CN108785156A - A kind of new application of cerasus humilis juice - Google Patents
A kind of new application of cerasus humilis juice Download PDFInfo
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- CN108785156A CN108785156A CN201710306230.4A CN201710306230A CN108785156A CN 108785156 A CN108785156 A CN 108785156A CN 201710306230 A CN201710306230 A CN 201710306230A CN 108785156 A CN108785156 A CN 108785156A
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- CN
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- Prior art keywords
- cerasus humilis
- facial mask
- juice
- humilis juice
- cerasus
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
Abstract
The present invention relates to application of the cerasus humilis juice in preparing external application to have the cosmetics or pharmaceutical preparation of whitening effect.The present invention is with obvious effects in terms of whitening studies have shown that cerasus humilis juice can reduce dermal melanin value.
Description
Technical field
The present invention relates to a kind of new applications of cerasus humilis juice, and in particular to a kind of cerasus humilis juice has whitening preparing external application
The cosmetics or the new application in terms of pharmaceutical preparation of effect.
Background technology
Europe Lee (calcium fruit) Cerasus humilis belong to rose family cherry category undershrub, peculiar for China, and foreign countries are without this
One species, it is wild to be distributed mainly on the Inner Mongol, Liaoning, Jilin, Heilungkiang, Shanxi, Hebei, Beijing, Tianjin, Henan, Shandong, Shan
The areas such as west.Contain the various mineral elements beneficial to human body in Europe Lee (calcium fruit) fruit, especially the content of calcium constituent is than one
As fruit it is all high, therefore also known as " calcium fruit ".Europe Lee (calcium fruit) economic value is high, and purposes is very extensive, and pulp is edible, and benevolence is
Brush-cherry seed medicinal material, root can also be used as medicine, and flower is like oriental cherry, and too beautiful to be absorbed all at once, exploitation prospect is boundless.
How red Europe Lee (calcium fruit) fruit is, sparkling and crystal-clear lovely, and fruit is in oblate, round, jujube is round, pointed stake shape differs, meat
Thick juice is more, sour-sweet moderate, and taste is unique, full of nutrition, as many as type containing nutrition, the height of content, better than cherry, Lee, apricot, peach
Equal walnuts class fruit.Wherein vitamin A, vitamin B2, vitamin B12, vitamin C, vitamin E, mineral element potassium, calcium, magnesium,
Phosphorus, iron, manganese, zinc equal size are abundant, and the overwhelming majority is higher than several times to tens times of above-mentioned fruit, and containing including lysine
18 kinds of amino acid, ripening fruits sugar content are up to 14%~19%.Content per hectogram fresh fruit calcium and iron be respectively apple 7~
10 times and 6~10 times, up to 60~90 milligrams and 1.5~2.5 milligrams.
Whitening active substance refers to that can reduce skin coloration or mitigation pigmentation, the day for the purpose of reaching skin-whitening
Right or artificial synthesized compound.Due in melanin synthesis process tyrosinase activity and melanin conveying etc. links be easy
By external influence, to provide the foundation for the effect link of whitening active substance.The master of day common whitening active substance
It is to inhibit tyrosinase activity, influence the links such as metabolism and the transhipment of melanin to want action target spot.It can be by skin-whitening
Approach and whitening product be summarized as follows：(1) melanocyte selects toxicity：Quinhydrones；(2) it inhibits tyrosinase activity：Kojic acid,
Ursin, vitamin C and its derivative etc.；(3) inhibit the activity of dopachrome interconvertible enzyme：Licoflavone；(4) inhibit DHICA
The activity of one oxidizing ferment：Kojic acid and its derivative, vitamin C and its derivative；(5) inhibit the transport process of melanosome：Ni Ke
Amide；(6) promote the Absorption And Metabolism of pigment：Tartaric acid, intacellin, Chinese herbal medicine promoting blood circulation and removing blood stasis etc.；(7) oxygen radical is removed：Dimension
Raw element C and its derivative, SOD, vitamin E and its derivative, beta carotene；(8) work of melanocyte and tyrosinase is adjusted
Property：Endothelin antagonist, MSH antagonists；(9) the tanned effect of ultraviolet light is prevented：Various sun-screening agents.
