CN108812916A - A kind of hunchbacked milk tablet and its preparation with auxiliary hyperglycemic function - Google Patents
A kind of hunchbacked milk tablet and its preparation with auxiliary hyperglycemic function Download PDFInfo
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- CN108812916A CN108812916A CN201810498455.9A CN201810498455A CN108812916A CN 108812916 A CN108812916 A CN 108812916A CN 201810498455 A CN201810498455 A CN 201810498455A CN 108812916 A CN108812916 A CN 108812916A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/18—Milk in dried and compressed or semi-solid form
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
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Abstract
The present invention discloses a kind of hunchbacked milk tablet with auxiliary hyperglycemic function, it is characterized in that, in parts by weight, including hunchbacked milk powder 99.50-99.68%, Se-enriched yeast 0.32-0.50%, the hunchbacked milk tablet, it is proved by functional trial hypoglycemic rapid-action, it is i.e. effective after administration 4 weeks, and reduce about 90% hunchbacked milk cream usage amount, present composition MTD is greater than 15000mg/kgbw, belong to nontoxic grade, with 3.0, 6.5, tri- dosage of 10.0g/kgbw/d give rat 30 days, animal subject hematological indices and biochemical indicator are as the result is shown, indices are in normal range (NR)；Each internal organs histopathologic examination is showed no pathological change related with given the test agent, it is seen that the present composition is safe and reliable.
Description
Technical field：
The invention belongs to field of food, specifically, the invention belongs to a kind of technical fields of auxiliary hyperglycemic camel milk tablet.
Background technique：
Diabetes are a kind of common chronic endocrine and metabolism disease of global pandemic, the hair of the disease and its complication
Sick rate, illness rate and the death rate with the development of economy, urbanization process, aging of population and living and diet mode change
Increase constantly, and cause huge social economical burden, have become China so that worldwide in one urgently
The public health problem of solution.The relevant information of the World Health Organization show the illness rate, disability rate and case fatality rate of diabetes with
And the extent of injury to general health, the 3rd of Chronic Non-Communicable Diseases has been occupy, it is dead caused by diabetes and its complication
Die the 5th that number has also occupy world's cause of death.Studies have reported that world's diabetes number of patients in 2013 has reached
3.82 hundred million, and expect the year two thousand thirty and increase to 5.52 hundred million people.Past 30 Years, with China's economic development, the trouble of domestic diabetes
Sick rate increases more than ten times.Currently, the disease incidence of China's diabetes is 9. 7%, up to more than 1.3 hundred million people, 20% with cardiovascular and cerebrovascular
Complication after having 2.5 million peoples, also has as many as million people by its ability of losing the job that disables.China has become glycosuria
The most country of sick number of patients, diabetes have become the main task of chronic diseases in China prevention and treatment.
Camel milk is one of the important milk supply of desert and Semi-desert Area, and the Inner Mongol, Gansu, Xinjiang, Qinghai are China white horses with a black mane
The major production areas of hunchbacked milk.It is unique that camel milk nutrition is constituted, absorption easy to digest, and is rich in lactoferrin, immunoglobulin, peroxide
The protective proteins such as compound enzyme, lysozyme are worth with high nutrition and health care.Modern pharmacology research shows camel milk
Have the effects that anti-oxidant, liver protection, anti-inflammatory, antibacterial, it may also be used for treatment pulmonary tuberculosis, women's diseases, auxiliary for treating cancer, glycosuria
Disease, prevention children rachitis etc..The investigation such as R.P.Agrawal discovery, resident's impaired fasting glucose (IFG) of often feeding camel milk,
Impaired glucose tolerance (IGT) incidence and diabetes morbidity are obviously lower than not drinking the people of camel milk.Type I diabetes patient is daily
Drinking 0.5L camel milk can make insulin dosage averagely reduce 30%.Camel milk assists in the treatment of type II diabetes and prevents also to have
Effect.Camel milk can promote diabetes wound healing, and camel milk lactalbumin can increase serum insulin level, and it is dynamic to reduce diabetes
Object blood glucose, blood lipid level；Body Free Radical Level is reduced, it is anti-to improve hydroxyproline, proinflammatory cytokine and β-in wound tissue
The content of element 1,2,3 is defended, to improve the immune response of wound tissue's cell, mitigates diabetic complication to reinforce diabetic
Wound healing.
Although camel milk can be used for preventing and treating diabetes, there are onset time it is long (Agraw al P.P. and
S.Y.Wang is reported respectively takes 3 months and 14 weeks), dosage big (500ml/ days) long up to maximum efficacy time the problem of.And
And by resource constraint, camel milk yield is very low, and price can not have always been high any more, develops relevant healthcare food with it and all exists always
High cost problem.
