CN108815409A - A kind of preparation method of spray that treating canker sore - Google Patents
A kind of preparation method of spray that treating canker sore Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention belongs to technical field of oral cavity disease treatment, especially a kind of preparation method for the spray for treating canker sore specifically includes following steps：（1）Weigh raw material；（2）Radix Angelicae Sinensis is crushed, frying obtains angelica powder；（3）If fresh pitaya peel, wheat leaf and water are mixed with beating, mild fire heating is cooled to room temperature, sealed fermenting, and mild fire heating is cooled to room temperature, filters, take filtrate, must ferment infusion liquid；（4）Chinese yam polysaccharide, momordica grosvenori polysaccharide, toad bark extract, Fols Rosae extract and hyacinth bean leaf extract are put into fermentation infusion liquid and stirred evenly, purple sweet potato starch is added, mild fire is heated and is stirred continuously, is cooled to room temperature, and carries out magnetization treatment；（5）Obtain finished product；The raw material of addition carries out coordinated effect, enhances drug effect, so that drug effect is double, also carries out magnetization treatment during the preparation process, effectively enhances the activity of effective component, have apparent therapeutic effect to traumatic canker sore and recurrent oral ulceration.
Description
Technical field
The invention belongs to technical field of oral cavity disease treatment, especially a kind of preparation side for the spray for treating canker sore
Method.
Background technique
Stomatocace class disease mainly includes recurrent oral ulceration and traumatic canker sore, epidemiological survey
The disease incidence of display recurrent oral ulceration is up to 20%, and independent, round or ellipse exulceratio simplex occurs in patient, bursts
The obvious cusalgia in ulcer face, asexuality, age and racial difference, recurrent oral ulceration have the characteristics that easy to recur, periodically strong, category
Self-limited disease, in research at home and abroad, the pathogenic factor and mechanism of recurrent oral ulceration are unclear, it is clinical at present still
Reach 90% or more active drug without radical cure recurrent oral ulceration or cure rate completely；With being gradually increased for life stress,
Ulcer disease incidence increases increasingly, wherein gloomy, nervous and flu and indigestion etc. can based on women
Cause ulcer, ulcer spot is common in lingual surface, lip, gum etc., if be not treated in time, eats the foods such as cool, peppery, numb, hot
When pain it is strong, interference body feed reduces quality of life；So being badly in need of inventing a kind of medicament for treating canker sore, in turn
Guarantee the normal quality of life of people.
Summary of the invention
In view of the above-mentioned problems, the present invention is intended to provide a kind of preparation method for the spray for treating canker sore.
The invention is realized by the following technical scheme：
A kind of preparation method of spray that treating canker sore, specifically includes following steps：
（1）Raw material is weighed by weight, if 28 ~ 30 parts of fresh pitaya peel, 10 ~ 11 parts of wheat leaf, 6.6 ~ 7.2 parts of Radix Angelicae Sinensis, Chinese yam
0.11 ~ 0.13 part of polysaccharide, 0.19 ~ 0.21 part of momordica grosvenori polysaccharide, 0.07 ~ 0.08 part of toad bark extract, Fols Rosae extract
0.14 ~ 0.16 part, 0.24 ~ 0.26 part of hyacinth bean leaf extract, 1.2 ~ 1.4 parts of purple sweet potato starch, 55 ~ 60 parts of water；
（2）Radix Angelicae Sinensis is crushed, merging temperature is constant temperature 6 ~ 8min of frying in 47 ~ 49 DEG C of rotary frying pan, be warming up to 81 ~ 83 DEG C after
Continuous 11 ~ 13min of constant temperature frying, obtains angelica powder；
（3）If fresh pitaya peel, wheat leaf and water are mixed with beating, it is 74 ~ 78 DEG C that mild fire, which is heated to temperature, is cooled to room temperature,
Being placed in temperature is 120 ~ 140h of constant-temperature enclosed fermentation under conditions of 33 ~ 35 DEG C, and it is 84 ~ 88 DEG C that mild fire, which is heated to temperature, is cooled to
Room temperature, filtering, takes filtrate, must ferment infusion liquid；
（4）Chinese yam polysaccharide, momordica grosvenori polysaccharide, toad bark extract, Fols Rosae extract and hyacinth bean leaf extract are put into hair
It being stirred evenly in ferment infusion liquid, purple sweet potato starch is added, mild fire is heated to temperature and is 79 ~ 81 DEG C and is stirred continuously, is cooled to room temperature,
Magnetization treatment is carried out, the spray of canker sore must be treated；
（5）Filling, sterilizing obtains finished product.
