CN108902929A - Xuancheng's pawpaw lucidum spore powder tablet and its preparation method and application - Google Patents
Xuancheng's pawpaw lucidum spore powder tablet and its preparation method and application Download PDFInfo
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- CN108902929A CN108902929A CN201810959993.3A CN201810959993A CN108902929A CN 108902929 A CN108902929 A CN 108902929A CN 201810959993 A CN201810959993 A CN 201810959993A CN 108902929 A CN108902929 A CN 108902929A
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- xuancheng
- pawpaw
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- powder
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- 244000189799 Asimina triloba Species 0.000 title claims abstract description 57
- 235000006264 Asimina triloba Nutrition 0.000 title claims abstract description 57
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- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 229940000492 pawpaw extract Drugs 0.000 claims abstract description 51
- 241000222336 Ganoderma Species 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 150000004676 glycans Chemical class 0.000 claims abstract description 22
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 22
- 239000005017 polysaccharide Substances 0.000 claims abstract description 22
- 230000003064 anti-oxidating effect Effects 0.000 claims abstract description 21
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- 239000012153 distilled water Substances 0.000 claims abstract description 14
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001481296 Malus spectabilis Species 0.000 description 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 108010013639 Peptidoglycan Proteins 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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- 229930003268 Vitamin C Natural products 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
- DZRJLJPPUJADOO-UHFFFAOYSA-N chaetomin Natural products CN1C(=O)C2(Cc3cn(C)c4ccccc34)SSC1(CO)C(=O)N2C56CC78SSC(CO)(N(C)C7=O)C(=O)N8C5Nc9ccccc69 DZRJLJPPUJADOO-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- QKUSRAKPUWQSJS-UHFFFAOYSA-N diazanium 3-ethyl-2H-1,3-benzothiazole-6-sulfonate Chemical class [NH4+].[NH4+].[O-]S(=O)(=O)C1=CC=C2N(CC)CSC2=C1.[O-]S(=O)(=O)C1=CC=C2N(CC)CSC2=C1 QKUSRAKPUWQSJS-UHFFFAOYSA-N 0.000 description 1
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- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
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- 238000005374 membrane filtration Methods 0.000 description 1
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- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 230000005855 radiation Effects 0.000 description 1
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- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
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- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3472—Compounds of undetermined constitution obtained from animals or plants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention designs health product technology field, and in particular to a kind of Xuancheng's pawpaw ganoderma spove powder tablet and its preparation method and application.The Xuancheng's pawpaw lucidum spore powder tablet includes following components：（1）Xuancheng's pawpaw extract 15-40 parts by weight；（2）Ganoderma spove powder 60-85 parts by weight.The preparation method of the tablet includes the following steps：After Xuancheng's pawpaw extract is mixed in proportion with ganoderma spove powder, tabletting is carried out after oven drying is handled after completely dissolution with distilled water, the tablet is obtained after tabletting.Polysaccharide, triterpene compound and anti-oxidation active substance are higher in tablet of the present invention, and degree of adhesion is high, meet the development trend of ganoderma spove powder tablet, have broad application prospects.
Description
Technical field
The present invention relates to health product technology fields, relate generally to troche of health products field, and in particular to a kind of Xuancheng's pawpaw broken wall spirit
Ganoderma lucidum spore powder tablet and its preparation method and application.
Background technique
Lucidum spore powder has the whole inhereditary materials and health-care effect of ganoderma lucidum.Its medical value is paid more and more attention, spirit
Ganoderma lucidum spore powder contains polysaccharide, peptidoglycan, protein, enzyme, the terpene etc. more richer than ganoderma lucidum, can enhance immunity of organisms,
The effects of inhibition tumour, protection hepatic injury, analgesic, radiation protection.Since Reishi sporule has crust, by shell remove or
After broken wall, the effective component in spore can just be absorbed by the body, therefore currently, common preparation method is to pass through lucidum spore powder
After broken wall, using tabletting is carried out after various auxiliary materials or ganoderma lucidum fruitbody mixing, the troche of health products containing lucidum spore powder is made.
A kind of troche of health products and its preparation and application are provided application No. is 200610050554.8 patent, described
Agent main component be ganoderma lucidum water extract, panax ginseng super powder, glossy ganoderma ultra-fine powder, ganoderma spove powder and vitamin E, additionally plus
Enter adhesive and glidant, which combines ginseng, ganoderma lucidum and vitamin E, and Chinese and Western medicine is used cooperatively, and can greatly enhance product
Anti-aging, it is antifatigue and improve body's immunity, be added adhesive（Hypromellose sodium or sucrose）And glidant
（Dolomol or superfine silica gel powder）, the adhesive property of tablet can be improved.
