CN108794140A - A kind of solid pharmaceutical preparation and its preparation method and application containing alginic acid and trace element built - Google Patents
A kind of solid pharmaceutical preparation and its preparation method and application containing alginic acid and trace element built Download PDFInfo
- Publication number
- CN108794140A CN108794140A CN201710307348.9A CN201710307348A CN108794140A CN 108794140 A CN108794140 A CN 108794140A CN 201710307348 A CN201710307348 A CN 201710307348A CN 108794140 A CN108794140 A CN 108794140A
- Authority
- CN
- China
- Prior art keywords
- trace element
- pharmaceutical preparation
- solid pharmaceutical
- solid
- alginic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000010443 alginic acid Nutrition 0.000 title claims abstract description 54
- 229920000615 alginic acid Polymers 0.000 title claims abstract description 54
- 150000004781 alginic acids Chemical class 0.000 title claims abstract description 54
- 239000000783 alginic acid Substances 0.000 title claims abstract description 53
- 229960001126 alginic acid Drugs 0.000 title claims abstract description 53
- 239000011573 trace mineral Substances 0.000 title claims abstract description 51
- 235000013619 trace mineral Nutrition 0.000 title claims abstract description 51
- 239000007787 solid Substances 0.000 title claims abstract description 44
- 239000000825 pharmaceutical preparation Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000004563 wettable powder Substances 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims description 34
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 16
- 239000011701 zinc Substances 0.000 claims description 15
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 14
- 235000013339 cereals Nutrition 0.000 claims description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 10
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 10
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 9
- 239000011777 magnesium Substances 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 229910052742 iron Inorganic materials 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 7
- 239000011787 zinc oxide Substances 0.000 claims description 7
- -1 alkyl phenol Chemical compound 0.000 claims description 6
- 229910052796 boron Inorganic materials 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 6
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 6
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 6
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 claims description 6
- 229940007718 zinc hydroxide Drugs 0.000 claims description 6
- 229910021511 zinc hydroxide Inorganic materials 0.000 claims description 6
- 241001474374 Blennius Species 0.000 claims description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 5
- 229910052749 magnesium Inorganic materials 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 5
- 229910052725 zinc Inorganic materials 0.000 claims description 5
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 4
- 229920002261 Corn starch Polymers 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 4
- 239000002518 antifoaming agent Substances 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000009833 condensation Methods 0.000 claims description 4
- 230000005494 condensation Effects 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- 239000008120 corn starch Substances 0.000 claims description 4
- 229940099112 cornstarch Drugs 0.000 claims description 4
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 4
- 239000002270 dispersing agent Substances 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 4
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 4
- 239000000347 magnesium hydroxide Substances 0.000 claims description 4
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 4
- 235000010755 mineral Nutrition 0.000 claims description 4
- 239000011707 mineral Substances 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- 239000011667 zinc carbonate Substances 0.000 claims description 4
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 4
- 235000004416 zinc carbonate Nutrition 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical group [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 229960000892 attapulgite Drugs 0.000 claims description 3
- 239000007859 condensation product Substances 0.000 claims description 3
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 3
- 150000002191 fatty alcohols Chemical class 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 235000012055 fruits and vegetables Nutrition 0.000 claims description 3
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 3
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 claims description 3
- 229910052625 palygorskite Inorganic materials 0.000 claims description 3
- 229920001983 poloxamer Polymers 0.000 claims description 3
- 239000001384 succinic acid Substances 0.000 claims description 3
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 125000005227 alkyl sulfonate group Chemical group 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- 238000004821 distillation Methods 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 229920005610 lignin Polymers 0.000 claims description 2
- ZPEJZWGMHAKWNL-UHFFFAOYSA-L zinc;oxalate Chemical compound [Zn+2].[O-]C(=O)C([O-])=O ZPEJZWGMHAKWNL-UHFFFAOYSA-L 0.000 claims description 2
- 150000004696 coordination complex Chemical class 0.000 claims 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 claims 1
- 239000003337 fertilizer Substances 0.000 abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 26
- 239000000203 mixture Substances 0.000 abstract description 21
- 239000008187 granular material Substances 0.000 abstract description 9
- 239000006185 dispersion Substances 0.000 abstract description 8
- 239000013049 sediment Substances 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 description 14
- 230000000903 blocking effect Effects 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 230000012010 growth Effects 0.000 description 6
- 230000029553 photosynthesis Effects 0.000 description 6
- 238000010672 photosynthesis Methods 0.000 description 6
- 238000001556 precipitation Methods 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 230000004060 metabolic process Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 239000012190 activator Substances 0.000 description 3
- 229930002875 chlorophyll Natural products 0.000 description 3
- 235000019804 chlorophyll Nutrition 0.000 description 3
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 229930192334 Auxin Natural products 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229920001732 Lignosulfonate Polymers 0.000 description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 150000008052 alkyl sulfonates Chemical class 0.000 description 2