As invention further embodiment：The toad bark extract, is prepared according to the following steps：By Toad Skin powder
Broken, constant temperature 11 ~ 13min of frying in the rotary frying pan that merging temperature is 92 ~ 96 DEG C, addition weight is Toad Skin weight 2.3 ~ 2.5
Amount, the water that temperature is 54 ~ 58 DEG C are mixed evenly again, continue 24 ~ 28min of mild fire infusion after being boiled by slow fire, and filtering takes filter
Liquid, being placed in and being dried to moisture content in the drying box that temperature is 81 ~ 85 DEG C is 5% ~ 7%, obtains toad bark extract.
As invention further embodiment：The Fols Rosae extract, is prepared according to the following steps：By fresh Chinese rose
Flower and 1.3 ~ 1.5 times of its weight amounts, the ethanol solution that mass fraction is 27% ~ 29% are mixed with beating, and are 320 ~ 330W, frequency in power
Rate is ultrasonically treated 24 ~ 28min under conditions of being 162 ~ 168kHz, continues 14 ~ 16min of mild fire infusion after being boiled by slow fire, and filtering takes
Filtrate, vacuum freeze drying to moisture content is 2% ~ 4% under conditions of temperature is -10 ~ -8 DEG C, obtains Fols Rosae extract.
As invention further embodiment：The hyacinth bean leaf extract, is prepared according to the following steps：By fresh hyacinth bean
Leaf and 1.7 ~ 1.9 times of its weight amounts, the ethanol solution that mass fraction is 33% ~ 35% are mixed with beating, and are 270 ~ 280W, frequency in power
Rate is ultrasonically treated 17 ~ 19min under conditions of being 132 ~ 136kHz, in the condition that power is 180 ~ 190W, frequency is 92 ~ 96kHz
10 ~ 12min of lower ultrasonic treatment continues 18 ~ 20min of mild fire infusion after being boiled by slow fire, filtering takes filtrate, is -15 ~ -13 in temperature
Vacuum freeze drying to moisture content is 2% ~ 4% under conditions of DEG C, obtains hyacinth bean leaf extract.
As invention further embodiment：Step（4）The magnetization treatment, in the condition that magnetic field strength is 0.6 ~ 0.7T
6 ~ 7min of lower magnetization treatment, 3 ~ 4min of magnetization treatment under conditions of magnetic field strength is 1.0 ~ 1.1T, above-mentioned is a circulation, altogether
Circular treatment 2 times.
As invention further embodiment：A kind for the treatment of oral cavity of the preparation method preparation of spray that treating canker sore
The spray of ulcer.
Beneficial effects of the present invention：A kind of preparation method of spray for treating canker sore provided by the invention is added
Raw material carry out coordinated effect, effectively facilitate the interaction of each material effective component, enhance drug effect, so that drug effect is turned over
Times, magnetization treatment is also carried out during the preparation process, is effectively enhanced the activity of effective component, is made its effective component and bacterium protein
Amino acid combines, and all has stronger killing effect to a variety of pathogens, may also suppress capillary permeability in inflammatory process,
Eliminate and become silted up swollen around ulcer wound surface, inhibit the medium of inflammatory process to discharge, play the effect of analgesic, containing various trace elements,
Vitamin, flavones etc. have the function of antibacterial, analgesia, wound healing, also can be used as immunoactivator, and enhancing macrophage is thin
Born of the same parents' phagocytic activity, hence it is evident that reduce ulcer area and shorten pain time, mitigate pain and shorten red and swollen regression time, accelerate newborn
Granulation tissue generates and the healing of ulcer, activating microcirculation and removing stasis medicinal, the synthesis for yin-nourishing production of sperm, improving microcirculation, inhibiting bacterio protein, tool
There is antibacterial effect, moreover it is possible to which the effect of playing anti-inflammatory analgetic, clearing heat and detoxicating effect, playing activating microcirculation and removing stasis medicinal accelerates ulcer surface
Healing and the blood circulation for improving affected part make the growth of epithelial cell to make the cell in affected part, the enhancing of histogenic immunity resistance
Accelerate, promotees ulcer surface as early as possible and heal completely, reduce late relapse, have to traumatic canker sore and recurrent oral ulceration bright
Aobvious therapeutic effect.
