CN108785378A - Compound disinfectant and preparation method and application thereof - Google Patents
Compound disinfectant and preparation method and application thereof Download PDFInfo
- Publication number
- CN108785378A CN108785378A CN201710308647.4A CN201710308647A CN108785378A CN 108785378 A CN108785378 A CN 108785378A CN 201710308647 A CN201710308647 A CN 201710308647A CN 108785378 A CN108785378 A CN 108785378A
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- chitosan
- derivative
- condom
- dissolved
- water
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 24
- 150000001875 compounds Chemical class 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 7
- 239000010687 lubricating oil Substances 0.000 claims abstract description 6
- 239000006260 foam Substances 0.000 claims abstract description 5
- 239000000314 lubricant Substances 0.000 claims abstract description 5
- 229920001661 Chitosan Polymers 0.000 claims description 45
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 235000011187 glycerol Nutrition 0.000 claims description 12
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 11
- 239000000284 extract Substances 0.000 claims description 11
- 229960005150 glycerol Drugs 0.000 claims description 11
- 229920002674 hyaluronan Polymers 0.000 claims description 11
- 229960003160 hyaluronic acid Drugs 0.000 claims description 11
- 229940105902 mint extract Drugs 0.000 claims description 11
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 claims description 9
- 239000001329 FEMA 3811 Substances 0.000 claims description 8
- 208000015181 infectious disease Diseases 0.000 claims description 8
- 229940089953 neohesperidin dihydrochalcone Drugs 0.000 claims description 8
- 235000010434 neohesperidine DC Nutrition 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 230000006196 deacetylation Effects 0.000 claims description 6
- 238000003381 deacetylation reaction Methods 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 4
- 238000001556 precipitation Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000008236 heating water Substances 0.000 claims description 3
- 230000000249 desinfective effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 241000700605 Viruses Species 0.000 abstract description 7
- 201000010099 disease Diseases 0.000 abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
- 230000001900 immune effect Effects 0.000 abstract description 2
- 230000009329 sexual behaviour Effects 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract 1
- 239000003223 protective agent Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 229920002101 Chitin Polymers 0.000 description 12
- 239000006286 aqueous extract Substances 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 description 4
- 230000002155 anti-virotic effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 150000002576 ketones Chemical class 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- ARGKVCXINMKCAZ-UZRWAPQLSA-N neohesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UZRWAPQLSA-N 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 241000607764 Shigella dysenteriae Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000002781 deodorant agent Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 210000004392 genitalia Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 description 1
- YUJKFUOJLSEPQW-UHFFFAOYSA-N 3-(1-methylcyclohexa-2,4-dien-1-yl)-1-phenylprop-2-en-1-one Chemical compound C=1C=CC=CC=1C(=O)C=CC1(C)CC=CC=C1 YUJKFUOJLSEPQW-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000175212 Herpesvirales Species 0.000 description 1
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 description 1
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 description 1
- 229940025878 hesperidin Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a compound disinfectant and a preparation method and application thereof. The immune protective agent has an efficient immune effect on condom (condom) lubricating oil, condom (condom) lubricating agent, liquid (foam) condoms and the physiological environment of the protective type of the human body infected parts, can efficiently repair and prevent gynecological diseases caused by sexual behaviors, and realizes the protection of women. The use of the version aiming at the virus can prevent diseases caused by the virus such as venereal disease and the like, and the original pure physical protection of the condom is changed into the combination of biochemistry and physics, so that the safety of a user is ensured; for the easily infected parts of the human body, daily-grade immunity can also protect the human body on the premise of no toxic or side effect.
Description
Technical field
The present invention relates to a kind of compound disinfectant more particularly to the disinfectants of a kind of chitin and chitosan and its derivative
And its preparation method and application.
Background technology
Chitin is also known as chitin, chitin, English name Chitin, chitin be of wide application it is general, through deacetylated
It is known as chitosan afterwards.Chitin is industrially used for many different use, and chitin is used for water and purification of waste water, as
Food additives, which are applied in drug, plays thickening power, stabilizing food and medicine state.
Currently on the market, the medicament of chitin and chitosan ingredient apply including：Oral supplementation drug, meat antistaling agent with
And deodorant etc..Such as the function of profuse sweating gland cell tube wall is repaired in deodorant using film forming to reach deodorizing effect.But at present
This technology is applied in many fields also in development even space state, and technology is immature, and manner of formulation is different, the work(of medicament
Energy effect is unstable, causes a large amount of blank in the market or existing procucts quality irregular.
