CN108853207A - A kind of compound gingkgo exosper pine evaporates oily ointment - Google Patents

A kind of compound gingkgo exosper pine evaporates oily ointment Download PDF

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CN108853207A
CN108853207A CN201811154785.2A CN201811154785A CN108853207A CN 108853207 A CN108853207 A CN 108853207A CN 201811154785 A CN201811154785 A CN 201811154785A CN 108853207 A CN108853207 A CN 108853207A
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pine
evaporates
poisonous weeds
gingko episperm
extract
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张奎昌
张婷婷
张路
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Pizhou Gas Star Pharmaceutical Technology Service Co Ltd
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Pizhou Gas Star Pharmaceutical Technology Service Co Ltd
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Abstract

The invention particularly discloses a kind of compound gingkgo exosper pines to evaporate oily ointment, which is made of following weight proportion raw material：Gingko episperm in oily ointment, five poisonous weeds composite extract 50-150g are evaporated in every kilogram of compound gingkgo exosper pine, pine evaporates oily 50-150g, lanolin 100-300g, and surplus is vaseline.Product has good therapeutic efficiency as treatment eczema, dermatitis, skin tinea such as tinea of feet and hands, ringworm of the body, tinea versicolor, psoriasic purposes, and cure rate is high, and product has good application and popularization value.

Description

A kind of compound gingkgo exosper pine evaporates oily ointment
Technical field
The invention belongs to field of traditional Chinese medicine preparation, it is related to a kind of compound gingkgo exosper pine and evaporates oily ointment.
Background technique
Skin disease is also the common disease for seriously affecting health of people, and traditional Chinese medicine thinks, has some diseases can be in human body It is reflected by skin, many diseases are the external manifestations of viscera disease, i.e., the basic reason that skin occurs is that yin-yang is lost It adjusts, caused by blood dirt stasis blocking, toxin buildup.But some skin diseases are then because fungi, bacterial skin infections etc. cause.In short, skin Disease is skin（Including hair and first）After being influenced by internal and external factor, form, structure and function change, and generate disease Reason process, and various clinical successively performances are generated accordingly.Common skin disease has psoriasis, eczema, dermatitis, nerve skin Inflammation, verruca vulgaris, anaphylaxis erythema, scabies, whelk, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch etc., these skin diseases The often happy life of puzzlement people, annoyings the soul and spirit of people.Accurate perfect treatment can be such that people are full of to life It is living to have deep love for and self-confident.Existing Chinese medicine treats skin disease, and formula has single type or limitation or medicinal material composition compatibility It is unreasonable, or because imperfect to the extraction of its effective component during processing or processing or extraction is unreasonable, not in place, The effect of depth therapy is not achieved to a certain extent, thus treatment is caused to be not thorough easy recurrence.There are also with regard to existing Western medicine or Chinese medicine addition steroids or antibiotics different degrees of in treatment skin disease, there are certain toxic side effect or are easy Antibody is generated, treatment is not achieved there are also some drugs and repairs the purpose of diseased region.Just commonly treated for skin disease at present Effect limitation is undesirable, and cure rate is low, recurrent exerbation, especially some common such as dermatitis, neurodermatitis, acne, scabies, sweat The drug effects such as spot, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch are unobvious, stress and burden can not only be caused to patient, together When return patient increase financial burden.A kind of exact pure Chinese medicinal preparation of effect is developed, it is secondary to avoid the poison of Western medicine in the treatment Effect, is the main object of the present invention.Using with antipruritic, anti-inflammatory, convergence and promote absorption, be usually used in chronic dermatitis, The pine of the treatments such as eczema, seborrhea, psoriasis evaporates oil, and has effects that antibacterial anti-inflammatory, antalgesic-antipruritic, often outer for wet Rash, the gingko episperm that dermatitis, skin tinea act on, and have effects that clearing heat and detoxicating, inducing diuresis to remove edema, it is usually used in band-like blister Rash, eczema, carbuncle and furuncle and pyogenic infections, five poisonous weeds composite extracts of snakebite and bugbite effect are made a kind of compound gingkgo exosper pine and evaporate oil Ointment, through retrieving there is not yet related application and related document report.