Application No. is 201010520783.8 patents to provide a kind of no auxiliary material superfine powder tablets and preparation method, is not adding
In the case where adding auxiliary material, tablet is made after the liquid extract as adhesive is mixed with superfine powder, the liquid extract is mushroom
Any one in entity, Agricus blazei fructification and ganoderma lucidum fruitbody is the extract of raw material, and a kind of no auxiliary material has been prepared, has had
Imitate the high superfine powder tablets of content.
Summary of the invention
Present invention solves the technical problem that being：Triterpene in lucidum spore powder（<3.5g/100g）And polysaccharide（>2.0g/
100 g）It is the main active of its physiological activity, but its content is not high.Tested through antioxidation activity in vitro, activity compared with
Difference.Simultaneously as lucidum spore powder partial size is smaller, it is difficult to bond tabletting, is mentioned using existing auxiliary material or addition ganoderma lucidum fruitbody
It takes object to carry out tabletting as adhesive, the content of its active constituent is influenced less and related activity does not improve effect.
Xuancheng's pawpaw main chemical compositions are triterpenes, Polyphenols, carbohydrate, organic acid etc., have antitumor, liver protection, resist
The biological effects such as inflammation analgesia, wind-damp dispelling and antibacterial.
The present inventor has found afterwards after study, using the stronger Xuancheng's pawpaw extract of bonding force as the viscous of lucidum spore powder
Mixture, while can be improved active constituent triterpenes content, the antioxidant activity of tablet is improved, ganoderma spove powder piece is met
The development trend of agent.
The purpose of the present invention is：It is used as by using the Xuancheng's pawpaw extract for containing abundant polysaccharide and triterpene compound broken
The adhesive of wall lucidum spore powder tablet will improve tablet effective active composition content and its antioxidant activity, and be conducive to brokenly
The preservation of wall lucidum spore powder provides a kind of natural glossy ganoderma conidia powder tablet.
In order to solve the above technical problems, the present invention provides the pieces of a kind of extract containing Xuancheng's pawpaw and ganoderma spove powder
Agent.
Specifically, in view of the deficiencies of the prior art, the present invention provides following [a1]：
Xuancheng's pawpaw lucidum spore powder tablet, which is characterized in that include following components：
（1）Xuancheng's pawpaw extract 15-40 parts by weight；With
（2）Ganoderma spove powder 60-85 parts by weight.
Preferably, in above-mentioned tablet, described Xuancheng's pawpaw extract weight part is 20-40 parts by weight, preferably 25-40 parts by weight；
The conidia powder parts by weight are 60-80 parts by weight, preferably 60-75 parts by weight.
Preferably, in above-mentioned tablet, the tablet includes polysaccharide, triterpene compound and anti-oxidation active substance, described
The mass fraction that polysaccharide accounts for tablet is 4-10wt%, preferably 4-8wt%, more preferably 4.8-7wt%, the triterpene compound
The mass fraction for accounting for tablet is 3-8wt%, preferably 3-6wt%, more preferably 3-5.5wt%, and anti-oxidation active substance content is
0.05-0.6wt%, preferably 0.07-0.50wt%.
It preferably, include polysaccharide, triterpene compound and antioxidant activity in the Xuancheng's pawpaw extract in above-mentioned tablet
Substance, the mass fraction that the polysaccharide accounts for Xuancheng's pawpaw extract is 10 wt %-30 wt %, preferably 15-30%, more preferably
18-25%；The mass fraction of triterpene compound is 7 wt %-40 wt %, preferably 18-36wt%；Anti-oxidation active substance
Mass fraction is 1 wt%-4 wt %, preferably 1.5-4wt%, more preferably 2-4wt%.
Preferably, in above-mentioned tablet, the Xuancheng's pawpaw extract is prepared by the method included the following steps：
（1）Xuancheng's pawpaw is subjected to HIGH PRESSURE TREATMENT, condition is：90-120 DEG C of temperature, pressure 0.04-0.1MPa obtains Xuancheng's pawpaw powder；
（2）Xuancheng's pawpaw powder is subjected to refluxing extraction processing, obtains Xuancheng's pawpaw extracting solution, wherein the reflux solution is 0-
The ethanol solution of 100wt%；
（3）Xuancheng's pawpaw extract will be obtained after the drying of Xuancheng's pawpaw extracting solution.
Preferably, in above-mentioned tablet, the step（1）In, the temperature of the high pressure is 100-120 DEG C.
Preferably, in above-mentioned tablet, the reflux solution is the ethanol solution of 0-70wt%.
Preferably, in above-mentioned tablet, the step（2）In, the reflux solution is water.
Preferably, in above-mentioned tablet, the time of the high pressure is 20-80min.
Preferably, in above-mentioned tablet, the mass volume ratio of the Xuancheng's pawpaw powder and reflux solution is 1:（10-50）, preferably
It is 1：（20-40）, more preferably 1：（20-30）.
Preferably, in above-mentioned tablet, the reflux temperature is 80-100 DEG C.