In addition, though its dosage is usually right studies have reported that selenium has anti-diabetic and insulin-mimickers effect
Human body have toxicity (Ezaki O..J Biol Chem, 1990.Mueller A.S., et al.J Nutr Biochem.,
2006.Stein brenner H.,et al..J Clin Biochem Nutr,2011.).Also, epidemiological study in recent years
The result of investigation and randomized clinical trial may cause type II diabetes it has also been found that the crowd of eutrophy is under the conditions of high selenium
(Stra nges S.,et al..BMC Public Health,2010).Some internal in vitro studies also indicate that, low selenium or height
Selenium level can increase risk (Labunskyy V. M., the et al..Antioxid Redox of type II diabetes generation
Signal,2011)。
Summary of the invention：
For currently with camel dairy produce auxiliary hyperglycemic, onset time is long, long up to the greatest treatment efficacy time and dosage is big,
Health food problem at high cost is made, the present invention provides hunchbacked milk tablet auxiliary is obviously improved while a kind of reduction camel milk dosage
The method of function of blood sugar reduction：Se-enriched yeast is creatively added, using in the para-insulin activity and camel milk of wherein selenium element
Synergistic function occurs for each ingredient, generates to the intracorporal insulin secretion metabolism of people and the uptake and utilization of glucose positive
Effect, so that the function of blood sugar reduction of hunchbacked milk powder is obviously improved.It is another object of the present invention to select suitable selenium source, and lead to
It crosses repeated screening and determines safe and efficient additive amount.Selenium is divided to two kinds in the existing way of nature, poison of the inorganic selenium to human body
Side reaction and gastrointestinal irritability are big, and organic selenium exists generally in the form of selenomethionine, compared to inorganic selenium more safety and to stomach
Enteron aisle stimulation is small.Thus, it is a kind of safe and efficient by selecting suitable selenium source and determining that reasonable additive amount is possible to obtain
Auxiliary hyperglycemic camel milk tablet.The present invention can play synergistic function while guaranteeing the intake of selenium in safe range again,
Reduction camel milk dosage is reached, has reduced cost of material, shorten the purpose of onset time, have a wide range of applications promotional value.
The present invention specifically provides a kind of hunchbacked milk tablet with auxiliary hyperglycemic function, in parts by weight, including hunchbacked milk
Powder 99.50-99.68%, Se-enriched yeast 0.32-0.50%.
Preferably, the present invention specifically provides a kind of hunchbacked milk tablet with auxiliary hyperglycemic function, in parts by weight, packet
Include hunchbacked milk powder 99.65-99.60%, Se-enriched yeast 0.35-0.40%.
In the present invention, in a kind of hunchbacked milk tablet with auxiliary hyperglycemic function, casein, α-lactalbumin, the white egg of serum
White, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein total content >=20%, 10.0mg/kg >=Se content
≥6.4mg/kg。
It is furthermore preferred that casein, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase
Enzyme, antalzyme protein total content >=20%, 8.0mg/kg >=Se content >=7.0mg/kg.
Meanwhile the present invention provides the preparation method of above-mentioned hunchbacked milk tablet, specifically uses following technical step：
(1) pretreatment of camel milk：It selects standard compliant camel milk as raw material, is filtered through duplex strainer, used
Milk clarifier purification, and raw milk is standardized；
(2) preparation of hunchbacked milk powder：By the raw milk after the standardization of step (1) preparation, through homogeneous, sterilization, concentration, it is sprayed
Dry, bean jelly and it is sieved into hunchbacked milk powder；
(3) mixing film-making：The hunchbacked milk powder for taking step (2) to prepare is sufficiently mixed with Se-enriched yeast, and tabletting to obtain the final product.
By implementing technical solution of the present invention, following beneficial effect can achieve：
(1) in the present invention, a kind of hunchbacked milk tablet with auxiliary hyperglycemic function provided, hypoglycemic onset time is compared
In hunchbacked milk powder, Se content at least shortens 2 weeks lower than the hunchbacked milk tablet of the present composition.Animal experiments show that hunchbacked milk powder and its
The hunchbacked milk tablet of his composition effective (P after administration 6 weeks<0.05), hunchbacked milk tablet provided by the invention is i.e. aobvious after administration 4 weeks
Imitate (P<0.05) effect is obviously improved (P after, being administered 6 weeks<0.01), and after administration 8 weeks effect has significantly compared to (4 weeks) when working
Property improve (P<0.05).Human experiment experiment also indicates that, takes the present composition 2 months and shows auxiliary hyperglycemic work
With Time of Administration, which is considerably less than disclosed in the prior art, to be needed to drink hunchbacked milk 3 months or more (0.5L/ days).