Summary of the invention
The purpose of the present invention is using have with antipruritic, anti-inflammatory, convergence and promote absorption, be usually used in chronic dermatitis, The pine of the treatments such as eczema, seborrhea, psoriasis evaporates oil, with antibacterial anti-inflammatory, analgesic, itching-relieving efficacies gingko episperm A kind of compound gingkgo exosper pine is prepared into five poisonous weeds with clearing heat and detoxicating, inducing diuresis to remove edema, function of detoxification and evaporates oily ointment, is had The psoriasis such as tinea manuum, the ringworm of the foot, ringworm of the body, jock itch, piebald caused by targetedly solving because of various bacteriums, fungi, virus, allergy etc. Tinea, favus of the scalp, bubble, psoriasis, scrotum tinea etc., dermatitis such as neurodermatitis, contact dermatitis, seborrhea, solar lentigines skin Inflammation etc., the treatment problem of the crowds such as all kinds of eczemas, pruitus, tinea pedis, skin allergy, bite by mosquitos.
To achieve the goals above, the following technical solutions are specifically adopted by the present invention：
A kind of compound gingkgo exosper pine of the present invention evaporates oily ointment, which is characterized in that it is made of following weight proportion raw material： Gingko episperm in oily ointment, five poisonous weeds composite extract 50-150g are evaporated in every kilogram of compound gingkgo exosper pine, pine evaporates oil 50-150g, lanolin 100-300g, surplus are vaseline, and preparation method is as follows：Vaseline and lanolin are set into appropriate vessel Interior, in heating fusing in water-bath, letting cool to 60 DEG C makes into half flow regime, and pine is added and evaporates oil after mixing evenly, adds ginkgo Exosper, five poisonous weeds extracts are full and uniform to obtain the final product；Wherein the five poisonous weeds composite extract of gingko episperm is by with lower section Method is made：It is matched by the weight ratio of gingko episperm 500g, five poisonous weeds 500g and sesame oil 1000g, takes gingko episperm and five Poisonous weeds, which are added in sesame oil, to be impregnated 1 week, and squeezing, filtering obtain oil liquid 800g, then it is 95%v/v ethyl alcohol that concentration, which is added, in filter residue 2000g impregnates 1 week, and filtering, filtrate is set in water-bath after heating recovery ethyl alcohol to no alcohol taste, is slightly concentrated and obtains extract 200g, Extract is merged with oil liquid, makes full dose to 1000g, it is full and uniform to obtain the final product.
A kind of currently preferred compound gingkgo exosper pine evaporates oily ointment, which is characterized in that it is matched by following weight It is made than raw material：Gingko episperm in oily ointment, five poisonous weeds composite extract 100g are evaporated in every kilogram of compound gingkgo exosper pine, Pine evaporates oily 100g, lanolin 200g, and surplus is vaseline, and preparation method is as follows：Vaseline and lanolin are set into appropriate vessel Interior, in heating fusing in water-bath, letting cool to 60 DEG C makes into half flow regime, and pine is added and evaporates oil after mixing evenly, adds ginkgo Exosper, five poisonous weeds extracts are full and uniform to obtain the final product；Wherein the five poisonous weeds composite extract of gingko episperm is by with lower section Method is made：It is matched by the weight ratio of gingko episperm 500g, five poisonous weeds 500g and sesame oil 1000g, takes gingko episperm and five Poisonous weeds, which are added in sesame oil, to be impregnated 1 week, and squeezing, filtering obtain oil liquid 800g, then it is 95%v/v ethyl alcohol that concentration, which is added, in filter residue 2000g impregnates 1 week, and filtering, filtrate is set in water-bath after heating recovery ethyl alcohol to no alcohol taste, is slightly concentrated and obtains extract 200g, Extract is merged with oil liquid, makes full dose to 1000g, it is full and uniform to obtain the final product.
A kind of compound gingkgo exosper pine of the present invention evaporates oily ointment as treatment eczema, dermatitis, skin tinea such as tinea of feet and hands, body Tinea, tinea versicolor, psoriasic purposes.