Invention content
The purpose of the present invention is to provide cerasus humilis juices to prepare cosmetics or pharmaceutical preparation of the external application with whitening effect
In application.
Cosmetics or pharmaceutical preparation of the present invention include facial mask, face paste, lotion, ointment, emulsifiable paste etc..
Cerasus humilis juice of the present invention is that Europe plum fruit is prepared using conventional crushing technique.
Preferably, the cerasus humilis juice soluble solid content is 10%~21%；It is further preferred that Europe Lee
Fruit juice soluble solid content is 13%~17%.
The present invention further provides a kind of Europe Lee facial masks, and the facial mask is using cerasus humilis juice as material composition；Wherein, the Europe
Plum juice content is 5%~10% (weight percent)；Preferably, the cerasus humilis juice content is 5%~8%；It is further excellent
Choosing, the cerasus humilis juice a concentration of 5%~6%；Most preferably, the cerasus humilis juice a concentration of 5%.
The cerasus humilis juice soluble solid content is 10%~21%；It is further preferred that the cerasus humilis juice can
Dissolubility solid content is 13%~17%.
Further, the facial mask further includes following adjunct ingredient：Moisturizer, such as glycerine, 1,3 butanediols, propylene glycol；Thickening
Agent, such as xanthan gum；Whitening agent, such as dipotassium glycyrrhizinate；Lubricant, such as allantoin, water-soluble jojoba oil.
Preferably, the supplementary material group of the facial mask becomes：Cerasus humilis juice 4%~10%, 1,3-BDO 2%~6%, the Chinese
Raw rubber 0.2%~0.6%, dipotassium glycyrrhizinate 0.05%~0.2%, glycerine 1%~4%, allantoin 0.05%~0.2%, water
Dissolubility jojoba oil 0.1%~0.5%, propylene glycol 0.3%~1%, excess water.
It is further preferred that the supplementary material group of the facial mask becomes：Cerasus humilis juice 4%~8%, 1,3-BDO 3%~
5%, xanthan gum 0.3%~0.5%, dipotassium glycyrrhizinate 0.08%~0.15%, glycerine 1%~3%, allantoin 0.08%~
0.15%, water-soluble jojoba oil 0.2%~0.4%, propylene glycol 0.4%~0.8%, excess water.
Most preferably, the supplementary material group of the facial mask becomes：Cerasus humilis juice 5%, 1,3-BDO 4%, xanthan gum
0.4%, dipotassium glycyrrhizinate 0.1%, glycerine 2%, allantoin 0.1%, water-soluble jojoba oil 0.3%, propylene glycol 0.5% is remaining
Measure water.
" material composition " of the present invention is the ingredient with whitening effect, i.e. cerasus humilis juice；" adjunct ingredient " is
The ingredient of the effects that thickening, lubrication, moisturizing, such as 1,3-BDO, xanthan gum, dipotassium glycyrrhizinate.
The present invention studies have shown that under high temperature, severe cold, ultraviolet light irradiation condition, stablize, and is not easy by outer by cerasus humilis juice property
Phenomena such as influence of boundary's condition generates precipitation, discoloration, aoxidizes, is rotten, it is possible to be added in the making and production of cosmetics.
Human experimentation shows that cerasus humilis juice can reduce melanin value, shows that it is with obvious effects in terms of whitening.
Description of the drawings
Influence of the facial mask that Fig. 1 cerasus humilis juice contents are 2% to dermal melanin value
Influence of the facial mask that Fig. 2 cerasus humilis juice contents are 5% to dermal melanin value
Specific implementation mode
The preparation of 1 cerasus humilis juice of embodiment
Step a, sorting are squeezed the juice：After full ripe Europe plum fruit crusher in crushing, squeezed the juice using juice extractor；
Step b, refined filtration：By the fruit juice of step a multilayer filtered through gauze；
Step c, clarification：Fruit juice after refined filtration is placed on freezing clarification one week at 0 DEG C, refilters, obtains subsider juice；
Step e, sterilization cooling：It is taken out after 80 DEG C of sterilizations being put in autoclave after the sealing of subsider juice that step c is obtained 30 seconds,
It is cooled to 38 DEG C or less.
The measurement of 2 cerasus humilis juice physicochemical property of embodiment
To the pH value of cerasus humilis juice prepared by embodiment 1, soluble solid content, conductivity and high temperature, severe cold are ultraviolet
Stability under the conditions of line.