For the defect of present technology, the present patent application provide a kind of chitin, chitosan and its derivative compound group
The application in preparing disinfectant is closed, by increasing different elements, increases on original function and sterilizes the functions such as antibacterial, to make
Its application range is wider, including but not limited to condom (sheath) lubricating oil, condom (sheath) lubricant, liquid (bubble
Foam) purposes such as sheath and the protection of external application easy infection position, realize smell and thalline dynamic equilibrium and antiviral function.
Invention content
The purpose of the present invention is to provide chitin and chitosan and its derivative for above-mentioned defect and preparing disinfection
Application in agent field, to meet the greater demand of daily necessities so that the use of daily necessities can be to avoid the generation of disease.
Specifically, the present patent application provides a kind of compound disinfectant, mainly includes the various components of following mass parts：
1, chitosan and its derivative：0.1 to 10 part；
2, granatum water extract：0.1 to 3 part；
3, neohesperidin dihydrochalcone：0.01 to 2 part；
4, glycerine：1 to 10 part；
5, hyaluronic acid：0.1 to 1 part；
6, mint extract：0.03 to 0.3 part；
7, water：In right amount.
Further, the chitosan and its derivative is deacetylation 80 to 99, and molecular weight is more than 3000Da, is preferable over
10000 to 450,000 Da molecular weight.
Further, the molecular weight of the chitosan and its derivative is 10,000 to 450,000 Da.
Further, it is granatum water extract that the chitosan and its derivative, which forms the complementary disinfecting substance benefited,.
Chitosan and its derivative, using marine organisms such as shrimp crab and mushroom such as mushroom as extracting object, to former material
After material carries out edible alcohol dehydration, further deep processing is that chitosan can be to specific doing of position for its derivative
It closes, is subject to functional group.Granatum water extract takes granatum to shine dry and beats powder, with water Hybrid Heating, takes extracting solution.Other are former
Material can all use mature industry flow to prepare.New hesperidin methyl dihydrochalcone be extracted from citrus natural plants it is new
Aurantiamarin is a kind of functional sweetener with debitter and flavor improvement through flavone derivative made of over hydrogenation.
The extracting method of any of the above component is the prior art or can be by commercially available acquisition, and this will not be repeated here.
The present patent application also provides the preparation method of above-mentioned compound disinfectant, includes the following steps：
1. chitosan and its derivative solution is prepared：It takes quantitative chitosan and its derivative to be dissolved in suitable water, stirs
Machine high-speed stirred (>=5000 revs/min) is completely dissolved to it；Alternatively, it is suitable that quantitative chitosan and its derivative will be taken to be dissolved in
The weak acid of amount, until it is dissolved；
2. granatum water extract, neohesperidin dihydrochalcone, mint extract, glycerine, hyaluronic acid are all liquid
Or it is soluble easily in water in itself, quantitative above-mentioned substance is can use, the obtained chitosan and its derivative solution of step 1 is dissolved in, it is high
Speed stirs (>=5000 revs/min) to no precipitation.
Further, in step 1, after taking quantitative chitosan and its derivative to be dissolved in suitable water or weak acid, 40- is used
60 DEG C of heating water bath 20-40 minutes.
The present patent application also provides above-mentioned compound disinfectant and moistens in condom (sheath) lubricating oil, condom (sheath)
The application of lubrication prescription, liquid (foam) sheath and external application easy infection position.
Disinfectant of the present invention, main component are chitosan and its derivative, granatum aqueous extract, neohesperidin two
Hydrogen looks into youngster's ketone, glycerine, hyaluronic acid and mint extract.Chitosan and its derivative is divided between deacetylation 80 to 99
Son amount is more than 3000, and excellent when being taken at 10,000 to 450,000, by the composite of molecular weight, for condom (sheath)
The physiology of lubricating oil, condom (sheath) lubricant, liquid (foam) sheath and human body easy infection position type of protection
Environment has efficient immune effect, and gynaecological disease caused by sexual behaviour can efficiently be repaired and be prevented, and realizes for female
The protection of property.And use the version for virus, the disease that can cause with the virus such as prevention of STD, by the pure object of script condom
Reason protection becomes the combination for biochemical and physics, ensures safety for user；It, can also be nontoxic for human body easy infection position
Under the premise of evil effect, the immunoprotection human body of daily grade.
