CN108888741A - A kind of antitumor Chinese medicine composition and preparation method thereof - Google Patents
A kind of antitumor Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of antitumor Chinese medicine compositions, belong to technical field of traditional Chinese medicines, including component A and B component；Component A includes jujube, Chinese yam, semen coicis, Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, rhizoma polygonati, Radix Notoginseng, malt, lily, black rice, Testa sojae atricolor, black fungus, lotus seeds, tremella, rock sugar and garlic juice；B component includes ground bettle, Caulis Spatholobi, oldenlandia diffusa, dandelion, curcuma zedoary, Prunella vulgaris, Paris polyphylla, Radix Angelicae Sinensis, ginseng, Radix Astragali, cordyceps sinensis, ganoderma lucidum, kuh-seng, Rhizoma Chuanxiong, dried orange peel, Radix Glycyrrhizae, cow-bezoar, Cortex Phellodendri and honey.Antitumor Chinese medicine composition provided by the invention, being capable of effective melanoma, prostate cancer, lung cancer, colon cancer, liver cancer, cancer of pancreas, the cancer of the esophagus, sdenocarcinoma of stomach, lymthoma, breast cancer and cervical carcinoma.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of antitumor Chinese medicine composition and preparation method thereof.
Background technique
Malignant tumour (cancer) is the major disease that a kind of death rate is high, life cycle is short, the in recent years morbidity of malignant tumour
Rate and lethality are in rising trend, seriously endanger the health and lives of the mankind.It is most for the treatment of tumor patient at present
Using operative treatment combination Radiotherapy chemotherapy method, still, this method is larger to the physical trauma of patient, and medical expense is high, and
Curative effect is unsatisfactory.
Summary of the invention
The purpose of the present invention is to provide a kind of antitumor Chinese medicine compositions, are inhibited by taking Chinese medicine composition swollen
Tumor avoids operation and the treatment method bring of Radiotherapy chemotherapy is combined to endanger.
The present invention provides a kind of antitumor Chinese medicine compositions, including component A and B component；
The component A includes the component of following parts by weight：
5~15 parts of jujube, 1~5 part of Chinese yam, 2~10 parts of semen coicis, 1~5 part of Rhizoma Atractylodis Macrocephalae, 1~5 part of Radix Codonopsis, Radix Salviae Miltiorrhizae 1~5
Part, 1~10 part of Radix Glycyrrhizae, 1~5 part of rhizoma polygonati, 1~5 part of Radix Notoginseng, 1~10 part of malt, 1~5 part of lily, 1~5 part of black rice, Testa sojae atricolor
1~5 part, 1~5 part of black fungus, 1~5 part of lotus seeds, 1~5 part of tremella, 10~25 parts of rock sugar and 50~120 parts of garlic juice；
In terms of the parts by weight of jujube, the B component includes the component of following parts by weight：
1~5 part of ground bettle, 2~10 parts of Caulis Spatholobi, 1~5 part of oldenlandia diffusa, 1~5 part of dandelion, 1~5 part of curcuma zedoary,
2~10 parts of Prunella vulgaris, 0.1~2 part of Paris polyphylla, 0.5~3 part of Radix Angelicae Sinensis, 0.1~5 part of ginseng, 0.5~3 part of Radix Astragali, cordyceps sinensis 0.1
~1 part, 0.5~3 part of ganoderma lucidum, 1~5 part of kuh-seng, 0.5~3 part of Rhizoma Chuanxiong, 1~5 part of dried orange peel, 0.5~3 part of Radix Glycyrrhizae, cow-bezoar 0.5~2
Part, 1.0~5 parts of Cortex Phellodendri and 1~5 part of honey.
Preferably, including component A and B component：
The component A includes the component of following parts by weight：
10 parts of jujube, 2 parts of Chinese yam, 5 parts of semen coicis, 2 parts of Rhizoma Atractylodis Macrocephalae, 3 parts of Radix Codonopsis, 2 parts of Radix Salviae Miltiorrhizae, 3 parts of Radix Glycyrrhizae, 2 parts of rhizoma polygonati, three
72 parts, 3 parts of malt, 3 parts of lily, 3 parts of black rice, 2 parts of Testa sojae atricolor, 3 parts of black fungus, 3 parts of lotus seeds, 3 parts of tremella, 20 parts of rock sugar and
100 parts of garlic juice；
In terms of the parts by weight of jujube, the B component includes the component of following parts by weight：
3 parts of ground bettle, 5 parts of Caulis Spatholobi, 3 parts of oldenlandia diffusa, 3 parts of dandelion, 2 parts of curcuma zedoary, 5 parts of Prunella vulgaris, Paris polyphylla 0.5
It is part, 1 part of Radix Angelicae Sinensis, 0.5 part of ginseng, 1 part of Radix Astragali, 0.2 part of cordyceps sinensis, 1 part of ganoderma lucidum, 2 parts of kuh-seng, 1 part of Rhizoma Chuanxiong, 3 parts of dried orange peel, sweet
1 part of grass, 1 part of cow-bezoar, 1.5 parts of Cortex Phellodendri and 2 parts of honey.
The present invention also provides a kind of preparation methods of Chinese medicine composition described in above-mentioned technical proposal, including following step
Suddenly：
1) by jujube, Chinese yam described in above-mentioned technical proposal, semen coicis, Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, rhizoma polygonati, Radix Notoginseng,
Malt, lily, black rice, Testa sojae atricolor, black fungus, lotus seeds, tremella, rock sugar carry out first after mixing with water and decoct, and obtain the first medicine
Liquid and first dregs of a decoction；
2) the first medical fluid that the step 1) obtains is mixed with garlic juice described in claim 1, obtains component A；
3) by ground bettle, Caulis Spatholobi described in above-mentioned technical proposal, oldenlandia diffusa, dandelion, Prunella vulgaris, ganoderma lucidum, winter worm
Summer grass, Cortex Phellodendri, Radix Glycyrrhizae carry out second after mixing with water and decoct, and the second medical fluid and second dregs of a decoction are obtained, by the second medical fluid wind
After dry, the first air dry matter is obtained；
4) curcuma zedoary, Paris polyphylla described in above-mentioned technical proposal, Radix Angelicae Sinensis, ginseng, Radix Astragali, kuh-seng, Rhizoma Chuanxiong, dried orange peel ethyl alcohol is molten
Liquid impregnates, and after filtering, obtained filtrate is air-dried, obtains the second air dry matter；
5) the first air dry matter that the step 3) obtains is mixed with the second air dry matter that step 4) obtains, is air-dried
The air dry matter is mixed with cow-bezoar, honey described in above-mentioned technical proposal, obtains the mixture containing honey by object, will be described
Mixture containing honey is mixed with cyclodextrin, obtains B component.