- 239000002363 auxin Substances 0.000 description 2
- UDHMTPILEWBIQI-UHFFFAOYSA-N butyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(=O)OCCCC)=CC=CC2=C1 UDHMTPILEWBIQI-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 229940116318 copper carbonate Drugs 0.000 description 2
- GEZOTWYUIKXWOA-UHFFFAOYSA-L copper;carbonate Chemical compound [Cu+2].[O-]C([O-])=O GEZOTWYUIKXWOA-UHFFFAOYSA-L 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N hexanedioic acid Natural products OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
- 229960001763 zinc sulfate Drugs 0.000 description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 description 2
- LDMOEFOXLIZJOW-UHFFFAOYSA-N 1-dodecanesulfonic acid Chemical compound CCCCCCCCCCCCS(O)(=O)=O LDMOEFOXLIZJOW-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 1
- 108050008072 Cytochrome c oxidase subunit IV Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 108010074122 Ferredoxins Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108090000913 Nitrate Reductases Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000004103 aerobic respiration Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 238000004178 biological nitrogen fixation Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- VEPSWGHMGZQCIN-UHFFFAOYSA-H ferric oxalate Chemical compound [Fe+3].[Fe+3].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O VEPSWGHMGZQCIN-UHFFFAOYSA-H 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- 239000004021 humic acid Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 208000006278 hypochromic anemia Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052622 kaolinite Inorganic materials 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000019691 monocalcium phosphate Nutrition 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 239000003375 plant hormone Substances 0.000 description 1
- 230000007198 pollen germination Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000022558 protein metabolic process Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C05—FERTILISERS; MANUFACTURE THEREOF
- C05D—INORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C; FERTILISERS PRODUCING CARBON DIOXIDE
- C05D9/00—Other inorganic fertilisers
-
- C—CHEMISTRY; METALLURGY
- C05—FERTILISERS; MANUFACTURE THEREOF
- C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
- C05G3/00—Mixtures of one or more fertilisers with additives not having a specially fertilising activity
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Fertilizers (AREA)
Abstract
The present invention provides a kind of solid pharmaceutical preparation and its preparation method and application containing alginic acid and trace element built, the solid pharmaceutical preparation includes alginic acid and solid-state trace element, the solid-state trace element refers to that trace element exists in solid form, which can be wettable powder or water dispersion granule.The solid pharmaceutical preparation provided by the invention effectively prevents the generation of sediment when bucket mixes, strainer and nozzle will not be blocked, to make the composition containing the alginic acid and trace element built be more readily processed and store, good fluidity, and substantially increase the fertilizer efficiency of alginic acid and trace element.
Description
Technical field
The present invention relates to fertilizer field, has and be related to a kind of solid pharmaceutical preparation and its preparation method and application more particularly to one
Solid pharmaceutical preparation and its preparation method and application of the kind containing alginic acid and trace element built.
Background technology
Seaweed acids foliar fertilizer be integrate nutritional ingredient, antibiotics, plant hormone new-type fertilizer.It is by special
Different biochemical process processing, essence substance is efficiently extracted out from natural seaweed, natural activity component is greatly remained, contains
Various mineral matter elements such as a large amount of non-nitrogen containing organic matter, terrestrial plant incomparable K, Ca, Mg, Fe, Zn, Cu, B and abundant
Vitamin, especially rich in specific algal polysaccharides, alginic acid, highly unsaturated fatty acid and a variety of natural plants in seaweed
Growth regulator.Therefore, liquid seaweed manure is a kind of novel and multifunctional liquid fertilizer.
Trace element, especially Zn, Mg, Fe, B element are one of trace elements necessary to plant.Zn is with cationic Zn2+Shape
State is absorbed by plants.Mobility of the Zn in plant belongs to medium.Zn affects the synthesis of auxin indirectly in crop body, as
Growth cellulose content when object lacks Zn in stem and bud is reduced, and growth stays cool, and plant is short and small；Zn is also many enzymes simultaneously
Activator by generating wide influence to plant carbon and nitrogen metabolism, therefore contributes to photosynthesis；Zn can also enhance plant simultaneously
The resistance of object；Kernel weight is improved, the ratio of seed and cane is changed.Mg is the micro battalion needed for plant normal growth development
Element is supported, is the constituent of chlorophyll and plant element, lacking Mg chlorophyll cannot form, and photosynthesis can not carry out；Mg is a variety of
The activator of enzyme can promote conversion and its metabolic process of carbohydrate, to the respiration in the metabolism of carbohydrate, crop body
Play an important roll；Mg can promote the synthesis of fat and protein, can make phposphate enzyme activation, moreover it is possible to promote vitamin A and C
Formation, improve vegetables and fruit quality.Although Fe is not the ingredient of chlorophyll, when ferro element subalimentation, leaf can be made
The synthesis of green element is hindered, and chlorosis phenomenon occurs for blade, influences the formation of photosynthesis and carbohydrate, is photosynthesis
Essential element；Fe is the indispensable cytochrome oxidase of plant aerobic respiration, catalase, peroxidase
Deng group ingredient；Ferredoxin (Fd) is an iron-containing electron transfer protein, is present in chloroplaset (full iron in plant
80% be contained in chloroplaset), take part in the electron transmission of photosynthesis, nitrate reductase, biological nitrogen fixation etc..Boron element promotes thin
Born of the same parents extend and tissue differentiation, accelerate enzyme metabolism and lignin is formed, carbohydrate transport and protein metabolism, promote root system life
Long development, enhances crop anti-adversity, promotes early ripening of the crops modification, promotes pollen germination and pollen tube growth.
