CN108992527A - A kind of preparation method for treating skin disease external application plastics - Google Patents
A kind of preparation method for treating skin disease external application plastics Download PDFInfo
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- CN108992527A CN108992527A CN201811156543.7A CN201811156543A CN108992527A CN 108992527 A CN108992527 A CN 108992527A CN 201811156543 A CN201811156543 A CN 201811156543A CN 108992527 A CN108992527 A CN 108992527A
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- skin disease
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- 229920003023 plastic Polymers 0.000 title claims abstract description 29
- 239000004033 plastic Substances 0.000 title claims abstract description 29
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- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
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- 208000002474 Tinea Diseases 0.000 claims abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
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Abstract
The invention particularly discloses a kind of preparation methods for treating skin disease external application plastics.This method is to take vinyl alcohol 15g, dimethyl sulfoxide 50g, distilled water 100g by Chinese medical extract 200g, glycerol 100g, and concentration is made of 75%v/v alcohol 535g.This method prepares the plastics of the treatment such as dermatitis, neurodermatitis, acne, scabies, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch caused by one kind is targetedly solved the problems, such as because of various bacteriums, fungi etc..Plastics of the present invention are pure Chinese medicine preparation, it is small to maintain natural drug toxicity, eutherapeutic feature, curative effect is clear, since the present invention is that the extract component of drug is made to a kind of external application painting plastics, preparation method is simple, without material of mounting, and it is easy to use, plastics are applied to affected part, there is certain resistance to fracture in the film that affected part is formed, plastics are applied to affected part, after forming film by the mobility that can reduce drug, it discharges drug gradually and plays therapeutic effect, absorb contained drug equilibrium and generate curative effect.
Description
Technical field
The invention belongs to field of traditional Chinese medicine preparations, and in particular to a kind of preparation method for treating skin disease external application plastics.
Background technique
Traditional Chinese medicine thinks have some diseases that can reflect by skin in human body, and many diseases are viscera diseases
The basic reason that external manifestation, i.e. skin occur is imbalance of yin and yang, caused by blood dirt stasis blocking, toxin buildup.But some skin diseases
It is then because fungi, bacterial skin infections etc. cause.In short, skin disease is shadow of the skin (including hair and first) by internal and external factor
After sound, form, structure and function change, and generate pathologic process, and generate various clinical successively performances accordingly.Skin
Skin disease is also the common disease for seriously affecting health of people, common skin disease have psoriasis, eczema, dermatitis, neurodermatitis,
Verruca vulgaris, anaphylaxis erythema, scabies, whelk, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch etc., these skin diseases are frequent
The happy life for perplexing people, annoyings the soul and spirit of people.Accurate perfect treatment can be such that people are full of to life
Have deep love for and self-confident.Existing Chinese medicine treats skin disease, and formula has single type or limitation or medicinal material composition compatibility not to conform to
Reason, or because imperfect to the extraction of its effective component during processing or processing or extraction is unreasonable, not in place, certain
The effect of depth therapy is not achieved in degree, thus treatment is caused to be not thorough easy recurrence.There are also with regard to existing Western medicine or Chinese medicine
Different degrees of addition steroids or antibiotics, there are certain toxic side effect or are easy to produce in treatment skin disease
Antibody is not achieved treatment there are also some drugs and repairs the purpose of diseased region.Just at present for common aqua of skin disease etc.
Curative effect limitation is undesirable, and cure rate is low, recurrent exerbation, especially it is some it is common as dermatitis, neurodermatitis, acne, scabies,
The drug effects such as sweat stain, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch are unobvious, can not only cause stress and burden to patient,
Patient is returned simultaneously increases financial burden.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of preparation sides for treating skin disease external application plastics
Method prepares dermatitis, neurodermatitis, acne, scabies, hand caused by one kind is targetedly solved because of various bacteriums, fungi etc.
The plastics of the treatment problem of tinea pedis, onychomycosis, tinea versicolor, ringworm of the body, jock itch etc..
