CN1049343C - Achyranthes bidentata alcohol extract and application in preventing and treating gastritis and gastric ulcer - Google Patents
Achyranthes bidentata alcohol extract and application in preventing and treating gastritis and gastric ulcer Download PDFInfo
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- CN1049343C CN1049343C CN93117176A CN93117176A CN1049343C CN 1049343 C CN1049343 C CN 1049343C CN 93117176 A CN93117176 A CN 93117176A CN 93117176 A CN93117176 A CN 93117176A CN 1049343 C CN1049343 C CN 1049343C
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- gastric ulcer
- radix achyranthis
- achyranthis bidentatae
- alcohol extract
- achyranthes bidentata
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Abstract
The present invention relates to a radix achyranthis bidentatae ethanol extractive which belongs to traditional Chinese medicine for treating gastritis and ulcers. The present invention is prepared by the following steps: firstly, ethanol at the concentration of 50% is extracted by reflux for three times and is then filtered for ethanol recovery, and water is added into an extract formed by concentration for refrigerated storage; secondly, precipitates are further removed by centrifugation and is concentrated to 1 g/ml so as to form the radix achyranthis bidentatae ethanol extractive which can be prepared into an oral taking liquid type formulation or other formulations after being filled and sterilized. The medicine has the advantages of simple and easy implemented preparation technology and small administration dosage, and can be used for treating the gastritis and gastric ulcer with the effects of safety, effectiveness and no toxicity or side effects.
Description
The present invention relates to the medicinal plants Radix Achyranthis Bidentatae is the medicinal preparation of raw material.
Radix Achyranthis Bidentatae is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae (Achyranthes.bidentata Blume), Henan, the place of production.Nature and flavor acid is flat, goes into liver, kidney channel.Its effect: give birth to and stimulate the menstrual flow tire under the eliminating mass, easing joint movement, conducting blood to flow downwards with removing blood stasis; Ripe invigorating the liver and kidney, the strong waist knee joint used.According to the modern pharmacological research report, Radix Achyranthis Bidentatae has multiple pharmacological effect, as known its function of promoting blood circulation to disperse blood clots is arranged, and reduces whole blood viscosity, pain relieving, antiinflammatory, free radical resisting, blood sugar lowering, antifertility, protein assimilation etc., but this medicine of Shang Weiyou has the research report of anti-gastric-ulcer effect.
The existing Chinese medicine that is used for the treatment of gastritis and gastric ulcer mostly is that dosage is big by the compound preparation of kinds of traditional Chinese medicines prescription, and brings drug purchase, and prescription is concocted, the complexity of fried work, and quality is also wayward.Simultaneously, the existing Chinese medicine taking dose of controlling gastric ulcer is bigger.
The object of the present invention is to provide a kind of achyranthes bidentata alcohol extract, this medicine is made of the Radix Achyranthis Bidentatae folk prescription, and dosage is little, makes the preparation of pharmaceutical work and preparation process more more simple than herbal mixture.In the various gastric ulcers of treatment, littler than Chinese traditional compound medicine dosage, and safe and effective, have no side effect.
This Radix Achyranthis Bidentatae ethanol extraction is produced like this:
With the Radix Achyranthis Bidentatae decoction pieces with 50% alcohol reflux three times, each 1 hour; With three extracting liquid filterings and after merging, place about 24 hours the reuse paper pulp filtering at ambient temperature; Ethanol in this filtrate reclaimed and medicinal liquid is condensed into extractum make 1g extractum ≈ 0.5ml; Extractum is added 10 times of water gaging cold preservations at below 10 ℃ 24 hours; Become clear liquor through the centrifugal precipitation of going again, reconcentration is 1g/ml, becomes achyranthes bidentata alcohol extract, and its active ingredient is that total Saponin, betanin (0.7%) etc. can become oral liquid formulation through the embedding sterilization, also can add adjuvant or not add adjuvant granulation agent, tablet etc.
This Radix Achyranthis Bidentatae ethanol extraction is a kind of single medicinal material preparation, only needs a kind of medical material when pharmacy, and the work of purchasing, get the raw materials ready is very simple and clear, time saving and energy saving, does not have the weight proportion problem between the various medical materials, not only saves trouble but also error can not take place.Be easy to produce, quality controllability is difficult for taking place quality problems by force.Though this medicine is a single medicinal material, itself have blood circulation promoting and blood stasis dispelling, the multiple gastric ulcer factor that causes of antagonism, suppress pepsin activity, anti-inflammatory analgesic promotes multiple effects such as gastrointestinal peristalsis, thereby has and suppress from many aspects and resist the effect that causes the ulcer factor.In addition, it also has the effect of tonification liver, kidney, and health is had no adverse effects.To treatment gastritis, gastric ulcer safety, effectively, have no side effect, and littler than Chinese traditional compound medicine taking dose.
