickness of 0.6cm；
The step of moisturizing heating steams：Monkshood piece is placed in boiler, using method is gradually warmed up, is 105 DEG C, steams in temperature
Steam pressure steams 12min under conditions of being 0.02Mpa；It is steamed under conditions of temperature is 115 DEG C, steam pressure is 0.04Mpa
40min；40min is steamed under conditions of temperature is 130 DEG C, steam pressure is 0.1Mpa；And controlling humidity in boiler is 70%,
Water proof is carried out to steam；
The step that ginger Radix Glycyrrhizae is decocted altogether：Monkshood piece after steaming be placed in ginger and the decocting liquid of Radix Glycyrrhizae decoct altogether to receive juice it is complete
Finish；Wherein, the ginger and the decocting liquid of Radix Glycyrrhizae prepare it is as follows：Taking weight ratio is 3：Ginger and Radix Glycyrrhizae is added in 1 ginger, Radix Glycyrrhizae
The water that 6 times of weight, is once decocted, and is decocted temperature and is maintained at 85 DEG C, decocting time 1h, separating filtrate and filter residue；Filter residue
The water of ginger with 4 times of Radix Glycyrrhizae weight is added, carries out secondary decoction, decocts temperature and is maintained at 85 DEG C, decocting time 0.5h, mistake
Filter；Merge filtrate twice, obtains decocting liquid.
Dry step：Monkshood piece after decocting altogether is put in a drying box and is dried, dry condition is initial temperature
It is 120 DEG C, keeps 3h to get RADIX ACONITILATERALIS PREPARATA.
Effect assessment and performance detection
Appearance, toxic component, effective component in RADIX ACONITILATERALIS PREPARATA medicine materical crude slice made from embodiment 1-3 and comparative example 1-2 are carried out
Detection, detection project and result are referring to table 1.With《Chinese Pharmacopoeia》2015 editions RADIX ACONITILATERALIS PREPARATA preparation methods as a comparison case 1, comparative example 2
Using the processing procedure of embodiment 2, difference is to lack the step that ginger Radix Glycyrrhizae is decocted altogether, remaining step condition is identical.HPLC method
The diester-type alkaloids total amount of the RADIX ACONITILATERALIS PREPARATA of embodiment 1-3 and comparative example 1-2 is measured respectively (with aconitine, mesaconine, secondary
Aconitine total amount calculates) and monoester alkaloid total amount it is (secondary with benzoylmesaconine, benzoyl aconine, benzoyl
Aconitine calculates).
The appearance and active constituent content testing result of 1 RADIX ACONITILATERALIS PREPARATA medicine materical crude slice of 1 embodiment 1-3 of table and comparative example
Diester-type alkaloids are both the toxic component and effective component of monkshood, have the function of anti-inflammatory and antalgic, according to《In
State's pharmacopeia》2015 editions one regulation, RADIX ACONITILATERALIS PREPARATA diester-type alkaloids total amount is (with aconitine, mesaconine, Hypaconitine total amount
Calculate) must not exceed 0.020% and monoester alkaloid total amount (with benzoylmesaconine, benzoyl aconine, benzene first
Acyl Hypaconitine calculates) 0.010% must not be less than.As shown in Table 1, the present invention exists《Pharmacopeia》Under the guidance of preparation method, steaming is optimized
Technical process processed controls steaming temperature and steaming time, while guaranteeing detoxification effect, it is ensured that the content of effective component meets
Statutory standards guarantee the reproducibility and stability of medicine materical crude slice production, are easy to scale mass production and give parameter to production process
Change control, reduces the missing of human error or operation standard to the greatest extent to the potential risk of process of preparing, being allowed to be controlled in can connect
The low level risk range received, so that it is guaranteed that prepared slice quality meets statutory standards.
In addition, the research of the invention finds that monkshood can be improved diester-type alkaloids and be converted to by decocting altogether with ginger Radix Glycyrrhizae
The conversion ratio of nontoxic monoester alkaloid to more effectively reduce the toxicity of RADIX ACONITILATERALIS PREPARATA, and can preferably save dibasic acid esters
The content of type alkaloid, that is to say, that can preferably achieve the effect that be attenuated sustainability.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of RADIX ACONITILATERALIS PREPARATA processing procedure, which is characterized in that include the following steps：
The step of slice：Monkshood is thinly sliced；
The step of moisturizing heating steams：Monkshood piece is placed in boiler, using the method that is gradually warmed up, and humidity in boiler is controlled and is
60-70%, water proof steam 1-2h；
The step that ginger Radix Glycyrrhizae is decocted altogether：Monkshood piece after steaming is placed in ginger and the decocting liquid of Radix Glycyrrhizae to be decocted altogether to receipts juice and finish；
Dry step：Monkshood piece after decocting altogether is put in a drying box and is dried to get RADIX ACONITILATERALIS PREPARATA.