Gingko episperm is ginkgo seed（That is ginkgo）Part outside hard shell is commonly called as gingko clothing, the skin of gingko seeds The exosper of boundary between muscles matter, the mesosperm of sclerotin and film quality endotesta, the gingko episperm that the present invention uses is gingko seeds Meat exosper.Scientist is it has been investigated that exosper contains a large amount of hydroginkgoic acid, bilobol and gingko alcohol, also containing silver Apricot yellow element, isoginkgetin and polysaccharide component, there are also micro ginkgolides.Its interaction property and cyclophosphamide and ground plug rice Pine etc. is similar.The polysaccharide of gingko episperm can enhance cellular immune function, the generation to bone-marrow-derived lymphocyte during humoral immunity Effect is formed with antibody.Have document report, the alcohols intermediate in gingko episperm, to 22 kinds of clinical Common Pathogenic fungies Inhibition effective percentage be 81%；It is 92% that 0.1% hydroginkgoic acid, which inhibits the effective percentage of 25 kinds of clinical Common Pathogenic fungies,.According to report Road, ginkgoic acid have stronger sterilization and inhibiting effect, have suppression for staphylococcus, pyococcus, even for other fungies Production is used, and the wet tinea for treating fungal infection with it has obvious action.Have preferably to impetigo rash, verruca plana caused by virus Curative effect.
Five poisonous weeds, scientific name are the aerial part herb of polygonaceae plant polygonum perfoliatum Pulygunum perfoliatum L., again Name passes through leaf knotweed.Nature and flavor are sour, bitter, flat, slightly cold.Return lung, bladder meridian.With clearing heat and detoxicating, inducing diuresis for removing edema, cough-relieving function, for swallowing Larynx swelling and pain, cough with lung heat, children's pertussis, edema and little urine, damp-heat dysentery, eczema, furuncle, snakebite and bugbite.Mere formality offers introduction：Herb Glycosides containing indigo, flavonoids, anthra-glucoside, phenols, amino acid, organic acid, tannin and carbohydrate etc..Organic acid has caffeic acid, ferulic acid etc.；It is yellow Ketone has persicarin, Kaempferol, Quercetin, avicularin, rutin etc..Pharmacological action：1. bacteriostasis：Polygonum perfoliatum aqueous extract pair The common clinical pathogenic microorganisms such as staphylococcus aureus, Pasteurella, streptococcus, detection of Salmonella, escherichia coli have relatively strong Antibacterial action.2. antitussive effect：Polygonum perfoliatum draws cough experiment in apparent antitussive effect to mouse ammonium hydroxide.3. anti-inflammatory effect： Polygonum perfoliatum total extract position has significant anti-inflammatory activity.There are also suitable amount used externally, fresh goods mashes deposited or dry product and decocts washing affected part Record（Wang Guoqiang,《National Chinese herbal medicine compilation（Volume one）》, People's Health Publisher, 2 months 2014, the 3rd edition, page 217）.This Five poisonous weeds used are invented as the drying herb of aerial part.
It is partly sterilised's antiseptic that pine, which evaporates oil,.With Pinaceae（Pinaceae）Pinus（Pinus）The wood of plant pine tree or needle juniper Material obtains that pitch shape liquid contains turpentine oil, wood slips a variety of chemical combination such as oil, phenol, dimethylbenzene, acetic acid, naphthalene, guaiacol through destructive distillation Object has dissolution cutin, analgesic, anti-inflammatory, convergence and promotes the effects of absorbing.For chronic dermatitis, eczema, seborrhea, ox Psoriasis etc..
