CN108884135B - 治疗方法以及可用于其中的药剂 - Google Patents

治疗方法以及可用于其中的药剂 Download PDF

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Publication number
CN108884135B
CN108884135B CN201680074679.6A CN201680074679A CN108884135B CN 108884135 B CN108884135 B CN 108884135B CN 201680074679 A CN201680074679 A CN 201680074679A CN 108884135 B CN108884135 B CN 108884135B
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CN
China
Prior art keywords
epha4
amino acid
disease
human
protein
Prior art date
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CN201680074679.6A
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English (en)
Chinese (zh)
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CN108884135A (zh
Inventor
P·巴特莱特
A·博伊德
M·盖罗梅塔
L·库珀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Queensland UQ
QIMR Berghofer Medical Research Institute
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University of Queensland UQ
Queensland Institute of Medical Research QIMR
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Priority claimed from AU2015904387A external-priority patent/AU2015904387A0/en
Application filed by University of Queensland UQ, Queensland Institute of Medical Research QIMR filed Critical University of Queensland UQ
Publication of CN108884135A publication Critical patent/CN108884135A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201680074679.6A 2015-10-27 2016-10-27 治疗方法以及可用于其中的药剂 Active CN108884135B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015904387A AU2015904387A0 (en) 2015-10-27 A method of treatment and agents useful for same
AU2015904387 2015-10-27
PCT/AU2016/051010 WO2017070738A1 (en) 2015-10-27 2016-10-27 A method of treatment and agents useful for same

Publications (2)

Publication Number Publication Date
CN108884135A CN108884135A (zh) 2018-11-23
CN108884135B true CN108884135B (zh) 2024-03-26

Family

ID=58629613

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Application Number Title Priority Date Filing Date
CN201680074679.6A Active CN108884135B (zh) 2015-10-27 2016-10-27 治疗方法以及可用于其中的药剂

Country Status (8)

Country Link
US (1) US10617738B2 (cg-RX-API-DMAC7.html)
EP (1) EP3368551B1 (cg-RX-API-DMAC7.html)
JP (1) JP6877419B2 (cg-RX-API-DMAC7.html)
CN (1) CN108884135B (cg-RX-API-DMAC7.html)
AU (1) AU2016345063B2 (cg-RX-API-DMAC7.html)
CA (1) CA3003294A1 (cg-RX-API-DMAC7.html)
ES (1) ES2959601T3 (cg-RX-API-DMAC7.html)
WO (1) WO2017070738A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110702916B (zh) * 2019-04-15 2022-06-21 四川大学华西医院 一种整合蛋白质组和糖蛋白组的定量分析方法
AU2022239581A1 (en) * 2021-03-18 2023-10-26 Valery Krasnoperov Use of sephb4-hsa fusion protein as a first-line therapy in cancer treatment
US20240385190A1 (en) * 2021-11-11 2024-11-21 Eisai R&D Management Co., Ltd. Anti-epha4 antibody
WO2023154948A1 (en) * 2022-02-14 2023-08-17 Vasgene Therapeutics Inc. Ephrin type-b receptor 4 (ephb4) agents and production thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2260864A1 (en) * 2009-06-10 2010-12-15 University of Melbourne Therapeutic applications

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JP2752788B2 (ja) 1989-01-23 1998-05-18 カイロン コーポレイション 感染および過剰増殖障害の為の組換え療法
EP0425731B1 (de) 1989-11-03 1994-01-19 Siemens Aktiengesellschaft Controller-Bussystem für einen programmierbaren, flexiblen Digitalsignal-Multiplexer
GB9022788D0 (en) 1990-10-19 1990-12-05 Cortecs Ltd Pharmaceutical formulations
ES2107537T3 (es) 1991-04-25 1997-12-01 Univ Brown Res Found Vehiculo inmunoaislante biocompatible implantable para suministrar productos terapeuticos seleccionados.
US5854217A (en) 1992-09-28 1998-12-29 Bearsden Bio, Inc. Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
FI954774A0 (fi) 1993-04-27 1995-10-06 Cytotherapeutics Inc Aryylinitriiliin perustuvan polymeerin muodostama membraani
AU688776B2 (en) 1993-06-23 1998-03-19 Brown University Research Foundation Method and apparatus for sealing implantable, membrane encapsulation devices
EP1179350A3 (en) 1993-08-12 2003-01-02 Cytotherapeutics, Inc. Encapsulated cell system for implantation into the human CNS
US5550050A (en) 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US5776747A (en) 1994-07-20 1998-07-07 Cytotherapeutics, Inc. Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
CA2202747A1 (en) 1995-06-01 1996-12-05 Dennis Keen Warren Communication system to provide called party location and pre-call warning
IN181898B (cg-RX-API-DMAC7.html) 1995-06-07 1998-10-24 Cytotherapeutics Inc
WO1997012635A1 (en) 1995-10-02 1997-04-10 Cytotherapeutics, Inc. Method for treating amyotrophic lateral sclerosis
AUPP674898A0 (en) * 1998-10-27 1998-11-19 Walter And Eliza Hall Institute Of Medical Research, The A method of treatment
TW200538739A (en) * 2004-02-27 2005-12-01 Oncotherapy Science Inc EphA4 as therapeutic target of PRC and PDACa
US20080003210A1 (en) * 2006-03-13 2008-01-03 Medimmune, Inc. Non-human primate receptor tyrosine kinases
EP2166110B1 (en) * 2007-06-08 2012-02-22 Eisai R&D Management Co., Ltd. Screening method utilizing novel substrate epha4 for gamma-secretase
DK2223999T3 (en) * 2007-11-30 2017-12-18 Eisai R&D Man Co Ltd EPHA4 POLYPEPTIDE WITH UNKNOWN ACTIVITY AND USE THEREOF
EP2653552B1 (en) * 2010-12-17 2016-10-19 Eisai R&D Management Co., Ltd. SCREENING METHOD USING GELATINASE-MEDIATED EphA4 CLEAVAGE REACTION AS AN INDICATOR
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2260864A1 (en) * 2009-06-10 2010-12-15 University of Melbourne Therapeutic applications

Also Published As

Publication number Publication date
ES2959601T3 (es) 2024-02-27
US10617738B2 (en) 2020-04-14
EP3368551A1 (en) 2018-09-05
WO2017070738A1 (en) 2017-05-04
EP3368551B1 (en) 2023-07-12
AU2016345063B2 (en) 2021-08-05
US20180339020A1 (en) 2018-11-29
CA3003294A1 (en) 2017-05-04
CN108884135A (zh) 2018-11-23
JP6877419B2 (ja) 2021-05-26
EP3368551A4 (en) 2019-06-05
AU2016345063A1 (en) 2018-05-17
JP2019501112A (ja) 2019-01-17
AU2016345063A2 (en) 2018-07-19

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