It has been investigated that alginic acid and trace-element fertilizer (micro- fertilizer) collocation are more preferable using fertilizer efficiency, there is synergistic function,
Especially zinc fertilizer can more effectively inhibit the generation of virosis.However alga fertilizer and micro- fertilizer currently on the market is water solubility
Liquid fertilizer.Mixed in use, since water-soluble alga fertilizer is different from water-soluble micro- adipic acid alkalinity matter in bucket, alga fertilizer shows alkali
Property, micro- fertilizer is aobvious acid, is susceptible to precipitation, while reducing the fertilizer efficiency of alginic acid and micro- fertilizer, and the sediment of formation also has blocking to filter
The possibility of net and nozzle, makes troubles to user, reduces alga fertilizer and micro- fertile possibility used of arranging in pairs or groups.
CN103044162B discloses a kind of organic water soluble fertilizer containing alginic acid；Wherein 40~50 parts of alginic acids, 15
~25 parts of humic acid, 10~20 parts of compound amino acids, 3~5 parts of vitamins and trace element mixture, 3~5 parts of urea, 5~8
Part P2O5, 5~8 parts of K2O, 300~500 parts of water compositions.Wherein the vitamin and trace element is that kelp crushes liquid extraction institute
?.Although the patent is alginic acid and trace element built product, but still be liquid fertilizer, and thoroughly solve alga fertilizer with it is micro-
Fertilizer may lead to the problem of precipitation because of acid-base value difference.
Invention content
It is water-soluble liquid fertilizer to overcome alga fertilizer on the market and micro- fertilizer, bucket mixes use and is likely to occur precipitation, blocks
Mister head and reduce alginic acid and micro- fertilizer fertilizer efficiency defect, the present invention provides one kind can overcome the above problem and
The solid pharmaceutical preparation and its preparation method and application of alginic acid and trace element built that is easy to process, storing and use.
For this purpose, present invention employs following technical schemes：
In a first aspect, the present invention provides a kind of solid pharmaceutical preparation containing alginic acid and trace element built comprising sea
Alginic acid and solid-state trace element.
The present invention is to provide a kind of solid pharmaceutical preparation containing alginic acid and trace element built, i.e. said preparation is with solid
Can be specifically wettable powder or water dispersion granule existing for the form of composition.
Use the composition containing alginic acid and trace element built obtained in the form of solid pharmaceutical preparation, the solid pharmaceutical preparation
The defect present in previous Water-soluble liquid fertilizer can effectively be overcome, for example, being needed to it when using Water-soluble liquid fertilizer
It carries out the mixed dilution of bucket, and precipitation is easy tod produce due to the incompatibility between alginic acid and trace element when the mixed dilution of bucket, from
And the fertilizer efficiency of alginic acid and trace element can be not only reduced, while the precipitation can also block sprayer strainer and nozzle, cause to set
Standby abrasion；However when solid pharmaceutical preparation using the present invention, then there is no the generation precipitated when dilution is blended, sea is improved
The fertilizer efficiency of alginic acid and trace element；Since it is mixed without bucket, mobility is more preferable, keeps storage transport more convenient.
In the solid pharmaceutical preparation, mass percentage shared by alginic acid is 20~70%, such as 20%, 22%, 25%,
28%, 30%, 32%, 35%, 38%, 40%, 42%, 45%, 48%, 50%, 52%, 54%, 58%, 60%, 62%,
65% or 70%, the mass percentage shared by solid-state trace element is 3~30%, such as 3%, 5%, 8%, 10%, 12%,
15%, 18%, 20%, 22%, 25%, 28% or 30%.
In the present invention, the solid-state trace element refers to that trace element exists in solid form, and preferably trace element is with oxygen
At least one of compound, hydroxide, metal inorganic salt, metal organic salt or metallic complex salt form exists, such as
Same element, can be oxidized object simultaneously and hydroxide mixing is added to as solid-state trace element in alginic acid.
