CN108902483A - Application of the ox feed and N- carbamylglutamic acid of the carbamylglutamic acid containing N- in terms of preventing and treating pulmonary heart and lung diseases - Google Patents
Application of the ox feed and N- carbamylglutamic acid of the carbamylglutamic acid containing N- in terms of preventing and treating pulmonary heart and lung diseases Download PDFInfo
- Publication number
- CN108902483A CN108902483A CN201810516666.0A CN201810516666A CN108902483A CN 108902483 A CN108902483 A CN 108902483A CN 201810516666 A CN201810516666 A CN 201810516666A CN 108902483 A CN108902483 A CN 108902483A
- Authority
- CN
- China
- Prior art keywords
- feed
- heart
- carbamylglutamic acid
- cattle
- pulmonary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LCQLHJZYVOQKHU-VKHMYHEASA-N carglumic acid Chemical compound NC(=O)N[C@H](C(O)=O)CCC(O)=O LCQLHJZYVOQKHU-VKHMYHEASA-N 0.000 title claims abstract description 35
- 208000004186 Pulmonary Heart Disease Diseases 0.000 title claims abstract description 17
- 208000019693 Lung disease Diseases 0.000 title claims abstract description 14
- 241000283690 Bos taurus Species 0.000 claims abstract description 60
- 230000002708 enhancing effect Effects 0.000 claims abstract description 12
- 230000004199 lung function Effects 0.000 claims abstract description 12
- 208000002815 pulmonary hypertension Diseases 0.000 claims abstract description 12
- 239000000654 additive Substances 0.000 claims abstract description 7
- 230000000996 additive effect Effects 0.000 claims abstract description 7
- 239000011449 brick Substances 0.000 claims abstract description 5
- 208000008445 altitude sickness Diseases 0.000 claims description 13
- 235000013305 food Nutrition 0.000 claims description 7
- 241000283730 Bos primigenius Species 0.000 claims description 6
- 239000003651 drinking water Substances 0.000 claims description 6
- 235000020188 drinking water Nutrition 0.000 claims description 6
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 claims description 5
- 241001416152 Bos frontalis Species 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 claims description 5
- 241001416153 Bos grunniens Species 0.000 claims description 4
- 239000003674 animal food additive Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 241000364432 Acutifrons Species 0.000 claims description 2
- 241001121501 Barisia planifrons Species 0.000 claims description 2
- 241000283728 Bos javanicus Species 0.000 claims description 2
- 241001247317 Bos mutus Species 0.000 claims description 2
- 241000946464 Bos sauveli Species 0.000 claims description 2
- 208000019622 heart disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 13
- 201000010099 disease Diseases 0.000 abstract description 9
- 206010021143 Hypoxia Diseases 0.000 abstract description 8
- 230000002265 prevention Effects 0.000 abstract description 8
- 230000004872 arterial blood pressure Effects 0.000 abstract description 7
- 210000001147 pulmonary artery Anatomy 0.000 abstract description 6
- 230000002792 vascular Effects 0.000 abstract description 5
- 210000004204 blood vessel Anatomy 0.000 abstract description 4
- 208000018875 hypoxemia Diseases 0.000 abstract description 4
- 230000035488 systolic blood pressure Effects 0.000 abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 26
- XJLLGTXEGDEZNX-DFWYDOINSA-N C(N)(=O)N[C@@H](CCC(=O)O)C(=O)O.[N] Chemical compound C(N)(=O)N[C@@H](CCC(=O)O)C(=O)O.[N] XJLLGTXEGDEZNX-DFWYDOINSA-N 0.000 description 19
- 235000013336 milk Nutrition 0.000 description 10
- 239000008267 milk Substances 0.000 description 10
- 210000004080 milk Anatomy 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 239000004475 Arginine Substances 0.000 description 8
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 7
- 229960003753 nitric oxide Drugs 0.000 description 7
- 230000002685 pulmonary effect Effects 0.000 description 6
- 201000006306 Cor pulmonale Diseases 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 241000283725 Bos Species 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 3
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000007954 hypoxia Effects 0.000 description 3
- 244000144972 livestock Species 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000004089 microcirculation Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 210000004767 rumen Anatomy 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 230000002612 cardiopulmonary effect Effects 0.000 description 2
- 210000000748 cardiovascular system Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000036593 pulmonary vascular resistance Effects 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 210000002460 smooth muscle Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000008944 intestinal immunity Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000005135 methemoglobinemia Diseases 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000004143 urea cycle Effects 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/22—Compounds of alkali metals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/26—Compounds containing phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to the application of the ox feed of the carbamylglutamic acid containing N- and N- carbamylglutamic acid in terms of preventing and treating pulmonary heart and lung diseases.The invention further relates to cattle feed, feed addictive or the water additive for enhancing cattle heart lung function and prevention and treatment pulmonary heart and lung diseases and lick brick.The edible feed containing N- carbamylglutamic acid, the available expansion of the blood vessel of ox, to enough significantly reduce average pulmonary artery blood pressure and periphery systolic blood pressure, heart rate, and the disease incidence of pulmonary hypertension, hypoxemia damage caused by cattle heart vascular system is reduced, to play the role of prevention or treat the pulmonary heart and lung diseases of ox.