(2) in the present invention, a kind of hunchbacked milk tablet with auxiliary hyperglycemic function provided, under the premise of guaranteeing drug effect,
Hunchbacked milk cream usage amount can be greatly reduced.The day taking dose of the present composition is only that 6.0g (is equivalent to and takes camel milk powder
5.976-5.981g), and the prior art discloses, Type I diabetes patient take orally camel milk (be equivalent to and take 50-82g within 0.5L/ days
Hunchbacked milk powder) fasting blood-glucose of diabetic, postprandial blood sugar are significantly improved, take rosiglitazone in treating II type sugar
Oral camel milk is beneficial to reduce blood glucose the patient for urinating disease for 14 weeks 0.5L/ days simultaneously.It can be seen that present invention reduces about 90% camels
Milk cream usage amount.Clinical test shows：Take 2 times/day of the present composition, 3 pieces/times, continuous 2 months.Test-meal group after test-meal
The clinical symptoms such as polydipsia, polyorexia, diuresis, fatigue and weakness have clear improvement, and symptom total mark is lower than control group (P<
0.05).Fasting blood-glucose, 2h-plasma glucose test-meal group are lower than control group (P after test-meal<0.05)；Self pair compares, and test-meal group is empty
Before being below test-meal after abdomen blood glucose, postprandial 2h blood glucose test-meal, fasting blood-glucose decline 11.52%, 2h-plasma glucose decline
10.63% (P<0.05).The present invention passes through the rational proportion of hunchbacked milk powder and Se-enriched yeast in the feelings for being substantially reduced hunchbacked Feeding volume
Still good auxiliary hyperglycemic effect is obtained under condition, composition good security has auxiliary with the art of this patent preparation
The hunchbacked milk tablet of hypoglycemic effect can at least save 40% or so cost, highly beneficial to industrialization production.
(3) in the present invention, a kind of hunchbacked milk tablet with auxiliary hyperglycemic function provided, in terms of 3.0g/kgbw/d,
The practical intake of selenium is only 0.243-0.380 μM/kgbw/d, far below the report of the prior art, can be reached with hunchbacked milk
Synergistic function, auxiliary hyperglycemic effect are substantially better than simple hunchbacked milk powder, better than other compositions.Zoopery table
Bright, the blood glucose value and Area under the curve of blood glucose of 3.0g/kgbw/d group 0.5h, 2h are below model control group (P<0.05),
1.0g/kgbw/d group Area under the curve of blood glucose is lower than model control group (P<0.05), the present composition can be substantially reduced height
The lasting blood glucose level of blood glucose animal pattern improves model mouse fasting blood sugar, increases hepatic glycogen, muscle glycogen storage level, improves
The glycogen metabolic capability of diabetes rat, hence it is evident that reduce the organ index of each group rat, and not will cause body cholesterol and sweet
The content of oily three esters increases.
(4) in the present invention, a kind of hunchbacked milk tablet with auxiliary hyperglycemic function provided, just by the proportion of selenium and hunchbacked milk
It can reach apparent synergistic function, can ensure composition safety.Animal experiments show that present composition MTD is big
In 15000mg/kgbw, belong to nontoxic grade；Salmonella reversion test, mouse marrow cell micro nuclear test, mouse inbred strain, knot
Fruit is feminine gender；Rat is given 30 days with tri- 3.0,6.5,10.0g/kgbw/d dosage, animal subject ordinary circumstance is good,
The change without exception of weight, food utilization, organ weights, organ coefficient；Hematological indices and biochemical indicator are the results show that each
Item index is in normal range (NR)；Each internal organs histopathologic examination is showed no pathological change related with given the test agent, it is seen that this
Inventive composition is safe and reliable.
Specific embodiment
With reference to embodiment, the embodiment of the present invention is furthur described in detail, but the present invention is not limited to
Following embodiments.
Instrument and equipment used in the present invention：DG5033A type enzyme-linked immunosorbent assay instrument, duplex strainer, milk clarifier.
Reagent used in the present invention：Se-enriched yeast, streptozotocin (STZ), glycogen kit, total superoxide dismutase
Enzyme (T-SOD) kit, malonaldehyde (MDA) kit, triglyceride determination kit, blood sugar detection kit, cholesterol are surveyed
Determine kit.
In addition, in following embodiments, unless otherwise instructed, all reagents, raw material and the instrument selected in the present invention
It is all well known in the art selection, but does not limit implementation of the invention, other some reagents well known in the art and equipment all may be used
Implementation suitable for following implementation of the present invention.
Embodiment one：The preparation of hunchbacked milk tablet with auxiliary hyperglycemic function
Hunchbacked milk tablet with auxiliary hyperglycemic function is specifically prepared using following technical step：
(1) pretreatment of camel milk：It selects standard compliant camel milk as raw material, is filtered through duplex strainer, used
Milk clarifier purification, and raw milk is standardized；(2) preparation of hunchbacked milk powder：By the raw material after the standardization of step (1) preparation
Cream through homogeneous, sterilization, concentration, spray drying, bean jelly and is sieved into hunchbacked milk powder；(3) mixing film-making：Step (2) are taken to prepare
Hunchbacked milk powder be sufficiently mixed with Se-enriched yeast, tabletting to obtain the final product.