Specific embodiment
Illustrate the present invention with specific embodiment below, but is not limitation of the present invention.
Embodiment 1
In the embodiment of the present invention, a kind of preparation method of spray that treating canker sore specifically includes following steps：
（1）Weigh raw material by weight, if 28 parts of fresh pitaya peel, 10 parts of wheat leaf, 6.6 parts of Radix Angelicae Sinensis, 0.11 part of Chinese yam polysaccharide,
0.19 part of momordica grosvenori polysaccharide, 0.07 part of toad bark extract, 0.14 part of Fols Rosae extract, 0.24 part of hyacinth bean leaf extract, purple
1.2 parts of sweet potato starch, 55 parts of water；
（2）Radix Angelicae Sinensis is crushed, constant temperature frying 6min in the rotary frying pan that merging temperature is 47 DEG C is warming up to 81 DEG C of continuation constant temperature and fries
11min processed, obtains angelica powder；
（3）If fresh pitaya peel, wheat leaf and water are mixed with beating, it is 74 DEG C that mild fire, which is heated to temperature, is cooled to room temperature, and is placed in
Temperature is constant-temperature enclosed fermentation 120h under conditions of 33 DEG C, and it is 84 DEG C that mild fire, which is heated to temperature, is cooled to room temperature, and filters, takes filter
Liquid, must ferment infusion liquid；
（4）Chinese yam polysaccharide, momordica grosvenori polysaccharide, toad bark extract, Fols Rosae extract and hyacinth bean leaf extract are put into hair
It being stirred evenly in ferment infusion liquid, purple sweet potato starch is added, mild fire is heated to temperature and is 79 DEG C and is stirred continuously, is cooled to room temperature, into
Row magnetization treatment must treat the spray of canker sore；
（5）Filling, sterilizing obtains finished product.
As invention further embodiment：The toad bark extract, is prepared according to the following steps：By Toad Skin powder
Broken, constant temperature frying 11min in the rotary frying pan that merging temperature is 92 DEG C, it is that 2.3 times of Toad Skin weight amounts, temperature are that weight, which is added,
54 DEG C of water is mixed evenly, and continues mild fire infusion 24min after being boiled by slow fire, and filtering takes filtrate, and merging temperature is 81 DEG C
It is 5% ~ 7% that moisture content is dried in drying box, obtains toad bark extract.
As invention further embodiment：The Fols Rosae extract, is prepared according to the following steps：By fresh Chinese rose
Flower and 1.3 times of its weight amounts, the ethanol solution that mass fraction is 27% are mixed with beating, power is 320W, frequency is 162kHz's
Under the conditions of be ultrasonically treated 24min, continue mild fire infusion 14min after being boiled by slow fire, filtering takes filtrate, is -10 DEG C of item in temperature
Vacuum freeze drying to moisture content is 2% ~ 4% under part, obtains Fols Rosae extract.
As invention further embodiment：The hyacinth bean leaf extract, is prepared according to the following steps：By fresh hyacinth bean
Leaf and 1.7 times of its weight amounts, the ethanol solution that mass fraction is 33% are mixed with beating, power is 270W, frequency is 132kHz's
Under the conditions of be ultrasonically treated 17min, 10min is ultrasonically treated under conditions of power is 180W, frequency is 92kHz, after being boiled by slow fire
Continue mild fire infusion 18min, filtering takes filtrate, under conditions of temperature is -15 DEG C vacuum freeze drying to moisture content be 2% ~
4%, obtain hyacinth bean leaf extract.
As invention further embodiment：Step（4）The magnetization treatment, magnetic under conditions of magnetic field strength is 0.6T
Change processing 6min, magnetization treatment 3min under conditions of magnetic field strength is 1.0T, above-mentioned is a circulation, altogether circular treatment 2 times.
As invention further embodiment：A kind for the treatment of oral cavity of the preparation method preparation of spray that treating canker sore
The spray of ulcer.