1 experimental method
1.1 cerasus humilis juice pH, soluble solid content, the measurement of conductivity
The measurement of pH value：It is measured with pH meter
The measurement of soluble solid content：With electronics soluble solid content instrument, Europe Lee under the conditions of 25 DEG C is measured
The soluble solid content of fruit juice
The measurement of conductivity：The conductivity of cerasus humilis juice under the conditions of 25 DEG C is measured with electronic conductivity instrument
1.2 cerasus humilis juice stability experiments
Cerasus humilis juice is measured in high temperature, whether severe cold, the stability under the conditions of ultraviolet light weighs its property with color change
It changes.Cerasus humilis juice color change situation is investigated using the method for absorbance change, and then evaluates its stability.Absorbance
Variation, which is investigated, selects 500nm to be measured.
1.2.1 hot conditions：5 test tubes are filled into 10g cerasus humilis juice samples respectively, are put into 45 DEG C of baking ovens, it is every to take out one for 24 hours
Branch, dark shady place storage, the 6h after taking out measure absorbance change situation.It is repeated 2 times.
1.2.2 severe cold condition：5 test tubes are filled into 10g cerasus humilis juice samples respectively, are put into -5 DEG C of refrigerators, it is every to take out one for 24 hours
Branch, dark shady place storage, the 6h after taking out measure absorbance change situation.It is repeated 2 times.
1.2.3 ultraviolet light condition：10g cerasus humilis juice samples are put into quartzy culture dish, the distance 30cm under 20w ultraviolet lamps
0.5h, 1h, 1.5h, 2h, 2.5h, 3h, 3.5h, 4h irradiation are carried out respectively, have been irradiated sample and have been packed into test tube, dark shady place is deposited
It puts, 6h is placed after all taking out, measure absorbance change situation.It is repeated 2 times.Sample is placed in quartzy culture dish by selection to carry out
It is impervious ultraviolet light that irradiation, which is because of common glass culture dish, but quartzy culture dish can penetrate ultraviolet light.
2 experimental results
The pH of 2.1 cerasus humilis juices, solid content, conductivity
By the pH that the measurement of each instrument obtains, soluble solid content, conductivity is as follows：
18 DEG C of cerasus humilis juice pH value are 3.56.
Soluble solid content is 11.3%.
Conductivity is 2620us/cm.
The stability of 2.2 cerasus humilis juices
2.2.1 the stability under hot conditions：Cerasus humilis juice is visually observed without apparent color change, measures absorbance change
Situation is as shown in table 1.
Absorbance change situation under 1 hot conditions of table
Table 1 shows cerasus humilis juice absorbance value variation range and the equal very little of change rate in 45 DEG C of baking oven 5d, therefore Ou Liguo
Juice property under 45 DEG C of hot conditions is stablized.
2.2.2 the stability under severe cold condition：Cerasus humilis juice is visually observed without apparent color change, measures absorbance change
Situation is as shown in table 2.
Absorbance change situation under 2 severe cold condition of table
Table 2 shows cerasus humilis juice absorbance value variation range and the equal very little of change rate under -5 DEG C of severe cold conditions, therefore Europe Lee
Fruit juice property under -5 DEG C of severe cold conditions is stablized.
2.2.3 the stability under ultraviolet light irradiation condition：Cerasus humilis juice is visually observed without apparent color change, measures extinction
It is as shown in table 3 to spend situation of change.
Absorbance change situation under the conditions of 3 ultraviolet light of table
Table 3 show the lengthening by ultraviolet irradiation time, cerasus humilis juice absorbance value variation range and change rate compared with
It is small, therefore cerasus humilis juice property under ultraviolet light irradiation is stablized.
To sum up, cerasus humilis juice property under high temperature, severe cold, ultraviolet irradiation is stablized, and is not easy to be influenced to generate by external condition
Phenomena such as precipitating, discoloration, aoxidizing, is rotten, so, cerasus humilis juice is applicable in the making and production of cosmetics.
The preparation of 3 Europe Lee's facial mask of embodiment
The preparation of 4 Europe Lee's facial mask of embodiment
Be formulated with embodiment 3 it is essentially identical, difference lies in cerasus humilis juice content be 2%.