Description
Technical field
The present invention relates to animal-breeding technical field, in particular to the carbamylglutamic acid containing N- ox feed with
And application of the N- carbamylglutamic acid in terms of preventing and treating pulmonary heart and lung diseases.
Background technique
Qinghai-Tibet Platean has unique High aititude low-oxygen environment, and High aititude anoxic causes livestock to be susceptible to suffer from altitude sickness to High aititude
Regional livestock-raising industry brings biggish economic loss.Research report height above sea level is higher than 2500 meters and just has the danger for suffering from altitude sickness
Danger, and as the raising disease incidence of height above sea level increases.The mean sea level of China Qinghai-xizang Plateau Region is higher than 2500 meters, while Gansu
It saves and Sichuan Province some areas height above sea level has also exceeded 2500 meters, have the danger for suffering from altitude sickness in the livestock of these area cultivation.
Ox class is the common livestock of highlands, for example, holstein cow because the high milk-quality of its output of milk is good introduce a fine variety extensively at home it is feeding
It grows, but is ignored for a long time by people in high altitude localities holstein cow altitude sickness, made without obtaining effectively preventing
At certain economic loss.The holstein cow altitude sickness disease incidence for being introduced into Lhasa and Shigatse District is very high, high
Former disease seriously hinders the development of these regional holstein cow aquacultures.
Ox class altitude sickness has document report to be referred to as " cor pulmonale ", refers to due to alveolar hypoxia and metarteriole receipts
Contracting, causes pulmonary hypertension and pulmonary vascular resistance increase to lead to right cardiectasis, hypertrophy, then heart failure, is often commonly referred to as lung source
Property heart disease.Animal is mainly shown as with altitude sickness：It expiratory dyspnea, too fast, veutro oedema aroused in interest and phlebectasia and and fights
Dynamic is the special medical treatment symptom of cor pulmonale.Intracorporal nitric oxide (NO) is that arginine is catalyzed at nitricoxide synthase (NOS)
Lower generation.Research finds that NO is a kind of simple gas molecule of structure, and energy vasodilator reduces blood pressure.The function in lungs of NO
Can be mainly：It realizes diastole Pulmonary Vascular, reduces pulmonary arterial pressure, inhibit the effect of vascular smooth muscle cell proliferation.Many mankind are high
Former disease the study found that pulmonary vascular inner membrance nitricoxide synthase high expression under hypoxemia stimulation, play inhibition proliferation of smooth muscle,
Expand the effect that blood vessel reduces vascular resistence.
Microcirculation mainly also can be promoted by feeding arginine discovery for the research of NO effect at present, protected
Cardiovascular system promotes intestinal microcirculation and reparation, improves intestine immunity and radicals scavenging, improves the NO concentration in blood
Effect.Or be directly sucked in NO can effective relaxing smooth muscle, reduce pulmonary vascular resistance and pulmonary artery pressure.
But due to the ignorance to ox class altitude sickness, without will be in these technical applications to altitude sickness treatment.While this
A little technologies have the defects that it is certain be primarily due to that arginine price is more expensive, be difficult to apply in the treatment of prevention altitude sickness；Separately
One side arginine is easy to be degraded by rumen microorganism and can not be reached small intestine in cow rumen, so as to cause arginine in tumor
Stomach degrades and can not reach small intestine and be absorbed by milk cow, so application of the arginine on milk cow is restricted.Arginine is in tumor
6 hours degradation rates are more than 50% in gastric juice, reach within 12 hours 99.3%, degradation rate is 100% within 24 hours.And it is directly sucked in an oxygen
The higher requirement to appointed condition of cost for changing nitrogen is high, and long-term inhaled nitric oxide also results in methemoglobinemia.This
A little factors all limit inhaled nitric oxide in the application in treatment pulmonary hypertension field.