Embodiment 2
In the embodiment of the present invention, a kind of preparation method of spray that treating canker sore specifically includes following steps：
（1）Raw material is weighed by weight, if 29 parts of fresh pitaya peel, 10.5 parts of wheat leaf, 6.9 parts of Radix Angelicae Sinensis, Chinese yam polysaccharide 0.12
Part, 0.2 part of momordica grosvenori polysaccharide, 0.075 part of toad bark extract, 0.15 part of Fols Rosae extract, 0.25 part of hyacinth bean leaf extract,
1.3 parts of purple sweet potato starch, 58 parts of water；
（2）Radix Angelicae Sinensis is crushed, constant temperature frying 7min in the rotary frying pan that merging temperature is 48 DEG C is warming up to 82 DEG C of continuation constant temperature and fries
12min processed, obtains angelica powder；
（3）If fresh pitaya peel, wheat leaf and water are mixed with beating, it is 76 DEG C that mild fire, which is heated to temperature, is cooled to room temperature, and is placed in
Temperature is constant-temperature enclosed fermentation 130h under conditions of 34 DEG C, and it is 86 DEG C that mild fire, which is heated to temperature, is cooled to room temperature, and filters, takes filter
Liquid, must ferment infusion liquid；
（4）Chinese yam polysaccharide, momordica grosvenori polysaccharide, toad bark extract, Fols Rosae extract and hyacinth bean leaf extract are put into hair
It being stirred evenly in ferment infusion liquid, purple sweet potato starch is added, mild fire is heated to temperature and is 80 DEG C and is stirred continuously, is cooled to room temperature, into
Row magnetization treatment must treat the spray of canker sore；
（5）Filling, sterilizing obtains finished product.
As invention further embodiment：The toad bark extract, is prepared according to the following steps：By Toad Skin powder
Broken, constant temperature frying 12min in the rotary frying pan that merging temperature is 94 DEG C, it is that 2.4 times of Toad Skin weight amounts, temperature are that weight, which is added,
56 DEG C of water is mixed evenly, and continues mild fire infusion 26min after being boiled by slow fire, and filtering takes filtrate, and merging temperature is 83 DEG C
It is 5% ~ 7% that moisture content is dried in drying box, obtains toad bark extract.
As invention further embodiment：The Fols Rosae extract, is prepared according to the following steps：By fresh Chinese rose
Flower and 1.4 times of its weight amounts, the ethanol solution that mass fraction is 28% are mixed with beating, power is 325W, frequency is 165kHz's
Under the conditions of be ultrasonically treated 26min, continue mild fire infusion 15min after being boiled by slow fire, filtering takes filtrate, is -9 DEG C of item in temperature
Vacuum freeze drying to moisture content is 2% ~ 4% under part, obtains Fols Rosae extract.
As invention further embodiment：The hyacinth bean leaf extract, is prepared according to the following steps：By fresh hyacinth bean
Leaf and 1.8 times of its weight amounts, the ethanol solution that mass fraction is 34% are mixed with beating, power is 275W, frequency is 134kHz's
Under the conditions of be ultrasonically treated 18min, 11min is ultrasonically treated under conditions of power is 185W, frequency is 94kHz, after being boiled by slow fire
Continue mild fire infusion 19min, filtering takes filtrate, under conditions of temperature is -14 DEG C vacuum freeze drying to moisture content be 2% ~
4%, obtain hyacinth bean leaf extract.
As invention further embodiment：Step（4）The magnetization treatment, under conditions of magnetic field strength is 0.65T
Magnetization treatment 6.5min, magnetization treatment 3.5min under conditions of magnetic field strength is 1.05T, above-mentioned is a circulation, is recycled altogether
Processing 2 times.
As invention further embodiment：A kind for the treatment of oral cavity of the preparation method preparation of spray that treating canker sore
The spray of ulcer.
Embodiment 3
In the embodiment of the present invention, a kind of preparation method of spray that treating canker sore specifically includes following steps：
（1）Weigh raw material by weight, if 30 parts of fresh pitaya peel, 11 parts of wheat leaf, 7.2 parts of Radix Angelicae Sinensis, 0.13 part of Chinese yam polysaccharide,
0.21 part of momordica grosvenori polysaccharide, 0.08 part of toad bark extract, 0.16 part of Fols Rosae extract, 0.26 part of hyacinth bean leaf extract, purple
1.4 parts of sweet potato starch, 60 parts of water；
（2）Radix Angelicae Sinensis is crushed, constant temperature frying 8min in the rotary frying pan that merging temperature is 49 DEG C is warming up to 83 DEG C of continuation constant temperature and fries
13min processed, obtains angelica powder；
（3）If fresh pitaya peel, wheat leaf and water are mixed with beating, it is 78 DEG C that mild fire, which is heated to temperature, is cooled to room temperature, and is placed in
Temperature is constant-temperature enclosed fermentation 140h under conditions of 35 DEG C, and it is 88 DEG C that mild fire, which is heated to temperature, is cooled to room temperature, and filters, takes filter
Liquid, must ferment infusion liquid；
（4）Chinese yam polysaccharide, momordica grosvenori polysaccharide, toad bark extract, Fols Rosae extract and hyacinth bean leaf extract are put into hair
It being stirred evenly in ferment infusion liquid, purple sweet potato starch is added, mild fire is heated to temperature and is 81 DEG C and is stirred continuously, is cooled to room temperature, into
Row magnetization treatment must treat the spray of canker sore；
（5）Filling, sterilizing obtains finished product.