Preferably, in above-mentioned tablet, the return time is 30-150min, preferably 40-120min.
Preferably, in above-mentioned tablet, the recovery rate of the Xuancheng's pawpaw extract is 5-95%, preferably 30-95%, more preferably
For 75-95%.
Preferably, in above-mentioned tablet, the Xuancheng's pawpaw extract is prepared by the method included the following steps：
By Xuancheng's pawpaw dried product and ethanol solution（Second alcohol and water）It is extracted after mixing, collects filtrate, obtain Xuancheng's pawpaw extraction
Object.
Preferably, in above-mentioned tablet, the concentration of alcohol in the ethanol solution is 0%-100%, the Xuancheng's pawpaw dried product
Mass volume ratio with ethanol solution is 1g:（10-50） mL.
Preferably, in above-mentioned tablet, the extracting method is selected from reflux, ultrasonic wave extraction, extraction or after HIGH PRESSURE TREATMENT
Refluxing extraction.
Preferably, in above-mentioned tablet, the extraction time is 1-3 h, and extraction time is 2-5 times.
It preferably, further include the process that filtrate is dry, the drying process side in above-mentioned tablet, after the extraction process
Method is selected from rotary evaporation drying or vacuum freeze drying, preferably vacuum freeze drying.
Preferably, in above-mentioned tablet, the process of the vacuum freeze drying includes the following steps：
By filtrate after -20 DEG C of pre-freeze 24-36h, in vacuum degree less than 100 Pa, condenser temperature is lower than under the conditions of -50 DEG C, vacuum
Xuancheng's pawpaw extract is obtained after freeze-drying.
The present invention also provides the preparation methods of above-mentioned tablet, which is characterized in that includes following step：
After Xuancheng's pawpaw extract is mixed in proportion with ganoderma spove powder, with distilled water after completely dissolution through oven drying at
Tabletting is carried out after reason, and the tablet is obtained after tabletting.
The present invention also provides above-mentioned tablets in food, the application of field of health care products.
The beneficial effects of the invention are as follows：
（1）The present invention feature abundant using polyoses content in Xuancheng's pawpaw extract, as the adhesive of lucidum spore powder, bonding
There is retentiveness while ability is strong, keep the integrality of tablet, improve the bonding effect of tablet, to improve wall-breaking lucidum spore
The purity of sub- powder realizes the requirement of tablet high-purity, and tablet friability is preferable.
（2）Organic acid, triterpenes, polyphenol components have preferable anti-oxidant and antibacterial effect compared with horn of plenty in Xuancheng's pawpaw
Fruit is able to extend the shelf-life of tablet, especially has protective effect to ganoderma spove powder, delays ganoderma lucidium spore powder wall breaking
The effective component exposed afterwards is oxidized.
（3）Polysaccharide and triterpenes components in Xuancheng's pawpaw equally have preferable physiological activity with ganoderma spove powder,
By the addition of Xuancheng's pawpaw extract, the triterpene and polyoses content of ganoderma spove powder are improved, while being improved anti-oxidant
Activity.And organic acid ursolic acid and oleanolic acid have enhancing immunity of organism effect, can effectively improve exempting from for lucidum spore powder
Epidemic disease function.
Specific embodiment
To be improved in view of adhesive effects such as the various auxiliary materials of current troche of health products preparation process addition, the present invention provides
A kind of preparation method of the ganoderma spove powder tablet of the extract containing Xuancheng's pawpaw.
In a kind of preferred embodiment, Xuancheng's pawpaw extract is selected, prepares the operating procedure of lucidum spore powder tablet such as
Under：
（1）Take Xuancheng's pawpaw dried product and 70% ethyl alcohol by mass volume ratio 1g:After 10-50 mL is mixed, extract, extraction time
It for 1-3h, extracts repeatedly twice, merging filtrate obtains Xuancheng's pawpaw extracting solution.Xuancheng's pawpaw extracting solution is dried, is obtained
Xuancheng's pawpaw extract.Xuancheng's pawpaw extract polyoses content is abundant, more sticky, and strong for adherence after dry, non-pulverulence will
It is as ganoderma spove powder adhesive.
（2）By Xuancheng's pawpaw extract and conidia powder according to mass ratio 15:85-40:60 are mixed, using distilled water by two
Person is sufficiently dissolved, and is dried, and mixture is obtained.
（3）Mixture by moisture content after drying lower than 6% is ground, and crosses 40 meshes, directly progress tabletting.
The technical solution further limited is as follows：
Xuancheng's pawpaw dried product is extracted using 70% ethyl alcohol in step (1), obtains Xuancheng's pawpaw extract.
The drying means of Xuancheng's pawpaw extract can be the methods of freeze-drying, spray drying in step (1).
Xuancheng's pawpaw extract and conidia powder are according to mass ratio 20 in step (2):80-40:60 are mixed, and distilled water is utilized
The two is sufficiently dissolved, mixture is obtained.