To achieve the goals above, the following technical solutions are specifically adopted by the present invention:
A kind of preparation method for treating skin disease external application plastics, which is characterized in that it is by Chinese medical extract 200g, glycerol
100g takes vinyl alcohol 15g, dimethyl sulfoxide 50g, distilled water 100g, and concentration is made of 75%v/v alcohol 535g, and specific steps are such as
Under: it takes polyvinyl alcohol to be added in distilled water, is dipped to expansion, set after being dissolved by heating in water-bath, it is sub- to add glycerol, dimethyl
Sulfone is uniformly mixed, obtains mixed solution, mixed solution is merged with Chinese medical extract, then ethyl alcohol is slowly added into amalgamation liquid, together
When stir, dispense to obtain the final product；The Chinese medical extract is made by following methods: being taken rhamnus crenata sieb.et zucc 100g, is cut grass
50g, semen momordicae root skin 50g, gingko episperm 100g, ginkgo root skin 50g, frutus cnidii 30g, Chinese gall 30g, Chinese prickly ash 20g, point
Not by rhamnus crenata sieb.et zucc, cut grass, semen momordicae root skin, gingko episperm, ginkgo root skin, Chinese prickly ash are ground into 40 mesh powder, by frutus cnidii,
Chinese gall smashs into powder to pieces, is then uniformly mixed each medicinal material powder, is placed in percolator, and it is 30%g/g vinegar that 5 times of amount weight ratios, which are added,
Acid solution, after impregnating 50h, with 1mlmin-1Speed collect and just filter liquid 150g, continuous liquid of filtering is concentrated into 50g and merges with first liquid of filtering,
Filtering, obtains 200g Chinese medical extract, spare.
Made from the method for the present invention it is a kind of treat skin disease external application plastics as treatment dermatitis, neurodermatitis, acne,
Scabies, sweat stain, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, the purposes of jock itch.
Rhamnus crenata sieb.et zucc is Rhamnaceae Taxa of Rhamnus rhamnus crenata sieb.et zucc Rhamnus crenatus Sieb. et Zucc., with
Root is used as medicine.Its root chrysarobin containing anthraquinone analog compound (chrysarobin, C15H12O3), Chrysophanol (chrysophanol,
C15H10O4) etc..It is bitter in taste, pungent, it puts down.With clearing heat and promoting diuresis, the antipruritic function of desinsection.Scabies, stubborn dermatitis, eczema, impetigo are controlled in external application.
Grass is cut, is Chloranthaceae vegetable silk fringe tree Chloranthus fortunei(A.Gray) Solms-Lamb.
Herb or root.Nature and flavor are pungent, bitter, mild-natured.With expelling wind and activating blood flow, the efficacy of removing toxicity for detumescence energy.For rheumatic arthralgia, traumatic injury,
Boil tinea scabies, venomous snake bite.It is to cut careless herb that the present invention, which uses,.
Semen momordicae root is Curcurbitaceae balsam pear platymiscium semen momordicae Momrolica cochinchinensis (Lour.)
Spreng. root.With mass dissipating and swelling eliminating, attacks poison and treat sore function, be suitable for sore swollen toxin, acute mastitis, anal fistula, chronic eczema, the favus of the scalp.This hair
Bright use is its root skin.
Gingko episperm is the part outside ginkgo seed (i.e. ginkgo) hard shell, is commonly called as gingko clothing, the skin of gingko seeds
The exosper of boundary between muscles matter, the mesosperm of sclerotin and film quality endotesta, the gingko episperm that the present invention uses is gingko seeds
Meat exosper.Scientist is it has been investigated that exosper contains a large amount of hydroginkgoic acid, bilobol and gingko alcohol, also containing silver
Apricot yellow element, isoginkgetin and polysaccharide component, there are also micro ginkgolides.Its interaction property and cyclophosphamide and ground plug rice
Pine etc. is similar.The polysaccharide of gingko episperm can enhance cellular immune function, the generation to bone-marrow-derived lymphocyte during humoral immunity
Effect is formed with antibody.Have document report, the alcohols intermediate in gingko episperm, to 22 kinds of clinical Common Pathogenic fungies
Inhibition effective percentage be 81%；It is 92% that 0.1% hydroginkgoic acid, which inhibits the effective percentage of 25 kinds of clinical Common Pathogenic fungies,.According to report
Road, ginkgoic acid have stronger sterilization and inhibiting effect, have suppression for staphylococcus, pyococcus, even for other fungies
Production is used, and the wet tinea for treating fungal infection with it has obvious action.Have preferably to impetigo rash, verruca plana caused by virus
Curative effect.
Ginkgo root skin, according to the literature: ginkgo root skin also containing ginkgo, ginkgo leaf, gingko episperm it is identical at
Point.Ginkgo root skin, which also contains Bilobalide A, B, C, M(" national Chinese herbal medicine compilation ", writes group, and national Chinese medicine collects, the first volume,
1975, September, the 1st edition, page 801).
