CN108888705A - Watt cloth fritillaria propolis oral bacteriostasis agent and preparation method thereof - Google Patents
Watt cloth fritillaria propolis oral bacteriostasis agent and preparation method thereof Download PDFInfo
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- CN108888705A CN108888705A CN201810918241.2A CN201810918241A CN108888705A CN 108888705 A CN108888705 A CN 108888705A CN 201810918241 A CN201810918241 A CN 201810918241A CN 108888705 A CN108888705 A CN 108888705A
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- propolis
- watt
- borneol
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- 241000241413 Propolis Species 0.000 title claims abstract description 43
- 229940069949 propolis Drugs 0.000 title claims abstract description 43
- 241000605372 Fritillaria Species 0.000 title claims abstract description 38
- 239000004744 fabric Substances 0.000 title claims abstract description 38
- -1 al Species 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title description 4
- 229930006703 (-)-borneol Natural products 0.000 claims abstract description 27
- DTGKSKDOIYIVQL-QXFUBDJGSA-N (-)-borneol Chemical compound C1C[C@]2(C)[C@H](O)C[C@H]1C2(C)C DTGKSKDOIYIVQL-QXFUBDJGSA-N 0.000 claims abstract description 27
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 30
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- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 6
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 6
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 4
- 229940116229 borneol Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
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- DTGKSKDOIYIVQL-MRTMQBJTSA-N Isoborneol Natural products C1C[C@@]2(C)[C@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-MRTMQBJTSA-N 0.000 description 2
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- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
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- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
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- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Insects & Arthropods (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of watt cloth fritillaria propolis oral bacteriostasis agent, include following components：Propolis, watt cloth fritillaria, L-Borneol, honeysuckle, Radix Ophiopogonis and Radix Glycyrrhizae.It is an advantage of the invention that：It is easy to use, securely and reliably, the growth of pathogenic bacteria in oral cavity can be inhibited well.
Description
Technical field
The invention belongs to bacteriostatic agent preparation technical field, in particular to a kind of watt the propolis oral bacteriostasis agent of cloth fritillaria and its system
Preparation Method.
Background technique
Canker sore is common one of mouth disease at present, and also someone is known as " aphtha ", be it is a kind of shallow and small, round or
Oval ulcer.One of the most common type is " recurrent oral ulceration " in canker sore, usually raw on lip, tongue or oral cavity
Other positions, and can often recur.
The appearance of canker sore causes many inconvenience to our life, and the factor of canker sore is caused mainly to have：
(1) disease of digestive system and dysfunction；(2) hormonal change；(3) mental element；(4) other factors：Such as lack micro member
Plain zinc, iron, folic acid, vitamin B12, malnutrition etc., can reduce immune function, and increase causes the factor of canker sore to be fallen ill
Possibility；The bacteriums such as Streptococcus sanguis and helicobacter pylori are also in close relations with canker sore.Canker sore usually implies body
May there are potential systemic disease, canker sore and gastric ulcer, duodenal ulcer, ulcerative colitis, regional enteritis, plant
Object nerve dysfunction disease etc. is related.Therefore, a kind of pure natural plant type, can fundamentally dispel the production of oral cavity pathogen
Product are the eager demands of people.
Summary of the invention
In view of the above-mentioned problems, the object of the present invention is to provide a kind of safely and effectively watt cloth fritillaria propolis oral bacteriostasis agent.
To achieve the above object, the technical scheme adopted by the invention is that：
A kind of watt cloth fritillaria propolis oral bacteriostasis agent includes following components：Propolis, watt cloth fritillaria, L-Borneol, honeysuckle, wheat
Winter and Radix Glycyrrhizae.
Wherein, propolis is a kind of extremely rare natural resources, is known as the title of " purple gold ", the antibacterial having, anti-inflammatory
Analgesic eliminates fungal infection, promotes the effect of cytothesis, can treat canker sore, gastric ulcer, burn and scald, skin Tearing Pain etc.
Illness, the abundant and unique bioactive substance contained by propolis make it have antibacterial, anti-inflammatory, antipruritic, anti-oxidant, enhancing
The multiple functions such as immune have extensive medical treatment, health-care effect to human body.Propolis can sterilize, sterilize, sterilizing, is antibacterial, is mould proof,
Anti-corrosion solves the defect that antibiotic only works to single microorganism, and is free from side effects.In daily life to oral cavity disease
Disease has good therapeutic effect.Propolis is natural antiviral substance, has very strong inhibition and killing effect to a variety of viruses,
Can accelerate histocyte regeneration and wound healing, inhibit various bacteria and certain viruses growth, have wide spectrum antibacterial,
Antiinflammation.