Step（2）In, the method for drying process can be to be dried in 40-65 DEG C of baking oven, is also possible to spraying
Seasoning is dried.
In step (3), when mixture moisture content is lower than 6%, ground 40 mesh is carried out, directly progress compressing tablet process.
In the present invention, described " Xuancheng's pawpaw " refers to：《Chinese Pharmacopoeia》Specified in originate from Xuancheng Profile, anhui Province city a surname wood
Melon, specifically originates in the new Tian Town in Xuancheng City organic acid rich in, polysaccharide, triterpene and tannin compound, fresh pawpaw mouthfeel compared with
It is puckery.
In the present invention, described " conidia powder " refers to ganoderma spove powder and Common ganoderma lucidum conidia powder
Tablet of the present invention and its preparation method and application is further illustrated below by specific embodiment.Institute in embodiment
It is as follows with reagent and facility information：
Xuancheng's pawpaw dried product：Buy producer：Declare Malus spectabilis Food Co., Ltd in Xuancheng City；
Ganoderma spove powder：Buy producer：The happy ganoderma lucidum Co., Ltd of Huangshan Cloud.
The preparation of 1 Xuancheng's pawpaw extract of embodiment
Embodiment 1-1
Take 2 g of Xuancheng's pawpaw dried product and 70% ethyl alcohol by mass volume ratio 1:After 15 mix, extracts, mention under impregnation state
Taking the time is 3 h, is extracted repeatedly twice, merging filtrate obtains Xuancheng's pawpaw extracting solution.Extracting solution is placed in 24 h of -20 DEG C of pre-freezes,
In vacuum degree less than 100 Pa, condenser temperature is lower than under the conditions of -50 DEG C, and 36 h of vacuum freeze drying obtains Xuancheng's pawpaw extract.
Xuancheng's pawpaw extract is characterized using following methods：
（1）Recovery rate：With extract quality divided by former Xuancheng's pawpaw dried product quality, calculate Xuancheng's pawpaw recovery rate be 30%.
（2）Using the polyoses content in phenolsulfuric acid method measurement Xuancheng's pawpaw extract
It weighs in 105 DEG C of 20 mg of the glucose that drying to constant weight in 500 mL volumetric flask constant volumes, being made into concentration is 0.04 mg/mL
Glucose mother liquid.0.25 mL is taken, 0.5 mL, 0.7 mL, 1 mL, 1.25 mL, 1.5 mL, 1.75 mL, 2.0 mL are in test tube
Add distilled water to 2.0 mL, addition 1 mL, 6% phenol is rapidly added 5.0 mL of the concentrated sulfuric acid, shakes up, 5 min of standing, in boiling water bath
30 min are heated, room temperature is rapidly cooled to, light absorption value is surveyed at 490 nm, draw standard curve.
0.01g Xuancheng's pawpaw extract is taken, being configured to concentration is 0.01g/mL concentration, 0.25 mL, 0.5 mL, 0.7 mL are taken,
1 mL, 1.25 mL, 1.5 mL, 1.75 mL, 2.0 mL are in test tube plus distilled water is to 2.0 mL, and addition 1 mL, 6% phenol is fast
5.0 mL of the concentrated sulfuric acid is added in speed, shakes up, and stands 5 min, heats 30 min in boiling water bath, room temperature is rapidly cooled to, in 490 nm
Place surveys light absorption value, detects glucose content.
Measurement result：Polyoses content accounts for the 15.83% of extract total amount, and being equivalent to polysaccharide conversion in sample is glucose
Content afterwards.
（3）Using the triterpene compound content in vanillic aldehyde-glacial acetic acid method measurement Xuancheng's pawpaw extract
Accurately weigh in 80 DEG C of 4.6 mg of the ursolic acid that drying to constant weight in 10mL volumetric flask, with ethyl acetate constant volume.Take 0.0
ML, 0.1 mL, 0.4 mL, 0.8 mL, 1.2 mL, 1.6 mL standard black bearberry acid solutions, acetic acid second of volatilizing in 80 DEG C of water-baths
Ester.5% vanillic aldehyde-glacial acetic acid solution 0.5mL, 72% sulfuric acid 5mL is added, after heating 20 min in 65 DEG C of thermostat water baths, in
5 minutes are stood in ice water.Sample measures light absorption value at 532nm, draws standard curve.
0.01 g Xuancheng's pawpaw extract is taken, being configured to concentration is 0.01g/mL concentration, 0.0 mL, 0.1 mL, 0.4 mL are taken,
0.8 mL, 1.2 mL, 1.6 mL Xuancheng's pawpaw extract solutions, volatilize ethyl acetate in 80 DEG C of water-baths.5% vanillic aldehyde-is added
Glacial acetic acid solution 0.5mL, 72% sulfuric acid 5mL after heating 20 min in 65 DEG C of thermostat water baths, stand 5 minutes in ice water.