Preferably, the quality of the step 1) jujube and the volume ratio of water are (5~15) g:(450~550) ml.
Preferably, the step 1) first, which decocts, includes：Intense fire is cooked by slow fire 15~25min after boiling again.
Preferably, the quality of the step 3) ground bettle and the volume ratio of water are (1~5) g:(450~550) ml.
Preferably, the step 3) second, which decocts, includes：Intense fire is cooked by slow fire 50~70min after boiling again.
Preferably, the volume content of the step 4) ethanol solution is 60~80%.
Preferably, the time that the step 4) is impregnated is 40~56h.
Preferably, the mass ratio of the step 5) cow-bezoar and cyclodextrin is (0.5~2):(5~15).
The embodiment of the present invention is shown：Antitumor Chinese medicine composition provided by the invention, being capable of effective melanoma, preceding
Column gland cancer, lung cancer, colon cancer, liver cancer, cancer of pancreas, the cancer of the esophagus, sdenocarcinoma of stomach, breast cancer and cervical carcinoma.
Detailed description of the invention
Fig. 1 is the result for inhibiting the proliferation of human melanoma cell (A375)；
Fig. 2：Fig. 2-1 is concentration when being 0mg/L, induces the result of the apoptosis of A375 cell；Fig. 2-2 is that concentration is 2.5mg/
When L, the result of the apoptosis of A375 cell is induced；Fig. 2-3 is concentration when being 5mg/L, induces the result of the apoptosis of A375 cell；Figure
2-4 is concentration when being 10mg/L, induces the result of the apoptosis of A375 cell；Fig. 2-5 is concentration when being 20mg/L, and induction A375 is thin
The result of the apoptosis of born of the same parents；Fig. 2-6 is the concentration of DOX when being 1.25mg/L, induces the result of the apoptosis of A375 cell；
Fig. 3 is the result for inhibiting the migration of people's Melanoma cell (A375)；
Fig. 4 is the result for inhibiting the migration of people's Melanoma cell (A375)；
Fig. 5 is the result for effectively inhibiting the growth of knurl in what tumor Mice Body；
Fig. 6 is the result for effectively inhibiting the growth of knurl in what tumor Mice Body；
Fig. 7 is the result for inhibiting the proliferation of variety classes tumour cell.
Specific embodiment
The present invention provides a kind of antitumor Chinese medicine compositions, including component A and B component；
The component A includes the component of following parts by weight：
5~15 parts of jujube, 1~5 part of Chinese yam, 2~10 parts of semen coicis, 1~5 part of Rhizoma Atractylodis Macrocephalae, 1~5 part of Radix Codonopsis, Radix Salviae Miltiorrhizae 1~5
Part, 1~10 part of Radix Glycyrrhizae, 1~5 part of rhizoma polygonati, 1~5 part of Radix Notoginseng, 1~10 part of malt, 1~5 part of lily, 1~5 part of black rice, Testa sojae atricolor
1~5 part, 1~5 part of black fungus, 1~5 part of lotus seeds, 1~5 part of tremella, 10~25 parts of rock sugar and 50~120 parts of garlic juice；
In terms of the parts by weight of jujube, the B component includes the component of following parts by weight：
1~5 part of ground bettle, 2~10 parts of Caulis Spatholobi, 1~5 part of oldenlandia diffusa, 1~5 part of dandelion, 1~5 part of curcuma zedoary,
2~10 parts of Prunella vulgaris, 0.1~2 part of Paris polyphylla, 0.5~3 part of Radix Angelicae Sinensis, 0.1~5 part of ginseng, 0.5~3 part of Radix Astragali, cordyceps sinensis 0.1
~1 part, 0.5~3 part of ganoderma lucidum, 1~5 part of kuh-seng, 0.5~3 part of Rhizoma Chuanxiong, 1~5 part of dried orange peel, 0.5~3 part of Radix Glycyrrhizae, cow-bezoar 0.5~2
Part, 1.0~5 parts of Cortex Phellodendri and 1~5 part of honey.
The present invention provides a kind of antitumor Chinese medicine compositions, including component A and B component.
In the present invention, the component A includes the component of following parts by weight：5~15 parts of jujube, 1~5 part of Chinese yam, the heart of a lotus seed
2~10 parts of the seed of jog's tears, 1~5 part of Rhizoma Atractylodis Macrocephalae, 1~5 part of Radix Codonopsis, 1~5 part of Radix Salviae Miltiorrhizae, 1~10 part of Radix Glycyrrhizae, 1~5 part of rhizoma polygonati, Radix Notoginseng 1~5
Part, 1~10 part of malt, 1~5 part of lily, 1~5 part of black rice, 1~5 part of Testa sojae atricolor, 1~5 part of black fungus, 1~5 part of lotus seeds, silver
1~5 part of ear, 10~25 parts of rock sugar and 50~120 parts of garlic juice；Preferably 8~12 parts of jujube, 1.5~3 parts of Chinese yam, semen coicis 3~
8 parts, 1.5~3 parts of Rhizoma Atractylodis Macrocephalae, 2~4 parts of Radix Codonopsis, 2~4 parts of Radix Salviae Miltiorrhizae, 2~5 parts of Radix Glycyrrhizae, 1.5~3 parts of rhizoma polygonati, 1.5~3 parts of Radix Notoginseng,
2~5 parts of malt, 2~4 parts of lily, 2~4 parts of black rice, 1.5~3 parts of Testa sojae atricolor, 2~4 parts of black fungus, 2~4 parts of lotus seeds, tremella 2
~4 parts, 15~22 parts of rock sugar and 80~110 parts of garlic juice；More preferably 10 parts of jujube, 2 parts of Chinese yam, 5 parts of semen coicis, 2 parts of Rhizoma Atractylodis Macrocephalae,
It is 3 parts of Radix Codonopsis, 2 parts of Radix Salviae Miltiorrhizae, 3 parts of Radix Glycyrrhizae, 2 parts of rhizoma polygonati, 2 parts of Radix Notoginseng, 3 parts of malt, 3 parts of lily, 3 parts of black rice, 2 parts of Testa sojae atricolor, black
3 parts of agaric, 3 parts of lotus seeds, 3 parts of tremella, 20 parts of rock sugar and 100 parts of garlic juice.The present invention does not have special limit to the source of above-mentioned Chinese medicine
It is fixed, using conventional commercial product.