Watt cloth fritillaria is herbaceos perennial,《A Supplement to the Compendium of Materia Medica》Middle record：" tendril-leaved fritillary bulb one ", it is as present
Watt cloth fritillaria has the effects that stronger anti-inflammatory, antiulcer, antiviral.It can clearing heat and moistening lung, dispersing swelling and dissipating binds, the carbuncle that disappears apocenosis, resolving sputum
The function of cough-relieving, advantageously to the treatment concurrent pulmonary emphysema cough person of chronic bronchitis.
L-Borneol is the crystallization obtained from the resin and volatile oil of kapur, is almost pure L-Borneol, and pharmacology is made
With with antibacterial, anti-inflammatory effect.Experiment in vitro shows：The borneol (0.5%) of higher concentration has bacteriostasis, synthetic borneol and day
The bacteriostasis of right borneol is identical.Borneol, isoborneol have antibacterial action；And it is swollen to significantly inhibit rat egg white vola pedis
It is swollen；Isoborneol also has inhibiting effect to croton oil auricle edema, them is prompted to swell the inflammation such as the exudation of liquid and tissue edema
Journey has inhibiting effect.L-Borneol is to be widely used in prevention and treatment serious infectious diseases, chronic disease, occupational disease, endemic disease and spiritual disease
The important medication of disease.Have the function of it is penetrating, have one's ideas straightened out, ward off it is dirty, clean, prevent big epidemic disease, be prevention, medical treatment, health care formula broad spectrum type,
Succinct type Chinese medicine.
Honeysuckle, has a clearing heat and detoxicating, broad-spectrum antiseptic and antiviral and other effects, 70% or more flu, anti-inflammatory Chinese patent drug
In all contain honeysuckle.With " Chinese medicine antibiotic ", " title of antibacterial green element.Resisting pathogenic microbes effect.Honeysuckle is to a variety of
Pathogenic bacteria such as staphylococcus aureus, Escherichia coli, hemolytic streptococcus etc. have certain inhibiting effect.To pneumococcus, green
Purulence bacillus, tubercle bacillus, streptococcus mutans etc. have antibacterial and bactericidal effect, can treat canker sore, sore furuncle poison, periodontitis,
The diseases such as acute and chronic tonsillitis.
Radix Ophiopogonis has the function of nourishing Yin and promoting production of body fluid, moistening lung to arrest cough, deficiency-cold in spleen and stomach, the dry mouth and parching tongue, dry cough cough occurred to body
Blood etc. all can be alleviated and be treated with Radix Ophiopogonis soaked drink, and also have to the drying after palpitaition caused by insufficiency of heart yin, pyreticosis slow
Solution effect, Radix Ophiopogonis can improve immune function；There is inhibiting effect to various bacteria.
Radix Glycyrrhizae：For ulcer sores, abscess of throat etc..It can be applied alone, for oral administration or external application or compatibility application.
Preferably, the oral bacteriostasis agent is prepared from the following raw materials in parts by weight：5~8 part, watt cloth fritillaria 4 of propolis
~7 parts, 2~4 parts of L-Borneol, 1~3 part of honeysuckle, 1~3 part of Radix Ophiopogonis and 1~3 part of Radix Glycyrrhizae.
Preferably, the oral bacteriostasis agent is prepared from the following raw materials in parts by weight：65 parts of part, watt cloth fritillaria of propolis,
3 parts of L-Borneol, 2 parts of honeysuckle, 2 parts of Radix Ophiopogonis and 1 part of Radix Glycyrrhizae.
A method of the oral bacteriostasis agent is prepared, is included the following steps：
(1) according to parts by weight, watt cloth fritillaria, honeysuckle, Radix Ophiopogonis, a Radix Glycyrrhizae are weighed, is added water to cook, plant mixed liquor is obtained；
(2) the plant mixed liquor is concentrated, dry, obtains plant extracts；
(3) propolis and L-Borneol are added into the plant extracts, mixes.