In view of this, the present invention is specifically proposed.
Summary of the invention
The present invention improves arginic synthesis in vivo and increases by way of adding N- carbamylglutamic acid in ox feed
Add nitric oxide production generation, to play expansion blood vessel using nitric oxide, enhancing cattle heart lung function, reduce ox pulmonary artery height
Pressure, and then play the role of alleviation and treatment ox altitude sickness.
In addition, 24 hours degradation rates of N- carbamylglutamic acid only have 17.8%, so N- carbamylglutamic acid is not required to
Want rumen bypass coating that can be added in daily ration to play the role of reducing pulmonary artery pressure.
Cattle fooder N- carbamylglutamic acid can at least play following effect：
(1) promote microcirculation, lungs and cardiovascular system (2) is protected to play expansion blood vessel, reduce lungs blood and follow
Ring resistance, reduce blood pressure vessel retraction and the vascular lesion caused by (3) inhibition hypoxemia that promote blood circulation, and alleviates and treatment ox is high
The effect of former disease.
Specifically, in order to realize that above-mentioned purpose of the invention, the present invention use following technical scheme：
The present invention relates to a kind of cattle feeds for enhancing cattle heart lung function or preventing and treating pulmonary heart and lung diseases, to account for
Feed dry weight meter is stated, it includes the N- carbamylglutamic acids of 0.08w/w%~0.66w/w%.
According to an aspect of the present invention, the feeding the invention further relates to N- carbamylglutamic acid as enhancing cattle heart lung function
Feed additives, drinking water additive and ox lick the non-therapeutic use of brick.
According to an aspect of the present invention, the invention further relates to N- carbamylglutamic acids to prepare for enhancing cattle heart lung function
The food or the application in drug of energy or prevention and treatment pulmonary heart and lung diseases.
Invention effect：
According to the present invention, the feed containing N- carbamylglutamic acid, the available reinforcing of the cardio-pulmonary function of ox are eaten.
In addition, feeding N- carbamylglutamic acid can significantly reduce average pulmonary artery blood pressure and periphery systolic blood pressure, the heart
The disease incidence of rate and pulmonary hypertension reduces hypoxemia damage caused by cattle heart vascular system, to play prevention or control
Treat the effect of the pulmonary heart and lung diseases of ox.
Specific embodiment
The present invention relates to N- carbamylglutamic acid in preparation for enhancing cattle heart lung function or prevention and treatment pulmonary cardiopulmonary disease
Application in the food or drug of disease.
In some embodiments, the food with N- carbamylglutamic acid or drug can be used for preventing/treating/auxiliary
The pulmonary heart and lung diseases disease of ox is treated, such as (conditions associated with hypoxia) pulmonary hypertension, cor pulmonale or (conditions associated with hypoxia) high
Former disease.
Preferably, application as described above, the food are ox feed, ox feed additive, drinking water additive or ox
Lick brick.
Preferably, application as described above, to account in terms of the feed dry weight, the content of the N- carbamylglutamic acid is extremely
It is less 0.08w/w%.
Preferably, application as described above, to account in terms of the feed dry weight, the content of the N- carbamylglutamic acid is
0.08w/w%~0.66w/w%.
According to an aspect of the present invention, the feeding the invention further relates to N- carbamylglutamic acid as enhancing cattle heart lung function
The non-therapeutic use of feed additives or drinking water additive.
According to an aspect of the present invention, the N- carbamylglutamic acid for giving effective dose to ox can further increase strong
Health ox does not generate apparent side effect to the resistant states of high altitude anoxia.Since N- carbamylglutamic acid can enhance ox
Cardio-pulmonary function, thus the physical efficiency and labour capacity of highlands ox can be improved, to promote the production efficiency of ox.
