CN1087828A - Achyranthes bidentata alcohol extract and the application in preventing and treating gastritis and gastric ulcer thereof - Google Patents
Achyranthes bidentata alcohol extract and the application in preventing and treating gastritis and gastric ulcer thereof Download PDFInfo
- Publication number
- CN1087828A CN1087828A CN 93117176 CN93117176A CN1087828A CN 1087828 A CN1087828 A CN 1087828A CN 93117176 CN93117176 CN 93117176 CN 93117176 A CN93117176 A CN 93117176A CN 1087828 A CN1087828 A CN 1087828A
- Authority
- CN
- China
- Prior art keywords
- alcohol extract
- achyranthes bidentata
- gastric ulcer
- extract
- extractum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 239000000284 extract Substances 0.000 title claims abstract description 18
- 208000007107 Stomach Ulcer Diseases 0.000 title claims abstract description 15
- 201000005917 gastric ulcer Diseases 0.000 title claims abstract description 15
- 240000000031 Achyranthes bidentata Species 0.000 title claims abstract description 10
- 208000007882 Gastritis Diseases 0.000 title claims abstract description 7
- 238000001556 precipitation Methods 0.000 claims abstract description 3
- 238000010992 reflux Methods 0.000 claims abstract 2
- 239000007788 liquid Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- DHHFDKNIEVKVKS-FMOSSLLZSA-N Betanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC(C[C@H]2C([O-])=O)=C1[N+]2=C\C=C\1C=C(C(O)=O)N[C@H](C(O)=O)C/1 DHHFDKNIEVKVKS-FMOSSLLZSA-N 0.000 claims description 2
- DHHFDKNIEVKVKS-MVUYWVKGSA-N Betanin Natural products O=C(O)[C@@H]1NC(C(=O)O)=C/C(=C\C=[N+]/2\[C@@H](C(=O)[O-])Cc3c\2cc(O)c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)c3)/C1 DHHFDKNIEVKVKS-MVUYWVKGSA-N 0.000 claims description 2
- 229920001131 Pulp (paper) Polymers 0.000 claims description 2
- 235000012677 beetroot red Nutrition 0.000 claims description 2
- 239000001654 beetroot red Substances 0.000 claims description 2
- 235000002185 betanin Nutrition 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 238000004321 preservation Methods 0.000 claims description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 2
- 229930182490 saponin Natural products 0.000 claims description 2
- 150000007949 saponins Chemical class 0.000 claims description 2
- 239000000469 ethanolic extract Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 238000004064 recycling Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 12
- 238000002360 preparation method Methods 0.000 abstract description 6
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 239000012669 liquid formulation Substances 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 102000057297 Pepsin A Human genes 0.000 description 3
- 108090000284 Pepsin A Proteins 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 229940111202 pepsin Drugs 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229960004756 ethanol Drugs 0.000 description 2
- 238000002481 ethanol extraction Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 241000427159 Achyranthes Species 0.000 description 1
- 208000012895 Gastric disease Diseases 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000003509 anti-fertility effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229940071462 oralone Drugs 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000018556 stomach disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A kind of Chinese medicine for the treatment of gastritis and Peptic Ulcers---achyranthes bidentata alcohol extract, with 50% ethanol through three reflux, extract,, filter, reclaim ethanol, be condensed into and add water-cooled behind the extractum and hide, again through the centrifugal precipitation of going, be concentrated into 1g/ml, become achyranthes bidentata alcohol extract, become oral liquid formulation after the fill sterilization, also can be made into other dosage form.This medicine preparation process is simple, taking dose is little, is used for the treatment of gastritis and gastric ulcer is safe and effective, has no side effect.
Description
The present invention relates to the medicinal plants Radix Achyranthis Bidentatae is the medicinal preparation of raw material.
Radix Achyranthis Bidentatae is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae (Achyranthes.bidentata Blume), Henan, the place of production.Nature and flavor acid is flat, goes into liver, kidney channel.Its effect: give birth to and stimulate the menstrual flow tire under the eliminating mass, easing joint movement, conducting blood to flow downwards with removing blood stasis; Ripe invigorating the liver and kidney, the strong waist knee joint used.According to the modern pharmacological research report, Radix Achyranthis Bidentatae has multiple pharmacological effect, as known its function of promoting blood circulation to disperse blood clots is arranged, and reduces whole blood viscosity, pain relieving, antiinflammatory, free radical resisting, blood sugar lowering, antifertility, protein assimilation etc., but this medicine of Shang Weiyou has the research report of anti-gastric-ulcer effect.