Embodiment two：The preparation of hunchbacked milk tablet with auxiliary hyperglycemic function
The camel milk material of selection must meet《GB 19301-2010》Standard requirements, filter, adopt by duplex strainer
It is purified, and raw milk is standardized according to dairy safety concerned countries standard requirements, mark prepared by preceding step with milk clarifier
Raw milk after standardization through homogeneous, sterilization, concentration, spray drying, bean jelly and is sieved into hunchbacked milk powder, procedure of processing requirement
It is executed according to Dairy Industry custom requirements；The hunchbacked milk powder 99.68% of step preparation before taking, and Se-enriched yeast 0.32%, wherein junket
Albumen, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein total content
It is 25%, Se content is 6.4 mg/kg, is sufficiently mixed, according to the tabletting of Conventional compression technology to obtain the final product.
Embodiment three：The preparation of hunchbacked milk tablet with auxiliary hyperglycemic function
The camel milk material of selection must meet《GB 19301-2010》Standard requirements, filter, adopt by duplex strainer
It is purified, and raw milk is standardized according to dairy safety concerned countries standard requirements, mark prepared by preceding step with milk clarifier
Raw milk after standardization through homogeneous, sterilization, concentration, spray drying, bean jelly and is sieved into hunchbacked milk powder, procedure of processing requirement
It is executed according to Dairy Industry custom requirements；The hunchbacked milk powder 99.5% of step preparation before taking, and Se-enriched yeast 0.4%, wherein junket egg
White, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein total content are
24%, Se content is 10.0m g/kg, is sufficiently mixed, according to the tabletting of Conventional compression technology to obtain the final product.
Example IV：The preparation of hunchbacked milk tablet with auxiliary hyperglycemic function
The camel milk material of selection must meet《GB 19301-2010》Standard requirements, filter, adopt by duplex strainer
It is purified, and raw milk is standardized according to dairy safety concerned countries standard requirements, mark prepared by preceding step with milk clarifier
Raw milk after standardization through homogeneous, sterilization, concentration, spray drying, bean jelly and is sieved into hunchbacked milk powder, procedure of processing requirement
It is executed according to Dairy Industry custom requirements；The hunchbacked milk powder 99.65% of step preparation before taking, and Se-enriched yeast 0.35%, wherein junket
Albumen, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein total content
It is 25%, Se content is 7.0 mg/kg, is sufficiently mixed, according to the tabletting of Conventional compression technology to obtain the final product.
Embodiment five：The preparation of hunchbacked milk tablet with auxiliary hyperglycemic function
The camel milk material of selection must meet《GB 19301-2010》Standard requirements, filter, adopt by duplex strainer
It is purified, and raw milk is standardized according to dairy safety concerned countries standard requirements, mark prepared by preceding step with milk clarifier
Raw milk after standardization through homogeneous, sterilization, concentration, spray drying, bean jelly and is sieved into hunchbacked milk powder, procedure of processing requirement
It is executed according to Dairy Industry custom requirements；The hunchbacked milk powder 99.62% of step preparation before taking, and Se-enriched yeast 0.38%, wherein junket
Albumen, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein total content
It is 24%, Se content is 7.9 mg/kg, is sufficiently mixed, according to the tabletting of Conventional compression technology to obtain the final product.
Embodiment six：The preparation of hunchbacked milk tablet with auxiliary hyperglycemic function
The camel milk material of selection must meet《GB 19301-2010》Standard requirements, filter, adopt by duplex strainer
It is purified, and raw milk is standardized according to dairy safety concerned countries standard requirements, mark prepared by preceding step with milk clarifier
Raw milk after standardization through homogeneous, sterilization, concentration, spray drying, bean jelly and is sieved into hunchbacked milk powder, procedure of processing requirement
It is executed according to Dairy Industry custom requirements；The hunchbacked milk powder 99.60% of step preparation before taking, and Se-enriched yeast 0.40%, wherein junket
Albumen, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein total content
It is 24%, Se content is 8.0 mg/kg, is sufficiently mixed, according to the tabletting of Conventional compression technology to obtain the final product.
Embodiment seven：The preparation of hunchbacked milk tablet with auxiliary hyperglycemic function
The camel milk material of selection must meet《GB 19301-2010》Standard requirements, filter, adopt by duplex strainer
It is purified, and raw milk is standardized according to dairy safety concerned countries standard requirements, mark prepared by preceding step with milk clarifier
Raw milk after standardization through homogeneous, sterilization, concentration, spray drying, bean jelly and is sieved into hunchbacked milk powder, procedure of processing requirement
It is executed according to Dairy Industry custom requirements；The hunchbacked milk powder 99.66% of step preparation before taking, and Se-enriched yeast 0.34%, wherein junket
Albumen, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein total content
It is 26%, Se content is 6.8 mg/kg, is sufficiently mixed, according to the tabletting of Conventional compression technology to obtain the final product.
