CN108852913A - A kind of facial cleanser and preparation method thereof comprising salicylic acid microcapsules - Google Patents
A kind of facial cleanser and preparation method thereof comprising salicylic acid microcapsules Download PDFInfo
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Abstract
The present invention discloses a kind of facial cleanser and preparation method comprising salicylic acid microcapsules, this includes that the facial cleanser of salicylic acid microcapsules presses 100 parts of mass fraction calculating, it prepares raw material used by 3~10 parts of sodium sulfate of polyethenoxy ether of fatty alcohol, 3~6 parts of Cocoamidopropyl betaines, 1.0~1.5 parts of vitamin Es, 1.0~10.0 parts of glycerol, 1.0~10.0 part 1, 3- butanediol, 0.5~2.0 part of hard lanolin, 2~8 parts of salicylic acid microcapsules, 3.0~8.0 parts of Citric Acid Monos, 0.15~0.20 part of xanthan gum, 0.5~2.0 part of carbomer, 0.01~0.03 part of propyl p-hydroxybenzoate, the deionized water of 1.0-3.0 parts of sodium chloride and surplus composition.This includes that the facial cleanser of salicylic acid microcapsules is the facial cleanser that a kind of pair of skin has mild cleaning, moisturizing and antibacterial anti-acne effect.
Description
Technical field
The present invention relates to a kind of facial cleanser, in particular to a kind of facial cleanser comprising salicylic acid microcapsules and its preparation side
Method belongs to cosmetic field.
Background technique
Facial cleanser is the more universal one kind of cosmetic field, and cleaning action is mainly played in daily cosmetics, passes through it
The effect of middle surfactant reduces the adhesion work of dirt and skin surface, sufficiently soaks the contact surface of dirt and skin surface,
The interface energy for reducing skin and dirt interface, to make dirt crispatura from skin surface, and because of the selection of surfactant
Difference, foaminess, soil release performance are also different from.
Salicylic acid (Salicylic acid, abbreviation SA) i.e. septichen, is a kind of phenolic compound, salicylic acid energy
Enough cuticula of removal skin surface aging accumulation, improve texture, skin whitening, what is formed to parasteatosis is a series of
Skin problem can well solve.Due to having strong impulse to skin, salicylic application is restricted.The prior art
It discloses spray drying process and prepares the salicylic report of microencapsulation, by slow-release microcapsule technology, mitigate salicylic stimulation
Property, it is more suitable in cosmetics.
Citric Acid Mono (Citric acid monohydrate), citric acid are a kind of important organic acids also known as citron
Acid, clear crystal often contain a molecular crystalline water.In the application, the one kind of citric acid as tartaric acid, adjustable cutin update week
Phase；It is used as pH adjusting agent simultaneously, facial cleanser is made to maintain under mildly acidic conditions, to avoid, reduction pair excessively dry using rear skin
The irritation of skin.
As modern society's timing is more accelerated, young and student enrollment's diet, irregular be easy to cause carefully of working and resting
Bacterium property skin problem, such as：Acne, papule, useless fellow etc., and traditional face cleaning facial cleanser can only clean facial dirt,
Single effect；Meanwhile partial alkaline cleaning supplies will cause dry skin after, in turn result in skin surface itch, it is uncomfortable
It closes and is used for a long time.
Bibliography：
1, a kind of salicylic acid microcapsules of Ji Hongbing, Tan Aizhen, Ou Chun phoenix and preparation method thereof in skin care cream [P]
State；CN201410563809,2015.01.28.
Summary of the invention
An object of the present invention is to solve the characteristics of above-mentioned traditional face cleans facial cleanser single effect, addition
Antibacterial acne-removing；Meanwhile partial alkaline cleaning supplies will cause dry skin after, in turn result in skin surface itch etc.
Symptom is not suitable for being used for a long time, and then provides a kind of facial cleanser comprising salicylic acid microcapsules, should include salicylic acid microcapsules
Facial cleanser using Citric Acid Mono as pH adjusting agent, solve dry skin after above-mentioned traditional facial cleanser single effect and use,
The problems such as tight.The mildness of the above-mentioned facial cleanser comprising salicylic acid microcapsules is good, and irritation is low, and exfoliating ability is strong；It is imitating
On fruit, since salicylic acid and Citric Acid Mono act synergistically, has the function of stronger antibacterial, anti-acne, acne of dispelling, can have
The improvement skin of effect.
It, should the second object of the present invention is to propose a kind of preparation method of above-mentioned facial cleanser comprising salicylic acid microcapsules
Due to easy to operate, raw material is easy to get preparation method, and cost is relatively low, therefore has equipment requirement low, the simple and direct advantage of operating condition.