The trace element of solid-state form is used in the present invention, compares the trace element of the liquid form added in the past,
Such as sulfate, borate, calcium superphosphate to add etc. habitually in the past in the form of, spray liquid can be suspended in the form of granular solids
In, meet it is insoluble when water dilution, therefore can overcome water-soluble alga fertilizer and water-soluble micro- adipic acid it is alkaline it is different caused by
Deposited phenomenon so as to avoid the generation of sediment, and makes strainer and nozzle be not plugged up, improves alginic acid and micro member
The fertilizer efficiency of element.
Preferably, the trace element be in zinc, magnesium, iron, calcium, copper or boron element any one or at least two it is mixed
Close, then solid-state trace element be correspondingly iron, magnesium, iron, calcium, the oxide of copper or boron element, hydroxide, metal inorganic salt,
Metal organic salt or metallic complex salt etc..
The trace element of the present invention is preferably Zn-ef ficiency, this is because, Zn affects auxin indirectly in crop body
Synthesis, the growth cellulose content when crop lacks Zn in stem and bud are reduced, and growth stays cool, and plant is short and small；Zn simultaneously
It is the activator of many enzymes, by generating wide influence to plant carbon and nitrogen metabolism, therefore contributes to photosynthesis；Zn simultaneously
The resistance of plant can also be enhanced；Kernel weight is improved, changes the ratio of seed and cane, therefore when using alginic acid and solid-state
When zinc compounds, there is better facilitation for plant growth.
Preferably, the solid-state trace element can be zinc oxide, zinc hydroxide, zinc carbonate, zinc oxalate, iron oxide, hydrogen
In magnesia or calcium carbonate any one or at least two mixing, wherein typical but non-limiting be mixed into：Zinc oxide
With the mixing of zinc hydroxide, the mixing of zinc carbonate and iron oxide, the mixing of magnesium hydroxide and zinc hydroxide, calcium carbonate and zinc carbonate
Mixing.
Can also include several functions auxiliary agent, such as dispersant, wetting agent, defoaming in solid pharmaceutical preparation of the present invention
Any one in agent, glidant or filler or at least two mixing, it should be understood by those skilled in the art that being helped for functionality
Agent, can add one such, can also be the mixing of wherein two or more, those skilled in the art are according to actual needs
Corresponding adjustment can be made.
Preferably, the dispersant is alkylsulfonate, lignosulfonates, naphthalene sulphonate formaldehyde condensation polymer, fatty alcohol
In polyoxyethylene ether or thermally coupled distillation columns any one or at least two mixing, wherein typical but non-limit
Property processed is mixed into：The mixing of alkylsulfonate and lignosulfonates, naphthalene sulphonate formaldehyde condensation polymer and alkylsulfonate
Mixing, the mixing of fatty alcohol polyoxyethylene ether and naphthalene sulphonate formaldehyde condensation polymer.
Preferably, the wetting agent is dodecyl sodium sulfate, alkyl phenol, nonylphenol polyoxyethylene ether, succinic acid sulfonic acid
In salt, sodium butylnaphthalenesulfonate salt, alcohol ethoxylates or alkylnaphthalene sulfonate formaldehyde condensation products any one or
At least two mixing, wherein typical but non-limiting be mixed into：The mixing of dodecane sulfonate and alkyl phenol, nonyl phenol
The mixing of polyoxyethylene ether and alkyl phenol, the mixing of succinic acid sulfonate and sodium butylnaphthalenesulfonate salt, the contracting of fatty alcohol ethylene oxide
Close the mixing of object, alkylnaphthalene sulfonate formaldehyde condensation products and dodecyl sodium sulfate.
Preferably, the antifoaming agent is organosilicon or type siloxane, and for type siloxane, those skilled in the art should be bright
, refer to type siloxane antifoaming agent commonly used in the art, those skilled in the art according to actual needs can carry out it often
Rule selection.
Preferably, the glidant is any one in white carbon, talcum powder or Pluronic PE 6800 or at least two
The mixing of kind, wherein typical but non-limiting be mixed into：The mixing of white carbon and talcum powder, talcum powder and EO/PO blocks are total
The mixing of polymers, the mixing of white carbon, talcum powder and Pluronic PE 6800.
Preferably, the filler is kaolin, montmorillonite clay, attapulgite, white carbon, plant fiber, mineral fibres, breast
In sugar, cornstarch or sucrose any one or at least two mixing, wherein typical but non-limiting be mixed into：Kaolinite
Soil and montmorillonite clay mixing, the mixing of attapulgite and white carbon, the mixing of plant fiber and mineral fibres, cornstarch and
The mixing of sucrose, the mixing of lactose, cornstarch and sucrose.
