CN108815457A - 一种改善甲状腺癌患者术后月经过少的中药 - Google Patents
一种改善甲状腺癌患者术后月经过少的中药 Download PDFInfo
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Abstract
本发明涉及改善甲状腺癌患者术后月经过少的中药，可有效改善甲状腺癌术后多种临床症状，加速术后康复，提高患者生活质量的问题，该中药由：人参10‑20g、山药15‑25g、黄芪10‑20g、茯苓10‑20g、白术10‑20g、阿胶10‑25g、川芎10‑20g、当归10‑20g、白芍10‑20g、熟地黄10‑25g、杜仲10‑20g、枸杞子10‑20g、女贞子25‑30g、石斛15‑25g、麦冬25‑30g、墨旱莲25‑30g、桑葚25‑30g、益母草25‑30g、牛膝10‑20g、砂仁5‑15g和柴胡5‑15g制成，将上述中药加水煎煮，过滤，滤液浓缩至200‑300ml，本发明具有健脾益气，养血调经之功效，能够有效改善甲状腺癌患者术后月经过少等诸多临床症状，用药安全，加速患者术后康复，提高患者生活质量，防止和延缓甲状腺癌的复发和转移。
Description
技术领域
本发明涉及医药，特别是一种改善甲状腺癌患者术后月经过少的中药。
背景技术
甲状腺癌是头颈部较常见的恶性肿瘤，占全身恶性肿瘤的l%～2%，以女性多见，可见于任何年龄段。目前甲状腺癌的发病率呈逐年显著上升的趋势。甲状腺癌分为乳头状腺癌、滤泡状癌、未分化癌、髓样癌等多种类型。其中乳头状癌临床最常见，占甲状腺癌的50％～70%。甲状腺癌的治疗方法有手术治疗、放射治疗、化学治疗、内分泌治疗及中医药治疗等。目前“手术+131I治疗+甲状腺激素抑制”被公认为是乳头状癌的最佳综合治疗方案，可降低复发或转移的发生率。但由于乳头状癌属于低度恶性肿瘤，患者常常会忽略术后的康复治疗，手术只能切除可见的癌瘤，但并不能消除癌瘤对人体所造成的损坏，加之131I治疗的副作用，女性患者会在术后出现不同程度的经量减少，周期缩短，色淡，质稀如水，短暂性闭经，绝经年龄的轻度提前等不良反应。下丘脑-垂体-卵巢轴的生理调控下子宫内膜周期性剥脱性出血行成正常的月经周期，当上述轴上的任一组织或子宫本身发生病变或所分泌的激素发生变化时即可出现月经紊乱。其中甲状腺功能异常是导致上述异常的一个常见病因，且卵巢组织对射线较敏感，超过一定量的射线即可引起患者卵巢结构及功能的改变，且与卵巢接受的照射剂量有直接关系。故减少患者月经紊乱的不良反应，提高患者的生活质量，已成为不可回避和亟待解决的问题。目前越来越多的证据表明，中医药治疗可以改善手术本身带来的不良反应，提高免疫力，加速患者术后康复，减轻口服甲状腺素片的不良反应，减轻化疗副反应，抑制甲状腺球蛋白，降低血清甲状腺球蛋白水平，防止和延缓甲状腺癌的复发和转移等，特别对女性患者术后月经过少有独特的疗效。该症状多在甲状腺癌患者术后或放射性碘清甲治疗后逐渐出现，临床表现多为月经量少，或点滴即静，色淡无块，无痛经，质稀薄，皮肤干燥，视力下降，或伴头晕眼花或耳鸣，心悸怔仲，小腹空坠或冷痛，面色萎黄，情绪低落，腰膝酸软，或夜尿增多，舌淡红，脉细或脉沉等，病机多属气阴亏虚。其治疗现虽有多种药物，但由于种种原因，其使用并不尽人意，因此，药物上的改进与创新势在必行。
发明内容
针对上述情况，为解决现有技术之缺陷，本发明之目的就是提供一种改善甲状腺癌患者术后月经过少的中药，可有效改善甲状腺癌术后多种临床症状，加速术后康复，提高患者生活质量的问题。
