CN108785772B - Blood adsorption purification device - Google Patents
Blood adsorption purification device Download PDFInfo
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- CN108785772B CN108785772B CN201810607671.2A CN201810607671A CN108785772B CN 108785772 B CN108785772 B CN 108785772B CN 201810607671 A CN201810607671 A CN 201810607671A CN 108785772 B CN108785772 B CN 108785772B
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- blood
- adsorption purification
- solution
- adsorbent
- purification device
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- 239000008280 blood Substances 0.000 title claims abstract description 79
- 210000004369 blood Anatomy 0.000 title claims abstract description 79
- 238000001179 sorption measurement Methods 0.000 title claims abstract description 45
- 238000000746 purification Methods 0.000 title claims abstract description 37
- 238000000502 dialysis Methods 0.000 claims abstract description 30
- 239000006096 absorbing agent Substances 0.000 claims abstract description 8
- 230000004087 circulation Effects 0.000 claims abstract description 5
- 239000003463 adsorbent Substances 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 9
- 229920000858 Cyclodextrin Polymers 0.000 claims description 8
- 239000001116 FEMA 4028 Substances 0.000 claims description 8
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 8
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 8
- 229960004853 betadex Drugs 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 claims description 5
- 229940109239 creatinine Drugs 0.000 claims description 5
- 239000002808 molecular sieve Substances 0.000 claims description 4
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
- 239000010452 phosphate Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- -1 beta-cyclodextrin group compound Chemical class 0.000 claims description 2
- 239000002861 polymer material Substances 0.000 claims description 2
- 239000003053 toxin Substances 0.000 abstract description 14
- 231100000765 toxin Toxicity 0.000 abstract description 14
- 238000005516 engineering process Methods 0.000 abstract description 10
- 238000000926 separation method Methods 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 30
- 108700012359 toxins Proteins 0.000 description 13
- 239000002699 waste material Substances 0.000 description 6
- 238000001631 haemodialysis Methods 0.000 description 5
- 230000000322 hemodialysis Effects 0.000 description 5
- 230000008929 regeneration Effects 0.000 description 5
- 238000011069 regeneration method Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000000385 dialysis solution Substances 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 229920000049 Carbon (fiber) Polymers 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 230000002550 fecal effect Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
Abstract
The invention relates to a blood adsorption purification device, which adopts a blood adsorption purification technology that a dialysis separator is adopted to directly separate blood, and the separated small-flow dilute solution is directly mixed with a large-flow concentrated solution after toxin is fixed by an absorber. The device removes a dialysate circulation system in the traditional blood adsorption purification technology, adopts the direct blood separation and small-flow dilute solution adsorption purification technology, is small and compact, and provides a new technical idea for the development of a portable blood purifier, and has great economic and social significance.
Description
Technical Field
The invention relates to a blood adsorption purification device, in particular to a blood adsorption purification technology which adopts a dialyzer to directly separate blood, and the separated small-flow dilute solution is directly mixed with a large-flow concentrated solution after toxin is fixed by an absorber, and belongs to the technical field of blood purification devices.
Background
Hemodialysis is a dialysis process that filters toxins from a patient's blood using a hemodialysis machine in vitro. Most hemodialysis machines currently generally include a computer, a fluid pump, a blood line, a dialysate line, a dialyzer, and a drain line for draining the dialysis solution. Blood passes through a dialyzer containing a semipermeable membrane in a hemodialysis machine. The semipermeable membrane separates blood on one side from the dialysis solution on the other. The dialyzer removes waste, toxins and excess water from the blood, and the purified blood is returned to the body. Waste products and toxins are transferred from the blood through the semipermeable membrane to the dialysis solution, and the dialysate used in a single dialysis treatment is about 90-120 liters and then either discarded directly or disposed of. Obviously, large amounts of spent dialysate increase the cost of dialysis. Since the dialysate can also include various concentrations of substances that need to be introduced into the blood stream by diffusion, such as drugs, glucose, which components cannot enter the blood completely as they pass through the dialyzer, there is also a portion that is expelled with the discarded dialysate; in addition, some of the components of the blood that are beneficial to the human body pass through the semipermeable membrane into the spent dialysate. These factors result in increased cost and waste of hemodialysis and also cause environmental pollution. Therefore, a number of dialysate recovery and utilization techniques are developed, typical techniques being as follows:
a dialysate regeneration system for portable human dialysis is applied by Kami card technology Co., ltd. In the United states, chinese patent application No. 200480038117.3, PCT application No. PCT/US2004/043546 (2004.12.22), grant at 2012 month 08, grant bulletin No. CN1897993B, and the core technical flow is schematically shown in FIG. 1. The key technique of this patent employs a dialysate regeneration chamber 14, a toxin trap capable of selectively trapping toxins and rejecting selected cations, wherein the toxin trap comprises ion-selective urease-immobilized activated carbon fibers of an ion-selective barrier. The technology has the advantages of simple flow, reasonable structure and convenient carrying. It also has certain drawbacks: because the concentration of toxins in the dialysate entering the dialysate regeneration chamber is low, the required adsorbent adsorption area is large, the adsorbent adsorption efficiency per unit volume is low, and the adsorbent loading is high.