Frutus cnidii is the dry mature fruit of Umbelliferae cnidium monnieri platymiscium cnidium monnieri Cnidium monnieri Cuss..Property
Acrid flavour, hardship, temperature.With eliminating dampness wind-dispelling, desinsection is antipruritic, warming kidney and enhancing body function, is suitable for pruritus vulvae leukorrhagia, eczema itch, arthritis with fixed pain caused by dampness waist
Bitterly, impotence due to deficiency of the kidney, uterus cold infertile.
Chinese gall, scientific name Rhus chinensis Mill. post for the horned gall aphid or melaphis peitan Tsai et Tang female adult of Homoptera aphid section
It is born in Anacardiaceae plant " Chinese sumac " and its belongs to the tender leaf or petiole of other plant, stab and generate a kind of cryptomere consor object worm
Goitre, gained after baked drying.Its is cold in nature for Chinese gall, sour, puckery, has astringing lung-QI fall fire, relieving diarrhea with astringents, arrest sweating hemostasis, hygroscopic
Sore and other effects.For deficiency syndrome of the lung cough-relieving, hematochezia hemorrhoid blood, carbuncle sore tumefacting virus, the diseases such as skin moisture fester.
Chinese prickly ash is Rutaceae xanthoxylum pericarpium zanthoxyli schinifolii Zanthoxylum schinifolium Sieb. et Zucc.
And the dry mature skin of Chinese prickly ash Zanthoxylum bungeanum Maxim..Nature and flavor are acrid in flavour and warm in nature.With warm in pain, desinsection
Antipruritic function.Suitable for coldness and pain in the epigastrium, vomiting, diarrhea, abdominal pain due to enterositosis；It is used for eczema, pruritus vulvae outside.
Viscous liquid of the dimethyl sulfoxide (DMSO) for no color or smell clear oil, mildly bitter flavor, specific gravity 1.009-1.1014,
18.45 DEG C of fusing point, 189-192 DEG C of boiling point.It can arbitrarily be mixed with water, ethyl alcohol, acetone etc..This product is highly polar solvent, dissolves model
It encloses very extensively, to water-soluble, fat-soluble and many drugs for being insoluble in water, glycerol, ethyl alcohol, propylene glycol, fat oil, many inorganic salts
Also it can be dissolved in wherein, therefore have the title of " Dimethyl Sulfoxide ".The application of dimethyl sulfoxide in the present invention, then to organic in its medicinal material
Ingredient has very big solubilizing effect.
Beneficial effects of the present invention
Plastics made from a kind of preparation method for treating skin disease external application plastics of the present invention, used time are applied to affected part, and solvent is waved
Film is formed after hair so that lesion face must be protected, while gradually release contained drug plays the role for the treatment of.
The present invention is a kind of to treat skin disease external application plastics to kill based on various bacteriums and fungi, and takes into account desinsection, only
Itch, have significant curative effect to dermatitis, neurodermatitis, acne, scabies, sweat stain, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, jock itch etc.,
Preparation cost is low, can mitigate the financial burden of patient.The present invention treats dermopathic plastics as pure Chinese medicine preparation, maintains
Natural drug toxicity is small, and eutherapeutic feature, curative effect is clear, since the present invention is that the extract component of drug is made outside one kind
With plastics are applied, preparation method is simple, without material of mounting, and it is easy to use, plastics are applied to affected part, are coated with to plastics
After drying, there is certain resistance to fracture in the film that affected part is formed, the mobility of drug can be reduced, plastics are applied to affected part,
It after forming film, discharges drug gradually and plays therapeutic effect, contained drug equilibrium can be made to absorb and generate curative effect.It is answered from clinic
With seeing that plastics of the present invention are easy to use, dosage is small, and has preferable clinical therapeutic efficacy, and easy to use, Huan Zhepu
All over gladly receiving, drug price is lower, can show the dermopathic plastics of present invention treatment and have a good application prospect.