本发明解决的技术方案是，该中药由重量计的：人参10-20g、山药15-25g、黄芪10-20g、茯苓10-20g、白术10-20g、阿胶10-25g、川芎10-20g、当归10-20g、白芍10-20g、熟地黄10-25g、杜仲10-20g、枸杞子10-20g、女贞子25-30g、石斛15-25g、麦冬25-30g、墨旱莲25-30g、桑葚25-30g、益母草25-30g、牛膝10-20g、砂仁5-15g和柴胡5-15g制成，其中，将上述中药混合在一起，加中药重量6-8倍的水浸泡30分钟，武火煎沸，改用文火煎煮30分钟，过滤，得第一次滤液，滤渣加中药重量6-8倍的水，武火煎沸，改用文火煎煮30分钟，过滤，得第二次滤液，将两次滤液混合浓缩至200-300ml，即得。
本发明纯中药配制，具有健脾益气，养血调经之功效，能够有效改善甲状腺癌患者术后月经过少等诸多临床症状，用药安全，加速患者术后康复，提高患者生活质量，防止和延缓甲状腺癌的复发和转移，是甲状腺癌术后康复治疗药物上的创新。
具体实施方式
以下结合实施例对本发明的具体实施方式作进一步详细说明。
本发明在具体实施中可由以下实施例给出。
实施例1
本发明一种改善甲状腺癌患者术后月经过少的中药，该中药由重量计的：人参13-17g、山药18-22g、黄芪13-17g、茯苓13-17g、白术13-17g、阿胶15-20g、川芎13-17g、当归13-17g、白芍13-17g、熟地黄15-20g、杜仲13-17g、枸杞子13-17g、女贞子26-28g、石斛18-22g、麦冬26-28g、墨旱莲26-28g、桑葚26-28g、益母草26-28g、牛膝13-17g、砂仁8-12g和柴胡8-12g制成，其中，将上述中药混合在一起，加中药重量6-8倍的水浸泡30分钟，武火煎沸，改用文火煎煮30分钟，过滤，得第一次滤液，滤渣加中药重量6-8倍的水，武火煎沸，改用文火煎煮30分钟，过滤，得第二次滤液，将两次滤液混合浓缩至200-300ml。
实施例2
本发明一种改善甲状腺癌患者术后月经过少的中药，该中药由重量计的：人参10g、山药15g、黄芪10g、茯苓10g、白术10g、阿胶10g、川芎10g、当归10g、白芍10g、熟地黄10g、杜仲10g、枸杞子10g、女贞子25g、石斛15g、麦冬25g、墨旱莲25g、桑葚25g、益母草25g、牛膝10g、砂仁5g和柴胡5g制成，其中，将上述中药混合在一起，加中药重量8倍的水浸泡30分钟，武火煎沸，改用文火煎煮30分钟，过滤，得第一次滤液，滤渣加中药重量6倍的水，武火煎沸，改用文火煎煮30分钟，过滤，得第二次滤液，将两次滤液混合浓缩至200ml。
实施例3
本发明一种改善甲状腺癌患者术后月经过少的中药，该中药由重量计的：人参15g、山药20g、黄芪15g、茯苓15g、白术15g、阿胶17g、川芎15g、当归15g、白芍15g、熟地黄17g、杜仲15g、枸杞子15g、女贞子28g、石斛20g、麦冬28g、墨旱莲28g、桑葚28g、益母草28g、牛膝15g、砂仁10g和柴胡9g制成，其中，将上述中药混合在一起，加中药重量7倍的水浸泡30分钟，武火煎沸，改用文火煎煮30分钟，过滤，得第一次滤液，滤渣加中药重量7倍的水，武火煎沸，改用文火煎煮30分钟，过滤，得第二次滤液，将两次滤液混合浓缩至250ml。
实施例4
本发明一种改善甲状腺癌患者术后月经过少的中药，该中药由重量计的：人参20g、山药25g、黄芪20g、茯苓20g、白术20g、阿胶25g、川芎20g、当归20g、白芍20g、熟地黄25g、杜仲20g、枸杞子20g、女贞子30g、石斛25g、麦冬30g、墨旱莲30g、桑葚30g、益母草30g、牛膝20g、砂仁15g和柴胡15g制成，其中，将上述中药混合在一起，加中药重量8倍的水浸泡30分钟，武火煎沸，改用文火煎煮30分钟，过滤，得第一次滤液，滤渣加中药重量8倍的水，武火煎沸，改用文火煎煮30分钟，过滤，得第二次滤液，将两次滤液混合浓缩至300ml。