Technical solution of the present invention
A kind of facial cleanser comprising salicylic acid microcapsules is calculated by 100 parts of mass fractions, prepares raw material composition used
And content is as follows：
A kind of facial cleanser comprising salicylic acid microcapsules is calculated by 100 parts of mass fractions, prepares raw material composition used
And content is preferably as follows：
Above-mentioned salicylic acid microcapsules, are made of core material and wall material, calculate in mass ratio, core material：Wall material is 1:3；It is described
Core material is salicylic acid, and the wall material is that maltodextrin compounds to obtain with sodium carboxymethyl starch, maltodextrin and sodium carboxymethyl starch
Mass ratio be 6-7.5:1.
Core material and wall material are dissolved in two different solutions, core using Liquid phase emulsive method by above-mentioned salicylic acid microcapsules respectively
Material solution pours into wall material solution, by certain reaction condition, obtains salicylic acid microcapsules, specific preparation process includes such as
Lower step：
(1), the preparation of core material solution
Firstly, pressing Brij72：The mass ratio of Brij721 is 1：1.0-1.5 ratio compound to obtain emulsifier；
Then, by salicylic acid：Dehydrated alcohol：The mass ratio of emulsifier is 1：4.5-5.0：The ratio of 0.1-0.15, by water
Poplar acid, dehydrated alcohol and emulsifier mixing are even, obtain core material solution；
(2), the preparation of wall material solution
By maltodextrin：The mass ratio of sodium carboxymethyl starch is 6-7.5:1 ratio, by maltodextrin and carboxymethyl starch
Sodium is mixed, and wall material raw material is obtained；
Then wall material raw material is pressed：The mass ratio of deionized water is 1：1, above-mentioned wall material raw material is add to deionized water,
It is uniformly mixed, obtains wall material solution；
(3), it is 10-15ml/min by the resulting core material solution control drop rate of step (1), adds it to step
(2) in resulting wall material solution, then controlled at 40-45 DEG C, revolving speed is that 350-450r/min is stirred 2-2.5h, instead
After answering, cooled to room temperature, be filtered under diminished pressure at room temperature using 0.6-0.7MPa, resulting filter cake using go from
Sub- water carries out washing 2-3 times, is then dried controlled at 100-120 DEG C, finally obtains salicylic acid microcapsules.
In addition, Liquid phase emulsive method makes salicylic acid microcapsules, technological progress is significantly that conventionally spray-dried method is only fitted
For industrial mass production, production equipment requires height, and yield is lower, and Liquid phase emulsive method is emulsified by wall material and core material in liquid phase
It arrives, keeps salicylic acid dispersibility in system more preferable, there is production equipment to require low, the advantages that mild condition, yield is higher, due to
The difference improves salicylic utilization rate in facial cleanser, and manufacture craft simplifies, and reduces production cost.
A kind of preparation method of above-mentioned facial cleanser comprising salicylic acid microcapsules, specifically comprises the following steps：
(1), the preparation of oily phase
By raw material used in facial cleanser of the preparation comprising salicylic acid microcapsules：Sodium sulfate of polyethenoxy ether of fatty alcohol, cocounut oil
Amido propyl betaine, vitamin E, hard lanolin and propyl p-hydroxybenzoate sequentially add in container, protect after being heated to 80-85 DEG C
Warm 10-15min obtains 80-85 DEG C of oily phase；
(2), the preparation of water phase
By raw material used in facial cleanser of the preparation comprising salicylic acid microcapsules：Glycerol, 1,3 butylene glycol, Citric Acid Mono,
Xanthan gum, carbomer and deionized water sequentially add in another container, control 80-85 DEG C of temperature, revolving speed 400-600r/
Magnetic agitation obtains 80-85 DEG C of water phase to whole dissolutions under min；
(3), 80-85 DEG C obtained in step (1) of oil is mutually mixed with 80-85 DEG C obtained in step (2) of water phase,
Then control revolving speed is that 10000-11000r/min carries out homogeneous 5-10min, and resulting homogeneous mixed liquor is then controlled temperature
It is 80-85 DEG C, revolving speed is that 300-450r/min carries out magnetic agitation 20-50min, then naturally cools to 40-45 DEG C, then again
Sodium chloride is added to be uniformly mixed, the homogeneous mixed liquor after being thickened；
(4), salicylic acid microcapsules are added, into the homogeneous mixed liquor after step (3) resulting thickening controlled at 40-
45 DEG C, revolving speed is stirred 10-20min under the conditions of being 200-300r/min to get the facial cleanser comprising salicylic acid microcapsules.