As invention further embodiment：The toad bark extract, is prepared according to the following steps：By Toad Skin powder
Broken, constant temperature frying 13min in the rotary frying pan that merging temperature is 96 DEG C, it is that 2.5 times of Toad Skin weight amounts, temperature are that weight, which is added,
58 DEG C of water is mixed evenly, and continues mild fire infusion 28min after being boiled by slow fire, and filtering takes filtrate, and merging temperature is 85 DEG C
It is 5% ~ 7% that moisture content is dried in drying box, obtains toad bark extract.
As invention further embodiment：The Fols Rosae extract, is prepared according to the following steps：By fresh Chinese rose
Flower and 1.3 ~ 1.5 times of its weight amounts, the ethanol solution that mass fraction is 29% are mixed with beating, power is 330W, frequency is
It is ultrasonically treated 24 ~ 28min under conditions of 168kHz, continues mild fire infusion 16min after being boiled by slow fire, filtering takes filtrate, in temperature
Vacuum freeze drying to moisture content is 2% ~ 4% under conditions of being -8 DEG C, obtains Fols Rosae extract.
As invention further embodiment：The hyacinth bean leaf extract, is prepared according to the following steps：By fresh hyacinth bean
Leaf and 1.9 times of its weight amounts, the ethanol solution that mass fraction is 35% are mixed with beating, power is 280W, frequency is 136kHz's
Under the conditions of be ultrasonically treated 19min, 12min is ultrasonically treated under conditions of power is 190W, frequency is 96kHz, after being boiled by slow fire
Continue mild fire infusion 20min, filtering takes filtrate, under conditions of temperature is -13 DEG C vacuum freeze drying to moisture content be 2% ~
4%, obtain hyacinth bean leaf extract.
As invention further embodiment：Step（4）The magnetization treatment, magnetic under conditions of magnetic field strength is 0.7T
Change 6 ~ 7min of processing, magnetization treatment 4min under conditions of magnetic field strength is 1.1T, above-mentioned is a circulation, altogether circular treatment 2
It is secondary.
As invention further embodiment：A kind for the treatment of oral cavity of the preparation method preparation of spray that treating canker sore
The spray of ulcer.
Comparative example 1
A kind of preparation method of spray that treating canker sore, the difference from embodiment 1 is that, it is added without in the raw material
Radix Angelicae Sinensis, Chinese yam polysaccharide and toad bark extract, other conditions are all the same.
Comparative example 2
A kind of preparation method of spray that treating canker sore, the difference from embodiment 1 is that, it is added without in the raw material
If wheat leaf, momordica grosvenori polysaccharide and Fols Rosae extract, other conditions are all the same.
Comparative example 3
A kind of preparation method of spray that treating canker sore, the difference from embodiment 1 is that, it is added without in the raw material
Fresh pitaya peel, hyacinth bean leaf extract and purple sweet potato starch, other conditions are all the same.
Comparative example 4
A kind of preparation method of spray that treating canker sore, the difference from embodiment 1 is that, step（4）Without described
Magnetization treatment, other conditions are all the same.