在上述组分中，其中：
人参：大补元气，补脾益肺，生津，安神益智。用于元气虚脱证，肺脾心肾气虚证，热病气虚津伤口渴及消渴证，与解表药、攻下药等祛邪药配伍，用于气虚外感或里实热结而邪实正虚之证。
山药：补脾养胃，生津益肺，补肾涩精。用于脾虚证，肺虚证，肾虚证，消渴气阴两虚证。
黄芪：健脾补中，升阳举陷，益卫固表，利尿，托毒生肌。用于脾气虚证，肺气虚证，气虚自汗证，气血亏虚，疮疡难溃难腐，或溃久难敛，痹证、中风后遗症等气虚而致血滞，筋脉失养，症见肌肤麻木或半身不遂。
茯苓：利水渗湿，健脾，宁心。用于水肿，痰饮，脾虚泄泻，心悸，睡眠。
白术：益气健脾，燥湿利水，止汗，安胎。用于脾气虚证，气虚自汗，脾虚胎动不安。
阿胶：补血，滋阴，润肺，止血。用于血虚证，出血证，肺阴虚燥咳，热病伤阴之心烦失眠及阴虚风动，手足瘈疭等。
川芎：活血行气，祛风止痛。用于血瘀气滞痛证，头痛，风湿痹痛。
当归：补血调经，活血止痛，润肠通便。用于血虚诸证，血虚血瘀，月经不调，经闭，痛经，虚寒性腹痛，跌打损伤，痈疽疮疡，风寒痹痛，血虚肠燥便秘。
白芍：养血敛阴，柔肝止痛，平抑肝阳。用于肝血亏虚，月经不调，肝脾不和，胸胁脘腹疼痛，四肢挛急疼痛，肝阳上亢，头痛眩晕。
熟地黄：补血养阴，填精益髓。用于血虚诸证，肝肾阴虚诸证。
杜仲：补肝肾，强筋骨，安胎。用于肾虚腰痛及各种腰痛，胎动不安或习惯堕胎，高血压病。
枸杞子：滋补肝肾，益精明目。用于肝肾阴虚及早衰证。
女贞子：滋补肝肾，乌须明目。用于肝肾阴虚证。
石斛：益胃生津，滋阴清热。用于胃阴虚及热病伤津证，肾阴虚证。
麦冬：养阴生津，润肺清心。用于胃阴虚证，肺阴虚证，心阴虚证。
墨旱莲：滋补肝肾，凉血止血。用于肝肾阴虚证，阴虚血热的失血证。
桑葚：滋阴补血，生津润燥。用于肝肾阴虚证，津伤口渴、消渴及肠燥便秘等证。
益母草：活血调经，利水消肿，清热解毒。用于血滞经闭、痛经、经行不畅、产后恶露不尽、瘀滞腹痛，水肿，小便不利，跌打损伤，疮痈肿毒，皮肤瘾疹。
牛膝：活血通经，补肝肾，强筋骨，利水通淋，引火（血）下行。用于瘀血阻滞之经闭、痛经、经行腹痛、胞衣不下及跌扑伤痛，腰膝酸痛、下肢痿软，淋证、水肿、小便不利，火热上炎，阴虚火旺之头痛、眩晕、齿痛、口舌生疮、吐血、衄血。
砂仁：化湿行气，温中止泻，安胎。用于湿阻中焦及脾胃气滞证，脾胃虚寒吐泻，气滞妊娠恶阻及胎动不安。
柴胡：疏肝解郁，解表退热，升举阳气。用于肝郁气滞，表证发热，气虚下陷，脏器脱垂，疟疾寒热。
上述组份科学、合理配伍，互相支持，具有健脾益气，养血调经之功效，有效用于治疗甲状腺癌患者术后月经过少等不适症状，疗效好，用药安全，并经临床资料得到了充分证明，有关临床资料如下：
（一）、病例选择标准：
A、纳入标准：
（1）年龄在30-55岁之间的女性患者，无器质性病变；
（2）根据临床症状、体征、辅助检查等结果，符合甲状腺癌术后月经过少的诊断标准；
（3）有完整的临床及病理资料；
（4）有固定有效的联系方式；
（5）知晓本次研究的目的，签署知情同意书，自愿加入本次研究。
B、排除标准：
（1）妊娠、哺乳期、计划短期内（6个月）怀孕者；
（2）既往月经不规律者；
（3）既往有自然流产、异位的妊娠、妊娠高血压、妊娠糖尿病等病史者。
（4）心血管、肝、肾功能严重损害或其他恶性疾病者；
（5）精神病患者、认知功能障碍、病情严重不能积极配合者；