Advantageous effects of the invention
A kind of facial cleanser comprising salicylic acid microcapsules of the invention, due to being emulsified using by wall material and core material in liquid phase
Obtained salicylic acid microcapsules are raw material, to assign it with antibacterial acne-removal function, further, due to the thorn of salicylic acid itself
Sharp property is larger, and the present invention is by using salicylic acid microcapsules, so that salicylic acid slow release, reduces salicylic acid to the thorn of skin
Swash effect, has given full play to salicylic acid removing cutin, dissolution grease, prevented pore from blocking, mitigate the effect of acne symptom.
Further, a kind of facial cleanser comprising salicylic acid microcapsules of the invention, since preparation process uses a water lemon
Lemon acid, has and adjusts the cutin update cycle, enhances dirt-removing power；Citric Acid Mono can be used as pH adjusting agent simultaneously, make to wash
Face milk maintains under mildly acidic conditions, and protection cuticula avoids dry, tight, enhancing mildness, wetability, while inhibiting part
Bacteria breed, to preferably protect skin.
Further, a kind of facial cleanser comprising salicylic acid microcapsules of the present invention, since salicylic acid is cooperateed with Citric Acid Mono
Effect, so that the exfoliating ability of facial cleanser significantly increases, has the function of stronger antibacterial, anti-acne, acne of dispelling, can be effective
Improve skin.
Further, the preparation method of a kind of facial cleanser comprising salicylic acid microcapsules of the invention, it is former due to easy to operate
Material is easy to get, and cost is relatively low, therefore has equipment requirement low, the simple and direct advantage of operating condition.
Specific embodiment
The present invention is further described below by embodiment, but the contents of the present invention cannot be limited.
The information such as following table of the specification and manufacturer of part material used in the present invention or reagent：
The model of part instrument and equipment used in the present invention and the information of manufacturer such as following table：
Salicylic acid microcapsules used in various embodiments of the present invention, are made of core material and wall material, calculate in mass ratio, core
Material：Wall material is 1:3；The core material is salicylic acid, and the wall material is that maltodextrin compounds to obtain with sodium carboxymethyl starch, malt paste
Essence：The mass ratio of sodium carboxymethyl starch is 6.5:1
Core material and wall material are dissolved in two different solutions, core using Liquid phase emulsive method by above-mentioned salicylic acid microcapsules respectively
Material solution pours into wall material solution, by certain reaction condition, obtains salicylic acid microcapsules, specific preparation process includes such as
Lower step：
(1), the preparation of core material solution
Brij72 in mass ratio：Brij721 is 1：1.5 ratio compounds Brij72 and Brij721 to obtain emulsifier,
Then salicylic acid is pressed：Dehydrated alcohol：The volume ratio of emulsifier is 1：5.0：0.15 ratio, by salicylic acid, dehydrated alcohol and cream
Agent is uniformly mixed, and obtains core material solution；
(2), the preparation of wall material solution
By maltodextrin：The mass ratio of sodium carboxymethyl starch is 6:1 ratio, by maltodextrin and sodium carboxymethyl starch into
Row is uniformly mixed, and obtains wall material raw material；
Then wall material raw material is pressed：The mass ratio of deionized water is 1：Above-mentioned resulting wall material raw material is added to by 1 ratio
In deionized water, it is uniformly mixed, obtains wall material solution；
(3), the resulting core material solution control drop rate of step (1) is added it into step (2) institute for 15ml/min
In the wall material solution obtained, then controlled at 40 DEG C, revolving speed is that 450r/min is stirred 2h, after reaction, naturally cold
But to room temperature, use be filtered under diminished pressure controlled at 25 DEG C, pressure for 0.7MPa, resulting filter cake using deionized water into
Row washs 3 times, is then dried controlled at 110 DEG C, finally obtains salicylic acid microcapsules；
The dosage of the resulting core material solution of step (1) and step (2) resulting wall material solution, calculates, core material in mass ratio：
Wall material is 1:3.
Using to microcapsules yield analysis method, its weight is surveyed to the micro- glue of salicylic acid obtained, is obtained according to following formula
Salicylic acid microcapsules yield：
It is raw materials used total that salicylic acid microcapsules yield/%=obtains salicylic acid microcapsules total weight/prepares the micro- glue of salicylic acid
Weight
A kind of preparation side of conventionally spray-dried method (referring specifically to bibliography 1) production salicylic acid microcapsules is provided herein
Method：
(1), the preparation of core material solution
By salicylic acid：The volume ratio of dehydrated alcohol is 1：5.0 ratio, salicylic acid and dehydrated alcohol are uniformly mixed, and are obtained
To core material solution；
(2), the preparation of wall material solution
By maltodextrin：The mass ratio of sodium carboxymethyl starch is 6:1 ratio, by maltodextrin and sodium carboxymethyl starch into
Row is uniformly mixed, and obtains wall material raw material；
Then wall material raw material is pressed：The mass ratio of deionized water is 1：Above-mentioned resulting wall material raw material is added to by 1 ratio
In deionized water, it is uniformly mixed, obtains wall material solution；
It (3), is that 10-15ml/min adds it to step (2) by the resulting core material solution control drop rate of step (1)
In resulting wall material solution, then controlled at 40 DEG C, revolving speed is that 450r/min is stirred 2h, in 150 DEG C of inlet air temperature,
It is spray-dried under the conditions of 90 DEG C of leaving air temps, finally obtains the salicylic acid microcapsules prepared through conventionally spray-dried method,
The dosage of the resulting core material solution of step (1) and step (2) resulting wall material solution, calculates, core material in mass ratio：
Wall material is 1:3.