Comparative example 5
Watermelon crystal spray
Embodiment and comparative example treats the effect experiment of the aerosol therapy canker sore of canker sore：
（1）Animal
Male adult rat, 250 ± 20g of weight
（2）Traumatic canker sore rat model preparation
By rat with etherization, cotton balls containing carbolic acid is placed in one end (the glass dropper length for the glass dropper that diameter is 6mm
For 5cm), then cotton balls is placed at left and right sides of rat away from cheek film calcination 50s bicker 2mm at, makes local mucous membrane formation diameter 8mm's
White damage, next day visually observe visible rat lip side humidity, redness at cheek mucous membrane；
（3）The preparation of recurrent oral ulceration rat model
10 male rats are taken off neck to put to death, injecting normal saline under mucous membrane of mouth, be stripped under aseptic condition using eye scissors
Mucous membrane of mouth is put into the connective tissue for purging blood in physiological saline and wiping out remaining；It is shredded and is put into tissue homogenate
Device, the PBS buffer solution that 0.1mol/L, pH7.4 is added are made tissue homogenate, save in -70 DEG C of refrigerators；It is taken before each rat injection
The tissue homogenate of equivalent and complete Freund's adjuvant are sub-packed in syringe, are connected on Medical tee joint pipe, and alternating is injected, and make to be homogenized
It is sufficiently mixed with adjuvant, it is not stratified after placement to be successfully prepared benchmark for bright antigen emulsion；Modeling rat spine two sides are cut off
Mouse hair, 0.1mL antigen emulsion is subcutaneously injected in the every side of every rat after iodophor disinfection, 2 points of co-injection, injects 1 time every 2 weeks, altogether
Injection 5 times；The mixed liquor of rats in normal control group injecting normal saline and complete Fei Shi adjuvant, method are same as above.
（4）Animal packet and administration
100 rats are taken, 10 is randomly selected and is only used as recurrent oral ulceration model preparation source, remaining 90 rats take 45 at random
Traumatic Oral ulcer model is only prepared, 45 prepare recurrent oral ulceration rat model；Model is respectively divided into 3 after being successfully prepared
A embodiment group, 5 comparative example groups and model control group, every group 5；Rat starts to test after laboratory rearing 1 week, raises
The condition of supporting, operation are carried out in strict accordance with the requirement of animal experimental center；Embodiment group and comparative example group are dipped in disinfecting cotton swab respectively
The spray 1ml for taking each group to treat canker sore accordingly is applied at rat canker sore, model control group not drug treatment,
Normal raising；Successive administration after two weeks, puts to death rat, the aerosol therapy wound of detection embodiment and comparative example treatment canker sore
The effect of wound property canker sore and recurrent oral ulceration, respectively such as Tables 1 and 2：
Comparing result of 1 embodiment and comparative example of table to traumatic dental ulcer treatment effect
As it can be seen from table 1 the spray for the treatment of canker sore of the invention has efficient treatment to traumatic canker sore
Effect.
Comparing result of 2 embodiment and comparative example of table to recurrent oral ulceration therapeutic effect
From table 2 it can be seen that the spray for the treatment of canker sore of the invention has efficient treatment to recurrent oral ulceration
Effect.
Claims (6)
1. a kind of preparation method for the spray for treating canker sore, which is characterized in that specifically include following steps：
（1）Raw material is weighed by weight, if 28 ~ 30 parts of fresh pitaya peel, 10 ~ 11 parts of wheat leaf, 6.6 ~ 7.2 parts of Radix Angelicae Sinensis, Chinese yam
0.11 ~ 0.13 part of polysaccharide, 0.19 ~ 0.21 part of momordica grosvenori polysaccharide, 0.07 ~ 0.08 part of toad bark extract, Fols Rosae extract
0.14 ~ 0.16 part, 0.24 ~ 0.26 part of hyacinth bean leaf extract, 1.2 ~ 1.4 parts of purple sweet potato starch, 55 ~ 60 parts of water；
（2）Radix Angelicae Sinensis is crushed, merging temperature is constant temperature 6 ~ 8min of frying in 47 ~ 49 DEG C of rotary frying pan, be warming up to 81 ~ 83 DEG C after
Continuous 11 ~ 13min of constant temperature frying, obtains angelica powder；
（3）If fresh pitaya peel, wheat leaf and water are mixed with beating, it is 74 ~ 78 DEG C that mild fire, which is heated to temperature, is cooled to room temperature,
Being placed in temperature is 120 ~ 140h of constant-temperature enclosed fermentation under conditions of 33 ~ 35 DEG C, and it is 84 ~ 88 DEG C that mild fire, which is heated to temperature, is cooled to
Room temperature, filtering, takes filtrate, must ferment infusion liquid；
（4）Chinese yam polysaccharide, momordica grosvenori polysaccharide, toad bark extract, Fols Rosae extract and hyacinth bean leaf extract are put into hair
It being stirred evenly in ferment infusion liquid, purple sweet potato starch is added, mild fire is heated to temperature and is 79 ~ 81 DEG C and is stirred continuously, is cooled to room temperature,
Magnetization treatment is carried out, the spray of canker sore must be treated；
（5）Filling, sterilizing obtains finished product.
