CN108836993A - A kind of skin tinea externally applied drug and preparation method - Google Patents

Abstract

The invention discloses a kind of skin tinea externally applied drug and preparation methods, a kind of skin tinea externally applied drug cuts careless 31.25g by Shrubalthea Bark 31.25g in every 1000g skin tinea externally applied drug, the concentration of semen momordicae 31.25g, glacial acetic acid 180g and surplus is made of 65%-75%v/v ethyl alcohol；A kind of skin tinea externally applied drug of the present invention, used time is applied to affected part, to kill based on various bacteriums and fungi, and it is antipruritic to take into account desinsection, has significant curative effect to dermatitis, neurodermatitis, acne, scabies, sweat stain, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch etc., the present invention uses acetic acid and ethyl alcohol for solvent, not only have the function of sterilizing, while also irritating skin, softens the effect of blood vessel, also there is the drug effect for promoting each taste Chinese medicine to play, solvent also has the effect of long-term preservation.Externally applied drug of the invention is easy to use, and dosage is small, and drug price is lower, and patient generally gladly receives.

Description

A kind of skin tinea externally applied drug and preparation method

Technical field

The invention belongs to field of traditional Chinese medicine preparations, and in particular to a kind of skin tinea externally applied drug and preparation method.

Background technique

Traditional Chinese medicine thinks have some diseases that can reflect by skin in human body, and many diseases are viscera diseases The basic reason that external manifestation, i.e. skin occur is imbalance of yin and yang, caused by blood dirt stasis blocking, toxin buildup.But some skin diseases It is then because fungi, bacterial skin infections etc. cause.In short, skin disease is skin（Including hair and first）Shadow by internal and external factor After sound, form, structure and function change, and generate pathologic process, and generate various clinical successively performances accordingly.Skin Skin disease is also the common disease for seriously affecting health of people, common skin disease have psoriasis, eczema, dermatitis, neurodermatitis, Verruca vulgaris, anaphylaxis erythema, scabies, whelk, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch etc., these skin diseases are frequent The happy life for perplexing people, annoyings the soul and spirit of people.Accurate perfect treatment can be such that people are full of to life Have deep love for and self-confident.Existing Chinese medicine treats skin disease, and formula has single type or limitation or medicinal material composition compatibility not to conform to Reason, or because imperfect to the extraction of its effective component during processing or processing or extraction is unreasonable, not in place, certain The effect of depth therapy is not achieved in degree, thus treatment is caused to be not thorough easy recurrence.There are also with regard to existing Western medicine or Chinese medicine Different degrees of addition steroids or antibiotics, there are certain toxic side effect or are easy to produce in treatment skin disease Antibody is not achieved treatment there are also some drugs and repairs the purpose of diseased region.It is just directed to the common curative effect office of skin disease at present Limit undesirable, cure rate is low, recurrent exerbation, especially it is some it is common as dermatitis, neurodermatitis, acne, scabies, sweat stain, The drug effects such as tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch are unobvious, stress and burden can not only be caused to patient, simultaneously It returns patient and increases financial burden.Wang Guoqiang introduction, all tinea：Shrubalthea Bark cuts grass, each equal portions of semen momordicae.For smalls, with vinegar tune, Painting is cured（《National Chinese herbal medicine compilation》Volume one, People's Health Publisher, in September, 2014, the third edition, page 111）.It is tested according to it Side treatment all tineas of many cases, work well, but this method hardly result in it is universal, in order to allow vast tinea patient all to obtain very well Therapy apparatus meeting, spy improves this side, be fabricated to it is a kind of for facilitating the product of purchase, for this purpose, exclusively carried out retrieval, It yet there are no relevant patent application.

Summary of the invention

In view of the deficiencies of the prior art, the present invention provides a kind of skin tinea externally applied drugs, prepare a kind of targeted Solution because of dermatitis, neurodermatitis, acne, scabies, tinea of feet and hands, onychomycosis, tinea versicolor, body caused by various bacteriums, fungi etc. The external drug of the treatment problem of tinea, jock itch etc..

The present invention also provides the preparation methods of skin tinea externally applied drug.