2. RADIX ACONITILATERALIS PREPARATA processing procedure as described in claim 1, which is characterized in that in the step of being sliced, the thickness of the monkshood
Degree is 0.4-0.6cm.
3. RADIX ACONITILATERALIS PREPARATA processing procedure as described in claim 1, which is characterized in that described in the step of moisturizing heating steams
The condition for being gradually warmed up method is as follows：8-12min is steamed under conditions of temperature is 90-105 DEG C, steam pressure is 0.02Mpa；?
Temperature is 105-115 DEG C, steam pressure steams 20-40min under conditions of being 0.04Mpa；It is 120-130 DEG C, steam in temperature
Pressure steams 20-40min under conditions of being 0.1Mpa.
4. RADIX ACONITILATERALIS PREPARATA processing procedure as claimed in claim 3, which is characterized in that the condition for being gradually warmed up method is as follows：?
Temperature is 105 DEG C, steam pressure steams 10min under conditions of being 0.02Mpa；Temperature is 110 DEG C, steam pressure is
30min is steamed under conditions of 0.04Mpa；30min is steamed under conditions of temperature is 120 DEG C, steam pressure is 0.1Mpa.
5. RADIX ACONITILATERALIS PREPARATA processing procedure as described in claim 1, which is characterized in that described in the step that ginger Radix Glycyrrhizae is decocted altogether
Preparing for ginger and the decocting liquid of Radix Glycyrrhizae is as follows：Taking weight ratio is (1-3)：1 ginger, Radix Glycyrrhizae are added water, are once decocted, and decoct
Boiling the time is 0.5-1h, separating filtrate and filter residue；Water is added in filter residue, carries out secondary decoction, decocting time 0.5h, filtering；It closes
And filtrate twice, obtain decocting liquid.
6. RADIX ACONITILATERALIS PREPARATA processing procedure as claimed in claim 5, which is characterized in that the amount of water once decocted is ginger and Radix Glycyrrhizae
5-6 times of weight decocts temperature and is maintained at 75-85 DEG C；The amount of water of secondary decoction is 3-4 times of ginger and Radix Glycyrrhizae weight, is decocted
It boils temperature and is maintained at 80-85 DEG C.
7. RADIX ACONITILATERALIS PREPARATA processing procedure as claimed in claim 5, which is characterized in that the weight ratio of the ginger and Radix Glycyrrhizae is 2:1.
8. RADIX ACONITILATERALIS PREPARATA processing procedure as described in claim 1, which is characterized in that in dry step, the item of the drying
Part is that initial temperature is 100-120 DEG C, keeps 2-3h.
9. a kind of RADIX ACONITILATERALIS PREPARATA medicine materical crude slice, which is characterized in that the RADIX ACONITILATERALIS PREPARATA medicine materical crude slice is according to processing of any of claims 1-8
Technique is made.
10. RADIX ACONITILATERALIS PREPARATA medicine materical crude slice is in preparation for treating the insufficiency of the kidney yang, aversion to cold and cold limbs, wind-cold-dampness arthralgia according to claim 9
Pharmaceutical composition in application.
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| CN109820895A (en) * | 2018-12-26 | 2019-05-31 | 陕西师范大学 | A kind of novel concocting method of dry tag |
| CN113069487A (en) * | 2021-03-31 | 2021-07-06 | 建昌帮药业有限公司 | Radix aconiti lateralis praeparata tablet and preparation method thereof |
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| CN109820895A (en) * | 2018-12-26 | 2019-05-31 | 陕西师范大学 | A kind of novel concocting method of dry tag |
| CN113069487A (en) * | 2021-03-31 | 2021-07-06 | 建昌帮药业有限公司 | Radix aconiti lateralis praeparata tablet and preparation method thereof |
| CN113069487B (en) * | 2021-03-31 | 2022-05-20 | 建昌帮药业有限公司 | Radix aconiti lateralis praeparata tablet and preparation method thereof |
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Application publication date: 20181130 |