In the present invention, in terms of the parts by weight of jujube, the B component includes the component of following parts by weight：Ground bettle 1
~5 parts, 2~10 parts of Caulis Spatholobi, 1~5 part of oldenlandia diffusa, 1~5 part of dandelion, 1~5 part of curcuma zedoary, 2~10 parts of Prunella vulgaris, again
0.1~2 part of building, 0.5~3 part of Radix Angelicae Sinensis, 0.1~5 part of ginseng, 0.5~3 part of Radix Astragali, 0.1~1 part of cordyceps sinensis, ganoderma lucidum 0.5~3
Part, 1~5 part of kuh-seng, 0.5~3 part of Rhizoma Chuanxiong, 1~5 part of dried orange peel, 0.5~3 part of Radix Glycyrrhizae, 0.5~2 part of cow-bezoar, 1.0~5 parts of Cortex Phellodendri
With 1~5 part of honey；Preferably 2~4 parts of ground bettle, 3~8 parts of Caulis Spatholobi, 2~4 parts of oldenlandia diffusa, 2~4 parts of dandelion, cowherb
2~4 parts of art, 3~8 parts of Prunella vulgaris, 0.2~1 part of Paris polyphylla, 0.8~2 part of Radix Angelicae Sinensis, 0.2~3 part of ginseng, 0.8~1.5 part of Radix Astragali,
It is 0.15~0.5 part of cordyceps sinensis, 0.8~1.5 part of ganoderma lucidum, 1.5~3 parts of kuh-seng, 0.8~1.5 part of Rhizoma Chuanxiong, 2~4 parts of dried orange peel, sweet
0.8~1.5 part of grass, 0.8~1.5 part of cow-bezoar, 1.2~2.5 parts of Cortex Phellodendri and 1.5~2.5 parts of honey；More preferably 3 parts of ground bettle,
5 parts of Caulis Spatholobi, 3 parts of oldenlandia diffusa, 3 parts of dandelion, 2 parts of curcuma zedoary, 5 parts of Prunella vulgaris, 0.5 part of Paris polyphylla, 1 part of Radix Angelicae Sinensis, ginseng 0.5
Part, 1 part of Radix Astragali, 0.2 part of cordyceps sinensis, 1 part of ganoderma lucidum, 2 parts of kuh-seng, 1 part of Rhizoma Chuanxiong, 3 parts of dried orange peel, 1 part of Radix Glycyrrhizae, 1 part of cow-bezoar, Cortex Phellodendri
1.5 parts and 2 parts of honey.The present invention is not particularly limited the source of above-mentioned Chinese medicine, using conventional commercial product.
The present invention also provides the preparation method of the antitumor Chinese medicine composition described in above-mentioned technical proposal, including it is following
Step：
1) by jujube, Chinese yam described in above-mentioned technical proposal, semen coicis, Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, rhizoma polygonati, Radix Notoginseng,
Malt, lily, black rice, Testa sojae atricolor, black fungus, lotus seeds, tremella, rock sugar carry out first after mixing with water and decoct, and obtain the first medicine
Liquid and first dregs of a decoction；
2) the first medical fluid for obtaining the step 1) is mixed with garlic juice described in above-mentioned technical proposal, obtains component A；
3) by ground bettle, Caulis Spatholobi described in above-mentioned technical proposal, oldenlandia diffusa, dandelion, Prunella vulgaris, ganoderma lucidum, winter worm
Summer grass, Cortex Phellodendri, Radix Glycyrrhizae carry out second after mixing with water and decoct, and the second medical fluid and second dregs of a decoction are obtained, by the second medical fluid wind
After dry, the first air dry matter is obtained；
4) curcuma zedoary, Paris polyphylla described in above-mentioned technical proposal, Radix Angelicae Sinensis, ginseng, Radix Astragali, kuh-seng, Rhizoma Chuanxiong, dried orange peel ethyl alcohol is molten
Liquid impregnates, and after filtering, obtained filtrate is air-dried, obtains the second air dry matter；
5) the first air dry matter that the step 3) obtains is mixed with the second air dry matter that step 4) obtains, is air-dried
The air dry matter is mixed with cow-bezoar, honey described in above-mentioned technical proposal, obtains the mixture containing honey by object, will be described
Mixture containing honey is mixed with cyclodextrin, obtains B component.
The present invention is by jujube, Chinese yam, semen coicis, Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, rhizoma polygonati, Radix Notoginseng, malt, lily, black
Rice, Testa sojae atricolor, black fungus, lotus seeds, tremella, rock sugar carry out first after mixing with water and decoct, and obtain the first medical fluid and first dregs of a decoction.
In the present invention, the quality of the jujube and the volume ratio of water are preferably (5~15) g:(450~550) ml, it is more excellent
It is selected as (8~12) g:(480~520) ml, most preferably 10g:500ml.
In the present invention, first decoction preferably includes：Intense fire is cooked by slow fire 15~25min after boiling again, more preferably text
Fire boils 18~22min, is most preferably cooked by slow fire 20min.