Chinese patent (application number: 201510106383.5) provides a dialysate regeneration device, which adopts a reverse osmosis component and an electrocatalytic reactor based on BDD electrodes, and has the advantages of very high efficiency in oxidation process, capability of effectively converting and removing waste products and toxins in dialysate and good continuous operation performance by utilizing a very wide potential window and low adsorption capacity of the electrocatalytic reactor based on BDD electrodes. However, it has certain disadvantages, such as that the electrocatalytic reactor may catalyze components which may denature or produce substances harmful to the human body, such as beneficial components of human blood penetrating into the dialysate, substances in the dialysate which are not fully utilized and need to be introduced into the blood by diffusion (e.g. drugs or glucose, etc.).
Therefore, how to solve the problems in the above-mentioned techniques, and to use a blood purification technique with little or no use of a dialysate, has become one of the hot spots of research in this field.
Disclosure of Invention
The invention relates to a blood adsorption purification technology for directly separating blood by a dialysis separator, fixing toxin in a separated small-flow dilute solution by an adsorber, and directly mixing the small-flow dilute solution with a large-flow concentrated solution. The device removes a dialysate circulation system in the traditional blood adsorption purification technology, adopts the direct blood separation and small-flow dilute solution adsorption purification technology, is small and compact, and provides a new technical idea for the development of a portable blood purifier.
The aim of the invention is achieved by the following measures:
a blood adsorption purification device, characterized in that:
the blood adsorption purification device comprises a dialysis separator 32 and an adsorber 37: the blood led out from the blood leading-out line 30 of the human body is sent to the dialysis separator 32 after being pressurized by the blood booster pump 31, the higher concentration solution and the lower concentration solution are separated from the dialysis separator 32, wherein the higher concentration solution is sent to the mixer 34 from the concentrated solution side 32-1 of the dialysis separator 32 through the concentrated solution outlet line 33, the lower concentration solution is sent to the absorber 37 from the dilute solution side 32-2 of the dialysis separator 32 through the dilute solution booster pump 35 and the dilute solution line 36, the solution from the absorber 37 is sent to the mixer 34 through the purified dilute solution outlet line 38, and the blood mixed by the mixer 34 is returned to the human body 40 through the blood reflux line 39, thereby forming the absorption purification cycle of the blood of the human body.
The dialysis separator 32 includes a housing, a concentrate side 32-1, a semi-permeable membrane, and a diluent side 32-2.
The adsorber 37 is filled with an adsorbent.
The adsorbent comprises a specific adsorption material and a non-specific adsorption material.
The specific adsorption material comprises, but is not limited to, beta-cyclodextrin, a beta-cyclodextrin group compound, a beta-cyclodextrin crosslinked compound, a beta-cyclodextrin chemically modified compound, a polymer material polymerized by the beta-cyclodextrin chemically modified compound, a compound containing more than 6 carbon n-alkyl chain groups or any combination of the compounds in any proportion.
The non-specific adsorption material comprises at least any one of active carbon and molecular sieve or any combination of the active carbon and the molecular sieve in any proportion.
The adsorbent adopts an organosilicon material compatible with human blood as a carrier.