Second aspect, the present invention also provides the solids containing alginic acid and trace element built as described in relation to the first aspect
The preparation method of preparation comprising following steps：
(1) alginic acid and solid-state trace element and optional functional aid are sufficiently mixed in proportion；
(2) solid composite that pulverising step (1) obtains obtains the solid pharmaceutical preparation to 2~20 μm of the grain size needed.
In the present invention, in the preparation method of the solid pharmaceutical preparation, its operation step can be adjusted according to the form of final preparation
Suddenly, such as when preparing wettable powder, after each component is mixed, the particle size range that is needed by air-flow crushing, you can；
When preparing water dispersion granule, after each component is mixed, other than the particle size range that air-flow crushing to be passed through is needed, also
The enough water of extrudable thickener to be added in the mixture, paste extrudate is obtained by Squeezinggranulator, through being dried to obtain
Water dispersion granule.
For the particle size range obtained after crushing, usually controlled at 2~20 μm, for example, 2 μm, 5 μm, 10 μm, 12 μm,
15 μm, 18 μm or 20 μm, help to better disperse when suspending using the granule of the particle size range.
The solid pharmaceutical preparation provided by the invention can have and promote as the foliage spray of cereal crops, fruits and vegetables and flowers
Into the effect of cereal crops, fruits and vegetables and the production of flowers and plants.
Compared with prior art, the present invention at least has the advantages that：
(1) present invention is by using the combination containing alginic acid and trace element built obtained in the form of solid pharmaceutical preparation
Object can effectively overcome the precipitation generated in the past due to the incompatibility between alginic acid and trace element in the mixed dilution of bucket
Phenomenon to effectively prevent the generation of sprayer strainer and filter clogging, while also substantially increasing alginic acid and micro-
The fertilizer efficiency of secondary element；
(2) present invention is by compounding the trace element of alginic acid and solid form, the trace element of solid form
It is not soluble in water when meeting water dilution, but be suspended in spray liquid with solid particle forms, it is mixed that there is no need to buckets, said preparation stream
Dynamic property is good, keeps storage transport more convenient, is used convenient for peasant household.
Specific implementation mode
Of the invention for ease of understanding, it is as follows that the present invention enumerates embodiment.Those skilled in the art are it will be clearly understood that the implementation
Example is only to aid in the understanding present invention, should not be regarded as a specific limitation of the invention, " % " refers both to mass percentage below.
Embodiment 1：+ 30% zinc oxide wettable powder of 30% alginic acid
Preparation process：Each component is sufficiently mixed to obtain mixture by being formulated, makes mixture grain size D90 by air-flow crushing
Wettable powders of 15 μm of the < to get+30% zinc oxide of 30% alginic acid.
Embodiment 2：+ 20% zinc hydroxide water dispersion granule of 50% alginic acid
Preparation process：Each component is sufficiently mixed to obtain mixture by being formulated, makes mixture grain size D90 by air-flow crushing
15 μm of <；Then the enough water of extrudable thickener is added in the mixture；Paste-extruded object is obtained by Squeezinggranulator；It is dry
The extrudate then obtains the water dispersion granule of+20% zinc hydroxide of 50% alginic acid.
Embodiment 3：+ 10% iron oxide wettable powder of 60% alginic acid
Preparation process：Each component is added sequentially to enough water in the case of stirring by formula, is stirred,
It is sanded by sand mill so that product is sanded in mixture grain size D50≤3 μm, spray drying so that desciccate moisture contains
Amount is less than 0.5% to get the wettable powder of+10% iron oxide of 60% alginic acid.
Embodiment 4：+ 25% magnesium hydroxide water dispersion granule of 50% alginic acid
Preparation process：Each component is sufficiently mixed to obtain mixture by being formulated, makes mixture grain size D90 by air-flow crushing
15 μm of <, is then added the enough water of extrudable thickener in the mixture；Paste-extruded object is obtained by Squeezinggranulator；It is dry
The extrudate then obtains the water dispersion granule of+25% magnesium hydroxide of 50% alginic acid.
Embodiment 5：+ 20% basic copper carbonate wettable powder of 20% alginic acid
Preparation process：Each component is sufficiently mixed to obtain mixture by being formulated, makes mixture grain size D90 by air-flow crushing
Wettable powders of 15 μm of the < to get+20% basic copper carbonate of 20% alginic acid.
Embodiment 6：+ 25% calcium carbonate wettable powder of 45% alginic acid
Preparation process：Each component is sufficiently mixed to obtain mixture by being formulated, after first passing through mechanical crushing, then has air-flow powder
The broken wettable powder for making mixture grain size D90≤15 μm to get+25% calcium carbonate of 45% alginic acid.
Embodiment 7：+ 15% ferric oxalate wettable powder of 60% alginic acid
Preparation process：Each component is sufficiently mixed to obtain mixture by being formulated, after first passing through mechanical crushing, then has air-flow powder
The broken wettable powder for making mixture grain size D90≤15 μm to get+15% calcium oxalate of 60% alginic acid.