To achieve the goals above, the following technical solutions are specifically adopted by the present invention：

A kind of skin tinea externally applied drug, which is characterized in that by Shrubalthea Bark 31.25g in every 1000g skin tinea externally applied drug, cut grass The concentration of 31.25g, semen momordicae 31.25g, glacial acetic acid 180g and surplus is made of 65%-75%v/v ethyl alcohol, specific preparation method It is as follows：Take respectively Shrubalthea Bark, cut grass, semen momordicae pick completely, be ground into 55-65 mesh powder, be placed in closed container, separately take by matching The glacial acetic acid and 65%-75%v/v ethyl alcohol by weight 1 just measured:The acidic ethanol that 4 ratios mix, by acidic ethanol plus Enter into the closed container for being equipped with medicinal material powder, sufficiently stir evenly, is impregnated 15 days under room temperature, pour out supernatant, added in medicinal powder slag By the glacial acetic acid and 65%-75%v/v ethyl alcohol by weight 1 of formula ratio:The acidic ethanol that 4 ratios mix, under room temperature It impregnates again 7 days, pours out supernatant, recrement, which is put into squeezer, squeezes immersion liquid, the immersion liquid squeezed is merged with secondary supernatant, mistake Filter, stand for 24 hours, filtering, added from filter appropriate 65%-75%v/v ethyl alcohol be settled to specified amount to get.

A kind of preparation method of skin tinea externally applied drug, which is characterized in that steps are as follows：

（1）Take respectively Shrubalthea Bark, cut grass, semen momordicae pick completely, be ground into 55-65 mesh powder, be placed in closed container, it is spare；

（2）Take the glacial acetic acid and 65%-75%v/v ethyl alcohol by weight 1 by formula ratio:The acid second that 4 ratios mix Acidic ethanol is added in the closed container for being equipped with medicinal material powder by alcohol, is sufficiently stirred evenly, and is impregnated 15 days under room temperature, is poured out supernatant, It is spare；

（3）Medicinal powder slag adds the glacial acetic acid and 65%-75%v/v ethyl alcohol by weight 1 by formula ratio:4 ratios mix Acidic ethanol, impregnated again under room temperature 7 days, pour out supernatant, it is spare；

（4）Recrement after dipping is put into squeezer and squeezes immersion liquid, the immersion liquid squeezed is merged with secondary supernatant, is stood for 24 hours, Filtering, appropriate 65%-75%v/v ethyl alcohol is added from filter and is settled to specified amount to obtain the final product.

A kind of skin tinea externally applied drug conduct treatment dermatitis, neurodermatitis, acne, scabies, sweat made from the method for the present invention Spot, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, the purposes of jock itch.

Shrubalthea Bark also known as corter pseudolaricis are Pinaceae gold thread pine genus plant golden larch Pseudolarix amabilis (Nelson) root skin of Rehd..Nature and flavor are pungent, warm.It is toxic, there is dispelling wind and eliminating dampness, the antipruritic function of desinsection.Suitable for eczema, nerve Property dermatitis, scabies.

The difference of Shrubalthea Bark medicinal material and corter pseudolaricis：Corter pseudolaricis is thick, and color is red, and shape is big；And Shrubalthea Bark is thin, color is white, there is fiber（King Guoqiang,《National Chinese herbal medicine compilation》Volume one, People's Health Publisher, in September, 2014, the third edition, page 33）.

Grass is cut, is Chloranthaceae vegetable silk fringe tree Chloranthus fortunei（A.Gray）Solms-Lamb. Herb or root.Nature and flavor are pungent, bitter, mild-natured.With expelling wind and activating blood flow, the efficacy of removing toxicity for detumescence energy.For rheumatic arthralgia, traumatic injury, Boil tinea scabies, venomous snake bite.It is to cut careless herb that the present invention, which uses,.

Semen momordicae is Curcurbitaceae balsam pear platymiscium semen momordicae Momrolica cochinchinensis (Lour.) Spreng. seed.With mass dissipating and swelling eliminating, attacks poison and treat sore function, be suitable for sore swollen toxin, acute mastitis, anal fistula, chronic eczema, the favus of the scalp.This It is its root skin that invention, which uses,.