2. the preparation method of the spray for the treatment of canker sore according to claim 1, which is characterized in that the toad
Bark extract is prepared according to the following steps：Toad Skin is crushed, constant temperature is fried in the rotary frying pan that merging temperature is 92 ~ 96 DEG C
11 ~ 13min is made, the water that weight is 2.3 ~ 2.5 times of Toad Skin weight amounts, temperature is 54 ~ 58 DEG C is added and is mixed evenly, mild fire
Continue 24 ~ 28min of mild fire infusion after boiling, filtering takes filtrate, is dried in the drying box that merging temperature is 81 ~ 85 DEG C aqueous
Rate is 5% ~ 7%, obtains toad bark extract.
3. the preparation method of the spray for the treatment of canker sore according to claim 1, which is characterized in that the Chinese rose
Flower extract is prepared according to the following steps：It is 27% ~ 29% by new fresh China rose and 1.3 ~ 1.5 times of its weight amounts, mass fraction
Ethanol solution be mixed with beating, under conditions of power is 320 ~ 330W, frequency is 162 ~ 168kHz be ultrasonically treated 24 ~ 28min,
Continue 14 ~ 16min of mild fire infusion after being boiled by slow fire, filtering takes filtrate, and vacuum refrigeration is dry under conditions of temperature is -10 ~ -8 DEG C
It is dry to moisture content be 2% ~ 4%, obtain Fols Rosae extract.
4. the preparation method of the spray for the treatment of canker sore according to claim 1, which is characterized in that the hyacinth bean
Leaf extract is prepared according to the following steps：It is 33% ~ 35% by fresh hyacinth dolichos leaf and 1.7 ~ 1.9 times of its weight amounts, mass fraction
Ethanol solution be mixed with beating, under conditions of power is 270 ~ 280W, frequency is 132 ~ 136kHz be ultrasonically treated 17 ~ 19min,
It is ultrasonically treated 10 ~ 12min under conditions of power is 180 ~ 190W, frequency is 92 ~ 96kHz, continues mild fire after being boiled by slow fire and endures
18 ~ 20min is boiled, filters, takes filtrate, vacuum freeze drying to moisture content is 2% ~ 4% under conditions of temperature is -15 ~ -13 DEG C,
Obtain hyacinth bean leaf extract.
5. the preparation method of the spray for the treatment of canker sore according to claim 1, which is characterized in that step（）It is described
Magnetization treatment, magnetization treatment 6 ~ 7min under conditions of magnetic field strength is 0.6 ~ 0.7T is 1.0 ~ 1.1T in magnetic field strength
Under the conditions of magnetization treatment 3 ~ 4min, above-mentioned is a circulation, altogether circular treatment 2 times.
6. the treatment oral cavity of the preparation method preparation of the spray of described in any item treatment canker sore according to claim 1 ~ 5
The spray of ulcer.
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| CN201810901093.3A CN108815409A (en) | 2018-08-09 | 2018-08-09 | A kind of preparation method of spray that treating canker sore |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814208A (en) * | 2005-12-02 | 2006-08-09 | 钟祖光 | Oral Chinese medicine for treating and preventing recurrence of uecerative stomatitis |
| CN104800369A (en) * | 2015-04-15 | 2015-07-29 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine liquid for treating oral ulcer and preparation method of traditional Chinese medicine liquid |
| CN105796816A (en) * | 2016-04-28 | 2016-07-27 | 苏莹 | Traditional Chinese medicine for treating kidney-deficiency stagnated-fire type oral ulcer |
-
2018
- 2018-08-09 CN CN201810901093.3A patent/CN108815409A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814208A (en) * | 2005-12-02 | 2006-08-09 | 钟祖光 | Oral Chinese medicine for treating and preventing recurrence of uecerative stomatitis |
| CN104800369A (en) * | 2015-04-15 | 2015-07-29 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine liquid for treating oral ulcer and preparation method of traditional Chinese medicine liquid |
| CN105796816A (en) * | 2016-04-28 | 2016-07-27 | 苏莹 | Traditional Chinese medicine for treating kidney-deficiency stagnated-fire type oral ulcer |
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