The preparation of 5 Europe Lee's facial mask of embodiment
Be formulated with embodiment 3 it is essentially identical, difference lies in cerasus humilis juice content be 10%.
The preparation of 6 Europe Lee's facial mask of embodiment
Be formulated with embodiment 3 it is essentially identical, difference lies in cerasus humilis juice content be 15%.
The preparation of 7 Europe Lee's face paste of embodiment
Preparation process：
1, first, by 70% alcohol disinfecting of each production utensil and reaction kettle；
2, in B phases, Sodium Hyaluronate is dissolved in 1,3-BDO；
3, A phases, B phase each components are separately added into oil phase reaction kettle, 85 DEG C dissolved by heating stirring up to 25 minutes；
4,60 DEG C are cooled to, C phases are added and is quickly stirred, homogeneous 1-2 minutes or so vacuumizes, and stirs 5 minutes；
5,35 DEG C are cooled to, D phases are added and stir evenly；
6, shipment and (pay attention to disinfection) is filtered；
7,22 grams of face paste liquid is taken to be fitted into the face paste bag containing silk paper.
The preparation of 8 Europe Lee's ointment of embodiment
9 Europe Lee's facial mask anaphylaxis experiment of embodiment
Europe Lee's facial mask prepared by embodiment 3-6 is chosen respectively carries out human experimentation, the results showed that, when cerasus humilis juice content exists
Skin surface insentience is applied to when 5% or less；When cerasus humilis juice content is 15%, then to skin irritant, make office
Portion's skin have it is red, swell, itch, pain the phenomenon that.
The result shows that smearing the feeling for having refrigerant lubrication on the skin when cerasus humilis juice content is in 5%~10% range
And without other bad phenomenons.
10 Europe Lee's facial mask whitening effect experiment of embodiment
1 subject
1.1 selected condition：(1) Healthy Volunteers of the age between 18-60 Sui；(2) no active anaphylactia；
(3) previously to skin-care cosmetics without allergies person；(4) volunteer participates in and can empirically require to complete defined content.
1.2 number of subjects：Totally 12, boy student 6, schoolgirl 6, the age is at 20-30 Sui.
2 samples：Cerasus humilis juice facial mask (cerasus humilis juice content is respectively 2%, 5%) and do not add prepared by embodiment 3,4
Add the control facial mask of cerasus humilis juice (amount of cerasus humilis juice is supplemented with water, remaining ingredient is identical).
The smearing of 3 samples
The smearing of sample is responsible for by special messenger, and daily early, evening smears once, the data of acquisition in every 7 days, totally 14 days.
4 Mexameter18 erythema melanocyte measuring instrument gathered datas:One piece of skin is chosen in the side Medial upper arm of subject
The uniform skin of color, area about 4cm × 4cm apply cerasus humilis juice facial mask；Other side Medial upper arm applies control group facial mask.It will probe
It gently sets and is irradiated on selected skin, determine subject's bilateral upper arm skin melanin value.
5 melanin value measurement results
Dermal melanin value measurement result is shown in Table 4 and table 5, Fig. 1 and Fig. 2.The result shows that applying black after cerasus humilis juice facial mask
Plain value is reducing always, and when applying Europe Lee's facial mask the 14th day, the melanin value of 5% processing group of cerasus humilis juice is substantially less than control
Group, and difference is not notable between the melanin value and control group of 2% processing group of cerasus humilis juice.Dermal melanin value measurement result table
Bright, the facial mask of 5% content of cerasus humilis juice has white-skinned face function.
Table 4 applies dermal melanin value measurement result after 2% facial mask of cerasus humilis juice
| Apply the facial mask number day after tomorrow | Europe Lee's facial mask group | Control group |
| 0 | 173.8±8 | 175.2±9 |
| 7 | 170.5±6 | 171.2±11 |
| 14 | 168.7±7 | 184.5±9 |
Table 5 applies dermal melanin value measurement result after 5% facial mask of cerasus humilis juice
| Apply the facial mask number day after tomorrow | Europe Lee's facial mask group | Control group |
| 0 | 173.1±11 | 175.2±9 |
| 7 | 168.4±8 | 171.2±11 |
| 14 | 162.9±7 | 184.5±9* |
Note：* otherness level of signifiance P is indicated<0.05.