（6）接受其他中药、糖皮质激素及其它免疫抑制剂治疗者；
（7）近三月内参加其他药物临床试验者。
C、剔除标准：
（1）因病情恶化不能参与研究者；
（2）因其他原因自行退出者。
（二）、诊断标准
（1）经术前B超、甲状腺核素扫描或针吸活组织检查确诊，并经术后病理证实诊断为甲状腺癌；伴或不伴有甲状腺功能异常。
（2）具有月经过少症状，如月经量少，或点滴即静，色淡无块，无痛经，质稀薄，皮肤干燥，视力下降，或伴头晕眼花或耳鸣，心悸怔仲，小腹空坠或冷痛，面色萎黄，情绪低落，腰膝酸软，或夜尿增多，舌淡红，脉细或脉沉等。
（三）、疗效评定标准：
综合疗效判定标准：计算公式：（治疗前积分—治疗后积分）／治疗前积分，以百分数表示。
痊愈：症状体征基本消失，积分大于或等于95%；
显效：症状体征明显改善，积分积分大于或等于75%；
有效：症状体征有好转，积分大于或等于50%；
无效：症状体征无明显改善，甚或加重，积分不足50%。
（四）、治疗方案：
对诊断为甲状腺癌术后月经过少的患者，用本发明的中药进行治疗，服用时，早晚各一次，每次100-150ml，饭后两小时凉服，7天为一个疗程，4个疗程后统计疗效。
（五）、统计学处理：
入选患者共60例，女性，年龄为(37.4±13.2)岁。按上述（四）治疗方案，口服本发明给出的中药，4个疗程后统计，临床痊愈20例、显效32例、有效8例、无效0例，总有效率达100.00%，表明该发明中药治疗甲状腺癌患者术后胃肠道不适症状效果显著，达到了临床治疗目的，并且在治疗过程中，未见明显不良反应。
（六）、典型病例
为了更详细的说明治疗情况，以下给出典型病例及治疗的疗效情况：
病例1：刘某，女，50岁。甲状腺乳头状癌术后半月出现月经量少，色淡，无痛经，质稀薄，时有头晕，小腹空坠，皮肤干燥，面色萎黄，情绪低落，手术疤痕明显，舌淡红，脉细。服用本中药1个疗程后，患者月经量增多，颜色加深，头晕改善；继服至3个疗程后，上述症状均有明显改善；继服至4个疗程后，症状体征基本消失。
病例2：陈女，女，36岁，乳头状甲状腺癌术后，放射性碘清甲治疗10天后突然出月经点滴即静，色淡无块，无痛经，质稀薄，心悸怔仲，视力下降，小腹冷痛，情绪差，腰膝酸软，夜尿增多，颈部手术部位时有疼痛，颈部活动时稍有牵扯疼痛，舌淡红，脉沉迟等。服用本中药1个疗程后，患者上述症状减轻；继服至2个疗程后，月经量增多、色加深、质变稠，小腹冷痛、腰膝酸软、夜尿多明显改善；继服至4个疗程后，上述症状基本消失。
病例3：郭某，女，30岁，甲状腺乳头状癌术后2月逐渐出现月经量少，色淡无块，质稀薄，头晕耳鸣，心悸怔仲，皮肤干燥，视力下降，颈部手术部位僵硬，舌淡红，脉细弱。服用本中药1个疗程后，患者上述症状逐渐减轻；继服至3个疗程后，症状体征明显改善。
病例4：杨某，女，41岁，甲状腺乳头状癌术后，放射性碘清甲治疗2周出现月经量减少明显，有时或点滴即静，色淡无块，无痛经，质稀薄，头晕眼花，心悸怔仲，皮肤干燥，小腹空坠，面色淡白，情绪抑郁，腰部疼痛，舌淡红，脉沉弱。服用本中药1个疗程后，患者上述症状有所好转；继服至3个疗程后，上述症状明显改善；继服至4个疗程后，症状体征基本消失。
（七）、结论
由上述情况表明，本发明是用于治疗甲状腺癌患者术后月经过少的有效药物，有效率达100%，无毒副作用，疗效稳定，安全可靠，具有健脾益气，养血调经之功效，临床意义巨大，有显著的经济和社会效益。
Claims (5)