The adsorbent is used for adsorbing urea nitrogen.
The adsorbent is used for adsorbing creatinine.
The adsorbent is used for adsorbing phosphate.
The semi-permeable membrane in the dialysis separator 32 is used to separate small molecule waste products and toxins in the blood, including but not limited to urea nitrogen, creatinine and other small organic fecal molecules, water.
The blood adsorption purification device is provided with necessary blood anticoagulant adding facilities.
The blood adsorption purification device is provided with necessary facilities for replacing the adsorber and the adsorbent.
The blood adsorption purification device is provided with necessary detection instruments, valves, a control system and the like.
If necessary, an ultrafilter is provided to separate excess water from the blood adsorption purification device.
The unexplained technical characteristics of the invention are matched with the mature prior art.
Compared with the prior art, the invention has the following advantages:
1. the blood adsorption purification device cancels a dialysate circulation system of the traditional blood purification technology, is small and compact, and provides a new feasible technical idea for the development of a portable blood purifier;
2. substances which need to be introduced into blood flow through diffusion, such as medicines, glucose and the like, can be directly added into a mixer to enter human body for high-efficiency utilization;
3. the dialysis separator and the adsorber combined purification technology are adopted, and the dilute solution from the dialysis separator is subjected to low-flow adsorption purification of toxin, so that the adsorption material in the adsorber is effectively prevented from being in direct contact with macromolecular substances in blood, and the possible harm is eliminated; the loss of small molecular substances beneficial to human bodies caused by the circulation of the traditional dialysate can be effectively avoided.
Drawings
Fig. 1 is a schematic flow diagram of a dialysate regeneration system for portable human dialysis.
FIG. 2 is a schematic view of a blood adsorption purification device according to the present invention.
In fig. 2: 30-a blood withdrawal line; 31-a blood booster pump; 32-a dialysis separator; 32-1-concentrate side; 32-2-lean side; 33-concentrate outlet line; 34-a mixer; 35-a thin liquid booster pump; 36-dilute solution line; 37-adsorber; 38-a purified lean liquid outlet line; 39-a blood return line; 40-human body.
Detailed Description
The invention is described in further detail below with reference to the drawings and specific examples.
Example 1:
as shown in fig. 2, a blood adsorption purification device employed in the embodiment:
the blood adsorption purification device comprises a dialysis separator 32 and an adsorber 37: the blood led out from the blood leading-out line 30 of the human body is sent to the dialysis separator 32 after being pressurized by the blood booster pump 31, the higher concentration solution and the lower concentration solution are separated from the dialysis separator 32, wherein the higher concentration solution is sent to the mixer 34 from the concentrated solution side 32-1 of the dialysis separator 32 through the concentrated solution outlet line 33, the lower concentration solution is sent to the absorber 37 from the dilute solution side 32-2 of the dialysis separator 32 through the dilute solution booster pump 35 and the dilute solution line 36, the solution from the absorber 37 is sent to the mixer 34 through the purified dilute solution outlet line 38, and the blood mixed by the mixer 34 is returned to the human body 40 through the blood reflux line 39, thereby forming the absorption purification cycle of the blood of the human body.
The dialysis separator 32 includes a housing, a concentrate side 32-1, a semi-permeable membrane, and a diluent side 32-2.
The adsorber 37 is filled with an adsorbent.
The adsorbent is made of non-specific adsorption materials.
The non-specific adsorption material comprises activated carbon fibers.
The adsorbent adopts an organosilicon material compatible with human blood as a carrier.
The adsorbent is used for adsorbing urea nitrogen.
The adsorbent is used for adsorbing creatinine.
The adsorbent is used for adsorbing phosphate.
The semi-permeable membrane in the dialysis separator 32 is used to separate small molecule waste products and toxins in the blood, including but not limited to urea nitrogen, creatinine and other small organic fecal molecules, water.
The blood adsorption purification device is provided with necessary blood anticoagulant adding facilities.
The blood adsorption purification device is provided with necessary detection instruments, valves, a control system and the like.
If necessary, an ultrafilter is provided to separate excess water from the blood adsorption purification device.
The unexplained technical characteristics of the invention are matched with the mature prior art.
