CN108853211A - A kind of itch lotion - Google Patents

A kind of itch lotion Download PDF

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Publication number
CN108853211A
CN108853211A CN201811155088.9A CN201811155088A CN108853211A CN 108853211 A CN108853211 A CN 108853211A CN 201811155088 A CN201811155088 A CN 201811155088A CN 108853211 A CN108853211 A CN 108853211A
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CN
China
Prior art keywords
distillate
added
distillation
borneol
ethyl alcohol
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201811155088.9A
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Chinese (zh)
Inventor
张奎昌
汤先伟
花丽
张路
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Pizhou Gas Star Pharmaceutical Technology Service Co Ltd
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Pizhou Gas Star Pharmaceutical Technology Service Co Ltd
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Publication date
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Priority to CN201811155088.9A priority Critical patent/CN108853211A/en
Publication of CN108853211A publication Critical patent/CN108853211A/en
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention specifically discloses a kind of itch lotion, belongs to Chinese medicine preparation field.A kind of itch lotion of the present invention, which is characterized in that by following raw materials, five poisonous weeds 250g, gingko episperm 250g, borneol 10g composition is made by the following method：Five poisonous weeds and gingko episperm are taken to be respectively crushed into 42 mesh coarse powder, the ethyl alcohol 250g that concentration is 95%v/v is added in mixing, and fully mixing keeps its infiltration uniform, it places and infiltrates 15h in closed container, then it by the spice of infiltration, is placed in distiller, the ethyl alcohol 500g that concentration is 95%v/v is added, place dipping 3h, heating distillation, collects distillate 500g, obtains distillate A；The dregs of a decoction after distillation are added into distilled water 500g, stand 1h, heating distillation collects distillate, obtains distillate B；Take distillate A 500g, borneol 10g be added, is stirred to dissolve, filter, distillate 490g is added from filter, make to be settled to 1000g to get.Present invention process is simple, and energy consumption is few, and product has no toxic side effect, and dosage is small, and easy to use, product has a good application prospect.