Embodiment eight：The preparation of hunchbacked milk tablet with auxiliary hyperglycemic function
The camel milk material of selection must meet《GB 19301-2010》Standard requirements, filter, adopt by duplex strainer
It is purified, and raw milk is standardized according to dairy safety concerned countries standard requirements, mark prepared by preceding step with milk clarifier
Raw milk after standardization through homogeneous, sterilization, concentration, spray drying, bean jelly and is sieved into hunchbacked milk powder, procedure of processing requirement
It is executed according to Dairy Industry custom requirements；The hunchbacked milk powder 99.53% of step preparation before taking, and Se-enriched yeast 0.36%, wherein junket
Albumen, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein total content
It is 25%, Se content is 9.4 mg/kg, is sufficiently mixed, according to the tabletting of Conventional compression technology to obtain the final product.
Embodiment nine：The preparation of hunchbacked milk tablet with auxiliary hyperglycemic function
The camel milk material of selection must meet《GB 19301-2010》Standard requirements, filter, adopt by duplex strainer
It is purified, and raw milk is standardized according to dairy safety concerned countries standard requirements, mark prepared by preceding step with milk clarifier
Raw milk after standardization through homogeneous, sterilization, concentration, spray drying, bean jelly and is sieved into hunchbacked milk powder, procedure of processing requirement
It is executed according to Dairy Industry custom requirements；The hunchbacked milk powder 99.55% of step preparation before taking, and Se-enriched yeast 0.37%, wherein junket
Albumen, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein total content
It is 24%, Se content is 9.0 mg/kg, is sufficiently mixed, according to the tabletting of Conventional compression technology to obtain the final product.
Embodiment ten：The preparation of hunchbacked milk tablet with auxiliary hyperglycemic function
The camel milk material of selection must meet《GB 19301-2010》Standard requirements, filter, adopt by duplex strainer
It is purified, and raw milk is standardized according to dairy safety concerned countries standard requirements, mark prepared by preceding step with milk clarifier
Raw milk after standardization through homogeneous, sterilization, concentration, spray drying, bean jelly and is sieved into hunchbacked milk powder, procedure of processing requirement
It is executed according to Dairy Industry custom requirements；The hunchbacked milk powder 99.67% of step preparation before taking, and Se-enriched yeast 0.33%, wherein junket
Albumen, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein total content
It is 26%, Se content is 6.6 mg/kg, is sufficiently mixed, according to the tabletting of Conventional compression technology to obtain the final product.
Embodiment 11：Compliance test result test of the present invention
1. test method
Cleaning grade male SD rat 66, divide 11 groups.Embodiment two to ten sample of embodiment is set as 1.0g/kgbw/d,
Blank control group, model control group stomach-filling equal volume distilled water.Sample is investigated respectively to the shadow of hyperglycemia model rat sugar tolerance
It rings.
2. test result
Table 1：The Area under the curve of blood glucose of different formulations camel milk tablet effect
| Group | Area under the curve of blood glucose before being administered | Area under the curve of blood glucose after administration | P |
| Blank control group | 17.03±1.32 | 17.05±2.48 | |
| Two groups of embodiment | 17.13±1.81 | 20.29±0.97 | 0.091 |
| Three groups of embodiment | 16.85±1.49 | 20.48±1.58 | 0.181 |
| Example IV group | 16.96±2.00 | 18.75±1.71 | 0.011 |
| Five groups of embodiment | 17.20±1.95 | 19.02±1.22 | 0.013 |
| Six groups of embodiment | 16.88±1.64 | 19.07±1.47 | 0.016 |
| Seven groups of embodiment | 16.98±2.66 | 19.90±1.93 | 0.098 |
| Eight groups of embodiment | 16.97±1.98 | 20.07±2.09 | 0.138 |
| Nine groups of embodiment | 16.95±1.76 | 20.08±2.31 | 0.160 |
| Ten groups of embodiment | 16.87±2.04 | 20.00±1.56 | 0.084 |
| Model control group | 17.06±1.14 | 21.94±1.93 |
As shown in Table 1, the hunchbacked milk tablet hyperglycemic rat Area under the curve of blood glucose that embodiment two is provided to the formula of embodiment ten
It is below control group；Wherein, example IV, five, six the resulting Area under the curve of blood glucose of formula, compared to model control group,
Blood glucose reduces most obvious (P<0.05), while optimum formula of the invention is:Hunchbacked milk powder 99.60-99.65%, Se-enriched yeast
0.35-0.4 0%, wherein casein, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase
Enzyme, antalzyme protein total content >=20%, 8.0mg/kg >=Se content >=7.0 mg/kg.
Embodiment 12：There is the effect of hunchbacked milk tablet of auxiliary hyperglycemic function comparative test
1, test method
Cleaning grade male SD rat 75.If 2 groups of 1 group of composition (example IV proportion composition), composition (Se contents
For 3mg/kg, lower than the present invention claims), hunchbacked milk powder group be 3.0g/kgbw/d, blank control group, model control group stomach-filling
Equal volume distilled water.