Sample measures light absorption value at 532nm.
Measurement result：Triterpene compound content accounts for the 8.48% of extract total amount.
（4）Anti-oxidation active substance content is measured using ABTS method
Compound concentration be 0.01g/mL tablet extract solution after, through 0.45 μm of membrane filtration, accurately weigh 33 mg ABTS（Name
Claim：2,2- connection nitrogen-two (3- ethyl-benzothiazole -6- sulfonic acid) di-ammonium salts, molecular formula：C18H24N6O6S4）With 28.4mg mistake
Potassium sulfate sufficiently dissolves in 100mL water, uses after being placed in dark place 16h.Take different volumes（10-50μL）Xuancheng's pawpaw extracting solution
100 μ L are diluted to, dark place is placed in 100 μ LABTS and mixes after five minutes, read at 734nm with microplate reader, Xuancheng's pawpaw is calculated and mentions
It takes liquid to remove the IC50 of ABTS free radical, using vitamin C as standard items, and measures its IC50, when free radical scavenging activity is 50%
When, the percentage for accounting for extract total amount containing anti-oxidation active substance in every g Xuancheng's pawpaw extract is antioxidant activity in sample
Content of material.
Measurement result：Anti-oxidant kind compound content accounts for the 2.50wt% of extract total amount.
Embodiment 1-2
（1）The Xuancheng's pawpaw fruit for taking drying, pulverizes（40-120 mesh）, 10 mL distilled water and Xuancheng's pawpaw powder 2g are taken, are mixed
Conjunction is placed in reagent bottle with cover, is placed in high-pressure sterilizing pot, is carried out HIGH PRESSURE TREATMENT and is obtained mixture, treatment conditions are：Temperature 120
DEG C, pressure 0.1MPa, 40 min of time；
（2）By the Xuancheng's pawpaw mixture through HIGH PRESSURE TREATMENT, refluxing extraction processing is carried out, reflux solvent is second alcohol and water, the two body
Product ratio is 70：30, extraction time is 120 min, and solid-liquid ratio is 1 by mass volume ratio:40, extracting solution is kept in reflux course
80 DEG C slightly boiled；
（3）After time up to be extracted, the extruding of extracting solution filter cloth filters out decontamination, and being placed in revolving speed is 4000 r/min's
Centrifuge is centrifuged 5 min, and Xuancheng's pawpaw extracting solution can be obtained, and after removing solution to Xuancheng's pawpaw extracting solution progress rotary evaporation, obtains
Obtain extract.
It is detected with method identical in embodiment 1-1 to extract obtained, it is as a result as follows：
（1）Calculate Xuancheng's pawpaw recovery rate be 85.22%.
（2）Polyoses content accounts for the 23.57wt% of extract total amount, is equivalent to polysaccharide conversion in sample as after glucose
Content.
（3）Triterpene compound content accounts for the 35.92wt% of extract total amount.
（4）When free radical scavenging activity is 50%, extract total amount is accounted for containing anti-oxidation active substance in Xuancheng's pawpaw extract
2.65wt%.
Embodiment 1-3
（1）The Xuancheng's pawpaw fruit for taking drying, pulverizes, and takes 10 mL distilled water and Xuancheng's pawpaw powder 2g, carries out mixing and is placed on band
It in lid reagent bottle, is placed in high-pressure sterilizing pot, carries out high pressure sterilization and handle to obtain mixture, treatment conditions are：120 DEG C of temperature, pressure
0.1 MPa of power, 40 min of time；
（2）By the Xuancheng's pawpaw mixture through HIGH PRESSURE TREATMENT, refluxing extraction processing is carried out, reflux solvent is 100% distilled water, is extracted
Time is 40 min, and solid-liquid ratio is 1 by mass volume ratio:30, keep in reflux course 80 DEG C of extracting solution it is slightly boiled；
（3）After time up to be extracted, the extruding of extracting solution filter cloth filters out decontamination, and being placed in revolving speed is 4000 r/min's
Centrifuge is centrifuged 5 min, and Xuancheng's pawpaw extracting solution can be obtained.
It is following to Xuancheng's pawpaw extract to characterize under the conditions of embodiment 1-3：
（1）The recovery rate of Xuancheng's pawpaw is 93.31%.
（2）Polyoses content accounts for the 23.57wt% of extract total amount.
（3）Triterpene content accounts for the 7.59wt% of extract total amount.
（4）When free radical scavenging activity is 50%, extract total amount is accounted for containing anti-oxidation active substance in Xuancheng's pawpaw extract
3.98wt%.
The preparation of 2 tablet of embodiment
Embodiment 2-1
（1）By Xuancheng's pawpaw extract obtained by embodiment 1-1 and ganoderma spove powder according to 15 g of mass ratio:85 g are mixed
It closes, the two is sufficiently dissolved using distilled water, 3 h in 55 DEG C of baking ovens is placed in, is dried, obtains mixture.