Comparative example 1
Compared with Example 1, alginic acid is replaced with into sodium alginate, zinc oxide is replaced with into zinc sulfate, and add water, made
At water soluble fertilizer, specially：
Comparative example 2
Compared with Example 1, alginic acid is only replaced with into sodium alginate, and adds water, water soluble fertilizer is made, specifically
For：
Comparative example 3
Compared with Example 1, zinc oxide is only replaced with into zinc sulfate, and adds water, water soluble fertilizer is made, specially：
The sample that above-described embodiment 1~7 and comparative example 1~3 are prepared is diluted with water to application concentration, stirring point
It dissipates and uniformly obtains spray liquid, after standing spray liquid 1h, pass through the sieve of 325 mesh (44 μm), observation respectively in the case of stirring
Whether spray liquid has the ratio size that residue and residue account for test specimen, test result such as table 1 by situation and sieve
It is shown.
Ratio (%)=(M2-M1)/M samples * 100%
Wherein, M1：The nt wt net weight of sieve；M2：After dilution is by wet screening, the weight of sieve after weight is dried；M samples：Add
Enter into water the weight of test specimen.
Table 1
| Sample | Test result | Ratio |
| Embodiment 1 | It passes through, no blocking mesh phenomenon, almost noresidue on sieve | 0.55% |
| Embodiment 2 | It passes through, no blocking mesh phenomenon, almost noresidue on sieve | 0.39% |
| Embodiment 3 | It passes through, no blocking mesh phenomenon, almost noresidue on sieve | 0.21% |
| Embodiment 4 | It passes through, no blocking mesh phenomenon, almost noresidue on sieve | 0.63% |
| Embodiment 5 | It passes through, no blocking mesh phenomenon, almost noresidue on sieve | 0.46% |
| Embodiment 6 | It passes through, no blocking mesh phenomenon, almost noresidue on sieve | 0.42% |
| Embodiment 7 | It passes through, no blocking mesh phenomenon, almost noresidue on sieve | 0.50% |
| Comparative example 1 | It cannot pass through, Severe blockage mesh, there are many residue | 35.1% |
| Comparative example 2 | It cannot pass through, Severe blockage mesh, there are many residue | 40.2% |
| Comparative example 3 | It cannot pass through, Severe blockage mesh, there are many residue | 35.2% |
Test result in table 1 can illustrate, consolidating containing alginic acid and solid-state trace element built provided by the invention
Body preparation is without the possibility for blocking sprayer strainer and nozzle, the generation not precipitated, so as to improve alginic acid and micro member
The fertilizer efficiency of element；And due to its good fluidity, to keep storage and transport more convenient, peasant household's use of being also more convenient for.
Applicant states that the present invention illustrates detailed process equipment and the technological process of the present invention by above-described embodiment,
But the invention is not limited in above-mentioned detailed process equipment and technological processes, that is, it is above-mentioned detailed not mean that the present invention has to rely on
Process equipment and technological process could be implemented.Person of ordinary skill in the field it will be clearly understood that any improvement in the present invention,
The addition of equivalence replacement and auxiliary element to each raw material of product of the present invention, the selection etc. of concrete mode all fall within the present invention's
Within protection domain and the open scope.
Claims (9)
1. a kind of solid pharmaceutical preparation containing alginic acid and trace element built, which is characterized in that the solid pharmaceutical preparation includes seaweed
Acid and solid-state trace element.
2. solid pharmaceutical preparation as described in claim 1, which is characterized in that in the solid pharmaceutical preparation, the quality hundred shared by alginic acid
It is 20~70% to divide content, and the mass percentage shared by solid-state trace element is 3~30%.
3. solid pharmaceutical preparation as claimed in claim 1 or 2, which is characterized in that the solid pharmaceutical preparation is wettable powder or moisture
Scattered seed agent.
4. the solid pharmaceutical preparation as described in one of claim 1-3, which is characterized in that the solid-state trace element refers to trace element
Exist in solid form, preferably trace element is with oxide, hydroxide, metal inorganic salt, metal organic salt or metal complex
At least one of salt form exists.
5. the solid pharmaceutical preparation as described in one of claim 1-4, which is characterized in that the trace element is zinc, magnesium, iron, calcium, copper
In boron element any one or at least two mixing, preferred Zn-ef ficiency；
Preferably, the solid-state trace element be zinc oxide, zinc hydroxide, zinc carbonate, zinc oxalate, iron oxide, magnesium hydroxide or
In calcium carbonate any one or at least two mixing.
6. the solid pharmaceutical preparation as described in one of claim 1-5, which is characterized in that the solid pharmaceutical preparation further includes that functionality helps
Agent；
Preferably, the functional aid be dispersant, wetting agent, antifoaming agent, glidant or filler in any one or at least
Two kinds of mixing.