The effect of achyranthes bidentata alcohol extract treatment gastropathy can be by finding out in the following animal experiment:
(1) to the anti-effect of giving of acute gastric ulcer
1, to rat water logging stress gastric ulcer, achyranthes bidentata alcohol extract has shown obvious antagonism at 10g/Kg, 5g/kg dosage, is dose-effect relationship.
2, to rat pylorus ligation gastric ulcer, this medicine shows obvious antagonism at 10g/Kg, 5g/kg dosage.
(2) to the therapeutical effect of chronic gastric ulcer.
Radix Achyranthis Bidentatae extract 5g/kg, 1.25g/Kg, dosage, successive administration 11 days, can make 36% acetic acid burn due to the rat gastric ulcer area obviously reduce, statistical significance is arranged.
(3) to drug-induced gastric ulcer or mucosa injury model.
The Radix Achyranthis Bidentatae extract is at 5g/kg, and following dosage can resist rat gastric ulcer due to 0.6N hydrochloric acid and the dehydrated alcohol very significantly, and obvious dose-effect relationship is arranged.
(4) the gastrointestinal motility function there is remarkable facilitation
The Radix Achyranthis Bidentatae extract has remarkable promotion mice enterokinesia effect at 10g/Kg, 5g/kg.
(5) pepsin activity there is inhibitory action
Measure pepsin activity with Mett capillary wave duct method, Radix Achyranthis Bidentatae extract 10g/Kg has with remarkable inhibitory action pylorus ligation rat stomach liquid eggs Fructus Armeniacae Mume activity.
(6) function of promoting blood circulation to disperse blood clots
The Radix Achyranthis Bidentatae extract has reduction effect (10g/Kg * 20d) to the rat whole blood viscosity.
(7) antiinflammatory, analgesic activity
The Radix Achyranthis Bidentatae extract suppresses inflammatory granuloma propagation, suppresses the mouse writhing reaction that acetic acid causes.
Three, safety research
(1) acute toxicity
Radix Achyranthis Bidentatae was administered three times each 4 hours at interval to mice in oral one day, and LDSO is 66.8g/kg (73.8-60.5) 95% credibility interval.
(2) long term toxicity
Radix Achyranthis Bidentatae was to the oral successive administration of rat two months, and maximal dose is 20g/kg, does not see obvious toxicity, side effect.
Claims (1)
1, a kind of achyranthes bidentata alcohol extract for the treatment of gastritis and gastric ulcer, it is characterized in that: it is produced by following method: with Radix Achyranthis Bidentatae with 50% alcohol reflux three times, each 1 hour; With three extracting liquid filterings and after merging, place about 24 hours the reuse paper pulp filtering at ambient temperature; Be condensed into extractum with this filtrate recycling ethanol and with medicinal liquid, 1g extractum ≈ 0.5ml; Extractum is added 10 times of water gaging cold preservations at below 10 ℃ 24 hours; Become clear liquor through the centrifugal precipitation of going again, reconcentration is 1g/ml, becomes achyranthes bidentata alcohol extract, and its effective ingredient is total Saponin and betanin 0.7%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93117176A CN1049343C (en) | 1993-09-15 | 1993-09-15 | Achyranthes bidentata alcohol extract and application in preventing and treating gastritis and gastric ulcer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93117176A CN1049343C (en) | 1993-09-15 | 1993-09-15 | Achyranthes bidentata alcohol extract and application in preventing and treating gastritis and gastric ulcer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1087828A CN1087828A (en) | 1994-06-15 |
| CN1049343C true CN1049343C (en) | 2000-02-16 |
Family
ID=4991906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93117176A Expired - Fee Related CN1049343C (en) | 1993-09-15 | 1993-09-15 | Achyranthes bidentata alcohol extract and application in preventing and treating gastritis and gastric ulcer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1049343C (en) |
-
1993
- 1993-09-15 CN CN93117176A patent/CN1049343C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 吉林中医药 1983.4.1 梁福瑞，验方选登 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1087828A (en) | 1994-06-15 |
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