1.一种改善甲状腺癌患者术后月经过少的中药，其特征在于，该中药由重量计的：人参10-20g、山药15-25g、黄芪10-20g、茯苓10-20g、白术10-20g、阿胶10-25g、川芎10-20g、当归10-20g、白芍10-20g、熟地黄10-25g、杜仲10-20g、枸杞子10-20g、女贞子25-30g、石斛15-25g、麦冬25-30g、墨旱莲25-30g、桑葚25-30g、益母草25-30g、牛膝10-20g、砂仁5-15g和柴胡5-15g制成，其中，将上述中药混合在一起，加中药重量6-8倍的水浸泡30分钟，武火煎沸，改用文火煎煮30分钟，过滤，得第一次滤液，滤渣加中药重量6-8倍的水，武火煎沸，改用文火煎煮30分钟，过滤，得第二次滤液，将两次滤液混合浓缩至200-300ml。
2.根据权利要求1所述的改善甲状腺癌患者术后月经过少的中药，其特征在于，该中药由重量计的：人参13-17g、山药18-22g、黄芪13-17g、茯苓13-17g、白术13-17g、阿胶15-20g、川芎13-17g、当归13-17g、白芍13-17g、熟地黄15-20g、杜仲13-17g、枸杞子13-17g、女贞子26-28g、石斛18-22g、麦冬26-28g、墨旱莲26-28g、桑葚26-28g、益母草26-28g、牛膝13-17g、砂仁8-12g和柴胡8-12g制成，其中，将上述中药混合在一起，加中药重量6-8倍的水浸泡30分钟，武火煎沸，改用文火煎煮30分钟，过滤，得第一次滤液，滤渣加中药重量6-8倍的水，武火煎沸，改用文火煎煮30分钟，过滤，得第二次滤液，将两次滤液混合浓缩至200-300ml。
3.根据权利要求1所述的改善甲状腺癌患者术后月经过少的中药，其特征在于，该中药由重量计的：人参10g、山药15g、黄芪10g、茯苓10g、白术10g、阿胶10g、川芎10g、当归10g、白芍10g、熟地黄10g、杜仲10g、枸杞子10g、女贞子25g、石斛15g、麦冬25g、墨旱莲25g、桑葚25g、益母草25g、牛膝10g、砂仁5g和柴胡5g制成，其中，将上述中药混合在一起，加中药重量8倍的水浸泡30分钟，武火煎沸，改用文火煎煮30分钟，过滤，得第一次滤液，滤渣加中药重量6倍的水，武火煎沸，改用文火煎煮30分钟，过滤，得第二次滤液，将两次滤液混合浓缩至200ml。
4.根据权利要求1所述的改善甲状腺癌患者术后月经过少的中药，其特征在于，该中药由重量计的：人参15g、山药20g、黄芪15g、茯苓15g、白术15g、阿胶17g、川芎15g、当归15g、白芍15g、熟地黄17g、杜仲15g、枸杞子15g、女贞子28g、石斛20g、麦冬28g、墨旱莲28g、桑葚28g、益母草28g、牛膝15g、砂仁10g和柴胡9g制成，其中，将上述中药混合在一起，加中药重量7倍的水浸泡30分钟，武火煎沸，改用文火煎煮30分钟，过滤，得第一次滤液，滤渣加中药重量7倍的水，武火煎沸，改用文火煎煮30分钟，过滤，得第二次滤液，将两次滤液混合浓缩至250ml。
5.根据权利要求1所述的改善甲状腺癌患者术后月经过少的中药，其特征在于，该中药由重量计的：人参20g、山药25g、黄芪20g、茯苓20g、白术20g、阿胶25g、川芎20g、当归20g、白芍20g、熟地黄25g、杜仲20g、枸杞子20g、女贞子30g、石斛25g、麦冬30g、墨旱莲30g、桑葚30g、益母草30g、牛膝20g、砂仁15g和柴胡15g制成，其中，将上述中药混合在一起，加中药重量8倍的水浸泡30分钟，武火煎沸，改用文火煎煮30分钟，过滤，得第一次滤液，滤渣加中药重量8倍的水，武火煎沸，改用文火煎煮30分钟，过滤，得第二次滤液，将两次滤液混合浓缩至300ml。
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