Specific embodiment
Embodiment 1
The preparation for treating skin disease external application plastics:
Polyvinyl alcohol 15g is weighed, is added in distilled water 100g and is dipped to expansion, sets after being dissolved by heating in water-bath, adds glycerol
100g, dimethyl sulfoxide 50g are uniformly mixed, obtain 265g mixed solution, and 265g mixed solution and 200g Chinese medical extract are closed
And then by content concn be 75%v/v ethyl alcohol 535g be slowly added into amalgamation liquid, stir evenly simultaneously, obtain 1000g external application film
Agent, is sub-packed in 30ml vial, and spiral cover seals to obtain the final product；Wherein Chinese medical extract is made by following methods: taking rhamnus crenata sieb.et zucc
100g cuts careless 50g, semen momordicae root skin 50g, gingko episperm 100g, ginkgo root skin 50g, frutus cnidii 30g, Chinese gall 30g,
Chinese prickly ash 20g, respectively by rhamnus crenata sieb.et zucc, cut grass, semen momordicae root skin, gingko episperm, ginkgo root skin, Chinese prickly ash are ground into 40 mesh
Powder smashs into frutus cnidii, Chinese gall to pieces powder, is then uniformly mixed each medicinal material powder, is placed in percolator, 5 times of amount weight are added
Than for 30% acetate solution, after impregnating 50h, with 1mlmin-1Speed collect and just filter liquid 150g, continuing to collect continuous filter liquid and will continue
Liquid of filtering is concentrated into 50g and merges with liquid of just filtering, and filters, obtains 200g Chinese medical extract.
Clinical efficacy:
Affected part is applied using skin disease external application plastics of the present invention, treats neurodermatitis patient 6, wherein male 5, women
1, the age at 28-48 years old, takes local application 3 times a day, and 1 week as a treatment course, as a result cures through 2 courses for the treatment of for 5,1 is controlled
It treats 18 days and fully recovers, follow-up half a year, no case was recurrence.
Using skin disease external application plastics of the present invention, tinea pedis 4 are treated, patient is male, the age 22-28 years old, is used
3 times a day, 1 patient treats 5 days and cures for local application, and 3 are cured for treatment 7 days.
Claims (3)
1. a kind of preparation method for treating skin disease external application plastics, which is characterized in that it is by Chinese medical extract 200g, glycerol
100g takes vinyl alcohol 15g, dimethyl sulfoxide 50g, distilled water 100g, and concentration is made of 75%v/v alcohol 535g, and specific steps are such as
Under: it takes polyvinyl alcohol to be added in distilled water, is dipped to expansion, set after being dissolved by heating in water-bath, it is sub- to add glycerol, dimethyl
Sulfone is uniformly mixed, obtains mixed solution, mixed solution is merged with Chinese medical extract, then ethyl alcohol is slowly added into amalgamation liquid, together
When stir, dispense to obtain the final product；The Chinese medical extract is made by following methods: being taken rhamnus crenata sieb.et zucc 100g, is cut grass
50g, semen momordicae root skin 50g, gingko episperm 100g, ginkgo root skin 50g, frutus cnidii 30g, Chinese gall 30g, Chinese prickly ash 20g, point
Not by rhamnus crenata sieb.et zucc, cut grass, semen momordicae root skin, gingko episperm, ginkgo root skin, Chinese prickly ash are ground into 40 mesh powder, by frutus cnidii,
Chinese gall smashs into powder to pieces, is then uniformly mixed each medicinal material powder, is placed in percolator, and it is 30%g/g vinegar that 5 times of amount weight ratios, which are added,
Acid solution, after impregnating 50h, with 1mlmin-1Speed collect and just filter liquid 150g, continuous liquid of filtering is concentrated into 50g and merges with first liquid of filtering,
Filtering, obtains 200g Chinese medical extract.
2. according to claim 1 treatment skin disease external application plastics as treatment dermatitis, neurodermatitis, acne, scabies,
Sweat stain, tinea of feet and hands, onychomycosis, tinea versicolor, ringworm of the body, the purposes of jock itch.
3. obtained according to the method for claim 1 treat skin disease external application plastics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811156543.7A CN108992527A (en) | 2018-09-30 | 2018-09-30 | A kind of preparation method for treating skin disease external application plastics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811156543.7A CN108992527A (en) | 2018-09-30 | 2018-09-30 | A kind of preparation method for treating skin disease external application plastics |
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| Publication Number | Publication Date |
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| CN108992527A true CN108992527A (en) | 2018-12-14 |
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ID=64590440
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811156543.7A Withdrawn CN108992527A (en) | 2018-09-30 | 2018-09-30 | A kind of preparation method for treating skin disease external application plastics |
Country Status (1)
| Country | Link |
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| CN (1) | CN108992527A (en) |
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2018
- 2018-09-30 CN CN201811156543.7A patent/CN108992527A/en not_active Withdrawn
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Application publication date: 20181214 |