The present invention preferably decocts first obtained by first and decocts object by 4 layers of filtered through gauze, obtains the first medical fluid and the
One dregs of a decoction.
The present invention mixes the first medical fluid arrived with garlic juice described in above-mentioned technical proposal, obtains component A.
It when the temperature of the present invention preferably the first medical fluid is 50 DEG C, then is mixed with garlic juice, obtained mixture is preferably through 4 layers
After filtered through gauze, obtained filtrate is component containing jujube.The present invention is not particularly limited the preparation method of the garlic juice, uses
Customary preparation methods.
The present invention by ground bettle, Caulis Spatholobi described in above-mentioned technical proposal, oldenlandia diffusa, dandelion, Prunella vulgaris, ganoderma lucidum,
Cordyceps sinensis, Cortex Phellodendri, Radix Glycyrrhizae carry out second after mixing with water and decoct, and the second medical fluid and second dregs of a decoction are obtained, by second medicine
After liquid air-dries, the first air dry matter is obtained.
In the present invention, the quality of the ground bettle and the volume ratio of water are preferably (1~5) g:(450~550) ml, more
Preferably (2~4) g:(480~520) ml, most preferably 3g:500ml.
In the present invention, second decoction preferably includes：Intense fire is cooked by slow fire 50~70min after boiling again, more preferably text
Fire boils 55~65min, is most preferably cooked by slow fire 60min.
The present invention is by curcuma zedoary, Paris polyphylla described in above-mentioned technical proposal, Radix Angelicae Sinensis, ginseng, Radix Astragali, kuh-seng, Rhizoma Chuanxiong, dried orange peel second
Alcoholic solution impregnates, and after filtering, obtained filtrate is air-dried, obtains the second air dry matter.
In the present invention, the volume content of the ethanol solution is preferably 60~80%, and more preferably 65~75%, it is optimal
It is selected as 70%.
In the present invention, the time of the immersion is preferably 40~56h, more preferably 45~50h, most preferably 48h.
In the present invention, it is preferable to use 4 layers of gauzes to be filtered for the filtering.
The present invention mixes the first obtained air dry matter with the second obtained air dry matter, obtains air dry matter, air-dries described
Object is mixed with cow-bezoar, honey described in above-mentioned technical proposal, obtains the mixture containing honey, by the mixing containing honey
Object is mixed with cyclodextrin, obtains B component.
In the present invention, the mass ratio of the cow-bezoar and cyclodextrin is preferably (0.5~2):(5~15), more preferably
(0.8~1.5):(8~12), most preferably 1:10.
In the present invention, the application method of the Chinese medicine composition preferably includes：Oral 40~60ml of component A, 30 minutes
Take 1~2gB component again afterwards, more preferably oral 45~55ml of component A takes 1.2~1.8gB component again after 30 minutes, optimal
1.5gB component is taken again after selecting oral component A 50ml.
In the present invention, the tumour preferably include melanoma, prostate cancer, lung cancer, colon cancer, liver cancer, cancer of pancreas,
The cancer of the esophagus, sdenocarcinoma of stomach, breast cancer and cervical carcinoma.
The Chinese medicine composition and preparation method thereof antitumor to one kind of the present invention is done combined with specific embodiments below
Further details of introduction, technical solution of the present invention include but is not limited to following embodiment.
Embodiment 1
By 10g jujube, 2g Chinese yam, 5g semen coicis, 2g Rhizoma Atractylodis Macrocephalae, 3g Radix Codonopsis, 2g Radix Salviae Miltiorrhizae, 3g Radix Glycyrrhizae, 2g rhizoma polygonati, 2g Radix Notoginseng,
3g malt, 3g lily, 3g black rice, 2g Testa sojae atricolor, 3g black fungus, 3g lotus seeds, 3g tremella, 20g rock sugar carry out after mixing with water
One decocts, and obtains the first medical fluid and first dregs of a decoction；First decoction is to be cooked by slow fire 20min again after intense fire is boiled；The matter of jujube and water
Amount is than being 10:500；
2) the first medical fluid that the step 1) obtains is mixed with 100ml garlic juice, obtains component A；
3) by 3g ground bettle, 5g Caulis Spatholobi, 3g oldenlandia diffusa, 3g dandelion, 5g Prunella vulgaris, 1g ganoderma lucidum, 0.2g winter worm
Summer grass, 1.5g Cortex Phellodendri, 1g Radix Glycyrrhizae carry out second after mixing with water and decoct, and the second medical fluid and second dregs of a decoction are obtained, by described second
After medical fluid air-dries, the first air dry matter is obtained；Second decoct include：Intense fire is cooked by slow fire 60min after boiling again；The matter of ground bettle and water
Amount is than being 3:500；
4) by 2g curcuma zedoary, 0.5g Paris polyphylla, 1g Radix Angelicae Sinensis, 0.5g ginseng, 1g Radix Astragali, 2g kuh-seng, 1g Rhizoma Chuanxiong, 3g dried orange peel with 75%
After filtering, obtained filtrate is air-dried, obtains the second air dry matter for alcohol solution dipping；
5) the first air dry matter that the step 3) obtains is mixed with the second air dry matter that step 4) obtains, is air-dried
The air dry matter is mixed with 1g cow-bezoar, 2g honey, obtains the mixture containing honey, by the mixing containing honey by object
Object is mixed with 20g cyclodextrin, obtains B component.