Type II diabetes rat mould is induced using primary low dose of intraperitoneal injection streptozotocin (STZ, 50mg/kgBW)
Type.Fasting blood-glucose>300mg/dL is included in test.Stomach-filling 8 weeks, record amount of drinking water and food ration daily, observation rat macroscopic features,
Padding humidity, color and smell variation.Cutting tail every 2 weeks takes blood to survey blood glucose value (being deprived of food but not water 6h).Etherization is put to death and is solved
It cuts open, thought-read is dirty, liver, spleen and kidney weight in wet base.
2, test result
Table 2：Influence (n=6) to type II diabetes rat fasting blood-glucose value
* the P compared with model group<0.05, * * P compared with model group<0.01；# P compared with the group the 4th week<0.05
Compared with composition 2, hunchbacked milk powder, composition 1 (example IV proportion composition) can be substantially reduced hyperglycemia model
The lasting blood glucose level of animal.The present composition can effectively improve rat model fasting blood sugar, obviously rise after administration 4 weeks
Imitate (P<0.05) effect promoting (P after, being administered 6 weeks<0.01) effect has conspicuousness to improve (P for 4 weeks compared to what is worked after, being administered 8 weeks
<0.05).Composition 2, hunchbacked milk powder then work after administration 6 weeks (P<0.05) 8 weeks effect promotings, are administered.
Table 3：Influence (n=5) to type II diabetes Rats Organs and Tissues index
In terms of organ index, diabetes rat liver, spleen, renal index increased compared with blank group, composition 1
After (example IV proportion composition) is treated 8 weeks, hence it is evident that liver index, the index and spleen index for reducing each group rat reduce sugar
The internal organs burden of sick rat is urinated, and its influence to liver index is better than hunchbacked milk powder and 2 groups of composition, 2 groups of composition are only dropped
Low index and spleen index (the P of rat<0.05).
Embodiment 13：The effect of having the hunchbacked milk tablet of auxiliary hyperglycemic function, tests
Under the performance of above-mentioned series embodiment, it is further provided the hunchbacked milk slice prescription of optimization：Make hunchbacked milk powder and richness
In the mixture of selenium yeast, casein, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase
Enzyme, antalzyme protein total content >=20%, 6.4mg/kg >=Se content >=10.0mg/kg.Animal experiments show that control selenium contains
The range in 7. 0-8.0mg/kg is measured, good synergistic function can not only be reached, and mixture is with more good
Safety.
1, test method
Cleaning grade SD health male rat 105,198~258g of original body mass.If the present composition (match by example IV
Than) high, medium and low dosage group 3.0,1.0,0.5g/kgbw/ d, blank control group, model control group, model control group is with nothing
Bacterium water replaces tested material, and blank control group is not dealt with.Stomach-filling amount 1.0mL/100gbw, stomach-filling 34d.
1.1, normal rat hypoglycemic is tested
It selects healthy rat to be grouped by the blood glucose level of fasting 4h, divides control group, high dose group at random, every group 15.Control
Group gives solvent, and high dose group gives high dose concentration of test sample, and continuous 34d surveys fasting blood sugar (before fasting is with experiment),
Compare two groups of animal blood glucose values.
1.2, hyperglycemia model hypoglycemic is tested
The evaluation criterion requirement modeling that medicine supervises auxiliary hyperglycemic function test in guarantorization [2012] 107 is eaten according to state.It sees
Examine influence of the sample to sugar tolerance, cholesterol, triglycerides.
Blood glucose declines blood glucose value × 100% before %=(blood glucose value after blood glucose value-experiment before testing) ÷ is tested.
Area under the curve of blood glucose=0.5 × (+0.5 hour blood glucose value of 0 hour blood glucose value)/2+1.5 × (2 hours blood glucose values
+ 0.5 hour blood glucose value)/2
2, test result
2.1, test front and back the weight of animals situation of change
2.1.1, normal rat test front and back changes of weight situation
The original body mass of rat, 3.0g/kgbw/d group is compared with blank control group without significant difference (P>0.05), i.e.,
The original body mass of rat is more balanced between each group.Rat body weight after orally administration rat camel milk tablet 34d, 3.0g/kgbw/d
Group is compared with blank control group without significant difference (P>0.05).
2.1.2, changes of weight situation before and after hyperglycemia model rat test
The original body mass 0.5 of rat, 1.0,3.0g/kgbw/d, blank control group are compared with model control group without significant
Difference (P>0.05), i.e., the original body mass of rat is more balanced between each group.The hunchbacked milk tablet of orally administration rat various dose
34d, 0.5,1.0,3.0g/kgbw/d, blank control group weight compared with model control group without significant difference (P>0.05).