Description

A kind of itch lotion
Technical field
The invention belongs to Chinese medicine preparation fields, are related to a kind of itch lotion.
Background technique
Skin disease is also the common disease for seriously affecting health of people, and traditional Chinese medicine thinks, has some diseases can be in human body It is reflected by skin, many diseases are the external manifestations of viscera disease, i.e., the basic reason that skin occurs is that yin-yang is lost It adjusts, caused by blood dirt stasis blocking, toxin buildup.But some skin diseases are then because fungi, bacterial skin infections etc. cause.In short, skin Disease is skin（Including hair and first）After being influenced by internal and external factor, form, structure and function change, and generate disease Reason process, and various clinical successively performances are generated accordingly.Common skin disease has psoriasis, eczema, dermatitis, nerve skin Inflammation, verruca vulgaris, anaphylaxis erythema, scabies, whelk, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch etc., these skin diseases The often happy life of puzzlement people, annoyings the soul and spirit of people.Accurate perfect treatment can be such that people are full of to life It is living to have deep love for and self-confident.Existing Chinese medicine treats skin disease, and formula has single type or limitation or medicinal material composition compatibility It is unreasonable, or because imperfect to the extraction of its effective component during processing or processing or extraction is unreasonable, not in place, The effect of depth therapy is not achieved to a certain extent, thus treatment is caused to be not thorough easy recurrence.There are also with regard to existing Western medicine or Chinese medicine addition steroids or antibiotics different degrees of in treatment skin disease, there are certain toxic side effect or are easy Antibody is generated, treatment is not achieved there are also some drugs and repairs the purpose of diseased region.Just commonly treated for skin disease at present Effect limitation is undesirable, and cure rate is low, recurrent exerbation, especially some common such as dermatitis, neurodermatitis, acne, scabies, sweat The drug effects such as spot, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch are unobvious, stress and burden can not only be caused to patient, together When return patient increase financial burden.A kind of exact pure Chinese medicinal preparation of effect is developed, it is secondary to avoid the poison of Western medicine in the treatment Effect, is the main object of the present invention.
Summary of the invention
The purpose of the present invention is reducing swelling using having clearing heat and promoting diuresis, analgesic, the Chinese medicine of itching-relieving efficacies prepares a kind of tinea medicine Water, targetedly solve because dermatitis caused by various bacteriums, fungi etc., neurodermatitis, acne, ringworm of the body, the tinea manuum, tinea pedis, The treatment problem of onychomycosis, eczema etc..
To achieve the goals above, the following technical solutions are specifically adopted by the present invention：
A kind of itch lotion of the present invention, which is characterized in that it is by following raw materials, five poisonous weeds 250g, gingko episperm 250g, ice Piece 10g composition, is made by the following method：It takes five poisonous weeds and gingko episperm to be respectively crushed into 42 mesh coarse powder, mixes, concentration is added For the ethyl alcohol 250g of 95%v/v, fully mixing makes its infiltration uniformly, places and infiltrates 15h in closed container, then by the medicine of infiltration Material is placed in distiller, and the ethyl alcohol 500g that concentration is 95%v/v is added, and places dipping 3h, and distillate is collected in heating distillation 500g obtains distillate A；The dregs of a decoction after distillation are added into distilled water 500g, stand 1h, heating distillation is collected distillate, must be steamed Distillate B；Distillate A 500g is taken, borneol 10g is added, is stirred to dissolve, is filtered, distillate 490g is added from filter, it is fixed to make Hold to 1000g to get.
A kind of itch lotion of the present invention is as the purposes for treating dermatitis, neurodermatitis, ringworm of the body, tinea of feet and hands, eczema.
Five poisonous weeds, scientific name are the aerial part herb of polygonaceae plant polygonum perfoliatum Pulygunum perfoliatum L., again Name passes through leaf knotweed.Nature and flavor are sour, bitter, flat, slightly cold.Return lung, bladder meridian.With clearing heat and detoxicating, inducing diuresis for removing edema, cough-relieving function, for swallowing Larynx swelling and pain, cough with lung heat, children's pertussis, edema and little urine, damp-heat dysentery, eczema, furuncle, snakebite and bugbite.Mere formality offers introduction：Herb Glycosides containing indigo, flavonoids, anthra-glucoside, phenols, amino acid, organic acid, tannin and carbohydrate etc..Organic acid has caffeic acid, ferulic acid etc.；It is yellow Ketone has persicarin, Kaempferol, Quercetin, avicularin, rutin etc..Pharmacological action：1. bacteriostasis：Polygonum perfoliatum aqueous extract pair The common clinical pathogenic microorganisms such as staphylococcus aureus, Pasteurella, streptococcus, detection of Salmonella, escherichia coli have relatively strong Antibacterial action.2. antitussive effect：Polygonum perfoliatum draws cough experiment in apparent antitussive effect to mouse ammonium hydroxide.3. anti-inflammatory effect： Polygonum perfoliatum total extract position has significant anti-inflammatory activity.There are also suitable amount used externally, fresh goods mashes deposited or dry product and decocts washing affected part Record（Wang Guoqiang,《National Chinese herbal medicine compilation（Volume one）》, People's Health Publisher, 2 months 2014, the 3rd edition, page 217）.
Five poisonous weeds that the present invention uses for fresh goods, through alcohol infiltration distillation and water distill combined process, to its effective component into Row extracts, and entire technical process distilled after being infiltrated using ethyl alcohol, and then row water distills its dregs of a decoction again, so that alcohol-soluble, waving Hair property and water soluble ingredient obtain beneficial extraction, damage caused by avoiding its effective component as far as possible because of high temperature decocting method It loses.
Gingko episperm is ginkgo seed（That is ginkgo）Part outside hard shell is commonly called as gingko clothing, the skin of gingko seeds The exosper of boundary between muscles matter, the mesosperm of sclerotin and film quality endotesta, the gingko episperm that the present invention uses is gingko seeds Meat exosper.Scientist is it has been investigated that exosper contains a large amount of hydroginkgoic acid, bilobol and gingko alcohol, also containing silver Apricot yellow element, isoginkgetin and polysaccharide component, there are also micro ginkgolides.Its interaction property and cyclophosphamide and ground plug rice Pine etc. is similar.The polysaccharide of gingko episperm can enhance cellular immune function, the generation to bone-marrow-derived lymphocyte during humoral immunity Effect is formed with antibody.Have document report, the alcohols intermediate in gingko episperm, to 22 kinds of clinical Common Pathogenic fungies Inhibition effective percentage be 81%；It is 92% that 0.1% hydroginkgoic acid, which inhibits the effective percentage of 25 kinds of clinical Common Pathogenic fungies,.According to report Road, ginkgoic acid have stronger sterilization and inhibiting effect, have suppression for staphylococcus, pyococcus, even for other fungies Production is used, and the wet tinea for treating fungal infection with it has obvious action.Have preferably to impetigo rash, verruca plana caused by virus Curative effect.
Borneol also known as borneolum syntheticum, 55.0% or more borneol content.Nature and flavor are pungent, bitter, slightly cold.Return heart, spleen, lung channel.Have Inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain function.Suitable for pyreticosis coma, faint from fear, apoplexy coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, middle breath stupor, the thoracic obstruction heart Bitterly, hot eyes, aphtha, abscess of throat, purulent ear canal.Borneol is used as transdermal enhancer in a medicament, moreover it is possible to increase cutaneous penetration medicine The transmitance of object.
A kind of itch lotion of the present invention, antibacterial, anti-inflammatory, clearing away heat to and alleviating pain, antipruritic therapeutic efficiency can be played by being applied to affected part.This hair It is bright to be infiltrated using five poisonous weeds and gingko episperm through alcohol, distill acquisition alcohol matter distillate, then dregs of a decoction distilled water is continued again Water quality distillate is distilled to obtain, beneficial extraction can be obtained by solving alcohol-soluble, volatile component and water soluble ingredient, in order to protect The refining effect of distillate is demonstrate,proved, thus, only greatly preferably, the solvent of addition is allowed to the distillation being distilled off to the dosage of solvent Liquid is lucky with formulation dosage, avoids the excessive dose for causing distillate of molten amount insufficient.The present invention utilizes outer kind of five poisonous weeds and ginkgo Peculiar effect of skin, manufactured itch lotion can treat ringworm of the body, tinea pedis, the tinea manuum, eczema etc. can put 3- on the skin daily with affected part is put outside medical fluid on the skin 4 times, it is also possible to which absorbent cotton impregnates medical fluid soak, if being used for treating onychomycosis, sick first can be reamed, and is impregnated and is suffered from suitable itch lotion Place, generally by the dipped sick first of medical fluid, 1-2 times daily, each 20-30min, 10-15 days are 1 course for the treatment of.Pass through clinical application, treatment Onychomycosis 6.It is treated using the above method, wherein 4 medications, one course for the treatment of is cured, 1 treatment, two course for the treatment of recoveries from illness, 1 medication Two courses for the treatment of take a favorable turn；Tinea pedis 10 are treated using itch lotion of the present invention, ringworm of the body 7, scabies 26, is treating a course for the treatment of Recovery from illness, it can be found that there is unique curative effect for general tinea from practice.
Manufacture craft of the present invention is simple, and energy consumption is few, and product has no toxic side effect, and dosage is small, easy to use, and product has fine Application prospect.
Specific embodiment
Embodiment 1
First five poisonous weeds, gingko episperm are picked completely, drying weighs five poisonous weeds 250g, gingko episperm 250g is carried out respectively It crushes, crosses 42 meshes, the ethyl alcohol 250g that concentration is 95%v/v is added in mixing, and fully mixing makes its infiltration uniformly, places closed 15h is infiltrated in container, then by the spice of infiltration, is placed in distiller, and the ethyl alcohol 500g that concentration is 95%v/v is added, places 3h is impregnated, heating distillation collects distillate 500g, obtains distillate A；The dregs of a decoction after distillation are added into distilled water 500g, are stood 1h, heating distillation, collects distillate, obtains distillate B；Distillate A 500g is taken, borneol 10g is added, is stirred to dissolve, is filtered, Distillate 490g is added from filter, makes to be settled to 1000g, is sub-packed in 30ml vial, seals to obtain the final product.