Claims (10)
1. application of the cerasus humilis juice in preparing external application there are the cosmetics or pharmaceutical preparation of whitening effect.
2. application as described in claim 1, which is characterized in that the cosmetics or preparation include facial mask, face paste, lotion, soft
Cream, emulsifiable paste.
3. application as described in claim 1, which is characterized in that the cerasus humilis juice prepared through squeezing process for Europe plum fruit and
At.
4. application as described in claim 1, which is characterized in that the cerasus humilis juice soluble solid content is 10%~
21%；It is further preferred that the cerasus humilis juice soluble solid content is 13%~17%.
5. a kind of Europe Lee facial mask, which is characterized in that the content of cerasus humilis juice is 5%~10% in the facial mask.
6. facial mask as claimed in claim 5, which is characterized in that the cerasus humilis juice soluble solid content be 13%~
17%.
7. facial mask as claimed in claim 5, which is characterized in that the cerasus humilis juice content is 5%~8%.
8. a kind of Europe Lee facial mask, which is characterized in that the supplementary material group of the facial mask becomes：Cerasus humilis juice 4%~10%, 1,3- fourth
Glycol 2%~6%, xanthan gum 0.2%~0.6%, dipotassium glycyrrhizinate 0.05%~0.2%, glycerine 1%~4%, allantoin
0.05%~0.2%, water-soluble jojoba oil 0.1%~0.5%, propylene glycol 0.3%~1%, excess water.
9. facial mask as claimed in claim 8, which is characterized in that the supplementary material group of the facial mask becomes：Cerasus humilis juice 4%~
8%, 1,3-BDO 3%~5%, xanthan gum 0.3%~0.5%, dipotassium glycyrrhizinate 0.08%~0.15%, glycerine 1%~
3%, allantoin 0.08%~0.15%, water-soluble jojoba oil 0.2%~0.4%, propylene glycol 0.4%~0.8%, surplus
Water.
10. facial mask as claimed in claim 8, which is characterized in that the supplementary material group of the facial mask becomes：Cerasus humilis juice 5%, 1,
3- butanediols 4%, xanthan gum 0.4%, dipotassium glycyrrhizinate 0.1%, glycerine 2%, allantoin 0.1%, water-soluble jojoba oil
0.3%, propylene glycol 0.5%, excess water.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710306230.4A CN108785156B (en) | 2017-05-04 | 2017-05-04 | New application of cerasus humilis juice |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710306230.4A CN108785156B (en) | 2017-05-04 | 2017-05-04 | New application of cerasus humilis juice |
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| Publication Number | Publication Date |
|---|---|
| CN108785156A true CN108785156A (en) | 2018-11-13 |
| CN108785156B CN108785156B (en) | 2021-07-23 |
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|---|---|---|---|
| CN201710306230.4A Active CN108785156B (en) | 2017-05-04 | 2017-05-04 | New application of cerasus humilis juice |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112316009A (en) * | 2020-12-02 | 2021-02-05 | 宁夏医科大学 | Application of cerasus humilis extract in preparation of antibacterial product |
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| CN100998433A (en) * | 2007-01-17 | 2007-07-18 | 北京市农林科学院 | Beverage contg. juice of cerasus humilis sok fruit and its preparing method |
| KR20120002870A (en) * | 2010-07-01 | 2012-01-09 | 주식회사 바이오랜드 | Composition for whitening and anti-aging comprising the extract of semen pruni humilis |
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2017
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| CN100998433A (en) * | 2007-01-17 | 2007-07-18 | 北京市农林科学院 | Beverage contg. juice of cerasus humilis sok fruit and its preparing method |
| KR20120002870A (en) * | 2010-07-01 | 2012-01-09 | 주식회사 바이오랜드 | Composition for whitening and anti-aging comprising the extract of semen pruni humilis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112316009A (en) * | 2020-12-02 | 2021-02-05 | 宁夏医科大学 | Application of cerasus humilis extract in preparation of antibacterial product |
| CN112316009B (en) * | 2020-12-02 | 2022-04-08 | 宁夏医科大学 | Application of cerasus humilis extract in preparation of antibacterial product |
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| CN108785156B (en) | 2021-07-23 |
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