Preferably, plant mixed liquor is dissolved with water, is splined on after the drying process in the step (2)
Resin model is the macroporous absorbent resin of HP-2-MG, uses mass percent concentration for 60% ethanol elution, collects elution
Liquid after concentrate drying, obtains plant extracts.
In the present invention, resin model is also used to compare for the macroporous absorbent resin of D-101 and AB-8, finds HP-2-
The macroporous absorbent resin of MG is preferable to the absorption of plant mixed liquor and desorption ability.Therefore, the macroporous absorption tree of HP-2-MG is selected
Rouge.
The present invention also provides a kind of watt cloth fritillaria propolis oral bacteriostasis agent, and the oral bacteriostasis agent is by following parts by weight
Raw material be made：5~8 4~7 parts of part, watt cloth fritillaria extract of propolis, 2~4 parts of L-Borneol, 1~3 part of Honegsukle flower P.E, Radix Ophiopogonis
1~3 part of extract, 1~3 part of licorice and 80~120 parts of water.
Preferably, the oral bacteriostasis agent is prepared from the following raw materials in parts by weight：7 part, watt cloth fritillaria of propolis is extracted
6 parts of object, 3 parts of L-Borneol, 2 parts of Honegsukle flower P.E, 2 parts of ophiopogon japonicus extract, 2 parts of licorice and 100 parts of water.
The present invention also provides a kind of methods for preparing the oral bacteriostasis agent, include the following steps：In parts by weight, claim
Propolis, watt cloth fritillaria extract, L-Borneol, Honegsukle flower P.E, ophiopogon japonicus extract, licorice are taken, is dissolved in water, is filtered,
It is filling, packaging to get.
The invention has the advantages that：
For the present invention using watt cloth fritillaria as primary raw material, addition propolis, L-Borneol, honeysuckle, Radix Ophiopogonis and Radix Glycyrrhizae, each component are mutual
Effect, safety is good, also has good fungistatic effect.The fungistatic effect for being detected this product is：Escherichia coli bacteriostasis rate
(2min) >=90%, staphylococcus glucose coccus bacteriostasis rate (2min) >=90%, Candida albicans (2min) >=90%.In room temperature
Lower bacteriostasis is at least kept 2 years.
Specific embodiment
Specific embodiments of the present invention will be further explained below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but and does not constitute a limitation of the invention.In addition, invention described below
Technical characteristic involved in each embodiment can be combined with each other as long as they do not conflict with each other.
Embodiment 1
A method of oral bacteriostasis agent is prepared, is included the following steps：
(1) according to parts by weight, 5 parts of watt cloth fritillaria, 2 parts of honeysuckle, 2 parts of Radix Ophiopogonis and 1 part of Radix Glycyrrhizae are weighed, is added water to cook,
Obtain plant mixed liquor；
(2) the plant mixed liquor is concentrated, dry, obtains plant extracts；
(3) 6 parts and 3 parts of L-Borneol of propolis are added into the plant extracts, mixes, is dissolved in water, filters, filling, packet
Dress to get.
Embodiment 2
A method of oral bacteriostasis agent is prepared, is included the following steps：
(1) according to parts by weight, 7 parts of watt cloth fritillaria, 3 parts of honeysuckle, 3 parts of Radix Ophiopogonis and 3 parts of Radix Glycyrrhizae are weighed, are added water to cook,
Obtain plant mixed liquor；
(2) the plant mixed liquor is concentrated, dry, obtains plant extracts；
(3) 8 parts and 4 parts of L-Borneol of propolis are added into the plant extracts, mixes, is dissolved in water, filters, filling, packet
Dress to get.
Embodiment 3
A method of oral bacteriostasis agent is prepared, is included the following steps：
(1) according to parts by weight, 4 parts of watt cloth fritillaria, 1 part of honeysuckle, 1 part of Radix Ophiopogonis and 1 part of Radix Glycyrrhizae are weighed, is added water to cook,
Obtain plant mixed liquor；
(2) the plant mixed liquor is concentrated, dry, obtains plant extracts；
(3) 5 parts and 2 parts of L-Borneol of propolis are added into the plant extracts, mixes, is dissolved in water, filters, filling, packet
Dress to get.