Feed addictive or drinking water additive can be N- carbamylglutamic acid merely, can also add with pharmacy or
Acceptable carrier and/or auxiliary material are mixed to form feed addictive composition on food, not influence N- carbamylglutamic acid
Structure and bioactivity subject to.For example, carrier and/or auxiliary material can be selected minerals, adsorbent, microelement, in premix
It is one or more.
According to an aspect of the present invention, the invention further relates to for enhancing cattle heart lung function or prevention and treatment pulmonary heart and lung diseases
Cattle feed, to account in terms of the feed dry weight, it includes the N- carbamylglutamic acids of 0.08w/w%~0.66w/w%.
Preferably, application as described above or cattle feed, to account in terms of the feed dry weight, the N- carbamyl paddy ammonia
The content of acid is 0.13w/w%；It is also an option that 0.10w/w%, 0.12w/w%, 0.15w/w%, 0.20w/w%, 0.25w/
W%, 0.30w/w%, 0.35w/w%, 0.40w/w%, 0.45w/w%, 0.50w/w%, 0.55w/w% or 0.60w/w%.
Preferably, application or cattle feed, the ox include as described above：
Aurochs B.primigenius, sharp volume ox B.acutifrons, domestic yak Bos mutus, yak
B.grunniens, homalometopus ox B.planifrons, Java wild ox B.javanicus, gaur B.gaurus, gayal
One of B.frontalis, common ox B.taurus or Cambodia wild ox B.sauveli or a variety of.
Preferably, application or cattle feed, the common ox B.taurus are holstein cow as described above.
Preferably, cattle feed as described above, the cattle feed are packaged in the form of preservable.
According to an aspect of the present invention, the invention further relates to a kind of enhancing cattle heart lung function or prevention and treatment pulmonary cardiopulmonary diseases
The method of disease comprising to the N- carbamylglutamic acid of ox feeding effective dose.
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
It can be with conventional products that are commercially available.
Embodiment
1. the preparation of feed.
According to the present invention, N- carbamylglutamic acid can be used in mixed way with feed, such as perfect compound feed.Feed system
Preparation Method is simple, stirs evenly after base-material is mixed, and auxiliary material N- carbamylglutamic acid is added and mixes.
Premix is provided by Qinghai Province rivers source agriculture and animal husbandry development in science and technology Co., Ltd.
In the present embodiment, the formula of feed is as follows：
1 N of feed formula of table
Wherein, aforementioned proportion is in terms of dry weight.
The dry matter intake of every cow head is 3kg~25kg, and the day dosage of every cow head is 20g, shared feed
Proportional region 0.08w/w%~0.66w/w%.
2. animal and feeding method.
1) holstein cow that test uses is introduced into highlands (Lhasa) by low altitude area (Shaanxi Xi'an)
And it is raised 12 months in Lhasa.Select 10 pulmonary hypertension holstein cows and 10 healthy holstein cows.
2) fully mixed diet for the nitrogen carbamylglutamic acid that feeding addition obtains produced above is to milk cow；
3) it continuously feeds surrounding, first 1 day of on-test and the 28th day after starting, measures the physical signs of milk cow and acquisition
Blood sample.
4) jumpbogroup feeding experiment：700 holstein cows transported from low altitude area to Lhasa are selected, wherein 520
Milk cow feeds the feed of addition nitrogen carbamylglutamic acid daily, and 180 cow heads do not feed nitrogen carbamylglutamic acid.Feeding 100 days
17 cow head of nitrogen carbamylglutamic acid group selection is not being fed in feeding 12 cow head of nitrogen carbamylglutamic acid group selection at random afterwards
Measure physiological parameter.
5) milk cow takes scattered column raising to be freely eaten, free water.
3. result
The present invention after feeding the feed containing nitrogen carbamylglutamic acid to plateau infected cattle by having found：Add nitrogen carbamyl paddy
Propylhomoserin can increase plasma arginine, eNOS, nitric oxide production expression by promotion urea cycle, and can
Reduce the pulmonary artery pressure of milk cow and the periphery systolic blood pressure of pulmonary hypertension infected cattle.As a result as shown in Table 2,3.
Table 2 feeds influence of the nitrogen carbamylglutamic acid to nitric oxide synthetic parameters
Different letters represents significant difference (P in A, B same row<0.05).
1All parameters are being indicated with standard error；Every group of 10 oxen.