2.2, influence of the hunchbacked milk tablet to normal rat fasting blood-glucose
Before test, test after normal rat fasting blood-glucose 3.0g/kgbw/d group compared with blank group without significant difference
(P>0.05)。
Table 4：Influence (n=15) of the hunchbacked milk tablet to normal rat fasting blood-glucose (mmol/L)
| Grouping | Before test | After test |
| Blank control group | 6.96±0.64 | 6.98±0.56 |
| High dose group | 6.97±0.58 | 7.00±0.96 |
2.3, influence of the hunchbacked milk tablet to hyperglycemia model rat sugar tolerance
Measurement rat is to blood glucose value before glucose before test, to 0.5h, 2h blood glucose value after glucose, as the batch animal
Basic value.After the hunchbacked milk tablet 34d of orally administration rat various dose, each dosage group rat is measured to time point blood each before and after glucose
Sugar value, calculates Area under the curve of blood glucose.As a result, 0.5,1.0,3.0g/kgbw/d, fasting blood before blank control group rat test
Sugar, to 0.5h, 2h blood glucose value, Area under the curve of blood glucose after glucose compared with model control group, no significant difference (P>
0.05)。
Table 5：To the blood glucose value (n=15) before and after glucose before rat test
The blood glucose value and Area under the curve of blood glucose of model control group 0h, 0.5h, 2h are above blank control group (P<0.05),
Decision model carbohydrate metabolism disturbance is set up.The blood glucose value and Area under the curve of blood glucose of 3.0g/kgbw/d group 0. 5h, 2h are below
Model control group (P<0.05), 1. 0g/kgbw/d Area under the curve of blood glucose are lower than model control group (P<0.05).
Table 6：Influence (n=15) of the hunchbacked milk tablet to hyperglycemia model rat sugar tolerance
2.4, influence of the hunchbacked milk tablet to hyperglycemia model rat fat
The hunchbacked milk tablet 34d of orally administration rat various dose, measures each dosage group Rat Cholesterol and triglycerides.Knot
Fruit, model control group cholesterol and triglycerides are higher than blank control group, the statistically significant (P of difference<0.05), decision model
Disorders of lipid metabolism is set up.0.5,1.0,3.0g/kgbw/d group cholesterol and triglycerides are compared with model control group, difference
Not statistically significant (P>0.05).
Table 7：Influence (n=15) of the hunchbacked milk tablet to hyperglycemia model Serum Lipids in Experimental HypercholesterolemicRats
| Grouping | Cholesterol (mmol/L) | Triglycerides (mmol/L) |
| Blank control group | 1.15±0.17 | 1.28±0.26 |
| Low dose group | 1.35±0.20 | 1.36±0.91 |
| Middle dose group | 1.42±0.25 | 1.26±0.65 |
| High dose group | 1.32±0.27 | 1.23±0.74 |
| Model control group | 1.52±0.33 | 1.59±0.43 |
Hunchbacked milk tablet continuously gives normal rat 34d with 3.0g/kgbw/d, has no that it has the fasting blood-glucose of normal rat
It significantly affects.The blood glucose value and Area under the curve of blood glucose of model control group 0h, 0.5h, 2h are above blank control group (P<
0.05), model carbohydrate metabolism disturbance is set up.The blood glucose value and Area under the curve of blood glucose of 3.0g/kgbw/d group 0.5h, 2h are below
Model control group (P<0.05), 1.0g/kgbw/d group Area under the curve of blood glucose is lower than model control group (P< 0.05).Model
Control group cholesterol and triglycerides are higher than blank control group, the statistically significant (P of difference<0.05), model disorders of lipid metabolism
It sets up.0.5,1.0,3.0g/kgbw/d group cholesterol and triglycerides are compared with model control group, no significant difference
(P>0.05).According to evaluation criterion, camel milk tablet described in the invention patent has the function of auxiliary hyperglycemic.
Embodiment 14：The human feeding trial of hunchbacked milk tablet with auxiliary hyperglycemic function
1. test method
Selection state of an illness after diet control or oral hypoglycemic agents treatment is more stable, does not need replacement types of drugs and dosage,
Only take the adult Patients with NIDDM of maintenance dose.Using itself between group two kinds of control designs.According to the saccharification of subject
Hemoglobin and blood glucose level are randomly divided into test-meal group and control group, consider to influence as far as possible the principal element such as course of disease of result,
Type of taking medicine etc. carries out harmonious inspection, with the comparativity between guarantee group.It completes test-meal process and is included in statistics person totally 104,
Wherein test-meal group 52, control group 52.
1.1 edible dosage and time
Test-meal group takes given the test agent, and control group takes placebo.Instructions of taking：Oral, 2 times a day, 3 tablets once.Examination
Food observing time 60 days.
1.2 efficacy measures
Symptom Observation, fasting blood-glucose, 2h-plasma glucose.