Embodiment 4
A method of oral bacteriostasis agent is prepared, is included the following steps：In parts by weight, 7 part, watt cloth fritillaria of propolis is weighed
6 parts of extract, 3 parts of L-Borneol, 2 parts of Honegsukle flower P.E, 2 parts of ophiopogon japonicus extract, 2 parts of licorice add 100 parts of water dissolutions,
Filtering, it is filling, packaging to get.
Embodiment 5
A method of oral bacteriostasis agent is prepared, is included the following steps：In parts by weight, 8 part, watt cloth fritillaria of propolis is weighed
7 parts of extract, 4 parts of L-Borneol, 3 parts of Honegsukle flower P.E, 3 parts of ophiopogon japonicus extract and 3 parts of licorice add 120 parts of water dissolutions,
Filtering, it is filling, packaging to get.
Embodiment 6
A method of oral bacteriostasis agent is prepared, is included the following steps：In parts by weight, 5 part, watt cloth fritillaria of propolis is weighed
4 parts of extract, 2 parts of L-Borneol, 1 part of Honegsukle flower P.E, 1 part of ophiopogon japonicus extract and 1 part of licorice add 80 parts of water dissolutions,
Filtering, it is filling, packaging to get.
Embodiment 7
A method of oral bacteriostasis agent is prepared, is included the following steps：
(1) according to parts by weight, 5 parts of watt cloth fritillaria, 2 parts of honeysuckle, 2 parts of Radix Ophiopogonis and 1 part of Radix Glycyrrhizae are weighed, is added water to cook,
Obtain plant mixed liquor；
(2) the plant mixed liquor is concentrated, dry, is dissolved with suitable quantity of water, and being splined on resin model is the big of HP-2-MG
Macroporous adsorbent resin uses mass percent concentration for 60% ethanol elution, collects eluent, after concentrate drying, obtain plant and mention
Take object.
(3) 6 parts and 3 parts of L-Borneol of propolis are added into the plant extracts, mixes, is dissolved in water, filters, filling, packet
Dress to get.
The present invention is compatible with natural propolis and a watt cloth fritillaria, L-Borneol, honeysuckle, Radix Ophiopogonis, Radix Glycyrrhizae, has antibacterial, anti-inflammatory
The oral bacteriostasis spray of effect, and inhibit the growth of pathogenic bacteria in oral cavity, it is suitable for canker sore, aphthae, oral lesions
Etc. a series of heredity canker sore patient health disease areas.
Present invention is generally directed to there are canker sore recurrent exerbations in market not specifically for property, and contain chemistry thorn
Swash property at branch's stimulation to mucous membrane of mouth, contained perfume ingredient can not fundamentally dispel causing a disease for canker sore
Microorganism contained by bacterium or even some canker sore product itselfs just severely exceeds, and the serious body for jeopardizing people is strong
It is the disadvantages of health, special using having antibacterial, the natural propolis of antiinflammation and pure plant to be extracted into split-phase compounding, a plant is made
The dedicated product of object type canker sore fundamentally dispels the pathogenic bacteria of canker sore, and prevention canker sore recurrence is pollution-free,
It is safe and healthy, it is easy to use.
The present invention can fundamentally dispel the pathogenic bacteria of mouth disease, and can prevent each of canker sore recurrent exerbation
The generation of kind mouth disease, the canker sore product of the permanent broad-spectrum antibacterial action for keeping propolis.
The present invention has the following advantages that：
(1) with the antibacterial of natural propolis and plant extracts, anti-inflammation components, the pathogenic bacteria in oral cavity are quickly dispelled；
(2) promote cytothesis, accelerate the healing rate of wound；
(3) anti-inflammatory, sterilizing rate are high；
(4) clearing heat and detoxicating, torr sore myogenic, apocenosis, detumescence；
(5) safe, non-stimulated.
In order to verify the technical effects of the present invention, special that above-described embodiment products obtained therefrom is subjected to following tests：
Products obtained therefrom acts on 2min, 5min, 10min, 20min to Escherichia coli, and average bacteriostasis rate is 100%, prompt pair
The bacterium has stronger bacteriostasis；Products obtained therefrom acts on 2min, 5min, 10min, 20min to staphylococcus aureus, average to press down
Bacterium rate is 100%, prompts have stronger bacteriostasis to the bacterium；Products obtained therefrom to Candida albicans effect 2min, 5min,
10min, 20min, average bacteriostasis rate are 100%, prompt have stronger bacteriostasis to the bacterium；It is saved 90 days under the conditions of 37 DEG C
Afterwards, 2min, 5min, 10min, 20min are acted on to staphylococcus aureus, average bacteriostasis rate is 100%, prompt to have the bacterium compared with
Strong bacteriostasis.According to GB15979-2002《Disposable sanitary articles sanitary standard》Stability test method evaluation criterion,
The bacteriostasis of the product can at least be kept 2 years at room temperature.