Embodiment 1
One kind includes salicylic acid microcapsules mild facial cleanser, is calculated by 100 parts of mass fractions, and raw material used is prepared
Composition and content are as follows：
A kind of above-mentioned preparation method comprising salicylic acid microcapsules mild facial cleanser, specifically comprises the following steps：
(1), the preparation of oily phase
Preparation is included into sodium sulfate of polyethenoxy ether of fatty alcohol, cocounut oil acyl used in salicylic acid microcapsules mild facial cleanser
Amine propyl betaine, vitamin E, hard lanolin, propyl p-hydroxybenzoate raw material sequentially add in container, keep the temperature after being heated to 85 DEG C
15min obtains oily phase；
(2), the preparation of water phase
Preparation is included into glycerol, 1,3 butylene glycol, Citric Acid Mono, Huang used in salicylic acid microcapsules mild facial cleanser
Virgin rubber, carbomer, deionized water raw material sequentially add in another container, control 80 DEG C of temperature, revolving speed is magnetic under 450r/min
Power, which is stirred to raw material, all to be dissolved, and water phase is obtained；
(3), 80-85 DEG C obtained in step (1) of oil is mutually mixed with 80-85 DEG C obtained in step (2) of water phase,
Then control revolving speed is that 10000r/min carries out homogeneous 5min, and resulting homogeneous mixed liquor is controlled at 80 DEG C, revolving speed
350r/min continues magnetic agitation 30min, then naturally cools to 45 DEG C, then adds sodium chloride and thickened, and stir
It is uniformly mixed, the homogeneous mixed liquor after being thickened；
(4), salicylic acid microcapsules are added into the homogeneous mixed liquor after the thickening of step (3), at 45 DEG C of mixeding liquid temperature
Under the conditions of be stirred, revolving speed 250r/min stirs 10-20min to get including salicylic acid microcapsules mild facial cleanser.
It is measured to resulting salicylic acid microcapsules yield is appealed, the results showed that use above-mentioned preparation side of the invention
Method, obtained salicylic acid microcapsules yield are 86.53 ± 3.33/%.
Comparative examples 1
Difference with embodiment 1 is that the salicylic acid microcapsules in step (4) are substituted with the deionized water of equivalent, that is, is prepared
Process is added without salicylic acid microcapsules, other preparation conditions and method are same as Example 1, finally obtains and salicylic acid is not added
The facial cleanser of microcapsules.
Comparative examples 2
Difference with embodiment 1 is that the Citric Acid Mono in step (3) is substituted with the deionized water of equivalent, that is, is prepared
Journey is added without Citric Acid Mono, other preparation conditions and method are same as Example 1, finally obtains and Citric Acid Mono is not added
Facial cleanser.
Comparative examples 3
Difference with embodiment 1 is, the salicylic acid microcapsules in Citric Acid Mono, step (4) in step (3) with etc.
The deionized water of amount substitutes, i.e., salicylic acid microcapsules and Citric Acid Mono is added without in preparation process, other preparation conditions and side
Method is same as Example 1, finally obtains and is added without salicylic acid microcapsules, is also added without the facial cleanser of Citric Acid Mono.
Comparative examples 4
Difference with embodiment 1 is that the salicylic acid microcapsules that only preparation process is added are not that the present invention is emulsified using liquid phase
Legal system makees salicylic acid microcapsules, but uses the substitution of salicylic acid microcapsules made from spray drying process, i.e., other preparation conditions and
Method is same as Example 1, i.e., the salicylic acid microcapsules in the finally obtained facial cleanser comprising salicylic acid microcapsules are to pass through
What spray drying process was prepared.
It is measured to resulting salicylic acid microcapsules yield is appealed, the results showed that institute is prepared using above-mentioned spray drying process
The salicylic acid microcapsules yield obtained is 40.39 ± 3.91/%.
It can be seen that use Liquid phase emulsive method of the invention from embodiment 1 and 4 salicylic acid microcapsules yield of comparative examples
The salicylic acid microcapsules yield of preparation is significantly increased relative to salicylic acid microcapsules yield prepared by conventionally spray-dried method, and
And having experimental implementation simple, experimental facilities requires low, the advantages of being applicable to small-scale production.