2. test result
2.1 clinicing symptom observation
Table 8：Clinical symptoms total mark statistics
Table:9：The variation of clinical symptoms before and after test-meal
Before test-meal clinical symptoms integrated value test-meal group compared with the control group, no significant difference (P>0.05), that is, face
It is more balanced between test-meal group and control group before bed symptom integral value test-meal.The hunchbacked milk tablet of the test-meal present invention is after 60 days, clinical symptoms
Improve situation by table 8,9 as it can be seen that test-meal group clinical symptoms total mark value is lower than control group (P<0.05).Test-meal group polydipsia,
Polyorexia, diuresis, fatigue and weakness improvement rate be apparently higher than control group (P<0.05).
The influence of 2.2 pairs of fasting blood-glucoses
Table 10：Selenium-rich camel milk tablet is to fasting blood-glucose (mmol/L)Influence
Before test-meal test-meal group fasting blood-glucose compared with the control group, no significant difference (P>0. 05).Test-meal after test-meal
Group fasting blood-glucose is lower than control group, and fasting blood-glucose declines percentage and is higher than control group (P<0.05).Self pair ratio before and after test-meal
Compared with than averagely reducing by 11.52% (P before test-meal after test-meal group fasting blood-glucose test-meal<0.05).After control group fasting blood-glucose test-meal with
Compare before test-meal, no significant difference (P>0.05).
The influence of 2.3 pairs of 2h-plasma glucoses
Table 11：Selenium-rich camel milk tablet is to 2h-plasma glucose (mmol/L)Influence
Before test-meal test-meal group 2h-plasma glucose compared with the control group, no significant difference (P> 0.05).It is tried after test-meal
Food group 2h-plasma glucose is lower than control group, and 2h-plasma glucose declines percentage and is higher than control group (P<0.05).Test-meal front and back itself
Paired comparisons, 2h-plasma glucose is than averagely reducing by 10.63% (P after test-meal group test-meal before test-meal<0.05).The postprandial 2h of control group
After blood glucose test-meal compared with before test-meal, no significant difference (P>0.05).
These parameters are comprehensively compared, camel milk tablet composition provided by the invention works faster：Onset time is only 4 weeks, bright
It is aobvious that less than composition 2, hunchbacked milk powder, and after action 4 weeks, blood sugar decreasing effect is obviously improved (P<0.05), type II diabetes disease
People takes hunchbacked milk tablet 2 months of the invention, it is seen that auxiliary hyperglycemic function.The present invention passes through optimum organization, hence it is evident that improves hunchbacked milk
Auxiliary hyperglycemic effect of powder has positive effect to universal in diabetic population of hunchbacked milk powder.
The above embodiments be only preferred embodiments of the present invention will be described, not to the scope of the present invention into
Row limits, and without departing from the spirit of the design of the present invention, those of ordinary skill in the art make technical solution of the present invention
Various changes and improvements out, should all fall into present invention determine that protection scope in.
Claims (5)
1. a kind of hunchbacked milk tablet with auxiliary hyperglycemic function, which is characterized in that in parts by weight, including hunchbacked milk powder
99.50-99.68%, Se-enriched yeast 0.32-0.50%.
2. a kind of hunchbacked milk tablet with auxiliary hyperglycemic function as described in claim 1, which is characterized in that the hunchbacked milk powder
99.60%-99.65%, Se-enriched yeast 0.35%-0.40%.
3. a kind of hunchbacked milk tablet with auxiliary hyperglycemic function as described in claim 1, which is characterized in that the hunchbacked milk tablet
Middle casein, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein are total
Content >=20%, 10.0mg/kg >=Se content >=6.4mg/kg.
4. a kind of hunchbacked milk tablet with auxiliary hyperglycemic function as described in claim 1, which is characterized in that the hunchbacked milk tablet
Middle casein, alpha lactalbumin, seralbumin, lactoferrin, immunoglobulin, lactoperoxidase, antalzyme protein are total
Content >=20%, 8.0mg/kg >=Se content >=7.0mg/kg.
5. a kind of preparation method of the hunchbacked milk tablet with auxiliary hyperglycemic function as described in claim 1, which is characterized in that tool
Body uses following technical step：
（1）The pretreatment of camel milk：It selects standard compliant camel milk as raw material, is filtered through duplex strainer, using net cream
Machine purification, and raw milk is standardized；
（2）The preparation of hunchbacked milk powder：By step（1）Raw milk after the standardization of preparation, through homogeneous, sterilization, concentration, spraying dry
Dry, bean jelly and it is sieved into hunchbacked milk powder；
（3）Mixing film-making：Take step（2）Hunchbacked milk powder and the Se-enriched yeast of preparation are sufficiently mixed, and tabletting to obtain the final product.
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| CN116694720A (en) * | 2023-06-27 | 2023-09-05 | 新疆新驼乳业有限公司 | Camel milk enzymolysis polypeptide with blood sugar reducing, blood lipid reducing and anti-inflammatory effects and preparation method thereof |
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