The existing Chinese medicine that is used for the treatment of gastritis and gastric ulcer mostly is that dosage is big by the compound preparation of kinds of traditional Chinese medicines prescription, and brings drug purchase, and prescription is concocted, the complexity of fried work, and quality is also wayward.Simultaneously, the existing Chinese medicine taking dose of controlling gastric ulcer is bigger.
The object of the present invention is to provide a kind of achyranthes bidentata alcohol extract, this medicine is made of the Radix Achyranthis Bidentatae folk prescription, and dosage is little, makes the preparation of pharmaceutical work and preparation process more more simple than herbal mixture.In the various gastric ulcers of treatment, littler than Chinese traditional compound medicine dosage, and safe and effective, have no side effect.
This Radix Achyranthis Bidentatae ethanol extraction is produced like this:
The Radix Achyranthis Bidentatae decoction pieces is extracted each 1 hour three times with 50% ethanol, four streams; With three extracting liquid filterings and after merging, place about 24 hours the reuse paper pulp filtering at ambient temperature; Be condensed into extractum (1g extractum ≈ 0.5ml) with four receipts of ethanol in this filtrate and with medicinal liquid; Extractum is added 10 times of water gaging cold preservations (below 10 ℃) 24 hours; Become clear liquor through the centrifugal precipitation of going again, reconcentration is 1g/ml, becomes achyranthes bidentata alcohol extract, and its active ingredient is that total Saponin, betanin (0.7%) etc. can become oral liquid formulation through the embedding sterilization, also can add adjuvant or not add adjuvant granulation agent, tablet etc.
This Radix Achyranthis Bidentatae ethanol extraction is a kind of single medicinal material preparation, only needs a kind of medical material when pharmacy, and the work of purchasing, get the raw materials ready is very simple and clear, time saving and energy saving, does not have the weight proportion problem between the various medical materials, not only saves trouble but also error can not take place.Be easy to produce, quality controllability is difficult for taking place quality problems by force.Though this medicine is a single medicinal material, itself have blood circulation promoting and blood stasis dispelling, the multiple gastric ulcer factor that causes of antagonism, suppress pepsin activity, anti-inflammatory analgesic promotes multiple effects such as gastrointestinal peristalsis, thereby has and suppress from many aspects and resist the effect that causes the ulcer factor.In addition, it also has the effect of tonification liver, kidney, and health is had no adverse effects.To treatment gastritis, gastric ulcer safety, effectively, have no side effect, and littler than Chinese traditional compound medicine taking dose.
The effect of achyranthes bidentata alcohol extract treatment gastropathy can be by finding out in the following animal experiment:
(1) to the anti-effect of giving of acute gastric ulcer
1, to rat water logging irritability stomach infections, achyranthes bidentata alcohol extract has shown obvious antagonism at 10g/Kg, 5g/kg dosage, is dose-effect relationship.
2, to rat pylorus ligation gastric ulcer, this medicine shows obvious antagonism at 10g/Kg, 5g/kg dosage.
(2) to the therapeutical effect of chronic gastric ulcer.
Radix Achyranthis Bidentatae extract 5g/kg, 1.25g/kg, dosage, successive administration 11 days, can make 36% acetic acid burn due to the rat gastric ulcer area obviously reduce, statistical significance is arranged.
(3) to drug-induced gastric ulcer or mucosa injury model.
The Radix Achyranthis Bidentatae extract is at 5g/kg, and following dosage can resist rat gastric ulcer due to 0.6N hydrochloric acid and the dehydrated alcohol very significantly, and obvious dose-effect relationship is arranged.
(4) the gastrointestinal motility function there is remarkable facilitation
The Radix Achyranthis Bidentatae extract has remarkable promotion mice enterokinesia effect at 10g/Kg, 5g/kg.
(5) pepsin activity there is inhibitory action
Measure pepsin activity with Mett capillary wave duct method, Radix Achyranthis Bidentatae extract 10g/Kg has with remarkable inhibitory action pylorus ligation rat stomach liquid eggs Fructus Armeniacae Mume activity.
(6) function of promoting blood circulation to disperse blood clots
The Radix Achyranthis Bidentatae extract has reduction effect (10g/Kg * 20d) to the rat whole blood viscosity.
(7) antiinflammatory, analgesic activity
The Radix Achyranthis Bidentatae extract suppresses inflammatory granuloma propagation, suppresses the mouse writhing reaction that acetic acid causes.