Embodiment 2
By 15g jujube, 5g Chinese yam, 5g semen coicis, 5g Rhizoma Atractylodis Macrocephalae, 5g Radix Codonopsis, 5g Radix Salviae Miltiorrhizae, 10g Radix Glycyrrhizae, 5g rhizoma polygonati, 5g Radix Notoginseng,
10g malt, 10g lily, 5g black rice, 5g Testa sojae atricolor, 5g black fungus, 5g lotus seeds, 5g tremella, 20g rock sugar carry out after mixing with water
First decocts, and obtains the first medical fluid and first dregs of a decoction；First decoction is to be cooked by slow fire 20min again after intense fire is boiled；Jujube and water
Mass ratio is 10:500；
2) the first medical fluid that the step 1) obtains is mixed with 100ml garlic juice, obtains component A；
3) by 5g ground bettle, 10g Caulis Spatholobi, 5g oldenlandia diffusa, 5g dandelion, 10g Prunella vulgaris, 3g ganoderma lucidum, 1g winter worm
Summer grass, 5g Cortex Phellodendri, 3g Radix Glycyrrhizae carry out second after mixing with water and decoct, and the second medical fluid and second dregs of a decoction are obtained, by second medicine
After liquid air-dries, the first air dry matter is obtained；Second decoct include：Intense fire is cooked by slow fire 60min after boiling again；The quality of ground bettle and water
Than being 3:500；
4) by 5g curcuma zedoary, 2g Paris polyphylla, 3g Radix Angelicae Sinensis, 5g ginseng, 3g Radix Astragali, 5g kuh-seng, 3g Rhizoma Chuanxiong, 75% ethyl alcohol of 5g dried orange peel
Solution impregnates, and after filtering, obtained filtrate is air-dried, obtains the second air dry matter；
5) the first air dry matter that the step 3) obtains is mixed with the second air dry matter that step 4) obtains, is air-dried
The air dry matter is mixed with 2g cow-bezoar, 5g honey, obtains the mixture containing honey, by the mixing containing honey by object
Object is mixed with 20g cyclodextrin, obtains B component.
Embodiment 3
By 5g jujube, 1g Chinese yam, 2g semen coicis, 1g Rhizoma Atractylodis Macrocephalae, 1g Radix Codonopsis, 1g Radix Salviae Miltiorrhizae, 1g Radix Glycyrrhizae, 1g rhizoma polygonati, 1g Radix Notoginseng, 1g
Malt, 1g lily, 1g black rice, 1g Testa sojae atricolor, 1g black fungus, 1g lotus seeds, 1g tremella, 10g rock sugar carry out first after mixing with water
It decocts, obtains the first medical fluid and first dregs of a decoction；First decoction is to be cooked by slow fire 20min again after intense fire is boiled；The quality of jujube and water
Than being 10:500；
2) the first medical fluid that the step 1) obtains is mixed with 100ml garlic juice, obtains component A；
3) by 1g ground bettle, 2g Caulis Spatholobi, 1g oldenlandia diffusa, 1g dandelion, 2g Prunella vulgaris, 0.5g ganoderma lucidum, 0.1g winter
Worm summer grass, 1g Cortex Phellodendri, 0.5g Radix Glycyrrhizae carry out second after mixing with water and decoct, and obtain the second medical fluid and second dregs of a decoction, by described the
After two medical fluids air-dry, the first air dry matter is obtained；Second decoct include：Intense fire is cooked by slow fire 60min after boiling again；Ground bettle and water
Mass ratio is 3:500；
4) by 1g curcuma zedoary, 0.1g Paris polyphylla, 0.5g Radix Angelicae Sinensis, 0.1g ginseng, 0.5g Radix Astragali, 1g kuh-seng, 0.5g Rhizoma Chuanxiong, 1g dried orange peel
With 75% alcohol solution dipping, after filtering, obtained filtrate is air-dried, obtains the second air dry matter；
5) the first air dry matter that the step 3) obtains is mixed with the second air dry matter that step 4) obtains, is air-dried
The air dry matter is mixed with 0.5g cow-bezoar, 1g honey, obtains the mixture containing honey by object, will be described mixed containing honey
It closes object to mix with 20g cyclodextrin, obtains B component.
Embodiment 4
Effectively inhibit the proliferation-mtt assay detection of human melanoma cell (A375)
(1), experimental material and method：
A375 cell, 5mg/ml MTT, Tissue Culture Dish, cell culture medium.
1. cell passes on, it is inoculated in 96 orifice plates, 2000, every hole, overnight incubation.
2. preparing Chinese medical extract culture medium dilution：Rock sugar will not be added, and (rock sugar only plays in Yao medicinal composition to be changed
The effect of kind mouthfeel, on drug action without influencing) and garlic juice before component A 400mL it is concentrated freeze-dried, weighing freeze-dried powder weight is
300mg.It is 200mg that the content of active material allicin, which is estimated as 0.2%, 100mL content, in garlic juice, and 300mg is not contained rock sugar
Component A mixed with 100ml garlic juice, prepare component A solution, wherein in component A solution component A concentration be 1000mg/L.Claim
The B component 10mg before not adding cyclodextrin (cyclodextrin functions only as bonding and stable effect, on drug effect without influence) is taken, is added
70% ethyl alcohol of 10mL (adding ethanol solution herein is to prepare B component solution), prepares B component solution, wherein B component is molten
The concentration of B component is 1000mg/L in liquid.With DMEM cell culture medium component A solution and B component solution, component A solution
It is mixed in equal volume with B component solution, the total concentration of the two is made to be respectively 0,2.5,5,10 and 20mg/L, obtain Chinese medical extract training
Support base dilution.
Positive control：Doxorubicin hydrochloride (DOX) concentration is 1.25mg/L.
3. diluting 96 orifice plate Central Plains culture medium of fluid exchange, the traditional Chinese medicine extraction that every 12h more renews with Chinese medical extract culture medium
Object culture medium dilution and DOX solution.
Every hole is added 10 μ l MTT solution and continues to cultivate after 4.24h, and OD value is detected after 4h, statisticallys analyze, mapping.
(2), result：As shown in Figure 1, the Proliferation Ability of tumour cell is just all the more obvious with the increase of drug concentration.
Embodiment 5
Induce apoptosis-Flow cytometry of A375 cell
(1), experimental material and method：
A375 cell, streaming staining kit, Tissue Culture Dish, cell culture medium.
1. cell passes on, overnight incubation.
2. preparing Chinese medical extract culture medium dilution：Preparation method is the same as embodiment 4.
Positive control：Doxorubicin hydrochloride (DOX) concentration is 1.25mg/L.
