CN108785772A - A kind of Blood index purifier - Google Patents

A kind of Blood index purifier Download PDF

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Publication number
CN108785772A
CN108785772A CN201810607671.2A CN201810607671A CN108785772A CN 108785772 A CN108785772 A CN 108785772A CN 201810607671 A CN201810607671 A CN 201810607671A CN 108785772 A CN108785772 A CN 108785772A
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China
Prior art keywords
blood
index
adsorbent
purifier
purifier according
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CN201810607671.2A
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CN108785772B (en
Inventor
黄钢
王海波
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Shanghai University of Medicine and Health Sciences
Nanjing Reclaimer Environmental Technology Co Ltd
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Shanghai University of Medicine and Health Sciences
Nanjing Reclaimer Environmental Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

The present invention relates to a kind of Blood index purifier, which is directly separated blood using dialysis separator device, and the weak solution of the small flow separated is after absorber fixes toxin, then the Blood index purification techniques that is directly mixed with the concentrated solution of larger flow.The device eliminates the dialysis fluid circulation in conventional blood adsorption and purification technology, it is directly separated using blood, small flow weak solution adsorption and purification technology, device compact provides new technical thought for the development of portable blood clearing machine, and economy, social effect are huge.

Description

A kind of Blood index purifier
Technical field
The present invention relates to a kind of Blood index purifiers, more particularly to a kind of to be directly separated blood using dialyzer, point The weak solution of the small flow come is separated out to inhale after absorber fixes toxin, then with the blood that the concentrated solution of larger flow directly mixes Attached purification techniques belongs to apparatus for purifying blood technical field.
Background technology
Haemodialysis is a kind of external dialysis treatment for filtering toxin from the blood of patient using haemodialysis control unit.At present Most of haemodialysis control units generally comprise computer, fluid pump, blood lines, dialysate lines, dialyzer and for discharging The tapping line of dialysis solution.Blood passes through the dialyzer for including semi-permeable membrane in haemodialysis control unit.Semi-permeable membrane is by side Blood is separated with the dialysis solution at another layer.Dialyzer removes waste, toxin and excessive water, purified blood from blood Liquid returns to human body.Waste product and toxin are transferred to from blood in dialysis solution by semi-permeable membrane, are used in single dialysis treatment Dialyzate about 90-120 liters, then directly abandon or processing after discharge.Obviously, a large amount of used dialyzate can increase dialysis Cost.Since the needs that dialyzate can also include various concentration pass through the substance for spreading and being introduced into blood flow, such as drug, grape Sugar, these components when passing through dialyzer can not possibly completely into blood, thus also can some be discharged with discarded dialyzate; In addition, also having some components beneficial to human body to enter discarded dialyzate by semi-permeable membrane in blood.Above-mentioned various factors is led It causes the cost of haemodialysis to increase, waste increase, also can cause environmental pollution.Therefore, many dialyzate recycling profits are produced With technology, typical technology is as follows:
A kind of dialysate regeneration system for portable human dialysis of Chemica Technologies Inc. of U.S. application, in State's number of patent application is 200480038117.3, and the request for data of PCT application is PCT/US2004/043546 (2004.12.22) was authorized, Authorization Notice No. CN1897993B, core technology flow diagram on February 08th, 2012 As shown in Fig. 1.The key technology of the patent uses a kind of dialysate regeneration room 14, can selectively retain toxin and repel The toxin trap of the cation of selection, wherein the ion selection urase that the toxin trap includes ion selection barrier is fixed Activated carbon fiber.The advantages of technology is that flow is simple, reasonable for structure, easy to carry.But it also has the shortcomings that certain:Due into It is big to enter the low thus required adsorbent adsorption area of toxin concentration in the dialyzate of dialysate regeneration room, the suction of unit volume Attached dose of adsorption efficiency is relatively low, and adsorbent inventory is more.
Chinese patent (application number:201510106383.5) a kind of dialysate regeneration device is provided, using reverse osmosis group Part and electric catalysis reactor based on BDD electrodes utilize the very wide potential window of the electric catalysis reactor based on BDD electrodes and low Adsorption capacity, oxidation process is very efficient, effectively can convert and remove waste product and toxin in dialyzate, device it is continuous Runnability is good.But its also have the shortcomings that it is certain, if electric catalysis reactor may following components generate catalytic action, cause to become Property or generate harmful substance, such as penetrate in the blood of human body Hubeiwan of dialyzate, dialyzate and be not fully utilized Needs substance (such as drug or glucose) in blood is introduced by diffusion.
Therefore above-mentioned technology how is solved the problems, such as, using few use or even without the blood purification skill of dialyzate Art becomes one of hot subject of the area research.
Invention content
The present invention is in order to solve the problems existing in the prior art, to be directly separated blood using dialysis separator device, isolate The weak solution of the small flow come is after absorber fixes toxin, then the Blood index directly mixed with the concentrated solution of larger flow is net Change technology.The device eliminates the dialysis fluid circulation in conventional blood adsorption and purification technology, is directly separated using blood, is small Flow weak solution adsorption and purification technology, device compact provide new technology think of for the development of portable blood clearing machine Road.
The purpose of the present invention is what is realized by following measures:
A kind of Blood index purifier, it is characterised in that:
The Blood index purifier includes dialysis separator 32, absorber 37:Blood of human body is drawn pipeline 30 and is drawn The blood gone out is sent into dialysis separator 32 after the supercharging of blood booster pump 31, and it is molten to isolate higher concentration from dialysis separator 32 Liquid and lower concentration solutions, wherein higher concentration solution come out from the dope side 32-1 of dialysis separator 32, through dope outlet Line 33 is sent into mixer 34, and lower concentration solutions come out from the thin liquid side 32-2 of dialysis separator 32, through thin liquid booster pump 35, dilute Solution pipeline 36 is sent into absorber 37, and thin liquid outlet line 38 is sent into mixer 34 after the solution that absorber 37 comes out is purified, Human body 40 is returned to through blood return tube line 39 through 34 mixed blood of mixer, to form blood of human body adsorption cleaning cycle Process.
The dialysis separator 32 includes shell, dope side 32-1, semipermeable membrane, thin liquid side 32-2.
Adsorbent is housed in the absorber 37.
The adsorbent includes specific adsorption material and/or non-specific adsorption material.
The specific adsorption material includes but not limited to beta-cyclodextrin, the compound of beta-cyclodextrin group, β-ring paste Compound that compound, beta-cyclodextrin chemical modification after essence crosslinking are modified, beta-cyclodextrin is through the modified chemical combination of chemical modification The high molecular material that object is polymerized, the n-alkyl chain group containing 6 carbon or more compound in any one or it Between arbitrary proportion combination.
The non-specific adsorption material includes any one or appointing between them at least in activated carbon, molecular sieve Meaning ratio combines.
The adsorbent is using the organosilicon material compatible with blood of human body as carrier.
The adsorbent is for adsorbing urea nitrogen.
The adsorbent is for adsorbing creatinine.
The adsorbent is for adsorbing phosphate.
Semipermeable membrane in the dialysis separator 32 is used to detach small molecule waste product and the toxin in blood, including But it is not limited to urea nitrogen, creatinine and other small organic human waste molecules, water.
The Blood index purifier is equipped with necessary blood anticoagulant and facility is added.
The Blood index purifier is equipped with the facility of necessary replacement absorber and adsorbent.
The Blood index purifier is equipped with necessary detection instrument, valve and control system etc..
When needing, it is equipped with ultrafilter, extra moisture is isolated from Blood index purifier.
The unaccounted technical characteristic of the present invention is carried out mating using the ripe prior art.
The present invention has the following advantages that compared with prior art:
1, this Blood index purifier eliminates the dialysis fluid circulation of conventional blood purification techniques, and device is small and exquisite tight It gathers, new possible technique thinking is provided for the development of portable blood clearing machine;
2, the substance such as drug, glucose etc. being introduced by diffusion in blood flow is needed, mixer can be directly added into, is entered Human body efficiently utilizes;
3, using dialysis separator, absorber combination purification technology, the weak solution come out from dialysis separator uses small stream Measure adsorption cleaning toxin, sorbing material in absorber effectively avoided to be in direct contact with macromolecular substances in blood, eliminate because This issuable harm;The small-molecule substance loss beneficial to human body is effectively avoided caused by traditional dialyzate cycle.
Description of the drawings
Fig. 1 is a kind of dialysate regeneration system flow diagram for portable human dialysis.
Fig. 2 is a kind of Blood index purifier schematic diagram of the present invention.
In Fig. 2:30- blood draws pipeline;31- blood booster pumps;32- dialysis separators;32-1- dopes side;32-2- Thin liquid side;33- dope outlet lines;34- mixers;35- thin liquid booster pumps;36- weak solution pipelines;37- absorbers;38- is net Thin liquid outlet line after change;39- blood reflux pipelines;40- human bodies.
Specific implementation mode
Below in conjunction with the drawings and specific embodiments, present invention is further described in detail.
Embodiment 1:
As shown in Fig. 2, a kind of Blood index purifier that embodiment uses:
The Blood index purifier includes dialysis separator 32, absorber 37:Blood of human body draws what pipeline 30 was drawn Blood through blood booster pump 31 supercharging after, be sent into dialysis separator 32, from dialysis separator 32 isolate higher concentration solution and Lower concentration solutions, wherein higher concentration solution come out from the dope side 32-1 of dialysis separator 32, through dope outlet line 33 It is sent into mixer 34, lower concentration solutions come out from the thin liquid side 32-2 of dialysis separator 32, through thin liquid booster pump 35, weak solution Pipeline 36 is sent into absorber 37, and thin liquid outlet line 38 is sent into mixer 34 after the solution that absorber 37 comes out is purified, through mixed 34 mixed blood of clutch returns to human body 40 through blood return tube line 39, is circulated throughout to form blood of human body adsorption cleaning Journey.
The dialysis separator 32 includes shell, dope side 32-1, semipermeable membrane, thin liquid side 32-2.
Adsorbent is housed in the absorber 37.
The adsorbent uses non-specific adsorption material.
The non-specific adsorption material includes activated carbon fibre.
The adsorbent is using the organosilicon material compatible with blood of human body as carrier.
The adsorbent is for adsorbing urea nitrogen.
The adsorbent is for adsorbing creatinine.
The adsorbent is for adsorbing phosphate.
Semipermeable membrane in the dialysis separator 32 is used to detach small molecule waste product and the toxin in blood, including But it is not limited to urea nitrogen, creatinine and other small organic human waste molecules, water.
The Blood index purifier is equipped with necessary blood anticoagulant and facility is added.
The Blood index purifier is equipped with necessary detection instrument, valve and control system etc..
When needing, it is equipped with ultrafilter, extra moisture is isolated from Blood index purifier.
The unaccounted technical characteristic of the present invention is carried out mating using the ripe prior art.
Although the present invention has been described by way of example and in terms of the preferred embodiments, they be not for limiting the present invention, it is any to be familiar with This field technical professional can make various simple modifications, equivalent variations without departing from the spirit and scope of the invention, Still fall within the protection domain of technical solution of the present invention.