Beneficial effects of the present invention

A kind of skin tinea externally applied drug of the present invention, used time are applied to affected part, to kill based on various bacteriums and fungi, and take into account desinsection and stop Itch, have significant curative effect to dermatitis, neurodermatitis, acne, scabies, sweat stain, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch etc., The present invention uses acetic acid and ethyl alcohol for solvent, not only has the function of sterilizing, while also irritating skin, softens blood vessel Also there is the drug effect for promoting each taste Chinese medicine to play for effect, and solvent also has the effect of long-term preservation.Preparation cost of the present invention It is low, the financial burden of patient can be mitigated.Skin tinea externally applied drug of the present invention is pure Chinese medicine preparation, first with acidic ethanol to it Soakage extraction enables its soluble effective component to extract, then secondary again to be extracted using acidic ethanol, so that having in medicinal material Effect ingredient is sufficiently extracted, and the validity of natural drug ingedient is maintained, molten using glacial acetic acid and ethyl alcohol compound as extracting Agent, irritation is also small, and easy to use.Externally applied drug of the invention is easy to use from clinical application, and dosage is small, and has Preferable clinical therapeutic efficacy, patient generally gladly receive, and drug price is lower, can show outside present invention treatment skin tinea Medication has a good application prospect.

Specific embodiment

Embodiment 1

（1）Take respectively Shrubalthea Bark, cut grass, semen momordicae pick completely, weigh Shrubalthea Bark 31.25g, cut careless 31.25g, semen momordicae 31.25g is respectively crushed into 55 mesh powder with disintegrating apparatus, is placed in closed ceramic pot, spare；

（2）The acidic ethanol mixed by 90g glacial acetic acid and 360g 65%v/v ethyl alcohol is taken, acidic ethanol is added to（1） It is equipped in the closed ceramic pot of medicinal material powder, sufficiently stirs evenly, impregnate 15 days under normal temperature conditions, pour out supernatant, it is spare；

（3）Medicinal powder slag adds the acidic ethanol mixed by 90g glacial acetic acid and 360g 65%%v/v ethyl alcohol, in room temperature It is lower to impregnate 7 days, supernatant is poured out, it is spare；

（4）Recrement after dipping is put into squeezer and squeezes immersion liquid, by the immersion liquid squeezed with（1）With（2）Secondary supernatant merges, Filtering, be then allowed to stand for 24 hours, filtering, appropriate 65%%v/v ethyl alcohol is added from filter, be settled to 1000g to get.

Embodiment 2

（1）Take respectively Shrubalthea Bark, cut grass, semen momordicae pick completely, weigh Shrubalthea Bark 31.25g, cut careless 31.25g, semen momordicae 31.25g is respectively crushed into 60 mesh powder with disintegrating apparatus, is placed in closed ceramic pot, spare；

（2）The acidic ethanol mixed by 90g glacial acetic acid and 360g 70%v/v ethyl alcohol is taken, acidic ethanol is added to（1） It is equipped in the closed ceramic pot of medicinal material powder, sufficiently stirs evenly, impregnate 15 days under normal temperature conditions, pour out supernatant, it is spare；

（3）Medicinal powder slag adds the acidic ethanol mixed by 90g glacial acetic acid and 360g 70%%v/v ethyl alcohol, in room temperature It is lower to impregnate 7 days, supernatant is poured out, it is spare；

（4）Recrement after dipping is put into squeezer and squeezes immersion liquid, by the immersion liquid squeezed with（1）With（2）Secondary supernatant merges, Filtering, be then allowed to stand for 24 hours, filtering, appropriate 70%%v/v ethyl alcohol is added from filter, be settled to 1000g to get.