According to the Ministry of Public Health《Disinfection technology standard》(version in 2002) acute eye irritation test.This product is to experimental rabbit acute ocular
The scoring of irritant test result is determined as nonirritant by eye irritation reaction grade scale.
According to the Ministry of Public Health《Disinfection technology standard》(version in 2002) multiple intact skin irritant test.This product is to repeatedly complete
Whole Skin Irritation Test result scoring is nonirritant by skin irritatin strength grading standard determination.
7 products obtained therefrom of embodiment is preferably to retain effective active composition by refining spearation, is carrying out test survey
When examination, relative to the product of other embodiments, 100 times is diluted, also while being had the same effect, there is good clinical expansion
Meaning.
Above the embodiments of the present invention are described in detail, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (8)
1. a kind of watt cloth fritillaria propolis oral bacteriostasis agent, it is characterised in that：Include following raw material：Propolis, watt cloth fritillaria, L-Borneol,
Honeysuckle, Radix Ophiopogonis and Radix Glycyrrhizae.
2. according to claim 1 watt of cloth fritillaria propolis oral bacteriostasis agent, it is characterised in that：The oral bacteriostasis agent by with
The raw material of lower parts by weight is made：5~8 4~7 parts of part, watt cloth fritillaria of propolis, 2~4 parts of L-Borneol, 1~3 part of honeysuckle, Radix Ophiopogonis 1
~3 parts and 1~3 part of Radix Glycyrrhizae.
3. according to claim 2 watt of cloth fritillaria propolis oral bacteriostasis agent, it is characterised in that：The oral bacteriostasis agent by with
The raw material of lower parts by weight is made：65 parts of part, watt cloth fritillaria of propolis, 3 parts of L-Borneol, 2 parts of honeysuckle, 2 parts of Radix Ophiopogonis and 1 part of Radix Glycyrrhizae.
4. a kind of method for preparing any one of claim 1-3 oral bacteriostasis agent, it is characterised in that：Include the following steps：
(1) according to parts by weight, watt cloth fritillaria, honeysuckle, Radix Ophiopogonis, a Radix Glycyrrhizae are weighed, is added water to cook, plant mixed liquor is obtained；
(2) the plant mixed liquor is concentrated, dry, obtains plant extracts；
(3) propolis and L-Borneol are added into the plant extracts, mixes.
5. preparing the method for oral bacteriostasis agent according to claim 4, it is characterised in that：Plant mixes in the step (2)
Liquid is dissolved after the drying process with water, the macroporous absorbent resin that resin model is HP-2-MG is splined on, using matter
The ethanol elution that percent concentration is 60% is measured, eluent is collected, after concentrate drying, obtains plant extracts.
6. a kind of watt cloth fritillaria propolis oral bacteriostasis agent, it is characterised in that：The oral bacteriostasis agent by following parts by weight original
Material is made：5~8 4~7 parts of part, watt cloth fritillaria extract of propolis, 2~4 parts of L-Borneol, 1~3 part of Honegsukle flower P.E, Radix Ophiopogonis extract
1~3 part of object, 1~3 part of licorice and 80~120 parts of water.
7. according to claim 6 watt of cloth fritillaria propolis oral bacteriostasis agent, it is characterised in that：The oral bacteriostasis agent by with
The raw material of lower parts by weight is made：76 parts of part, watt cloth fritillaria extract of propolis, 3 parts of L-Borneol, 2 parts of Honegsukle flower P.E, Radix Ophiopogonis mention
Take 2 parts of object, 2 parts of licorice and 100 parts of water.
8. a kind of method for preparing the oral bacteriostasis agent of claim 6 or 7, it is characterised in that：Include the following steps：By weight
Number weighs propolis, watt cloth fritillaria extract, L-Borneol, Honegsukle flower P.E, ophiopogon japonicus extract, licorice, adds water-soluble
Solution, filtering, it is filling, packaging to get.
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Application publication date: 20181127 |