3. diluting fluid exchange original culture medium, the Chinese medical extract culture medium that every 12h more renews with Chinese medical extract culture medium
Dilution and DOX solution.
4. collecting cell afterwards for 24 hours, upper machine testing, is analyzed after handling by kit specification, mapping.
(2), result：As shown in Fig. 2, the apoptosis quantity of tumour cell is also increasing with the increase of drug concentration.
Embodiment 6
Inhibit the migration of people's Melanoma cell (A375)
(1), experimental material and method：
1. cell passes on, overnight incubation.
2. preparing Chinese medical extract culture medium dilution：Preparation method is the same as embodiment 4.
Positive control：Doxorubicin hydrochloride (DOX) concentration is 1.25mg/L.
3. scratch is simultaneously taken pictures as benchmark reference.
4. diluting fluid exchange original culture medium, the Chinese medical extract culture medium that every 12h more renews with Chinese medical extract culture medium
Dilution and DOX solution.
5. 6h, 12h and taking pictures for 24 hours after dosing respectively, measure, statistical analysis.
(2), result：As shown in Figures 3 and 4, the mobility of drug tumour cell is significantly pressed down with the increase of drug concentration
System, inhibitory effect are also more obvious than positive drug.
Embodiment 7
Effectively inhibit the growth of knurl in what tumor Mice Body
(1), experimental material：
C57/BL6 mouse 8, mouse melanoma cells (B16), syringe dissects equipment.
(2), experimental method：
1. buying mouse, and in animal house adaptability culture one week.
2. cell culture.
3. kind of tumor：Cell suspension is made in attached cell, is counted, cell is controlled 100 × 105A/ml.By every mouse
5×105A, i.e. 50 μ l cell suspensions are inoculated in subcutaneous on the inside of mouse forelimb.Random picking grouping after inoculation, every group 4
Only, totally 2 groups, i.e. control group and administration group.
4. administration：Start within the 8th day after inoculation to give Chinese medical extract culture medium dilution, Chinese medical extract culture medium dilution
Preparation method with embodiment 4, gastric infusion, drug dose 20mg/Kg/d, control group gives the physiology salt of equal volume
Water, successive administration 5 days.
5. dissection, takes knurl, weigh, statistical analysis.
(3), experimental result：
As it can be seen in figures 5 and 6, the gross tumor volume and weight of trial drug group are obviously reduced.
Embodiment 8
Effectively inhibit the proliferation of variety classes tumour cell
(1), experimental material：
Human Prostate Cancer Cells (PC-3), human lung carcinoma cell (A549), human colon cancer cell (HCT 116), human liver cancer are thin
Born of the same parents (Hep G2), people original position pancreas adenocarcinoma cell (BxPC-3), human esophagus cancer cell (Eca-109), human gastric adenocarcinoma (BGC-
823), human breast cancer cell (MCF-7) and human cervical carcinoma cell (Hela), 5mg/ml MTT.
(2), experimental method：
1. cell passes on, it is inoculated in 96 orifice plates, 2000, every hole, overnight incubation.
2. preparing Chinese medical extract culture medium dilution：Preparation method is the same as embodiment 4.
Positive control：Doxorubicin hydrochloride (DOX) concentration is 1.25mg/L.
3. diluting 96 orifice plate Central Plains culture medium of fluid exchange, the traditional Chinese medicine extraction that every 12h more renews with Chinese medical extract culture medium
Object culture medium dilution and DOX solution.
4. every hole is added 10 μ l MTT solution and continues to cultivate after for 24 hours, OD value is detected after 4h, is statisticallyd analyze, mapping.
(3), experimental result：As shown in fig. 7, the Proliferation Ability of tumour cell is just all the more bright with the increase of drug concentration
It is aobvious.
Embodiment 9
Chen, male, 29 years old, before medication：Melanoma, left thigh root outside and buttocks have obvious lesion at 17, maximum
Lesion diameter 1cm, minimum lesion diameter 2mm can feel obvious protrusion with hand touch.
After medication：Patient starts to take after this medicine the 3rd day, and lesion is largely killed because of tumour cell everywhere causes inflammation,
Affected area redness is itched, but is not festered.The 7th day affected area inflammation disappears after starting medication, raised foci disappearance, in skin
On leave behind the shallow spot of pigment deposition.Patient is discontinued after continuing medication 7 days, and subsequent examination shows that patient fully recovers.
Instructions of taking is：The 1.5gB component of the preparation of embodiment 1 is taken after component A 50ml prepared by oral embodiment 1 again.
Embodiment 10
Ma, male, 67 years old, before medication：Advanced Colon Cancer, concurrent liver, pelvic cavity, Lymph Node Metastasis.The larger lesion of colon is straight
At diameter 9.8cm and 9.2cm two, other big small lesions are several, and it is tangible to obvious lump shape lesion that hand presses abdomen.Patient body
Weakness, sense of discomfort is obvious (groan), and long-term bed, gatism is clouding of consciousness.
After medication：Patient was taken medicine for the first time after a few hours, and general malaise sense is substantially reduced (groan number is reduced).Take medicine the 2nd
It, patient's consciousness starts to restore, and can talk with other people, and stool and urine can exercise self restraints.It takes medicine the 3rd day, patient can voluntarily leave the bed
Short time activity is done, once a day, urine control is primary at one hour for stool.It takes medicine the 7th day, has been touched not with hand pressing abdomen
To obvious lump (tumour cell is killed, knurl softening).It takes medicine the 13rd day, patient can do a little light work with household.Patient
Continuous medication 16 days.According to subsequent examination, Physician Global judges that patient's body tumour cell is killed 60%~70%, and effect is bright
It is aobvious.
Instructions of taking is the same as embodiment 9.
Embodiment 11
Zhang, male, 54 years old, before medication：Advanced esophageal cancer, concurrent two Lung metastases, esophagus irritation unbearably, can only be eaten when swallowing
Liquid food.