Beneficial effects of the present invention
The present invention has antipruritic, anti-inflammatory, Thyme Extract using well known, be usually used in treating dermatitis, eczema, seborrhea, Psoriasic pine evaporate oil with have antibacterial anti-inflammatory, antalgesic-antipruritic effect, and be usually used in treatment eczema, dermatitis, skin tinea silver Apricot exosper and have effects that clearing heat and detoxicating, detumescence five poisonous weeds composite extracts are made a kind of compound gingkgo exosper pine and evaporate Oily ointment, clearing heat and detoxicating, antimicrobial antiphlogistic, antalgesic-antipruritic, convergent therapeutic efficiency can be played by being applied to affected part, and the present invention uses will be silver-colored Apricot exosper and five poisonous weeds are first through oil immersion, then with alcohol steep, it is therefore an objective to its fat-soluble effective component is sufficiently extracted, Its oil immersion process does not heat so that its effective component avoids losing, preferably to play its therapeutic effect, so that enhancing pine Evaporate the therapeutic effect of oil.Oily ointment is evaporated through treatment eczema case 18 using a kind of compound gingkgo exosper pine of the present invention, is used Daily coating is secondary, 7 days as one therapeutic course, and as a result a course for the treatment of cures 12, and two courses for the treatment of healings 5 are effective 1, efficient 100%, without discovery adverse reactions people in treatment patient, it is sufficient to illustrate that compound gingkgo exosper pine of the present invention evaporates oily ointment pair There is good effect in the treatment of eczema.Product of the present invention preparation process is simple, cheap, has and promotes and applies well Value.
Specific embodiment
Embodiment 1
Compound gingkgo exosper pine evaporates the preparation of oily ointment
（1）Gingko episperm, the preparation of five poisonous weeds compound collectings：Take gingko episperm 500g, five poisonous weeds 500g that sesame oil 1000g is added Middle to impregnate 1 week, squeeze and filter obtains oil liquid 800g, then the ethyl alcohol 2000g that concentration is 95%v/v is added in filter residue, impregnates 1 week, Filtering, filtrate are set in water-bath after heating recovery ethyl alcohol to no alcohol taste, are slightly concentrated and are obtained extract 200g, by extract and oil liquid Merge, make full dose to 1000g, it is full and uniform to obtain the final product；（2）Preparation：Vaseline 800g and lanolin 100g is taken to be placed in enamel cylinder, In heating fusing in water-bath, letting cool to 60 DEG C makes into half flow regime, and pine is added and evaporates oily 50g after mixing evenly, adds ginkgo Exosper, five poisonous weeds composite extract 50g are stirred to obtain the final product.
Embodiment 2
Compound gingkgo exosper pine evaporates the preparation of oily ointment
（1）Gingko episperm, the preparation of five poisonous weeds compound collectings：Take gingko episperm 500g, five poisonous weeds 500g that sesame oil 1000g is added Middle to impregnate 1 week, squeeze and filter obtains oil liquid 800g, then the ethyl alcohol 2000g that concentration is 95%v/v is added in filter residue, impregnates 1 week, Filtering, filtrate are set in water-bath after heating recovery ethyl alcohol to no alcohol taste, are slightly concentrated and are obtained extract 200g, by extract and oil liquid Merge, make full dose to 1000g, it is full and uniform to obtain the final product；（2）Preparation：Vaseline 400g and lanolin 300g is taken to be placed in enamel cylinder, In heating fusing in water-bath, letting cool to 60 DEG C makes into half flow regime, and pine is added and evaporates oily 150g after mixing evenly, adds ginkgo Exosper, five poisonous weeds composite extract 150g are stirred to obtain the final product.
Embodiment 3
Compound gingkgo exosper pine evaporates the preparation of oily ointment
（1）Gingko episperm, the preparation of five poisonous weeds compound collectings：Take gingko episperm 500g, five poisonous weeds 500g that sesame oil 1000g is added Middle to impregnate 1 week, squeeze and filter obtains oil liquid 800g, then the ethyl alcohol 2000g that concentration is 95%v/v is added in filter residue, impregnates 1 week, Filtering, filtrate are set in water-bath after heating recovery ethyl alcohol to no alcohol taste, are slightly concentrated and are obtained extract 200g, by extract and oil liquid Merge, make full dose to 1000g, it is full and uniform to obtain the final product；（2）Preparation：Vaseline 600g and lanolin 200g is taken to be placed in enamel cylinder, In heating fusing in water-bath, letting cool to 60 DEG C makes into half flow regime, and pine is added and evaporates oily 100g after mixing evenly, adds ginkgo Exosper, five poisonous weeds composite extract 100g are stirred to obtain the final product.