（2）Mixture by moisture content after drying lower than 6% is ground, and crosses 40 meshes, directly progress tabletting（ TDP-
1.5T single-punch tablet press, Shanghai surpass hundred million pharmaceutical machine equipment Co., Ltds）, obtain tablet.
Following characterizations are carried out to Xuancheng's pawpaw ganoderma lucidum tablet：
（1）Polyoses content
Method is：Using phenolsulfuric acid method described in embodiment 1-1 measurement sample in polyoses content, and using glucose as
Standard items carry out content analysis to polysaccharide.
As a result it is：Polyoses content is equivalent to containing 48.21 mg glucose/g tablet.
（2）Triterpene content
Method is：The measurement of triterpene content is carried out, and using vanillic aldehyde described in embodiment 1-1-glacial acetic acid method with ursolic acid
As standard items, triterpene content is analyzed.
As a result it is：Triterpene content is equivalent to containing 34.67 mg ursolic acid/g tablet.
（3）Anti-oxidation active substance content
Method is：Antioxidative Activity Determination is carried out using ABTS method described in embodiment 1-1, and using VC as standard items, confrontation
Oxidation activity is analyzed.
As a result it is：0.72 mg of VC is equivalent to containing anti-oxidation active substance in every gram of tablet.
（4）Friability detection
Foundation《Pharmacopoeia of People's Republic of China》2015 editions four general rules 0923, friability detector device are Beijing Hua Yunan special
The CS-A friability detector of science and technology limited Company：Internal diameter is about 286 mm, and depth is 39 mm, and inner wall polishing on one side may be used
The transparent wear plastic cylinder of opening.There is an arc partition extended from central axle sleeve to outer wall in cylinder（Internal diameter is 80 mm ± 1
Mm, inner arcuate surface and axle sleeve outer wall are tangent）, when making rotary drum, tablet generates rolling.Cylinder is fixed on coaxial level and turns
On, shaft is connected with motor, and revolving speed is 25 turns ± 1 turn per minute.Per revolution, tablet roll or slide into barrel or
On other tablets.
Inspection method：
If slice weight is that 0.65 g or following person take dry plate, making its gross weight is about 6.5 g；Slice weight is greater than 0.65 g person and takes 10.With
Hair dryer blows away the powder to fall off, and precise weighing is set in cylinder, rotates 100 times.Take out, with method remove powder, precise weighing,
Less loss weight must not cross 1%, and must not detect the piece of fracture, cracking and crushing.This test is general only to be made 1 time.As less loss weight is super
When 1%, answer repetition measurement 2 times, 3 average less loss weight must not cross 1%, and must not detect the piece of fracture, cracking and crushing.
Xuancheng's pawpaw lucidum spore powder tablet counterpoise is no more than 0.3 g, and about 0.65 is weighed after blowing away surface powder with ear washing bulb
G tablet carries out friability detection.
As a result it is：Weight is reduced to 1.092%.
Embodiment 2-2
（1）By Xuancheng's pawpaw extract obtained by embodiment 1-2 and ganoderma spove powder according to 20 g of mass ratio:80 g are mixed
It closes, the two is sufficiently dissolved using distilled water, 3 h in 55 DEG C of baking ovens is placed in, is dried, obtains mixture.
（2）Mixture by moisture content after drying lower than 6% is ground, and crosses 40 meshes, directly progress tabletting（ TDP-
1.5T single-punch tablet press, Shanghai surpass hundred million pharmaceutical machine equipment Co., Ltds）, obtain tablet.
Following characterizations are carried out to Xuancheng's pawpaw ganoderma lucidum tablet：
（1）Polyoses content
Method is：Using phenolsulfuric acid method described in embodiment 1-1 measurement sample in polyoses content, and using glucose as
Standard items carry out content analysis to polysaccharide.
As a result it is：Polyoses content is equivalent to containing 56.79 mg glucose/g tablet.
（2）Triterpene content
Method is：The measurement of triterpene content is carried out, and using vanillic aldehyde described in embodiment 1-1-glacial acetic acid method with ursolic acid
As standard items, triterpene content is analyzed.
As a result it is：Triterpene content is equivalent to containing 41.61 mg ursolic acid/g tablet.
（3）Antioxidative Activity Determination
Method is：Antioxidative Activity Determination is carried out using ABTS method described in embodiment 1-1, and using VC as standard items, confrontation
Oxidation activity is analyzed.
As a result it is：1.86 mg of VC is equivalent to containing anti-oxidation active substance in every gram of tablet.
（4）Tablet friability detection
Method is：Using friability detection method described in embodiment 2-1, friability is detected.
As a result it is：Tablet quality loss is 0.998%.