Claims (9)

1. a kind of Blood index purifier, it is characterised in that:
The Blood index purifier includes dialysis separator (32), absorber (37):Blood of human body draws pipeline (30) The blood of extraction through blood booster pump (31) supercharging after, be sent into dialysis separator (32), from dialysis separator (32) isolate compared with Highly concentrated solution and lower concentration solutions, wherein higher concentration solution come out from the dope side (32-1) of dialysis separator (32), It is sent into mixer (34) through dope outlet line (33), lower concentration solutions go out from the thin liquid side (32-2) of dialysis separator (32) Come, is sent into absorber (37) through thin liquid booster pump (35), weak solution pipeline (36), the solution come out from absorber (37) is purified Thin liquid outlet line (38) is sent into mixer (34) afterwards, is returned through blood return tube line (39) through mixer (34) mixed blood The Huis' body (40), to form blood of human body adsorption cleaning cyclic process.
2. Blood index purifier according to claim 1, it is characterised in that:
The dialysis separator (32) includes shell, dope side (32-1), semipermeable membrane, thin liquid side (32-2).
3. Blood index purifier according to claim 1, it is characterised in that:
Adsorbent is housed in the absorber (37);The adsorbent includes specific adsorption material and/or non-specificity Sorbing material.
4. Blood index purifier according to claim 3, it is characterised in that:
The specific adsorption material includes the change after beta-cyclodextrin, the compound of beta-cyclodextrin group, beta-cyclodextrin crosslinking Object, the compound that beta-cyclodextrin chemical modification is modified, beta-cyclodextrin is closed to be polymerized through the modified compound of chemical modification High molecular material, n-alkyl chain group containing six carbon or more compound in any one or it is arbitrary between them Ratio combines.
5. Blood index purifier according to claim 3, it is characterised in that:
The non-specific adsorption material includes any one in activated carbon, molecular sieve or the arbitrary proportion group between them It closes.
6. Blood index purifier according to claim 3, it is characterised in that:
The adsorbent is using the organosilicon material compatible with blood of human body as carrier.
7. Blood index purifier according to claim 3, it is characterised in that:
The adsorbent is for adsorbing creatinine.
8. Blood index purifier according to claim 3, it is characterised in that:
The adsorbent is for adsorbing phosphate.
9. Blood index purifier according to claim 3, it is characterised in that:
The adsorbent is for adsorbing urea nitrogen.
CN201810607671.2A 2018-06-13 2018-06-13 Blood adsorption purification device Active CN108785772B (en)

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Application Number Priority Date Filing Date Title
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CN108785772B CN108785772B (en) 2024-04-09

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11207150A (en) * 1998-01-21 1999-08-03 Terumo Corp Liquid purifier using live bacterial and liquid purifying device
US20010041892A1 (en) * 1998-02-19 2001-11-15 Nxstage Medical, Inc. Hemofiltration system including ultrafiltrate purification and re-infusion system
US20100268156A1 (en) * 2007-11-06 2010-10-21 Walter Milacek Medical device in the form of a catheter for supplying and/or removing fluid into and/or from, especially body cavities, especially the pleural cavity
US20140190886A1 (en) * 2013-01-09 2014-07-10 Medtronic, Inc. Recirculating dialysate fluid circuit for blood measurement
CN209075641U (en) * 2018-06-13 2019-07-09 上海健康医学院 A kind of Blood index purification device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11207150A (en) * 1998-01-21 1999-08-03 Terumo Corp Liquid purifier using live bacterial and liquid purifying device
US20010041892A1 (en) * 1998-02-19 2001-11-15 Nxstage Medical, Inc. Hemofiltration system including ultrafiltrate purification and re-infusion system
US20100268156A1 (en) * 2007-11-06 2010-10-21 Walter Milacek Medical device in the form of a catheter for supplying and/or removing fluid into and/or from, especially body cavities, especially the pleural cavity
US20140190886A1 (en) * 2013-01-09 2014-07-10 Medtronic, Inc. Recirculating dialysate fluid circuit for blood measurement
CN209075641U (en) * 2018-06-13 2019-07-09 上海健康医学院 A kind of Blood index purification device

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