After medication：It takes medicine the 3rd day, feeling of pain when patient swallows is substantially reduced, can be swallowed (before medication with normal posture
Can only be swallowed in a manner of facing upward), the harder food such as steamed bun can be eaten.In subsequent drug administration process, feeling of pain when patient swallows is held
It is continuous to mitigate.Patient continuously takes medicine this medicine 14 days.The younger sister of subsequent patient lover advises it to hospital's chemotherapy, as early as possible rehabilitation, Ke Yijin
Fast Out-migrant for work is made money, and is cut out this medicine then, is gone to hospitalize.
Instructions of taking is the same as embodiment 9.
Embodiment 12
Shao, male, 84 years old, before medication：Lymthoma, it is chemotherapy 3 times, in poor health.
After medication：Physical strength increases, sleep improvement, and appetite increases, weight gain.Subsequent inspection result shows blood samples of patients
Middle lymphoma cell significantly reduces.
Instructions of taking is the same as embodiment 9.
Embodiment 13
Fourth, male, 74 years old, before medication：Lung cancer.
After medication：Patient's medication totally 36 days, is during which the stimulation for avoiding allicin to stomach, often takes 12 days medicine intervals 14 days.
Subsequent examination shows that lesion does not increase, this medicine effectively inhibits the growth of patient lungs' tumor tissues.
Instructions of taking is the same as embodiment 9.
Embodiment 14
Journey, male, 54 years old, before medication：Lung cancer, concurrent mediastinum transfer, disappears through chemotherapeutic treatment posterior mediastinum transfer stove, lung
Though lesion reduces, still remain, lesion persistently increases after stopping chemotherapy, and patient body is weak.
After medication：It takes medicine the 7th day, patient obviously feels that the tired sense of body reduces, and physical strength increases, and sleep quality obviously changes
It is kind.After medication 30 days, patient's weight starts to obviously increase.Then, the inspection result before medication and after medication compares display, patient
Pulmonary lesions are obviously reduced and (are reduced to 3.7 × 4cm by 5 × 4cm), and effect is obvious.
Instructions of taking is the same as embodiment 9.
By above embodiments, it can be concluded that, antitumor Chinese medicine composition provided by the invention being capable of effective anti-melanin
Tumor, prostate cancer, lung cancer, colon cancer, liver cancer, cancer of pancreas, the cancer of the esophagus, sdenocarcinoma of stomach, lymthoma, breast cancer and cervical carcinoma.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of antitumor Chinese medicine composition, which is characterized in that including component A and B component；
The component A includes the component of following parts by weight：
It is 5~15 parts of jujube, 1~5 part of Chinese yam, 2~10 parts of semen coicis, 1~5 part of Rhizoma Atractylodis Macrocephalae, 1~5 part of Radix Codonopsis, 1~5 part of Radix Salviae Miltiorrhizae, sweet
Careless 1~10 part, 1~5 part of rhizoma polygonati, 1~5 part of Radix Notoginseng, 1~10 part of malt, 1~5 part of lily, 1~5 part of black rice, Testa sojae atricolor 1~5
Part, 1~5 part of black fungus, 1~5 part of lotus seeds, 1~5 part of tremella, 10~25 parts of rock sugar and 50~120 parts of garlic juice；
In terms of the parts by weight of jujube, the B component includes the component of following parts by weight：
1~5 part of ground bettle, 2~10 parts of Caulis Spatholobi, 1~5 part of oldenlandia diffusa, 1~5 part of dandelion, 1~5 part of curcuma zedoary, summer are withered
Careless 2~10 parts, 0.1~2 part of Paris polyphylla, 0.5~3 part of Radix Angelicae Sinensis, 0.1~5 part of ginseng, 0.5~3 part of Radix Astragali, cordyceps sinensis 0.1~1
Part, 0.5~3 part of ganoderma lucidum, 1~5 part of kuh-seng, 0.5~3 part of Rhizoma Chuanxiong, 1~5 part of dried orange peel, 0.5~3 part of Radix Glycyrrhizae, 0.5~2 part of cow-bezoar,
1.0~5 parts and 1~5 part of honey of Cortex Phellodendri.
2. Chinese medicine composition according to claim 1, which is characterized in that including component A and B component：
The component A includes the component of following parts by weight：
10 parts of jujube, 2 parts of Chinese yam, 5 parts of semen coicis, 2 parts of Rhizoma Atractylodis Macrocephalae, 3 parts of Radix Codonopsis, 2 parts of Radix Salviae Miltiorrhizae, 3 parts of Radix Glycyrrhizae, 2 parts of rhizoma polygonati, Radix Notoginseng 2
Part, 3 parts of malt, 3 parts of lily, 3 parts of black rice, 2 parts of Testa sojae atricolor, 3 parts of black fungus, 3 parts of lotus seeds, 3 parts of tremella, 20 parts of rock sugar and garlic juice
100 parts；
In terms of the parts by weight of jujube, the B component includes the component of following parts by weight：
3 parts of ground bettle, 5 parts of Caulis Spatholobi, 3 parts of oldenlandia diffusa, 3 parts of dandelion, 2 parts of curcuma zedoary, 5 parts of Prunella vulgaris, 0.5 part of Paris polyphylla,
1 part of Radix Angelicae Sinensis, 0.5 part of ginseng, 1 part of Radix Astragali, 0.2 part of cordyceps sinensis, 1 part of ganoderma lucidum, 2 parts of kuh-seng, 1 part of Rhizoma Chuanxiong, 3 parts of dried orange peel, Radix Glycyrrhizae 1
Part, 1 part of cow-bezoar, 1.5 parts of Cortex Phellodendri and 2 parts of honey.