Embodiment 3

（1）Take respectively Shrubalthea Bark, cut grass, semen momordicae pick completely, weigh Shrubalthea Bark 31.25g, cut careless 31.25g, semen momordicae 31.25g is respectively crushed into 65 mesh powder with disintegrating apparatus, is placed in closed ceramic pot, spare；

（2）The acidic ethanol mixed by 90g glacial acetic acid and 360g 75%v/v ethyl alcohol is taken, acidic ethanol is added to（1） It is equipped in the closed ceramic pot of medicinal material powder, sufficiently stirs evenly, impregnate 15 days under normal temperature conditions, pour out supernatant, it is spare；

（3）Medicinal powder slag adds the acidic ethanol mixed by 90g glacial acetic acid and 360g 75%%v/v ethyl alcohol, in room temperature It is lower to impregnate 7 days, supernatant is poured out, it is spare；

（4）Recrement after dipping is put into squeezer and squeezes immersion liquid, by the immersion liquid squeezed with（1）With（2）Secondary supernatant merges, Filtering, be then allowed to stand for 24 hours, filtering, appropriate 75%%v/v ethyl alcohol is added from filter, be settled to 1000g to get.

Clinical efficacy：

Using the skin tinea externally applied drug of the embodiment of the present invention 1, sweat stain tinea patient 12 is treated, wherein male 10, women 2, Take local application 3 times a day, 5 days as one therapeutic course, as a result a course for the treatment of cures 10, remaining 2 are treated two in medication Course for the treatment of recovery from illness.

Externally applied drug is made using the embodiment of the present invention 2 and treats dermatitis patients 15, local application is taken 3 times a day, is within 7 days One course for the treatment of, as a result a course for the treatment of cures 9, and 6 medications, two courses for the treatment of are cured.

Externally applied drug is made using the embodiment of the present invention 3 and treats tinea pedis patient 6, takes local application, 3 times a day, 5 days As a treatment course, as a result 5 medications, one course for the treatment of is cured, and 1 medication treatment in 8 days is cured.

Claims (3)

1. a kind of skin tinea externally applied drug, which is characterized in that by Shrubalthea Bark 31.25g in every 1000g skin tinea externally applied drug, cut grass The concentration of 31.25g, semen momordicae 31.25g, glacial acetic acid 180g and surplus is made of 65%-75%v/v ethyl alcohol, specific preparation method It is as follows：Take respectively Shrubalthea Bark, cut grass, semen momordicae pick completely, be ground into 55-65 mesh powder, be placed in closed container, separately take by matching The glacial acetic acid and 65%-75%v/v ethyl alcohol by weight 1 just measured:The acidic ethanol that 4 ratios mix, by acidic ethanol plus Enter into the closed container for being equipped with medicinal material powder, sufficiently stir evenly, is impregnated 15 days under room temperature, pour out supernatant, added in medicinal powder slag By the glacial acetic acid and 65%-75%v/v ethyl alcohol by weight 1 of formula ratio:The acidic ethanol that 4 ratios mix, under room temperature It impregnates again 7 days, pours out supernatant, recrement, which is put into squeezer, squeezes immersion liquid, the immersion liquid squeezed is merged with secondary supernatant, mistake Filter, stand for 24 hours, filtering, added from filter appropriate 65%-75%v/v ethyl alcohol be settled to specified amount to get.

2. a kind of preparation method of skin tinea externally applied drug according to claim 1, which is characterized in that steps are as follows：

（1）Take respectively Shrubalthea Bark, cut grass, semen momordicae pick completely, be ground into 55-65 mesh powder, be placed in closed container, it is spare；

（2）Take the glacial acetic acid and 65%-75%v/v ethyl alcohol by weight 1 by formula ratio:The acid second that 4 ratios mix Acidic ethanol is added in the closed container for being equipped with medicinal material powder by alcohol, is sufficiently stirred evenly, and is impregnated 15 days under room temperature, is poured out supernatant, It is spare；

（3）Medicinal powder slag adds the glacial acetic acid and 65%-75%v/v ethyl alcohol by weight 1 by formula ratio:4 ratios mix Acidic ethanol, impregnated again under room temperature 7 days, pour out supernatant, it is spare；

（4）Recrement after dipping is put into squeezer and squeezes immersion liquid, the immersion liquid squeezed is merged with secondary supernatant, is stood for 24 hours, Filtering, appropriate 65%-75%v/v ethyl alcohol is added from filter and is settled to specified amount to obtain the final product.

3. a kind of skin tinea externally applied drug is as treatment dermatitis, neurodermatitis, acne, scabies, sweat according to claim 1 Spot, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, the purposes of jock itch.