Claims (2)

1. a kind of itch lotion, which is characterized in that it is by following raw materials, five poisonous weeds 250g, gingko episperm 250g, borneol 10g composition, is made by the following method：It takes five poisonous weeds and gingko episperm to be respectively crushed into 42 mesh coarse powder, mixes, concentration, which is added, is The ethyl alcohol 250g of 95%v/v, fully mixing makes its infiltration uniformly, places and infiltrates 15h in closed container, then by the medicine of infiltration Material is placed in distiller, and the ethyl alcohol 500g that concentration is 95%v/v is added, and places dipping 3h, and distillate is collected in heating distillation 500g obtains distillate A；The dregs of a decoction after distillation are added into distilled water 500g, stand 1h, heating distillation is collected distillate, must be steamed Distillate B；Distillate A 500g is taken, borneol 10g is added, is stirred to dissolve, is filtered, distillate 490g is added from filter, it is fixed to make Hold to 1000g to get.
2. a kind of itch lotion a kind of as described in claim 1 is as treatment dermatitis, neurodermatitis, ringworm of the body, tinea of feet and hands, eczema Purposes.
CN201811155088.9A 2018-09-30 2018-09-30 A kind of itch lotion Withdrawn CN108853211A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811155088.9A CN108853211A (en) 2018-09-30 2018-09-30 A kind of itch lotion

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Application Number Priority Date Filing Date Title
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110236264A (en) * 2019-07-04 2019-09-17 邳州市尕星医药技术服务有限公司 A kind of luffa medicinal insole for preventing and treating tinea pedis
CN110301716A (en) * 2019-07-04 2019-10-08 邳州市尕星医药技术服务有限公司 A kind of insole for preventing and treating tinea pedis
CN110301717A (en) * 2019-07-04 2019-10-08 邳州市尕星医药技术服务有限公司 A kind of insole based on prevention and treatment tinea pedis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110236264A (en) * 2019-07-04 2019-09-17 邳州市尕星医药技术服务有限公司 A kind of luffa medicinal insole for preventing and treating tinea pedis
CN110301716A (en) * 2019-07-04 2019-10-08 邳州市尕星医药技术服务有限公司 A kind of insole for preventing and treating tinea pedis
CN110301717A (en) * 2019-07-04 2019-10-08 邳州市尕星医药技术服务有限公司 A kind of insole based on prevention and treatment tinea pedis

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Application publication date: 20181123