Efficacy test
Test object：
40 people of experimental group, male 19, women 21；Age, average age was 21.4 years old between 14-26 years old.
Control group 1,2,3,4, every group of 40 people, total 160 people, male 82, women 78；Age between 14-26 years old,
Average age is 20.0 years old.
Test object information --- use front face acne conditions
Acne is clinically divided into 3 degree, 4 grades according to acne lesions property and severity：1 grade (slight)：Only acne；
2 grades (moderate)：In addition to acne, there are also some inflamed papules；3 grades (moderate)：In addition to acne, there are also more inflamed papules or purulence
Blister；4 grades (severe)：In addition to having acne, inflamed papules and warts, nodosity, tumour or scar are gone back.
| Test group | Slight 1 grade | 2 grades of moderate | 3 grades of moderate | 4 grades of severe |
| Experimental group | 10 | 10 | 10 | 10 |
| Control group 1 | 10 | 11 | 9 | 10 |
| Control group 2 | 10 | 11 | 9 | 10 |
| Control group 3 | 10 | 10 | 10 | 10 |
| Control group 4 | 9 | 10 | 11 | 10 |
It is above-mentioned to be statistically analyzed, no significant difference (P>0.05) it, is comparable.
Test method：
Experimental group：Use gained in the embodiment of the present invention 1 (the salicylic acid microcapsules used are Liquid phase emulsive method preparation)
The facial cleanser comprising salicylic acid microcapsules,
Control group 1：Use comparative examples 1 (not containing salicylic acid microcapsules) resulting facial cleanser；
Control group 2：Use comparative examples 2 (not containing citric acid) resulting facial cleanser；
Control group 3：It washes one's face using comparative examples 3 (not containing citric acid, be also free of salicylic acid microcapsules) are resulting
Milk；
Control group 4：It is washed using comparative examples 4 (the salicylic acid microcapsules used are spray drying process preparation) are resulting
Face milk.
The method of the facial cleanser of above-mentioned different groups used：Use twice sooner or later daily (first facial warm water is moistened,
Then squeeze out appropriate facial cleanser in the palm of the hand, after both hands rubbing blistering, after both hands rubbing generates foam, facial cleanser is sufficiently applied put on the skin in
It is wet on the face, in a moment with clear water clean), be used continuously 2 weeks；
Evaluation test (1) --- face acnes situation of change
Effect is obvious：Face acnes take an evident turn for the better, and almost all disappears；Effectively：Face acnes symptom mitigates, and partially disappears
It loses；In vain：There is no significant change using rear face acne problems.Test result is as follows table：
As can be seen from the above table, (therein using the facial cleanser comprising salicylic acid microcapsules prepared in embodiment 1
Salicylic acid microcapsules using Liquid phase emulsive method prepare) experimental group and using comparative examples 1 it is resulting be free of the micro- glue of salicylic acid
The control group 1 of the facial cleanser of capsule is compared, and experimental group is more preferable than improvement of the control group 1 for face acnes, thus table
Salicylic acid microcapsules, which are illustrated, has dissolution grease, removes acne, cleans the effect of skin；
It can also be seen that by upper table (therein using the facial cleanser comprising salicylic acid microcapsules prepared in embodiment 1
Salicylic acid microcapsules are prepared using Liquid phase emulsive method) experimental group comparative examples 4 are used to the improvement ratios of face acnes
The control group 4 of (salicylic acid microcapsules therein are prepared using spray drying process) resulting facial cleanser comprising salicylic acid microcapsules
It is good to the improvement of face acnes, be indicated above it is of the invention comprising salicylic acid microcapsules, salicylic utilization rate is higher,
It is more preferable to face acnes improvement；
Further, washing one's face comprising salicylic acid microcapsules prepared in embodiment 1 is used by can also be seen that in upper table
The experimental group of milk (Citric Acid Mono and salicylic acid microcapsules add jointly) is to the improvement ratio use of face acnes to according to the facts
Apply the resulting control comprising salicylic acid microcapsules facial cleanser (containing salicylic acid microcapsules, but not containing Citric Acid Mono) of example 2
The improvement of 2 pairs of face acnes of group is slightly good, has been indicated above using citric acid and the microcapsule compounded facial cleanser of salicylic acid to Cuo
Sore improvement has facilitation, and analyzing its reason may be the synergistic effect due to salicylic acid and Citric Acid Mono, so that packet
The mild facial cleanser of the microcapsules containing salicylic acid has the function of stronger antibacterial, anti-acne, acne of dispelling, and can effectively improve skin
Situation.
Further, washing one's face comprising salicylic acid microcapsules prepared in embodiment 1 is used by can also be seen that in upper table
The experimental group of milk (Citric Acid Mono and salicylic acid microcapsules add jointly) is to the improvement of face acnes and use to according to the facts
The control group 3 for applying the resulting facial cleanser of example 3 (without containing salicylic acid microcapsules and Citric Acid Mono) is compared, 3 institute of comparative examples
The facial cleanser obtained can be ignored the improvement of face acnes substantially.
Above-mentioned a face acnes situation of change the experimental results showed that salicylic acid microcapsules have dissolution grease, remove Cuo
Sore cleans the effect of skin；In the facial cleanser comprising salicylic acid microcapsules of the invention, salicylic utilization rate is higher, right
Face acnes improvement is more preferable；And citric acid and the microcapsule compounded facial cleanser of salicylic acid have promotion to acne improvement
Effect, reason may be the result of the salicylic acid synergistic effect of citric acid and the effect release of salicylic acid Microencapsulated Slow.
Evaluation test (2) --- skin of face degree of drying
It is tight：1 hour after use, feels that skin is tight, touch no moist feeling with palm；It is dry：1 hour after use, sense
Feel pachylosis, touches no moist feeling with palm：Normally：1 hour after use, feels skin slip, touched with palm wet
Sense.
Test grouping：
Experimental group：Using the facial cleanser comprising salicylic acid microcapsules prepared in the embodiment of the present invention 1,
Control group 1：Use comparative examples 1 (not containing salicylic acid microcapsules) resulting facial cleanser；
Control group 2：Use comparative examples 2 (not containing citric acid) resulting facial cleanser；
Control group 3：It washes one's face using comparative examples 3 (not containing citric acid, be also free of salicylic acid microcapsules) are resulting
Milk；
Control group 4：It is washed using comparative examples 4 (the salicylic acid microcapsules used are spray drying process preparation) are resulting
Face milk.
The method of the facial cleanser of above-mentioned different groups used：Use twice sooner or later daily (first facial warm water is moistened,
Then squeeze out appropriate facial cleanser in the palm of the hand, after both hands rubbing blistering, after both hands rubbing generates foam, facial cleanser is sufficiently applied put on the skin in
It is wet on the face, in a moment with clear water clean), be used continuously 2 weeks；
Test result is as follows table：
As can be seen from the above table, using the facial cleanser (water therein for prepared by embodiment 1 including salicylic acid microcapsules
Poplar acid microcapsules are prepared using Liquid phase emulsive method) experimental group skin is tight, dry quantity is obviously no better than using control
Resulting pair comprising salicylic acid microcapsules facial cleanser (containing Citric Acid Mono, but not containing salicylic acid microcapsules) of embodiment 1
According to group 1, be indicated above citric acid provide alleviate dry skin whether added with salicylic acid microcapsules be associated with it is little；
It is from upper table it can also be seen that (therein using the facial cleanser prepared by embodiment 1 comprising salicylic acid microcapsules
Salicylic acid microcapsules are prepared using Liquid phase emulsive method) experimental group skin is tight, dry quantity be significantly lower than using using pair
Resulting according to embodiment 2 includes salicylic acid microcapsules facial cleanser (containing salicylic acid microcapsules, but not containing Citric Acid Mono)
Control group 2 has been indicated above citric acid and has provided to skin mildness, wetability, avoided having dry skin tight；
Further, it can also be seen that from upper table using the facial cleanser for prepared by embodiment 1 including salicylic acid microcapsules
The resulting experimental group and use comparative examples 4 of (salicylic acid microcapsules therein are prepared using Liquid phase emulsive method) includes bigcatkin willow
The control group 4 of the facial cleanser (salicylic acid microcapsules therein are prepared using spray drying process) of sour microcapsules is compared, i.e., is all adding
Under the premise of adding Citric Acid Mono, experimental group and control group 4, almost without difference, have been indicated above difference to skin dryness
The salicylic acid microcapsules of method preparation do not influence skin dryness；
Further, it can also be seen that from upper table using the facial cleanser comprising salicylic acid microcapsules prepared in embodiment 1
The experimental group of (Citric Acid Mono adds jointly with salicylic acid microcapsules) compares implementation to the improvement ratio use of face acnes
The resulting control group 3 comprising salicylic acid microcapsules facial cleanser (do not contain salicylic acid microcapsules, but contain Citric Acid Mono) of example 3
It compares, i.e., under the premise of all addition citric acids, experimental group slightly promotes skin mildness, wetability than control group, thus
Showing salicylic acid microcapsules has facilitation to maintenance skin wet.
Above-mentioned skin of face degree of drying the experimental results showed that, citric acid is provided to skin mildness, wetability, is kept away
Exempt to have dry skin tight, and salicylic acid microcapsules have little effect skin dryness.
Embodiment 2
A kind of facial cleanser comprising salicylic acid microcapsules is calculated by 100 parts of mass fractions, prepares raw material composition used
And content is preferably as follows：
Above-mentioned a kind of preparation method comprising salicylic acid microcapsules mild facial cleanser, specifically with embodiment 1, until most
Obtain eventually includes salicylic acid microcapsules mild facial cleanser.
Embodiment 3
A kind of facial cleanser comprising salicylic acid microcapsules is calculated by 100 parts of mass fractions, prepares raw material composition used
And content is preferably as follows：
Above-mentioned a kind of preparation method comprising salicylic acid microcapsules mild facial cleanser, specifically with embodiment 1, until most
Obtain eventually includes salicylic acid microcapsules mild facial cleanser.
Embodiment 4
A kind of facial cleanser comprising salicylic acid microcapsules is calculated by 100 parts of mass fractions, prepares raw material composition used
And content is preferably as follows：
Above-mentioned a kind of preparation method comprising salicylic acid microcapsules mild facial cleanser, specifically with embodiment 1, until most
Obtain eventually includes salicylic acid microcapsules mild facial cleanser.
In conclusion a kind of mild facial cleanser comprising salicylic acid microcapsules of the invention, improvement acne effect is obvious,
Effective test object accounting feels that the tight test object of skin of face is reduced by 45% to 7% up to 98%, and after use,
Its effect for improving tight feeling is preferable.Analyze its reason, it may be possible to due to the synergistic effect of salicylic acid and Citric Acid Mono, so that
Mild facial cleanser comprising salicylic acid microcapsules has the function of stronger antibacterial, anti-acne, acne of dispelling, and can effectively improve skin
Skin situation.
Above-described is only one embodiment of the present invention, for those of ordinary skill in the art, not
Under the premise of being detached from the invention design, various modifications and improvements can be made, these belong to protection model of the invention
It encloses.
Claims (8)
1. a kind of facial cleanser comprising salicylic acid microcapsules, it is characterised in that the facial cleanser comprising salicylic acid microcapsules,
It is calculated by 100 parts of mass fractions, it is as follows to prepare raw material composition and content used：
Above-mentioned salicylic acid microcapsules, are made of core material and wall material, calculate in mass ratio, core material：Wall material is 1:3；The core material
For salicylic acid, the wall material is that maltodextrin compounds to obtain with sodium carboxymethyl starch, the matter of maltodextrin and sodium carboxymethyl starch
Amount is than being 6-7.5:1, it is prepared by a method comprising the following steps：
(1), the preparation of core material solution
Firstly, pressing Brij72：The mass ratio of Brij721 is 1：1.0-1.5 ratio compound to obtain emulsifier；
Then, by salicylic acid：Dehydrated alcohol：The mass ratio of emulsifier is 1：4.5-5.0：The ratio of 0.1-0.15, by salicylic acid,
Dehydrated alcohol and emulsifier mixing are even, obtain core material solution；
(2), the preparation of wall material solution
By maltodextrin：The mass ratio of sodium carboxymethyl starch is 6-7.5:1 ratio, by maltodextrin and sodium carboxymethyl starch into
Row mixing, obtains wall material raw material；
Then wall material raw material is pressed：The mass ratio of deionized water is 1：1, above-mentioned wall material raw material is add to deionized water, is mixed
Uniformly, wall material solution is obtained；
(3), it is 10-15ml/min by the resulting core material solution control drop rate of step (1), adds it to step (2) institute
In the wall material solution obtained, then controlled at 40-45 DEG C, revolving speed is that 350-450r/min is stirred 2-2.5h, reaction knot
Shu Hou, cooled to room temperature, using control at room temperature, pressure is filtered under diminished pressure for 0.6-0.7MPa, resulting filter cake is adopted
Washing 2-3 times is carried out with deionized water and then is dried controlled at 100-120 DEG C, and salicylic acid microcapsules are finally obtained.
2. a kind of facial cleanser comprising salicylic acid microcapsules as described in claim 1, it is characterised in that the salicylic acid is micro-
In capsule, the wall material is that maltodextrin compounds to obtain with sodium carboxymethyl starch, the quality of maltodextrin and sodium carboxymethyl starch
Than being 6.5:1, preparation process forms：
In step (1), Brij72 in mass ratio：Brij721 is 1：1.5 ratio, salicylic acid：Dehydrated alcohol：The body of emulsifier
Product is than being 1：5.0：0.15；
In step (2), maltodextrin：The mass ratio of sodium carboxymethyl starch is 6:1；
Then wall material raw material is pressed：The mass ratio of deionized water is 1：1 ratio, by above-mentioned resulting wall material raw material be added to from
In sub- water, it is uniformly mixed, obtains wall material solution；
In step (3), it is dried controlled at 110 DEG C.
3. a kind of facial cleanser comprising salicylic acid microcapsules as claimed in claim 1 or 2, it is characterised in that by 100 parts of matter
It measures number to calculate, it is as follows to prepare raw material composition and content used：
4. a kind of facial cleanser comprising salicylic acid microcapsules as claimed in claim 3, it is characterised in that by 100 parts of mass parts
Number calculates, and it is as follows to prepare raw material composition and content used：
5. a kind of facial cleanser comprising salicylic acid microcapsules as claimed in claim 3, it is characterised in that by 100 parts of mass parts
Number calculates, and it is as follows to prepare raw material composition and content used：
6. a kind of facial cleanser comprising salicylic acid microcapsules as claimed in claim 3, it is characterised in that by 100 parts of mass parts
Number calculates, and it is as follows to prepare raw material composition and content used：
7. a kind of facial cleanser comprising salicylic acid microcapsules as claimed in claim 3, it is characterised in that by 100 parts of mass parts
Number calculates, and it is as follows to prepare raw material composition and content used：
8. a kind of preparation method of the facial cleanser comprising salicylic acid microcapsules as claimed in claim 1 or 2, it is characterised in that tool
Body includes the following steps：
(1), the preparation of oily phase
Preparation is included into raw material used in salicylic acid microcapsules mild facial cleanser：Sodium sulfate of polyethenoxy ether of fatty alcohol, cocounut oil
Amido propyl betaine, vitamin E, hard lanolin and propyl p-hydroxybenzoate sequentially add in container, protect after being heated to 80-85 DEG C
Warm 10-15min obtains 80-85 DEG C of oily phase；
(2), the preparation of water phase
Preparation is included into raw material used in salicylic acid microcapsules mild facial cleanser：Glycerol, 1,3 butylene glycol, Citric Acid Mono,
Xanthan gum, carbomer and deionized water sequentially add in another container, control 80-85 DEG C of temperature, revolving speed 400-600r/
Magnetic agitation obtains 80-85 DEG C of water phase to whole dissolutions under min；
(3), 80-85 DEG C obtained in step (1) of oil is mutually mixed with 80-85 DEG C obtained in step (2) of water phase, then
Controlling revolving speed is that 10000-11000r/min carries out homogeneous 5-10min, then by resulting homogeneous mixed liquor controlled at 80-
85 DEG C, revolving speed is that 300-450r/min carries out magnetic agitation 20-50min, then naturally cools to 40-45 DEG C, then adds
Sodium chloride is uniformly mixed, the homogeneous mixed liquor after being thickened；
(4), salicylic acid microcapsules are added, into the homogeneous mixed liquor after step (3) resulting thickening controlled at 40-45
DEG C, revolving speed is stirred 10-20min under the conditions of being 200-300r/min to get the facial cleanser comprising salicylic acid microcapsules.
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| CN201811130943.0A CN108852913A (en) | 2018-09-27 | 2018-09-27 | A kind of facial cleanser and preparation method thereof comprising salicylic acid microcapsules |
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|---|---|---|---|---|
| CN104306166A (en) * | 2014-10-21 | 2015-01-28 | 中山大学惠州研究院 | Salicylic acid microcapsule, preparation method and skin-protecting cream thereof |
| CN106913471A (en) * | 2017-03-10 | 2017-07-04 | 佛山市禅香新材料有限公司 | A kind of salicylic acid solid microcapsules and preparation method thereof |
| CN108210346A (en) * | 2018-01-10 | 2018-06-29 | 上海应用技术大学 | It is a kind of to load salicylic compound wall materials microcapsules and preparation method thereof |
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| CN104306166A (en) * | 2014-10-21 | 2015-01-28 | 中山大学惠州研究院 | Salicylic acid microcapsule, preparation method and skin-protecting cream thereof |
| CN106913471A (en) * | 2017-03-10 | 2017-07-04 | 佛山市禅香新材料有限公司 | A kind of salicylic acid solid microcapsules and preparation method thereof |
| CN108210346A (en) * | 2018-01-10 | 2018-06-29 | 上海应用技术大学 | It is a kind of to load salicylic compound wall materials microcapsules and preparation method thereof |
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Effective date of registration: 20200828 Address after: 201108 fourth floor, building 8, No. 210, Jindu Road, Minhang District, Shanghai Applicant after: Shanghai Jiuhe Tianxiang Biotechnology Co., Ltd Address before: 200235 Xuhui District, Caobao Road, No. 120, Applicant before: SHANGHAI INSTITUTE OF TECHNOLOGY |
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