2The feeding of nitrogen carbamylglutamic acid starts the previous day.
3The feeding of nitrogen carbamylglutamic acid or rear surrounding.
Table 3 feeds influence of the nitrogen carbamylglutamic acid to milk cow physiological parameter
1All parameters are being indicated with standard error；Every group of 10 oxen.
2The feeding of nitrogen carbamylglutamic acid starts the previous day.
3The feeding of nitrogen carbamylglutamic acid or rear surrounding.
We add nitrogen carbamylglutamic acid in the daily ration of milk cow and find that it can significantly reduce the hair of pulmonary hypertension
Sick rate, the ratio (1/12=8.3%) of pulmonary hypertension in feeding nitrogen carbamylglutamic acid group, and nitrogen carbamyl is not being fed
The ratio (9/17=52.94%) of pulmonary hypertension is significantly higher than nitrogen carbamylglutamic acid feeding group in the group of glutamic acid.Simultaneously
It was found that feeding nitrogen carbamylglutamic acid can significantly reduce heart rate, mean pulmonary arterial pressure power and periphery systolic blood pressure (table 4).
Table 4 feeds influence of the nitrogen carbamylglutamic acid to pulmonary hypertension disease incidence and physiological parameter
1Data are indicated with average and standard error, are fed 12 oxen of nitrogen carbamylglutamic acid group, are not fed nitrogen carbamyl paddy
17 oxen of propylhomoserin group.2Holstein cow feeds 20g nitrogen every ox of carbamylglutamic acid daily.
3Holstein cow does not feed nitrogen carbamylglutamic acid.
The cost calculation of 30,000 yuan of a cow head is introduced according to Lhasa city：
The pasture of one 2000 cow head reduces by 44.64% altitude sickness disease incidence, and being equivalent to reduces 892 cow heads
Death, directly reduce by 26,760,000 yuan of economic loss.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, but those skilled in the art should understand that：Its
It is still possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features
It is equivalently replaced；And these are modified or replaceed, various embodiments of the present invention skill that it does not separate the essence of the corresponding technical solution
The range of art scheme.
Claims (10)
1. for enhancing cattle heart lung function or preventing and treating the cattle feed of pulmonary heart and lung diseases, to account in terms of the feed dry weight,
N- carbamylglutamic acid comprising 0.08w/w%~0.66w/w%.
2. cattle feed according to claim 1, which is characterized in that the cattle feed is wrapped in the form of preservable
Dress.
3.N- carbamylglutamic acid licks the non-of brick as feed addictive, drinking water additive and the ox of enhancing cattle heart lung function
Therapeutical uses.
4.N- carbamylglutamic acid is in preparation for enhancing cattle heart lung function or preventing and treating the food or medicine of pulmonary heart and lung diseases
Application in product.
5. application according to claim 4, which is characterized in that the pulmonary heart and lung diseases include pulmonary hypertension or lung
Source property heart disease or altitude sickness.
6. application according to claim 4, which is characterized in that the food is ox feed, ox feed additive, drinking water
Additive or ox lick brick.
7. application according to claim 6, which is characterized in that account in terms of the feed dry weight, the N- carbamyl paddy
The content of propylhomoserin is at least 0.08w/w%.
8. application according to claim 7, which is characterized in that account in terms of the feed dry weight, the N- carbamyl paddy
The content of propylhomoserin is 0.08w/w%~0.66w/w%.
9. application according to claim 8, which is characterized in that account in terms of the feed dry weight, the N- carbamyl paddy
The content of propylhomoserin is 0.13w/w%.