7. solid pharmaceutical preparation as claimed in claim 6, which is characterized in that the dispersant is alkylsulfonate, lignin sulfonic acid
In salt, naphthalene sulphonate formaldehyde condensation polymer, fatty alcohol polyoxyethylene ether or thermally coupled distillation columns any one or
At least two mixing；
Preferably, the wetting agent is dodecyl sodium sulfate, alkyl phenol, nonylphenol polyoxyethylene ether, succinic acid sulfonate, fourth
Any one in base naphthalene sulfonate salt, alcohol ethoxylates or alkylnaphthalene sulfonate formaldehyde condensation products or at least two
The mixing of kind；
Preferably, the antifoaming agent is organosilicon or type siloxane；
Preferably, the glidant is any one in white carbon, talcum powder or Pluronic PE 6800 or at least two
Mixing；
Preferably, the filler be kaolin, montmorillonite clay, attapulgite, white carbon, plant fiber, mineral fibres, lactose,
In cornstarch or sucrose any one or at least two mixing.
8. the preparation method of the solid pharmaceutical preparation containing alginic acid and trace element built as described in one of claim 1-7,
It is characterized in that, includes the following steps：
(1) alginic acid and solid-state trace element and optional functional aid are sufficiently mixed in proportion；
(2) solid composite that pulverising step (1) obtains obtains the solid pharmaceutical preparation to 2~20 μm of the grain size needed.
9. the purposes of solid pharmaceutical preparation as described in one of claim 1-7 as the foliage spray of cereal crops, fruits and vegetables and flowers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710307348.9A CN108794140B (en) | 2017-05-04 | 2017-05-04 | Alginic acid and trace element compounded solid preparation and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710307348.9A CN108794140B (en) | 2017-05-04 | 2017-05-04 | Alginic acid and trace element compounded solid preparation and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108794140A true CN108794140A (en) | 2018-11-13 |
| CN108794140B CN108794140B (en) | 2022-05-03 |
Family
ID=64053592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710307348.9A Expired - Fee Related CN108794140B (en) | 2017-05-04 | 2017-05-04 | Alginic acid and trace element compounded solid preparation and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108794140B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114292142A (en) * | 2022-01-24 | 2022-04-08 | 安徽朴茂农业科技有限公司 | Polyuronic acid ecological fertilizer additive and application thereof |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101475420A (en) * | 2009-01-23 | 2009-07-08 | 深圳市朗钛生物科技有限公司 | Fertilizer water-dispersion granule and preparation thereof |
| CN101589710A (en) * | 2009-07-03 | 2009-12-02 | 深圳市朗钛生物科技有限公司 | A kind of agricultural water dispersible granule and its production and application |
| CN101805218A (en) * | 2010-03-31 | 2010-08-18 | 吴洪生 | Preparation method of multifunctional leaf-spraying growth prompter and application thereof |
| CN101913942A (en) * | 2009-07-10 | 2010-12-15 | 深圳市朗钛生物科技有限公司 | Agricultural effervescent granules and preparation method and application thereof |
| CN102167634A (en) * | 2010-12-23 | 2011-08-31 | 海南正业中农高科股份有限公司 | Oligosaccharide-containing foliar fertilizer composite and application thereof |
| CN103058750A (en) * | 2012-12-19 | 2013-04-24 | 华南农业大学 | Seaweed amino acid composite liquid manure and preparation method and application thereof |
| CN104355837A (en) * | 2014-11-11 | 2015-02-18 | 山东省农作物种质资源中心 | Traditional Chinese medicine compound leaf fertilizer for winter wheat and preparation method thereof |
| CN104496678A (en) * | 2014-12-18 | 2015-04-08 | 广西田园生化股份有限公司 | Compound composition containing methanesulphonyl myclobutanil and leaf fertilizer and preparation |
| CN104761413A (en) * | 2015-03-25 | 2015-07-08 | 青岛海力源生物科技有限公司 | Alginic acid fertilizer synergist with ammonia volatilization inhibiting effect and preparation method of alginic acid fertilizer synergist |
| CN105085075A (en) * | 2015-09-12 | 2015-11-25 | 顾伟 | Agricultural composition containing propamidine and foliage fertilizer |
| CN105859445A (en) * | 2016-06-08 | 2016-08-17 | 国乃胜 | Environment-friendly algae amino acid compound fertilizer |
-
2017
- 2017-05-04 CN CN201710307348.9A patent/CN108794140B/en not_active Expired - Fee Related
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101475420A (en) * | 2009-01-23 | 2009-07-08 | 深圳市朗钛生物科技有限公司 | Fertilizer water-dispersion granule and preparation thereof |