While the invention has been described in terms of preferred embodiments, it is not intended to be limited thereto, but to various simple modifications and equivalents may be made by those skilled in the art without departing from the spirit and scope of the present invention.
Claims (4)
1. A blood adsorption purification device, characterized in that:
the blood adsorption purification device comprises a dialysis separator (32) and an adsorber (37): the blood led out by the human blood leading-out pipeline (30) is sent to the dialysis separator (32) after being pressurized by the blood booster pump (31), the higher concentration solution and the lower concentration solution are separated from the dialysis separator (32), wherein the higher concentration solution is sent to the mixer (34) from the concentrated solution side (32-1) of the dialysis separator (32) through the concentrated solution outlet pipeline (33), the lower concentration solution is sent to the absorber (37) from the dilute solution side (32-2) of the dialysis separator (32) through the dilute solution booster pump (35) and the dilute solution pipeline (36), the solution from the absorber (37) is sent to the mixer (34) through the purified dilute solution outlet pipeline (38), and the blood mixed by the mixer (34) is returned to the human body (40) through the blood reflux pipeline (39), so that the human blood adsorption purification circulation process is formed;
the dialysis separator (32) comprises a shell, a concentrated solution side (32-1), a semi-permeable membrane and a thin solution side (32-2);
the adsorber (37) is filled with an adsorbent; the adsorbent comprises a specific adsorption material and/or a non-specific adsorption material; the adsorbent adopts an organosilicon material compatible with human blood as a carrier;
the specific adsorption material comprises beta-cyclodextrin, a beta-cyclodextrin group compound, a beta-cyclodextrin crosslinked compound, a beta-cyclodextrin chemically modified compound, a polymer material polymerized by the beta-cyclodextrin chemically modified compound, and any one of or any combination of the six carbon and above n-alkyl chain group-containing compounds; the non-specific adsorption material comprises any one of active carbon and molecular sieve or any combination of the active carbon and the molecular sieve in any proportion.
2. The blood adsorption purification device according to claim 1, wherein:
the adsorbent is used for adsorbing creatinine.
3. The blood adsorption purification device according to claim 1, wherein:
the adsorbent is used for adsorbing phosphate.
4. The blood adsorption purification device according to claim 1, wherein:
the adsorbent is used for adsorbing urea nitrogen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810607671.2A CN108785772B (en) | 2018-06-13 | 2018-06-13 | Blood adsorption purification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810607671.2A CN108785772B (en) | 2018-06-13 | 2018-06-13 | Blood adsorption purification device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108785772A CN108785772A (en) | 2018-11-13 |
| CN108785772B true CN108785772B (en) | 2024-04-09 |
Family
ID=64087042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810607671.2A Active CN108785772B (en) | 2018-06-13 | 2018-06-13 | Blood adsorption purification device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108785772B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11207150A (en) * | 1998-01-21 | 1999-08-03 | Terumo Corp | Liquid purifier using live bacterial and liquid purifying device |
| CN209075641U (en) * | 2018-06-13 | 2019-07-09 | 上海健康医学院 | A kind of Blood index purification device |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582385B2 (en) * | 1998-02-19 | 2003-06-24 | Nstage Medical, Inc. | Hemofiltration system including ultrafiltrate purification and re-infusion system |
| AT505614B1 (en) * | 2007-11-06 | 2009-03-15 | Walter Milacek | MEDICAL DEVICE IN THE FORM OF A CATHETER FOR, IN PARTICULAR, BOTTLING FLUID IN, IN PARTICULAR FROM BODY CAVES, IN PARTICULAR THE PLEURARAUM |
| US9713666B2 (en) * | 2013-01-09 | 2017-07-25 | Medtronic, Inc. | Recirculating dialysate fluid circuit for blood measurement |
-
2018
- 2018-06-13 CN CN201810607671.2A patent/CN108785772B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11207150A (en) * | 1998-01-21 | 1999-08-03 | Terumo Corp | Liquid purifier using live bacterial and liquid purifying device |
| CN209075641U (en) * | 2018-06-13 | 2019-07-09 | 上海健康医学院 | A kind of Blood index purification device |
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| Publication number | Publication date |
|---|---|
| CN108785772A (en) | 2018-11-13 |
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