CN108864053A - 一种新型微管蛋白抑制剂及其在抗肿瘤药物中的应用 - Google Patents
一种新型微管蛋白抑制剂及其在抗肿瘤药物中的应用 Download PDFInfo
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- CN108864053A CN108864053A CN201810632856.9A CN201810632856A CN108864053A CN 108864053 A CN108864053 A CN 108864053A CN 201810632856 A CN201810632856 A CN 201810632856A CN 108864053 A CN108864053 A CN 108864053A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
化合物 | IC50(nM) |
colchicine | 1782 |
COLO-201 | 160 |
COLO-202 | 174 |
COLO-203 | 175 |
COLO-204 | 167 |
COLO-205 | 178 |
COLO-206 | 178 |
COLO-207 | 169 |
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CN201810632856.9A CN108864053B (zh) | 2018-06-20 | 2018-06-20 | 一种微管蛋白抑制剂及其在抗肿瘤药物中的应用 |
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CN201810632856.9A CN108864053B (zh) | 2018-06-20 | 2018-06-20 | 一种微管蛋白抑制剂及其在抗肿瘤药物中的应用 |
Publications (2)
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CN108864053A true CN108864053A (zh) | 2018-11-23 |
CN108864053B CN108864053B (zh) | 2020-12-01 |
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CN201810632856.9A Active CN108864053B (zh) | 2018-06-20 | 2018-06-20 | 一种微管蛋白抑制剂及其在抗肿瘤药物中的应用 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014088657A1 (en) * | 2012-12-03 | 2014-06-12 | The Scripps Research Institute | C20'-urea derivatives of vinca alkaloids |
CN106565686A (zh) * | 2016-10-11 | 2017-04-19 | 深圳海王医药科技研究院有限公司 | 微管蛋白抑制剂 |
CN107163011A (zh) * | 2017-05-27 | 2017-09-15 | 上海应用技术大学 | 3‑(3,4,5‑三甲氧基苯甲酰)‑苯并呋喃类微管蛋白抑制剂及其制备方法和用途 |
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2018
- 2018-06-20 CN CN201810632856.9A patent/CN108864053B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014088657A1 (en) * | 2012-12-03 | 2014-06-12 | The Scripps Research Institute | C20'-urea derivatives of vinca alkaloids |
CN106565686A (zh) * | 2016-10-11 | 2017-04-19 | 深圳海王医药科技研究院有限公司 | 微管蛋白抑制剂 |
CN107163011A (zh) * | 2017-05-27 | 2017-09-15 | 上海应用技术大学 | 3‑(3,4,5‑三甲氧基苯甲酰)‑苯并呋喃类微管蛋白抑制剂及其制备方法和用途 |
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Inventor after: Chen Zhenjie Inventor after: Ming Zhu Inventor after: Lu Yanhong Inventor after: Sang Wenjun Inventor before: Sang Wenjun |
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Effective date of registration: 20201116 Address after: 314113 D7 Building, 555 Pioneer Road, Dayun Town, Jiashan County, Jiaxing City, Zhejiang Province (Residence Declaration) Applicant after: Zhejiang Pharmaceutical Garden Biotechnology Co.,Ltd. Address before: 250355 Ji'nan University Changqing science and Technology Park, University Road, Changqing 4655, Shandong University of Traditional Chinese Medicine Applicant before: Sang Wenjun |
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