Three, safety research
(1) acute toxicity
Radix Achyranthis Bidentatae was administered three times each 4 hours at interval to mice in oral one day, and LDSO is 66.8g/kg(73.8-60.5) 95% credibility interval.
(2) long term toxicity
Radix Achyranthis Bidentatae was to the oral successive administration of rat two months, and maximal dose is 20g/kg, does not see obvious toxicity, side effect.
Claims (2)
1, achyranthes bidentata alcohol extract is characterized in that it is produced by following method: Radix Achyranthis Bidentatae is returned alcohol reflux with 50% ethanol extract each 1 hour three times; With three extracting liquid filterings and after merging, place about 24 hours the reuse paper pulp filtering at ambient temperature; Be condensed into extractum (1g extractum ≈ 0.5ml) with this filtrate recycling ethanol and with medicinal liquid; Extractum is added 10 times of water gaging cold preservations (below 10 ℃) 24 hours; Become clear liquor through the centrifugal precipitation of going again, reconcentration is 1g/ml, becomes achyranthes bidentata alcohol extract.Its effective ingredient is total Saponin and betanin (0.7%) etc.
2, achyranthes bidentata alcohol extract as claimed in claim 1 is characterized in that this product is applied to treat gastritis and gastric ulcer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93117176A CN1049343C (en) | 1993-09-15 | 1993-09-15 | Achyranthes bidentata alcohol extract and application in preventing and treating gastritis and gastric ulcer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93117176A CN1049343C (en) | 1993-09-15 | 1993-09-15 | Achyranthes bidentata alcohol extract and application in preventing and treating gastritis and gastric ulcer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1087828A true CN1087828A (en) | 1994-06-15 |
| CN1049343C CN1049343C (en) | 2000-02-16 |
Family
ID=4991906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93117176A Expired - Fee Related CN1049343C (en) | 1993-09-15 | 1993-09-15 | Achyranthes bidentata alcohol extract and application in preventing and treating gastritis and gastric ulcer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1049343C (en) |
-
1993
- 1993-09-15 CN CN93117176A patent/CN1049343C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1049343C (en) | 2000-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101040950B (en) | Method of preparing compound Houttuynia cordata dropping pills | |
| CN1079152A (en) | Preparation method of quick-acting bone injury medicine | |
| CN1927351A (en) | Heat clearing and detoxicating drug for abating fever | |
| CN1049343C (en) | Achyranthes bidentata alcohol extract and application in preventing and treating gastritis and gastric ulcer | |
| CN111097029A (en) | Health care product for assisting gout and preparation method thereof | |
| CN1300164C (en) | Method for extracting vitexin, use and preparation | |
| CN113769030A (en) | Chinese herbal medicine capable of preventing gout and preparation method thereof | |
| CN1218726C (en) | Heat-clearing and stagnation-dissipating particle medicine and preparation method | |
| CN106075229A (en) | A kind of Chinese medicinal composition preparation treating anemopyretic cold | |
| CN1080175A (en) | The manufacture method of changweikang granule | |
| CN104548033A (en) | Copperleaf-herb traditional Chinese medicine preparation for treatment of enteritis and preparation method thereof | |
| CN1104253C (en) | Medicine for strengthening physique and strengthening immunity | |
| CN1237973C (en) | Chronic bronchitis treating traditional Chinese medicine | |
| CN112641884B (en) | Composition for repairing gastric mucosa and improving gastric motility and preparation method thereof | |
| CN116870076B (en) | Anti-inflammatory analgesic traditional Chinese medicine composition and preparation method and application thereof | |
| CN1101205C (en) | Natural herbal medicine composition with the functions of stopping itching, disinfection and antiphlogosis and its preparation | |
| CN1199662C (en) | Medicine for curing peptic ulcer and its preparation method | |
| CN1319562C (en) | Disinfectant bactericidal Chinese medicine preparation and producing process thereof | |
| CN100372546C (en) | Chinese medicinal preparation for treating prostatitis and its preparation method | |
| CN1124142C (en) | Compound Chinese medicinal preparation for treating affection of exogenous wind-heat and production method thereof | |
| CN1429596A (en) | Manufacturing process of Rujietai preparation | |
| CN1256125C (en) | Medicine for treating acute and chronic tonsillitis | |
| CN1025109C (en) | Process for preparing injection of bitter cassia holo-element | |
| CN105982974A (en) | Traditional Chinese medicine pill for treating gout | |
| RU2026077C1 (en) | Method for preparation of extract of elecampane |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| C10 | Entry into substantive examination | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |