CN106913471A - A kind of salicylic acid solid microcapsules and preparation method thereof - Google Patents
A kind of salicylic acid solid microcapsules and preparation method thereof Download PDFInfo
- Publication number
- CN106913471A CN106913471A CN201710140446.8A CN201710140446A CN106913471A CN 106913471 A CN106913471 A CN 106913471A CN 201710140446 A CN201710140446 A CN 201710140446A CN 106913471 A CN106913471 A CN 106913471A
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- CN
- China
- Prior art keywords
- salicylic acid
- solid microcapsules
- wall material
- preparation
- acid solid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
The invention discloses a kind of salicylic acid solid microcapsules and preparation method thereof.Salicylic acid solid microcapsules are made up of wall material and core, and its mass ratio is 4~6:1；Core is salicylic acid, and the wall material is sodium carboxymethylcellulose.Salicylic acid microcapsules prepared by the present invention, can reduce the original excitant of salicylic acid, and water solubility is greatly enhanced so that salicylic acid more fully can be applied in cosmetics, greatly strengthen fungistatic effect.
Description
Technical field
The invention belongs to microcapsules technology field, specifically, it is related to a kind of salicylic acid solid microcapsules and its preparation side
Method.
Background technology
Salicylic acid is beta-hydroxy acid (Beta Hydroxy Acid), and also known as BHA, B skin softening tartaric acid is present in nature
In willow bark, Gaultheria leaf and sweet birch tree.Salicylic acid is a kind of fat-soluble organic acid.Salicylic acid has dissolving facial pores
Excess oil and old dead and impaired horn cell, suppress the effect of sebum secretion and bacteria breed, can also desalinate pigment
Spot, reduce pore, removal fine wrinkles and improve that Exposure to Sunlight causes it is aging and other effects.Salicylic acid is current cosmetic field anti-acne
The main flow of product, but it is insoluble in water and with compared with strong and stimulating, thus its application is very limited.Prior art has disclosure
The relevant report of shitosan salicylic acid microcapsules, although this can reduce the excitant to skin, its water solubility is still inadequate
It is good, and have impact on salicylic acid effect release in itself.
The content of the invention
It is an object of the invention to overcome the deficiencies in the prior art, there is provided a kind of salicylic acid that can efficiently reduce is to skin
Intense stimulus, and water solubility greatly enhances, while the salicylic acid solid microcapsules of fungistatic effect can be strengthened.
To achieve these goals, present invention employs following technical scheme：
A kind of salicylic acid solid microcapsules, are made up of wall material and core, and its mass ratio is 4~6:1；Core is salicylic acid,
The wall material is sodium carboxymethylcellulose.
In above-mentioned salicylic acid solid microcapsules, the wall material is the mixing of sodium carboxymethylcellulose and polyacrylamide
Thing, its mass ratio is 1:1.
The preparation method of above-mentioned salicylic acid solid microcapsules, comprises the following steps：Wall material and core are mixed, is stirred
Mix, homogeneous, by spray drying form.
Compared with prior art, the present invention has the advantages that：Salicylic acid microcapsules prepared by the present invention, can reduce
The original excitant of salicylic acid, and water solubility greatly enhances so that and salicylic acid more fully can be applied in cosmetics, significantly
Enhance fungistatic effect.
Specific embodiment
The preparation of the salicylic acid solid microcapsules of embodiment 1
Take salicylic acid 30g and sodium carboxymethylcellulose 120g.Salicylic acid and sodium carboxymethylcellulose are mixed, is stirred
Mix, homogeneous, by spray drying salicylic acid solid microcapsules.
The preparation of the salicylic acid solid microcapsules of embodiment 2
Take salicylic acid 30g and sodium carboxymethylcellulose 150g.Salicylic acid and sodium carboxymethylcellulose are mixed, is stirred
Mix, homogeneous, by spray drying salicylic acid solid microcapsules.
The preparation of the salicylic acid solid microcapsules of embodiment 3
Take salicylic acid 30g and sodium carboxymethylcellulose 180g.Salicylic acid and sodium carboxymethylcellulose are mixed, is stirred
Mix, homogeneous, by spray drying salicylic acid solid microcapsules.
The preparation of the salicylic acid solid microcapsules of embodiment 4
(wall material is the mixture of sodium carboxymethylcellulose and polyacrylamide, its quality to take salicylic acid 30g and wall material 180g
Than being 1:1).Salicylic acid and wall material are mixed, are stirred, homogeneous, by spray drying salicylic acid solid microcapsules.
The preparation of the salicylic acid solid microcapsules of embodiment 5
(wall material is the mixture of sodium carboxymethylcellulose and polyacrylamide, its quality to take salicylic acid 30g and wall material 150g
Than being 1:1).Salicylic acid and wall material are mixed, are stirred, homogeneous, by spray drying salicylic acid solid microcapsules.
Comparative example 1：Change the wall material in embodiment 1 into shitosan, other are constant.
Comparative example 2：Change the wall material in embodiment 4 into maltodextrin, other are constant.
Comparative example 3：Change the wall material in embodiment 5 into gelatin, other are constant.
Antibacterial and solubility experiment：
The experimental result of embodiment 1-5 and comparative example 1-3 such as table 1.It can be seen that, embodiment 1-3 maintains the original suppression of salicylic acid
Bacterium activity, will not influence salicylic fungistatic effect because solid microcapsules are made.And embodiment 4-5, due to using special
Wall material combination, be made after solid microcapsules so that salicylic fungistatic effect is enhanced.Water-soluble aspect, embodiment 1-3
Water solubility it is more quite a lot of than comparative example, and the water solubility of embodiment 4-5 is even more and greatly strengthen.
Table 1
Note："-" represents insensitive, antibacterial circle diameter ＜ 7mm；"+" represents sensitive, 7~10mm of antibacterial circle diameter；" ++ " table
Show sensitivity, 10~15mm of antibacterial circle diameter；" +++ " represents sensitive, 15~20mm of antibacterial circle diameter；" ++++" represent sensitive, suppression
20~25mm of bacterium loop diameter.
Claims (3)
1. a kind of salicylic acid solid microcapsules, are made up of wall material and core, and its mass ratio is 4~6:1；Core is salicylic acid, its
It is characterised by that the wall material is sodium carboxymethylcellulose.
2. salicylic acid solid microcapsules as claimed in claim 1, it is characterised in that the wall material be sodium carboxymethylcellulose with
The mixture of polyacrylamide, its mass ratio is 1:1.
3. the preparation method of salicylic acid solid microcapsules described in claim 1, it is characterised in that comprise the following steps：By wall material and
Core is mixed, is stirred, homogeneous, is formed by spray drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710140446.8A CN106913471A (en) | 2017-03-10 | 2017-03-10 | A kind of salicylic acid solid microcapsules and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710140446.8A CN106913471A (en) | 2017-03-10 | 2017-03-10 | A kind of salicylic acid solid microcapsules and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106913471A true CN106913471A (en) | 2017-07-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710140446.8A Withdrawn CN106913471A (en) | 2017-03-10 | 2017-03-10 | A kind of salicylic acid solid microcapsules and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106913471A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108852913A (en) * | 2018-09-27 | 2018-11-23 | 上海应用技术大学 | A kind of facial cleanser and preparation method thereof comprising salicylic acid microcapsules |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306166A (en) * | 2014-10-21 | 2015-01-28 | 中山大学惠州研究院 | Salicylic acid microcapsule, preparation method and skin-protecting cream thereof |
-
2017
- 2017-03-10 CN CN201710140446.8A patent/CN106913471A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306166A (en) * | 2014-10-21 | 2015-01-28 | 中山大学惠州研究院 | Salicylic acid microcapsule, preparation method and skin-protecting cream thereof |
Non-Patent Citations (1)
| Title |
|---|
| 安立刚等: "微胶囊技术在医学生物学中的应用", 《实验动物科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108852913A (en) * | 2018-09-27 | 2018-11-23 | 上海应用技术大学 | A kind of facial cleanser and preparation method thereof comprising salicylic acid microcapsules |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170704 |