Granatum aqueous extract as a kind of complementation of chitosan and its derivative, benefits combination, can be in specific life
Managing enhances the anti-bacteria and anti-virus ability of integral formula under environment, benefited in high efficiency；In broad-spectrum antibacterial property, granatum
Aqueous extract can effectively cover staphylococcus aureus, hemolytic streptococcus, typhoid bacillus, paratyphosum Bacterium, cholera arc
Bacterium, shigella dysenteriae, Escherichia coli, proteus, Pseudomonas aeruginosa, tubercle bacillus, diplococcus meningitidis, helicobacter pylori, leaching ball
Bacterium, various shigella dysenteriaes, which part chitosan and its derivative can not cover, to realize for the comprehensive anti-of harmful bacteria
Shield, avoids the addition of preservative.For anti-virus aspect, can anti-genitals herpesviral, it can not only inhibit virus thin
The proliferation of intracellular also directly kills virus and prevents the effect of its adherent cell, and also has antivirus to HBV.
Neohesperidin dihydro looks into youngster's ketone, by being combined with chitosan and its derivative, granatum aqueous extract, realize for
The desensitization of daily necessities carrier covers physiology peculiar smell and shields the bitter taste of chemical substance.
Glycerine is used as solvent, lubricant, medicament and sweetener, ingredients externally-applied ointment or spray liniment etc..It is sweet in daily life
Oil also has the function of moisturizing, outside humectation.Glycerine has the function of protecting skin moisturizing, is conducive to chitosan and its derivative and plays
Antibiosis and antiviral functions.Glycerine easily and skin contact, and is easily contacted with chitosan and its derivative, is conducive to chitosan and its derivative
Object plays a role.Since glycerine has the effects that water lock, moisturizing, thus can be extended the shelf life with color protection, fresh-keeping, increase effect.
Above-mentioned formula can have comprehensive protection for physiological environment, realize the high added value of daily necessities, and be formulated main
Ingredient is widely used in food service industry, to ensure its safety and stability.It, can specific aim solution mesh by compound proportioning
Environment such as genitals cavity is marked, the special environments such as human body easy infection surface can when being added into daily necessities for the demand of health
Play the role of to prevent Dai Zhi.
Specific implementation mode
The technical solution described in the present patent application is illustrated below in conjunction with specific implementation mode, in order to the public
It more fully understands the technical solution, rather than arbitrary limitation is carried out to it.
The formula of embodiment one one
Compound disinfectant mainly includes the various components of following mass parts：
1, chitosan and its derivative：0.1 part；The chitosan and its derivative is deacetylation 80, and molecular weight is 10,000
Da；
2, granatum water extract：0.3 part；
3, neohesperidin dihydrochalcone：1 part；
4, glycerine：4 parts；
5, hyaluronic acid：0.6 part；
6, mint extract：0.1 part；
7, water：In right amount.
The preparation method of above-mentioned compound disinfectant, includes the following steps：
1. chitosan and its derivative solution is prepared：It takes 0.1 part of chitosan and its derivative to be dissolved in suitable water, stirs
Machine high-speed stirred (5000 revs/min) is completely dissolved with 40 DEG C of heating water baths 40 minutes to it；
2.0.3 part granatum water extract, 1 part of neohesperidin dihydrochalcone, 0.1 part of mint extract, 4 parts of glycerine,
0.6 part of hyaluronic acid is dissolved in the obtained chitosan and its derivative solution of step 1, and high-speed stirred (6000 revs/min) is extremely
Without precipitation.
The formula of embodiment two two
Compound disinfectant mainly includes the various components of following mass parts：
1, chitosan and its derivative：6 parts；Chitosan and its derivative is deacetylation 99, and molecular weight is 200,000 Da；
2, granatum water extract：1 part；
3, neohesperidin dihydrochalcone：0.05 part；
4, glycerine：7 parts；
5, hyaluronic acid：0.2 part；
6, mint extract：0.09 part；
7, water：In right amount.
This compound disinfectant experimental data：
1. chitosan and its derivative solution is prepared：6 parts of chitosan and its derivative is taken to be dissolved in suitable water, blender
High-speed stirred (8000 revs/min) is completely dissolved to it；
2.1 parts of granatum water extracts, 0.05 part of neohesperidin dihydrochalcone, 0.09 part of mint extract, 7 parts it is sweet
Oil, 0.2 part of hyaluronic acid, are dissolved in the obtained chitosan and its derivative solution of step 1, (5000 revs/min of high-speed stirred
Clock) to no precipitation.
Compound disinfectant described in the present patent application has the sterilization of wide spectrum to make Ge Lan the moon Salmonella and Ge Lanyang Salmonellas
With wherein being more than for 5 minutes Escherichia coli, staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa laboratory dissipation rates
99.9%；For viruses such as HSV, HPV, HIV, there is the function of direct killing, measured by laboratory suspension method, 1% to 3% is dense
The compound disinfecting agent solution of degree, can substantially HSV, HIV, HPV effective infection rate, for the IC50 values for inhibiting it to replicate, formula
Concentration may be implemented at 1%.