| CN101589710A (en) * | 2009-07-03 | 2009-12-02 | 深圳市朗钛生物科技有限公司 | A kind of agricultural water dispersible granule and its production and application |
| CN101913942A (en) * | 2009-07-10 | 2010-12-15 | 深圳市朗钛生物科技有限公司 | Agricultural effervescent granules and preparation method and application thereof |
| CN101805218A (en) * | 2010-03-31 | 2010-08-18 | 吴洪生 | Preparation method of multifunctional leaf-spraying growth prompter and application thereof |
| CN102167634A (en) * | 2010-12-23 | 2011-08-31 | 海南正业中农高科股份有限公司 | Oligosaccharide-containing foliar fertilizer composite and application thereof |
| CN103058750A (en) * | 2012-12-19 | 2013-04-24 | 华南农业大学 | Seaweed amino acid composite liquid manure and preparation method and application thereof |
| CN104355837A (en) * | 2014-11-11 | 2015-02-18 | 山东省农作物种质资源中心 | Traditional Chinese medicine compound leaf fertilizer for winter wheat and preparation method thereof |
| CN104496678A (en) * | 2014-12-18 | 2015-04-08 | 广西田园生化股份有限公司 | Compound composition containing methanesulphonyl myclobutanil and leaf fertilizer and preparation |
| CN104761413A (en) * | 2015-03-25 | 2015-07-08 | 青岛海力源生物科技有限公司 | Alginic acid fertilizer synergist with ammonia volatilization inhibiting effect and preparation method of alginic acid fertilizer synergist |
| CN105085075A (en) * | 2015-09-12 | 2015-11-25 | 顾伟 | Agricultural composition containing propamidine and foliage fertilizer |
| CN105859445A (en) * | 2016-06-08 | 2016-08-17 | 国乃胜 | Environment-friendly algae amino acid compound fertilizer |
Non-Patent Citations (3)
| Title |
|---|
| 中国食品添加剂和配料协会: "《十一五国家重点图书出版规划项目 食品添加剂手册 第3版》", 30 September 2012, 中国轻工业出版社 * |
| 方亮等: "《药用高分子材料学》", 31 August 2015, 中国医药科技出版社 * |
| 朱洪法等: "《催化剂手册》", 31 August 2008, 金盾出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114292142A (en) * | 2022-01-24 | 2022-04-08 | 安徽朴茂农业科技有限公司 | Polyuronic acid ecological fertilizer additive and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108794140B (en) | 2022-05-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104488924A (en) | Compound composition used for increasing crop fertilization rate | |
| CN101302129B (en) | Calcium hydrophosphate suspending agent | |
| CN103238600B (en) | Plant growth regulator containing gibberellin and preparation method thereof | |
| CN101984815A (en) | Fluazinam dry suspending agent and preparation method thereof | |
| CN101815691B (en) | A micronutrient fertilizer and method for producing same | |
| CN101869218A (en) | Environment protection fish-meal-free spot ietalurus punetaus compound feed and preparation method thereof | |
| CN102992851B (en) | Specific rotten fruit fermented fertilizer for corn | |
| CN108902160A (en) | Bactericidal composition and bactericide for preventing and treating stem blight of asparagus | |
| CN112125746A (en) | Biomass fertilizer and preparation method thereof | |
| CN104663668A (en) | Insecticidal and acaricidal composition containing acetyl coenzyme A inhibitor insecticide | |
| CN102258037A (en) | Sterilizing composition containing benziothiazolinone and tebuconazole | |
| CN113307698A (en) | Granulation method of microbial fertilizer | |
| CN101856018B (en) | Etofenprox emulsified powder and manufacture method | |
| CN112125745A (en) | Biomass organic fertilizer for improving soil and preparation method thereof | |
| CN101248795B (en) | Bactericial composition containing pyrazole aether bacterium ester and thiram and uses thereof | |
| CN102550568A (en) | Plant growth regulator mixing chlormequat chloride and paclobutrazol | |
| CN101911940A (en) | Germicide compounded from azoxystrobin, difenoconazole and cyproconazole and preparation method thereof | |
| CN108794140A (en) | A kind of solid pharmaceutical preparation and its preparation method and application containing alginic acid and trace element built | |
| CN101518235A (en) | Azoxystrobin water dispersible granule and preparation method thereof | |
| CN105061113A (en) | Special organic fertilizer for monocotyledon crops | |
| CN112851430A (en) | Seaweed fertilizer and pesticide mixed composition and application thereof | |
| CN102657192A (en) | Biological bactericide chelerythrine suspending agent and preparation method thereof | |
| CN106397035A (en) | Production-increasing disease-resistant fertilizer used for planting novel mat grass | |
| CN103098802A (en) | Penoxsulam effervescent tablet and preparation method thereof | |
| CN110590450A (en) | Production method of organic liquid fertilizer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220503 |