10. according to the described in any item applications of claim 4~9, which is characterized in that the ox includes：
Aurochs B.primigenius, it sharp volume ox B.acutifrons, domestic yak Bos mutus, yak B.grunniens, puts down
It is volume ox B.planifrons, Java wild ox B.javanicus, gaur B.gaurus, gayal B.frontalis, common
One of ox B.taurus or Cambodia wild ox B.sauveli or a variety of.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810516666.0A CN108902483A (en) | 2018-05-25 | 2018-05-25 | Application of the ox feed and N- carbamylglutamic acid of the carbamylglutamic acid containing N- in terms of preventing and treating pulmonary heart and lung diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810516666.0A CN108902483A (en) | 2018-05-25 | 2018-05-25 | Application of the ox feed and N- carbamylglutamic acid of the carbamylglutamic acid containing N- in terms of preventing and treating pulmonary heart and lung diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108902483A true CN108902483A (en) | 2018-11-30 |
Family
ID=64410596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810516666.0A Pending CN108902483A (en) | 2018-05-25 | 2018-05-25 | Application of the ox feed and N- carbamylglutamic acid of the carbamylglutamic acid containing N- in terms of preventing and treating pulmonary heart and lung diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108902483A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112314528A (en) * | 2020-12-14 | 2021-02-05 | 四川农业大学 | Method for improving fertility of grazed yaks |
| CN113133500A (en) * | 2020-01-17 | 2021-07-20 | 中国科学院亚热带农业生态研究所 | Feed additive for relieving cow altitude disease, use method thereof and feed |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349163A (en) * | 2013-07-05 | 2013-10-16 | 浙江大学 | Fodder for improving nitrogen utilization rate and production performance of dairy cows |
-
2018
- 2018-05-25 CN CN201810516666.0A patent/CN108902483A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349163A (en) * | 2013-07-05 | 2013-10-16 | 浙江大学 | Fodder for improving nitrogen utilization rate and production performance of dairy cows |
Non-Patent Citations (1)
| Title |
|---|
| 李新花等: "《N-氨甲酰谷氨酸在反刍动物生产中研究进展》", 《中国奶牛》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113133500A (en) * | 2020-01-17 | 2021-07-20 | 中国科学院亚热带农业生态研究所 | Feed additive for relieving cow altitude disease, use method thereof and feed |
| CN113133500B (en) * | 2020-01-17 | 2022-06-07 | 中国科学院亚热带农业生态研究所 | Feed additive for relieving cow altitude disease, use method thereof and feed |
| CN112314528A (en) * | 2020-12-14 | 2021-02-05 | 四川农业大学 | Method for improving fertility of grazed yaks |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4995893B2 (en) | Treatment of poultry to reduce feed conversion or to reduce the incidence of ascites | |
| CN106572683A (en) | Feed additive composition for reducing methane production of ruminants | |
| CN108935331A (en) | A kind of Yak fattening method | |
| CN108902483A (en) | Application of the ox feed and N- carbamylglutamic acid of the carbamylglutamic acid containing N- in terms of preventing and treating pulmonary heart and lung diseases | |
| CN109221735A (en) | A kind of pannage containing Chinese medicine | |
| CN106578529A (en) | Piglet production performance, intestinal health and antioxidant property improving composition and preparation method thereof | |
| CN107232133A (en) | A kind of efficient pig cultivation method for promoting to grow | |
| CN1689431A (en) | Beverage for fattening animals | |
| CN103975896B (en) | Reduce the raising method of partly raising heavy metal antibiotic residue in traditional black Meat scattered | |
| CN104664168B (en) | A kind of piglet specific complex vitamin microemulsion preparation and its preparation method and application | |
| KR100952041B1 (en) | The feed composition for pig | |
| CN105533170A (en) | Use method of additive for preventing and treating heat stress syndromes of beef cattle | |
| CN104982669A (en) | Organic compound acidifier added in domestic rabbit high-fiber feed and preparation method thereof | |
| CN107594121A (en) | A kind of fleshy duck fodder | |
| CN107348171A (en) | One kind improves soft-shelled turtle survival rate feed easy to digest | |
| US8716330B2 (en) | Supplement composition and method of use | |
| JP2018500026A (en) | Methods and formulations for reducing bovine emissions | |
| CN105409885A (en) | Special wild boar sow feeding method for preventing special wild boar piglet white diarrhea | |
| CN106107195A (en) | A kind of additive package promoting growth of meat chicken and application thereof | |
| CN108576415A (en) | A kind of premix and preparation method thereof | |
| CN107027976A (en) | Poultry Water Soluble Compound nutritious supplementary pharmaceutical and preparation method thereof | |
| CN101602684B (en) | Threonine manganese as well as preparation method and application thereof | |
| CN106719301A (en) | A kind of efficient free range chicken cultural method | |
| KR20050017865A (en) | Feed additives for the poultry feeding and the poultry meat with the increased iron content by the additives | |
| O'Doherty et al. | A note on the nutritive value of extruded and raw beans for growing and finishing pigs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181130 |