Embodiment 4
Compound gingkgo exosper, the compound pine of five poisonous weeds evaporate the preparation of oily ointment
（1）Gingko episperm extracts preparation：It takes gingko episperm 500g, five poisonous weeds 500g to be added in sesame oil 1000g to impregnate 1 week, Squeeze and filter obtains oil liquid 800g, then the ethyl alcohol 2000g that concentration is 95%v/v is added in filter residue, impregnates 1 week, filtering, filtrate is set In water-bath after heating recovery ethyl alcohol to no alcohol taste, slightly it is concentrated and obtains extract 200g, extract is merged with oil liquid, makes full dose To 1000g, it is full and uniform to obtain the final product；（2）Preparation：Take vaseline 680g and lanolin 150g be placed in enamel cylinder, in water-bath plus Heat fusing, letting cool to 60 DEG C makes into half flow regime, and pine is added and evaporates oily 70g after mixing evenly, adds gingko episperm, the five poisonous creatures: scorpion, viper, centipede, house lizard, toad Careless composite extract 100g is stirred to obtain the final product.

Claims (3)

1. a kind of compound gingkgo exosper pine evaporates oily ointment, which is characterized in that it is made of following weight proportion raw material：Every Kilogram compound gingkgo exosper pine evaporates gingko episperm in oily ointment, five poisonous weeds composite extract 50-150g, and pine evaporates oily 50- 150g, lanolin 100-300g, surplus are vaseline, and preparation method is as follows：Vaseline and lanolin are set in appropriate vessel, In heating fusing in water-bath, letting cool to 60 DEG C makes into half flow regime, and pine is added and evaporates oil after mixing evenly, adds outer kind of ginkgo Skin, five poisonous weeds extracts are full and uniform to obtain the final product；Wherein the five poisonous weeds composite extract of gingko episperm is by following methods system ?：It is matched by the weight ratio of gingko episperm 500g, five poisonous weeds 500g and sesame oil 1000g, takes gingko episperm and five poisonous weeds It is added in sesame oil and impregnates 1 week, squeezing, filtering obtain oil liquid 800g, then concentration is added as 95%v/v ethyl alcohol 2000g leaching in filter residue Bubble 1 week, filtering, filtrate are set in water-bath after heating recovery ethyl alcohol to no alcohol taste, are slightly concentrated and are obtained extract 200g, by extract Merge with oil liquid, make full dose to 1000g, it is full and uniform to obtain the final product.
2. a kind of compound gingkgo exosper pine evaporates oily ointment, which is characterized in that it is made of following weight proportion raw material：Every Kilogram compound gingkgo exosper pine evaporates gingko episperm in oily ointment, five poisonous weeds composite extract 100g, and pine evaporates oily 100g, wool Rouge 200g, surplus are vaseline, and preparation method is as follows：Vaseline and lanolin are set in appropriate vessel, in being heated in water-bath Fusing, letting cool to 60 DEG C makes into half flow regime, and pine is added and evaporates oil after mixing evenly, adds gingko episperm, five poisonous weeds mention Take object full and uniform to obtain the final product；Wherein the five poisonous weeds composite extract of gingko episperm is made by following methods：Outside by ginkgo The weight ratio of kind skin 500g, five poisonous weeds 500g and sesame oil 1000g match, and take gingko episperm and five poisonous weeds to be added in sesame oil and soak Bubble 1 week, squeezing, filtering obtain oil liquid 800g, then it is that 95%v/v ethyl alcohol 2000g impregnates 1 week that concentration, which is added, in filter residue, is filtered, filter Liquid is set in water-bath after heating recovery ethyl alcohol to no alcohol taste, is slightly concentrated and is obtained extract 200g, extract is merged with oil liquid, is made Full dose to 1000g, it is full and uniform to obtain the final product.
3. a kind of as compound gingkgo exosper pine claimed in claims 1-2 evaporates oily ointment as treatment eczema, dermatitis, skin tinea Such as tinea of feet and hands, ringworm of the body, tinea versicolor, psoriasic purposes.
CN201811154785.2A 2018-09-30 2018-09-30 A kind of compound gingkgo exosper pine evaporates oily ointment Withdrawn CN108853207A (en)

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