Embodiment 2-3
（1）By Xuancheng's pawpaw extract obtained by embodiment 1-3 and ganoderma spove powder according to 25 g of mass ratio:75 g are mixed
It closes, the two is sufficiently dissolved using distilled water, 3 h in 55 DEG C of baking ovens is placed in, is dried, obtains mixture.
（2）Mixture by moisture content after drying lower than 6% is ground, and crosses 40 meshes, directly progress tabletting（ TDP-
1.5T single-punch tablet press, Shanghai surpass hundred million pharmaceutical machine equipment Co., Ltds）, obtain tablet.
Following characterizations are carried out to Xuancheng's pawpaw ganoderma lucidum tablet：
（1）Polyoses content
Method is：Using phenolsulfuric acid method described in embodiment 1-1 measurement sample in polyoses content, and using glucose as
Standard items carry out content analysis to polysaccharide.
As a result it is：Polyoses content is equivalent to containing 66.81 mg glucose/g tablet.
（2）Triterpene content
Method is：The measurement of triterpene content is carried out, and using vanillic aldehyde described in embodiment 1-1-glacial acetic acid method with ursolic acid
As standard items, triterpene content is analyzed.
As a result it is：Triterpene content is equivalent to containing 50.29 mg ursolic acid/g tablet.
（3）Antioxidative Activity Determination
Method is：Antioxidative Activity Determination is carried out using ABTS method described in embodiment 1-1, and using VC as standard items, confrontation
Oxidation activity is analyzed.
As a result it is：VC 2.78mg is equivalent to containing anti-oxidation active substance in every gram of tablet.
（4）Tablet friability detection
Method is：Using friability detection method described in embodiment 2-1, friability is detected.
As a result it is：Tablet quality loss is 0.998%.
Embodiment 2-4
（1）By Xuancheng's pawpaw extract obtained by embodiment 1-3 and ganoderma spove powder according to 40 g of mass ratio:60 g are mixed
It closes, the two is sufficiently dissolved using distilled water, 3 h in 55 DEG C of baking ovens is placed in, is dried, obtains mixture.
（2）Mixture by moisture content after drying lower than 6% is ground, and crosses 40 meshes, directly progress tabletting（ TDP-
1.5T single-punch tablet press, Shanghai surpass hundred million pharmaceutical machine equipment Co., Ltds）, obtain tablet.
Following characterizations are carried out to Xuancheng's pawpaw ganoderma lucidum tablet：
（1）Polyoses content
Method is：Using phenolsulfuric acid method described in embodiment 1-1 measurement sample in polyoses content, and using glucose as
Standard items carry out content analysis to polysaccharide.
As a result it is：Polyoses content is equivalent to containing 92mg glucose/g tablet.
（2）Triterpene content
Method is：The measurement of triterpene content is carried out, and using vanillic aldehyde described in embodiment 1-1-glacial acetic acid method with ursolic acid
As standard items, triterpene content is analyzed.
As a result it is：Triterpene content is equivalent to containing 75.25 mg ursolic acid/g tablet.
（3）Antioxidative Activity Determination
Method is：Antioxidative Activity Determination is carried out using ABTS method described in embodiment 1-1, and using VC as standard items, confrontation
Oxidation activity is analyzed.
As a result it is：
5.5 mg of VC is equivalent to containing anti-oxidation active substance in every gram of tablet.
（4）Tablet friability detection
Method is：Using friability detection method described in embodiment 2-1, friability is detected.
As a result it is：Tablet quality loss is 0.997%.
Comparative example 1
Following characterizations are carried out to 100% lucidum spore powder：
（1）Polyoses content
Method is：Using phenolsulfuric acid method described in embodiment 1-1 measurement sample in polyoses content, and using glucose as
Standard items carry out content analysis to polysaccharide.
As a result it is：Polyoses content is equivalent to containing 37.25 mg glucose/g tablet.
（2）Triterpene content
Method is：The measurement of triterpene content is carried out, and using vanillic aldehyde described in embodiment 1-1-glacial acetic acid method with ursolic acid
As standard items, triterpene content is analyzed.
As a result it is：Triterpene content is equivalent to containing 17.56 mg ursolic acid/g tablet.
（3）Antioxidative Activity Determination
Method is：Antioxidative Activity Determination is carried out using ABTS method described in embodiment 2-1, and using VC as standard items, confrontation
Oxidation activity is analyzed.
As a result it is：0.26 mg of VC is equivalent to containing anti-oxidation active substance content in every gram of tablet.
（4）Friability test result：Tablet quality loss is 2.9%.
Comparative example 2
Comparative example 2 is similar with embodiment 2-2, and difference is only that：Xuancheng's pawpaw extract and ganoderma spove powder mass ratio are
10g：90g.