3. a kind of preparation method of Chinese medicine composition described in claim 1, includes the following steps：
1) by jujube described in claim 1, Chinese yam, semen coicis, Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, rhizoma polygonati, Radix Notoginseng, malt, hundred
Conjunction, black rice, Testa sojae atricolor, black fungus, lotus seeds, tremella, rock sugar carry out first after mixing with water and decoct, and obtain the first medical fluid and first
The dregs of a decoction；
2) the first medical fluid that the step 1) obtains is mixed with garlic juice described in claim 1, obtains component A；
3) by ground bettle, Caulis Spatholobi described in claim 1, oldenlandia diffusa, dandelion, Prunella vulgaris, ganoderma lucidum, cordyceps sinensis, Huang
Cypress, Radix Glycyrrhizae carry out second after mixing with water and decoct, and obtain the second medical fluid and second dregs of a decoction, after second medical fluid is air-dried, obtain
To the first air dry matter；
4) by curcuma zedoary described in claim 1, Paris polyphylla, Radix Angelicae Sinensis, ginseng, Radix Astragali, kuh-seng, Rhizoma Chuanxiong, dried orange peel alcohol solution dipping,
After filtering, obtained filtrate is air-dried, obtains the second air dry matter；
5) the first air dry matter that the step 3) obtains is mixed with the second air dry matter that step 4) obtains, obtains air dry matter, it will
The air dry matter is mixed with cow-bezoar described in claim 1, honey, obtains the mixture containing honey, contains honey for described
Mixture mixed with cyclodextrin, obtain B component.
4. preparation method according to claim 3, which is characterized in that the quality of the step 1) jujube and the volume ratio of water
For (5~15) g:(450~550) ml.
5. preparation method according to claim 3, which is characterized in that the step 1) first, which decocts, includes：Intense fire is boiled
It is cooked by slow fire 15~25min again afterwards.
6. preparation method according to claim 3, which is characterized in that the quality of the step 3) ground bettle and the volume of water
Than for (1~5) g:(450~550) ml.
7. preparation method according to claim 3, which is characterized in that the step 3) second, which decocts, includes：Intense fire is boiled
It is cooked by slow fire 50~70min again afterwards.
8. preparation method according to claim 3, which is characterized in that the volume content of the step 4) ethanol solution is 60
~80%.
9. preparation method according to claim 3, which is characterized in that the time that the step 4) is impregnated is 40~56h.
10. preparation method according to claim 3, which is characterized in that the mass ratio of the step 5) cow-bezoar and cyclodextrin
For (0.5~2):(5~15).
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793877A (en) * | 2019-04-03 | 2019-05-24 | 赤峰市肿瘤医院(赤峰学院第二附属医院) | A kind of Chinese medicine composition for treating tumour |
| CN111249406A (en) * | 2020-03-19 | 2020-06-09 | 杭州憶盛医疗科技有限公司 | Anti-tumor combined drug enhancer and preparation method thereof |
| CN112426491A (en) * | 2020-08-15 | 2021-03-02 | 仲崇允 | Traditional Chinese medicine composition for treating malignant melanoma |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1651064A (en) * | 2004-12-23 | 2005-08-10 | 黄文珍 | Medicinal composition for treating tumour and its preparation method |
| CN102274361A (en) * | 2011-07-29 | 2011-12-14 | 李丰曹 | Anticancer medicinal composition and preparation method of decoction thereof |
| CN104352887A (en) * | 2014-10-22 | 2015-02-18 | 安徽博格生物科技有限公司 | Anti-tumor comprehensive conditioning cream and preparing technology thereof |
-
2018
- 2018-09-30 CN CN201811153517.9A patent/CN108888741B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1651064A (en) * | 2004-12-23 | 2005-08-10 | 黄文珍 | Medicinal composition for treating tumour and its preparation method |
| CN102274361A (en) * | 2011-07-29 | 2011-12-14 | 李丰曹 | Anticancer medicinal composition and preparation method of decoction thereof |
| CN104352887A (en) * | 2014-10-22 | 2015-02-18 | 安徽博格生物科技有限公司 | Anti-tumor comprehensive conditioning cream and preparing technology thereof |
Non-Patent Citations (14)
| Title |
|---|
| 刘峰: "胃癌的中医药研究进展", 《中医药导报》 * |
| 卜祥兆等: "中西医结合治疗老年人中晚期肺癌临床观察", 《实用肿瘤学杂志》 * |
| 周敏等: "唐汉钧运用扶正祛邪法治疗外科疾病经验举隅", 《上海中医药杂志》 * |
| 孙丽红: "《生了癌，怎么吃：何裕民教授饮食抗癌新视点》", 31 January 2016, 上海科学技术出版社 * |
| 张业伟: "超声引导经皮射频微创技术联合天芝草胶囊治疗小肝癌90例分析", 《当代医学》 * |
| 彭成等: "《中国临床药物大辞典 中药成方制剂卷 下》", 31 August 2018, 中国医药科技出版社 * |
| 李星等: "中医治疗大肠癌近况", 《甘肃中医》 * |
| 王大庆等: "益气活血中药在恶性肿瘤化疗中的应用", 《临床肺科杂志》 * |
| 路臻等: "《日常生活饮食防癌速查手册》", 31 January 2017, 山西科学技术出版社 * |
| 金孝信: "《中西医结合临床感悟》", 30 September 2009, 中国古籍出版社 * |
| 陈凤春: "健脾化瘀药对胃癌前病变大鼠胃窦部P物质血管活性肠肽和降钙素基因相关肽的影响", 《实用中医内科杂志》 * |
| 陈晶晶等: "张念志主任医师扶正祛邪法论治原发性支气管肺癌经验撷萃", 《浙江中医药大学学报》 * |
| 马福春等: "自拟中药汤剂配合化疗对恶性肿瘤的近期疗效", 《实用医药杂志》 * |
| 黄智芬等: "健脾消积汤配合化疗治疗晚期大肠癌疗效观察", 《现代中西医结合杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793877A (en) * | 2019-04-03 | 2019-05-24 | 赤峰市肿瘤医院(赤峰学院第二附属医院) | A kind of Chinese medicine composition for treating tumour |
| CN111249406A (en) * | 2020-03-19 | 2020-06-09 | 杭州憶盛医疗科技有限公司 | Anti-tumor combined drug enhancer and preparation method thereof |
| CN112426491A (en) * | 2020-08-15 | 2021-03-02 | 仲崇允 | Traditional Chinese medicine composition for treating malignant melanoma |
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