Disinfectant principle active component of the present invention is recombination chitosan, the chitin of specific deacetylation and molecular weight
And its derivative, granatum aqueous extract, glycerine, neohesperidin dihydrochalcone, hyaluronic acid, mint extract, in structure
Any chemical preservative need not be added again, stronger chemical property is catalyzed out under distinctive component ratio, to reach more preferable
Sterilizing adsorb peculiar smell effect, no biotoxicity is nonirritant, edible, more healthier than the prior art, environmentally friendly, high
Effect.
Disinfectant principle active component of the present invention want ingredient be chitosan and its derivative, granatum aqueous extract,
Neohesperidin dihydro looks into youngster's ketone, glycerine, hyaluronic acid and mint extract, and it is anti-need not to add any chemistry in structure again
Rotten agent is catalyzed out stronger chemical property under distinctive component ratio to reach better antibacterial Disinfection Effect, biological safety
Height, non-stimulated, edible, and it is directed to specific environment such as human genitals cavity, when human skin surface, can have principle of readjustment, restructuring, consolidation and improvement
It can be used for but be not limited to condom lubricating oil and human body easy infection portion to property to avoid disease in the form of without side-effects
Position protection, it is more healthier than the prior art, environmentally friendly, efficient.
It should be understood that the above is not the limitation to the technical solution, in fact, in identical or approximate original
Under reason, to the improvement that the technical solution carries out, equivalent variations and modification still fall within the present patent application skill claimed
Within art scheme.
Claims (7)
1. a kind of compound disinfectant, which is characterized in that mainly include the various components of following mass parts：
Chitosan and its derivative：0.1 to 10 part；
Granatum water extract：0.1 to 3 part；
Neohesperidin dihydrochalcone：0.01 to 2 part；
Glycerine：1 to 10 part；
Hyaluronic acid：0.1 to 1 part；
Mint extract：0.03 to 0.3 part；
Water：In right amount.
2. compound disinfectant according to claim 1, it is characterised in that：The chitosan and its derivative is deacetylation
80 to 99, molecular weight is more than 3000Da.
3. compound disinfectant according to claim 2, it is characterised in that：The molecular weight of the chitosan and its derivative is
10000 to 450,000 Da.
4. requiring the compound disinfectant according to right 1, it is characterised in that：The chitosan and its derivative forms mutual subsidy
The disinfecting substance of benefit is granatum water extract.
5. the preparation method of compound disinfectant described in claim 1-3, which is characterized in that include the following steps：
Chitosan and its derivative solution is prepared：Quantitative chitosan and its derivative is taken to be dissolved in suitable water, blender high speed
It stirs to it and is completely dissolved；Alternatively, quantitative chitosan and its derivative will be taken to be dissolved in suitable weak acid, until it is dissolved；
Granatum water extract, neohesperidin dihydrochalcone, mint extract, glycerine, hyaluronic acid all be liquid or itself
It is soluble easily in water, quantitative above-mentioned substance is can use, the obtained chitosan and its derivative solution of step 1, high-speed stirred are dissolved in
To no precipitation.
6. the preparation method described in claim 4, it is characterised in that：In step 1）In, take quantitative chitosan and its derivative
After being dissolved in suitable water or weak acid, with 40-60 DEG C of heating water bath 20-40 minutes.
7. the compound disinfectant described in claim 1-4 is in condom（Sheath）Lubricating oil, condom（Sheath）Lubricant,
Liquid（Foam）The application of sheath and the protection of external application easy infection position.
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Address after: 518000 room 401-8, building 6, Shenzhen Software Park, 2 Gaoxin middle 2nd Road, Maling community, Yuehai street, Nanshan District, Shenzhen City, Guangdong Province Applicant after: Shenzhen Lukou Technology Co.,Ltd. Address before: 518000 Room 201, building a, No.1, Qianwan 1st Road, Qianhai Shenzhen Hong Kong cooperation zone, Shenzhen City, Guangdong Province (settled in Shenzhen Qianhai business secretary Co., Ltd.):1502, block F, Xihai Mingzhu building, Nanhai Avenue, Nanshan District, Shenzhen 518000 Room 201, No. 1 A, No. 1, front Bay, Qianhai Shenzhen Hong Kong cooperation zone, Qianhai, Shenzhen City, Qianhai business secretary Co., Ltd., Shenzhen City, Shenzhen City, Nanshan District, Nanhai Avenue, Pearl building 1502, No. 1502 Applicant before: SHENZHEN QIANHAI SAFETY INLET TECHNOLOGY Co.,Ltd. |
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