After being characterized according to the identical characterizing method of embodiment 2-1, result is：
Polyoses content：Polyoses content is equivalent to containing 39.25 mg glucose/g tablet.Triterpene content：Triterpene content is equivalent to
Contain 25.35 mg ursolic acid/g tablet.Anti-oxidation active substance content：Contain anti-oxidation active substance content in every gram of tablet
It is equivalent to 0.15 mg of VC.Friability test result：Tablet quality loss is 1.997%.
Comparative example 3
Comparative example 3 is similar with embodiment 2-3, and difference is only that：Xuancheng's pawpaw extract and ganoderma spove powder mass ratio are
50g：50g.
The identical method of [a2] embodiment 2-1 carries out compressing tablet process, and as a result tablet molding effect is bad, and occurs more
Serious sticking phenomenon can not carry out a large amount of tablettings.
In conclusion tablet of the present invention uses Xuancheng's pawpaw extract as adhesive, raw material is natural, improves in tablet
The content of polysaccharide, triterpene compound and anti-oxidation active substance is conducive to the preservation of ganoderma spove powder, meets broken wall spirit
The development trend of Ganoderma lucidum spore powder tablet, has broad application prospects.
Claims (10)
1. Xuancheng's pawpaw lucidum spore powder tablet, which is characterized in that the tablet includes following components：
（1）Xuancheng's pawpaw extract 15-40 parts by weight；With
（2）Ganoderma spove powder 60-85 parts by weight.
2. tablet according to claim 1, wherein described Xuancheng's pawpaw extract weight part is 20-40 parts by weight, preferably
25-40 parts by weight；The conidia powder parts by weight are 60-80 parts by weight, preferably 60-75 parts by weight.
3. tablet according to claim 1 or claim 2, wherein the tablet includes polysaccharide, triterpene compound and antioxidant activity
Substance, the mass fraction that the polysaccharide accounts for tablet is 4-10wt%, and the mass fraction that the triterpene compound accounts for tablet is 3-
8wt%, anti-oxidation active substance content are 0.05-0.6wt%.
4. any one of -3 tablet according to claim 1, wherein include polysaccharide, triterpenes in the Xuancheng's pawpaw extract
Object and anti-oxidation active substance are closed, the mass fraction that the polysaccharide accounts for Xuancheng's pawpaw extract is 10 wt %-30 wt %；Triterpenes
The mass fraction of compound is 7 wt %-40 wt %；The mass fraction of anti-oxidation active substance is 1 wt%-4 wt %.
5. any one of -4 tablet according to claim 1, wherein method of the Xuancheng's pawpaw extract by including the following steps
It is prepared：
（1）Xuancheng's pawpaw is subjected to HIGH PRESSURE TREATMENT, condition is：90-120 DEG C of temperature, pressure 0.04-0.1MPa obtains Xuancheng's pawpaw powder；
（2）Xuancheng's pawpaw powder is subjected to refluxing extraction processing, obtains Xuancheng's pawpaw extracting solution, wherein the reflux solution is 0-
The ethanol solution of 100wt%；
（3）Xuancheng's pawpaw extract will be obtained after the drying of Xuancheng's pawpaw extracting solution.
6. tablet according to claim 5, wherein the step（1）In, the temperature of the HIGH PRESSURE TREATMENT is 100-120 DEG C.
7. any one of -4 tablet according to claim 1, wherein method of the Xuancheng's pawpaw extract by including the following steps
It is prepared：
It is extracted after Xuancheng's pawpaw dried product is mixed with ethanol solution, collects filtrate, obtain Xuancheng's pawpaw extract.
8. tablet according to claim 7, wherein the concentration of alcohol in the ethanol solution is 0%-100%, the Xuancheng's pawpaw
The mass volume ratio of dried product and ethanol solution is 1g:（10-50） mL.
9. the preparation method of any one of the claim 1-4 tablet, which is characterized in that include following step：
After Xuancheng's pawpaw extract is mixed in proportion with ganoderma spove powder, with distilled water after completely dissolution through oven drying at
Tabletting is carried out after reason, and the tablet is obtained after tabletting.
10. any one of the claim 1-4 tablet is in food, the application of field of health care products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810959993.3A CN108902929A (en) | 2018-08-22 | 2018-08-22 | Xuancheng's pawpaw lucidum spore powder tablet and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810959993.3A CN108902929A (en) | 2018-08-22 | 2018-08-22 | Xuancheng's pawpaw lucidum spore powder tablet and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
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Cited By (1)
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| CN115381092A (en) * | 2022-08-26 | 2022-11-25 | 吉林省爱康寿生物科技有限公司 | Ganoderma lucidum spore powder polysaccharide and blueberry powder composite chewable tablet and preparation process thereof |
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| CN115381092A (en) * | 2022-08-26 | 2022-11-25 | 吉林省爱康寿生物科技有限公司 | Ganoderma lucidum spore powder polysaccharide and blueberry powder composite chewable tablet and preparation process thereof |
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